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中医综合护理干预对腰椎间盘突出症患者术后疼痛和睡眠质量的影响

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中西医结合护理（中英文） 2019年第10期5卷 53-55页

作者：朱凤祥朱洪英于红霞宋嘉琳赵红君颜晶邵海燕山东省文登整骨医院脊柱脊髓科山东威海264400 山东省文登整骨医院护理部山东威海264400

目的探讨中医综合护理干预对腰椎间盘突出症患者术后疼痛和睡眠质量的影响。方法选取2016年1月—2018年12月收治的行手术治疗的腰椎间盘突出症患者306例,随机分为观察组和对照组,各153例。对照组常规护理,观察组在对照组基础上给予中医... 详细信息

目的探讨中医综合护理干预对腰椎间盘突出症患者术后疼痛和睡眠质量的影响。方法选取2016年1月—2018年12月收治的行手术治疗的腰椎间盘突出症患者306例,随机分为观察组和对照组,各153例。对照组常规护理,观察组在对照组基础上给予中医综合护理干预。对比2组干预前、干预后睡眠质量和疼痛情况。结果干预后,2组阿森斯失眠量表(AIS)和疼痛数字分级评分法(NRS)评分均降低,且观察组AIS和NRS评分低于对照组,差异有统计学意义(P<0.05)。结论中医综合护理技术可以减轻腰椎间盘突出症患者术后疼痛,改善其睡眠的质量。

关键词：腰椎间盘突出症疼痛睡眠质量艾灸中西医结合护理

On-tissue chemical derivatization enables spatiotemporal heterogeneity visualization of oxylipins in esophageal cancer xenograft via ambient mass spectrometry imaging

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Chinese Chemical Letters 2023年第11期34卷 238-242页

作者： jialin Liu Qingce Zang Xinzhu Li Xinyi Tu Ying Zhu Lingzhi Wang Zitong Zhao Yongmei song Ruiping Zhang Zeper Abliz State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China State Key Laboratory of Molecular Oncology Cancer InstituteCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Mass Spectrometry Imaging and Metabolomics(Minzu University of China) National Ethnic Affairs CommissionBeijing 100081China Center for Imaging and Systems Biology College of Life and Environmental SciencesMinzu University of ChinaBeijing 100081China

On-tissue chemical derivatization(OTCD)effectively enhances ionization efficiency of low abundant and poorly ionized functional molecules to improve detection sensitivity and coverage of mass spectrometry imaging(MSI).Combination OTCD and MSI provides a novel strategy for visualizing previously undisclosed metabolic heterogeneity in ***,we present a method to visualize heterogeneous metabolism of oxylipins within tumor by coupling OTCD with airflow-assisted desorption electrospray ionization(AFADESI)-*** Girard’s P as a derivatization reagent,easily ionized hydrazide and quaternary amine groups were introduced into the structure of carbonyl metabolites via condensation ***,including 127 fatty aldehydes(FALs)and 71 oxo fatty acids(FAs),were detected and imaged in esophageal cancer xenograft with AFADESI-MSI after *** t-distributed stochastic neighbor embedding and random forest were exploited to precisely locate the distribution of oxylipins in heterogeneous tumor *** this method,we surprisingly found almost all FALs and oxo FAs significantly accumulated in the core region of tumor,and exhibited a gradual increase trend in tumor over *** results reveal spatiotemporal heterogeneity of oxylipins in tumor progression,highlighting the value of OTCD combined with MSI to gain deeper insights into understanding tumor metabolism.

关键词： On-tissue chemical derivatization Ambient mass spectrometry imaging Oxylipins Esophageal cancer Metabolic heterogeneity

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啤酒相关微生物对异构啤酒花提取物的耐受性

酿酒 2022年第5期49卷 73-77页

作者：王啸尘牟宏孙少康刘津尚徐恒远王玉宋家麟聂聪张浩军齐鲁工业大学(山东省科学院)生物工程学院山东济南250353

实验研究了三种市售异构酒花提取物对酿造相关微生物的生长抑制作用及对啤酒稳定性的影响。结果表明,异构酒花提取物对啤酒酿造有害微生物均有抑制作用,但对酿酒酵母影响较小,且其抗菌能力为六氢异α-酸>二氢异α-酸>四氢异α-酸。在后... 详细信息

实验研究了三种市售异构酒花提取物对酿造相关微生物的生长抑制作用及对啤酒稳定性的影响。结果表明,异构酒花提取物对啤酒酿造有害微生物均有抑制作用,但对酿酒酵母影响较小,且其抗菌能力为六氢异α-酸>二氢异α-酸>四氢异α-酸。在后续的模拟酿造试验中,我们发现其不仅能防止啤酒变质,还能够提高泡持性,增强非生物成分的稳定性。

关键词：异构酒花提取物抑菌作用酿造有害微生物非生物成分

Frontiers of CO_(2)Capture and Utilization(CCU)towards Carbon Neutrality

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Advances in Atmospheric Sciences 2022年第8期39卷 1252-1270页

作者： Lingyun ZHANG Yanfang song jialin SHI Qun SHEN Deng HU Qiang GAO Wei CHEN Kien-Woh KOW Chengheng PANG Nannan SUN Wei WEI CAS Key Laboratory of Low-Carbon Conversion Science&Engineering Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Department of Chemical and Environmental Engineering Faculty of Science and EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100China Key Laboratory for Carbonaceous Wastes Processing and Process Intensification Research of Zhejiang Province University of Nottingham Ningbo ChinaNingbo 315100China New Materials Institute the University of Nottingham Ningbo ChinaNingbo 315100China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China

CO_(2)capture,utilization,and storage(CCUS)technology is a rare option for the large-scale use of fossil fuels in a low-carbon way,which will definitely play a part in the journey towards carbon *** the CCUS nexus,CCU is especially interesting because these processes will establish a new“atmosphere-to-atmosphere”carbon cycle and thus indirectly offer huge potential in carbon *** study focuses on the new positioning of CCUS in the carbon neutrality scenario and aims to identify potential cutting-edge/disruptive CCU technologies that may find important application opportunities during the decarbonization of the energy and industrial *** this end,direct air capture(DAC),flexible metal-framework materials(MOFs)for CO_(2)capture,integrated CO_(2)capture and conversion(ICCC),and electrocatalytic CO_(2)reduction(ECR)were selected,and their general introduction,the importance to carbon neutrality,and most up-to-date research progress are summarized.

关键词： carbon neutrality carbon reduction decarbonization CO_(2) CCU

Building stabilized Cu_(0.17)Mn_(0.03)V_(2)O_(5−□)·2.16H_(2)O cathode enables an outstanding room‐/low‐temperature aqueous Zn‐ion batteries

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Carbon Energy 2024年第8期6卷 25-35页

作者： Ao Wang Dai‐Huo Liu Lin Yang Fang Xu Dan Luo Haozhen Dou Mengqin song Chunyan Xu Beinuo Zhang jialin Zheng Zhongwei Chen Zhengyu Bai Key Laboratory of Green Chemical Media and Reactions Ministry of EducationCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenanChina The State Key Laboratory of Catalysis(SKLC) Power Battery and System Research CenterDalian Institute of Chemical PhysicsChinese Academy of SciencesDalianChina

Vanadium oxide cathode materials with stable crystal structure and fast Zn^(2+) storage capabilities are extremely important to achieving outstanding electrochemical performance in aqueous zinc‐ion *** this work,a one‐step hydrothermal method was used to manipulate the bimetallic ion intercalation into the interlayer of vanadium *** pre‐intercalated Cu ions act as pillars to pin the vanadium oxide(V‐O)layers,establishing stabilized two‐dimensional channels for fast Zn^(2+) *** occupation of Mn ions between V‐O interlayer further expands the layer spacing and increases the concentration of oxygen defects(Od),which boosts the Zn^(2+) diffusion *** a result,as‐prepared Cu_(0.17)Mn_(0.03)V_(2)O_(5−□)·2.16H_(2)O cathode shows outstanding Zn‐storage capabilities under room‐and lowtemperature environments(e.g.,440.3 mAh g^(−1) at room temperature and 294.3 mAh g^(−1)at−60°C).Importantly,it shows a long cycling life and high capacity retention of 93.4%over 2500 cycles at 2 A g^(−1) at−60°***,the reversible intercalation chemistry mechanisms during discharging/charging processes were revealed via operando X‐ray powder diffraction and ex situ Raman *** strategy of a couple of 3d transition metal doping provides a solution for the development of superior room‐/lowtemperature vanadium‐based cathode materials.

关键词： aqueous zinc‐ion batteries Cu_(0.17)Mn_(0.03)V_(2)O_(5−□)·2.16H_(2)O oxygen defects room‐/lowtemperature performance stabilized nanostructure

Geochemical characteristics and environmental implications of loess sequences in the Loess Plateau

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High Technology Letters 2024年第3期30卷 310-321页

作者： ZHANG jialin ZHAO Zhongqiang XIA Dinghong LI Zhenyang ZENG Liyuan HE Hongming song Yinxian CHEN Zhong School of Land and Resources Engineering Kunming University of Science and TechnologyKunming 650093P.R.China Key Laboratory of Geological Disaster Prediction and Early Warning and Ecological Protection and Restoration of Plateau Mountain Ministry of Natural ResourcesKunming 650093P.R.China Yunnan Key Laboratory of Geological Disaster Prediction and Warning and Ecological Protection and Restoration of Plateau and Mountain Kunming 650093P.R.China School of Geographical Sciences East China Normal UniversityShanghai 200241P.R.China Institute of Soil and Water Conservation Ministry of Water ResourcesChinese Academy of SciencesYangling 712100P.R.China

The major,trace,and rare earth elements of the Duanjiapo(DJP)section in the south of the Loess Plateau,the Jiaxian(JX)section in the north,and the Jiuzhoutai(JZT)section in the west are *** results show that the main elemental characteristics of loess in three profiles are consistent with the upper continental crust(UCC).In terms of trace elements,Th,Nb,Zr,Hf,Y,Cs,W,Cr,V,Li,and Pb show relative enrichment compared with UCC;Rb,Ba,Sr and Be exhibit relative *** average ofΣREE is 171.91ppm with a negative anomaly forδEu and essentially no anomaly forδ*** results of K_(2)O/Na_(2)O,Rb/Sr ratios,as well as the leaching co-efficient from three profiles,indicate DJP>JX>JZT,suggesting that DJP experiences the strongest weathering leaching *** chemical index of alteration(CIA)reveals that all three profiles of loess are in the primary stage of Ca and Na *** is generally in the early to moderate stage of chemical weathering,while JX and JZT are both in the early stage.

关键词： loess chemical weathering element geochemistry chemical index of alteration(CIA)

Effects of dietary supplementation of Lactobacillus plantarum and Bacillus subtilis on growth performance,survival,immune response,antioxidant capacity and digestive enzyme activity in olive flounder(Paralichthys olivaceus)

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Aquaculture and Fisheries 2021年第3期6卷 283-288页

作者： Yangzhen Li Yingming Yang Limin song jialin Wang Yuanri Hu Qian Yang Peng Cheng Jianhai Li Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences(CAFS)Laboratory for Marine Fisheries Science and Food Production ProcessesPilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao266071China Tianjin Fisheries Research Institute Tianjin300221China Sangtong Bio-engineering(Weifang)CO.Ltd Weifang261210China

In present study,a 10-month feeding trial was carried out to investigate effects of dietary Lactobacillus plantarum and Bacillus subtilis supplementation singly on growth performance,innate immune response,antioxidant capacity and digestive enzyme activity of olive flounder under a commercial production *** experimental groups fed basal diet with supplementation of ***(5.0×107 CFU/g diet)and ***(1.0×108 CFU/g diet)respectively,and control group fed with basal diet without probiotics *** harvest,serum immune parameters,liver antioxidant indices and digestive enzyme activities in liver,stomach and intestines were *** fed with *** supplemented diet showed the highest growth rate which was significantly higher than *** supplemented group(P<0.05)which was also significantly higher than control group(P<0.05).Survival rate were significantly elevated by feeding diet with *** supplementation(P<0.05),while the improvement was not significant for *** supplemented diet compared to control *** the studied immune parameters in serum were substantially enhanced in both experimental *** results were observed for the antioxidant capacity in ***,the activities of digestive enzymes increased substantially in both experimental groups compared to control group and the detected improvement in dietary *** supplemented group were all higher than in *** supplemented group,though not all the improvements were *** summary,the separate supplementation of *** and *** in diet is more beneficial for growth performance and healthy status ***,in olive flounder aquaculture,favorable effects of compounded supplementation of *** and *** are expected.

关键词： Antioxidant capacity Digestive enzyme Growth performance Immune response Olive flounder Probiotics

MicroRNA-188-5p targeting Forkhead Box L1 promotes colorectal cancer progression via activating Wnt/β-catenin signaling

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Oncology Research 2021年第2期29卷 119-128页

作者： jialin WU ZEHONG CHEN WENWEI LIU YONGXIN ZHANG WEI FENG YUJIE YUAN JINNING YE LIANG WANG SHIRONG CAI YULONG HE SUIJING WU WU song Center of Gastrointestinal Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Hepatobiliary and Pancreatic Surgery Union Shenzhen HospitalHuazhong University of Science and TechnologyShenzhenChina Department of Gastrointestinal Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Hematology Guangdong General HospitalGuangzhouChina

Objective:MicroRNA-188-5p(miR-188)enhances oncologic progression in various human *** study aimed to explore its role in colorectal cancer(CRC).Materials and Methods:Human CRC tissues paired with normal tissues,and several CRC cell lines were ***-time quantitative PCR was applied to measure the expression of *** and knockdown were used to access the function of miR-188 and to investigate whether FOXL1/Wnt signaling mediates such *** proliferation,migration and invasion of cancer cells were evaluated by CCK8,wound-healing and transwell assays,*** FOXL1 acted as a direct target of miR-188 was verified by dual-luciferase reporter ***:Levels of miR-188 were upregulated in CRC tissues than in paired-normal tissues,as well as in various CRC cell *** expression of miR-188 was strongly associated with advanced tumor stage,accompanied with significant tumor cell proliferation,invasion and *** was confirmed that FOXL1 played positive crosstalk between miR-188 regulation and downstream Wnt/β-catenin signaling ***:All findings indicate that miR-188 promotes CRC cell proliferation and invasion through targeting FOXL1/Wnt signaling and could be served as a potential therapeutic target for human CRC in the future.

关键词： miR-188 Colorectal adenocarcinoma Oncogenesis Oncologic progression Wnt signaling

Wenjing Zhitong recipe exhibits potential anti-primary dysmenorrhea properties by inhibiting COX2 and PKC signaling pathway in rats induced by estradiol benzoate and oxytocin

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Journal of Traditional Chinese Medical Sciences 2023年第3期10卷 296-309页

作者： jialin Li Xiaoyao Liu Mei Jiang Yantong Xu Chunguo Wang Yujie Hu song Yang Jian Gao Weiling Wang Ting Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China Beijing Research Institute of Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China Key Laboratory of Famous Doctors and Famous Prescriptions State Administration of Traditional Chinese MedicineBeijing 100020China

Objective:To explore the effect and mechanism of action of the Wenjing Zhitong recipe(WZR)in primary dysmenorrhea(PD)***:Uterine contractions were induced by estradiol benzoate and oxytocin in a PD model and WZR was *** rate of change in uterine contractility and the writhing test were used to evaluate the effects of *** serum levels of prostaglandin F_(2a)(PGF_(2a))and prostaglandin E_2(PGE_2),and the activity of cyclooxygenase-2(COX2)were detected by enzyme-linked immunosorbent assay(ELISA).The changes in phosphor-phospholipase C(pPLC/PLC),phosphor-protein kinase C(pPKC/PKC),and connexin 43(CX43)expression were detected using immunohistochemistry and western ***:WZR significantly reduced the rate of change in uterine contractility and writhing times in the PD *** treatment inhibited the enzymatic activity of COX2 and reduced the levels of PGF_(2a),PGF_(2a)/PGE2and COX2 in the PD *** also significantly reduced the expression of pPLC/PLC,pPKC/PKC and *** the inhibition of COX2 activity,caffeic acid and 1-acetyl-β-carboline were validated as the active ingredients in WZR responsible for reducing uterine ***:WZR attenuated PD by inhibiting COX2 activity,downregulating PGF_(2a)/PGE_2 expression,and inhibiting the PKC signaling pathway.

关键词： Wenjing zhitong recipe Primary dysmenorrhea Network pharmacology PGF2a PKC system