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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi jiali song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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Arabidopsis PRK6 interacts specifically with AtRopGEF8/12 and induces depolarized growth of pollen tubes when overexpressed

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Science China(Life Sciences) 2018年第1期61卷 100-112页

作者： Yuexuan Yu jiali song Xiaohui Tian Haiwen Zhang Legong Li Huifen Zhu College of Life Sciences Capital Normal University

The pollen receptor kinases (PRK) are critical regulators of pollen tube growth. The Arabidopsis genome encodes eight PRK genes, of which six are highly expressed in pollen tubes. The potential functions of AtPRK1 through AtPRK5, but not of AtPRK6,in pollen growth were analyzed in tobacco. Herein, AtPRK6 was cloned, and its function was identified. AtPRK6 was expressed specifically in pollen tubes. A yeast two-hybrid screen of AtPRK6 against 14 Arabidopsis Rop guanine nucleotide exchange factors (RopGEFs) showed that AtPRK6 interacted with AtRopGEF8 and AtRopGEF12. These interactions were confirmed in Arabidopsis mesophyll protoplasts. The interactions between AtPRK6 and AtRopGEF8/12 were mediated by the C-termini of AtRopGEF8/12 and by the juxtamembrane and kinase domain of AtPRK6, but were not dependent on the kinase activity. In addition, transient overexpression of AtPRK6::GFP in Arabidopsis protoplasts revealed that AtPRK6 was localized to the plasma membrane. Tobacco pollen tubes overexpressing AtPRK6 exhibited shorter tubes with enlarged tips. This depolarized tube growth required the kinase domain of AtPRK6 and was not dependent on kinase activity. Taken together, the results show that AtPRK6,through its juxtamembrane and kinase domains (KD), interacts with AtRopGEF8/12 and plays crucial roles in polarized growth of pollen tubes.

关键词： pollen receptor kinase pollen tube polarized growth RopGEF Arabidopsis

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TSERING CHUGTSO AND HERROAD TO SUCCESS

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China's Tibet 2018年第2期29卷 38-45页

作者： song jiali

I met Tsering Chugtso in the most beautiful season of Paltang ***,a young lady born in 1988,in her dark green Tibetan dress and white high heels with a Michael Kors cross-body bag,was a sight for sore *** talked on he... 详细信息

关键词：道路高跟鞋迈克尔电话

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Heteroatom substitution-induced asymmetric A–D–A type non-fullerene acceptor for efficient organic solar cells

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Journal of Energy Chemistry 2020年第1期29卷 144-150,I0006页

作者： Chao Lia jiali song Yunhao Cai Guangchao Han Wenyu Zheng Yuanping Yi Hwa Sook Ryu Han Young Woo Yanming Sun School of Chemistry Beihang UniversityBeijing 100191China Beijing National Laboratory for Molecular Science Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China Department of Chemistry College of ScienceKorea UniversitySeoul 136-713Republic of Korea

Research on asymmetric A–D–A structured non-fullerene acceptors has lagged far behind the development of symmetric *** this contribution,by simply replacing one sulfur atom in indacenodithiophene unit with a selenium atom,an asymmetric building block Se PT and a corresponding asymmetric non-fullerene acceptor Se PT-IN have been *** Se PT-IN achieved a high efficiency of 10.20% in organic solar cells when blended with PBT1-C,much higher than that of symmetric TPT-IN counterpart(8.91%).Our results demonstrated an effective heteroatom substitution strategy to develop asymmetric A–D–A structured non-fullerene acceptors.

关键词： Asymmetric non-fullerene acceptors Heteroatom substitution Organic solar cells Power conversion efficiency

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A chloride efflux transporter,BIG RICE GRAIN 1,is involved in mediating grain size and salt tolerance in rice

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Journal of Integrative Plant Biology 2021年第12期63卷 2150-2163页

作者： Zhijie Ren Fenglin Bai Jingwen Xu Li Wang Xiaohan Wang Qian Zhang Changxin Feng Qi Niu Liying Zhang jiali song Fang Bao Liangyu Liu Yikun He Ligeng Ma Wang Tian Congcong Hou Legong Li College of Life Sciences Capital Normal Universityand Beijing Key Laboratory of Plant Gene Resources and Biotechnology for Carbon Reduction and Environmental ImprovementBeijing 100048China School of Advanced Agricultural Sciences Peking UniversityBeijing 100871China

Grain size is determined by the size and number of cells in the *** regulation of grain size is crucial for improving crop yield;however,the genes and molecular mechanisms that control grain size remain ***,we report that a member of the detoxification efflux carrier/Multidrug and Toxic Compound Extrusion(DTX/MATE)family transporters,BIG RICE GRAIN 1(BIRG1),negatively influences grain size in rice(Oryza sativa L.).BIRG1 is highly expressed in reproductive organs and *** birg1 grain,the outer parenchyma layer cells of spikelet hulls are larger than in wild-type(WT)grains,but the cell number is *** expressed in Xenopus laevis oocytes,BIRG1 exhibits chloride efflux *** with this role of BIRG1,the birg1 mutant shows reduced tolerance to salt stress at a toxic chloride ***,grains from birg1 plants contain a higher level of chloride than those of WT plants when grown under normal paddy field conditions,and the roots of birg1 accumulate more chloride than those of WT under saline ***,the data suggest that BIRG1 in rice functions as a chloride efflux transporter that is involved in mediating grain size and salt tolerance by controlling chloride homeostasis.

关键词： chloride efflux transporter DTX/MATE grain size rice salt tolerance

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A transceptor-channel complex couples nitrate sensing to calcium signaling in Ambidopsis

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Molecular Plant 2021年第5期14卷 774-786页

作者： Xiaohan Wang Changxin Feng LiLi Tian Congcong Hou Wang Tian Bin Hu Qian Zhang Zhijie Ren Qi Niu jiali song Dongdong Kong Liangyu Liu Yikun He Ligeng Ma Chengcai Chu Sheng Luan Legong Li College of Life Sciences Capital Normal UniversityBeijing 100048China State Key Laboratory of Plant Genomics Institute of Genetics and Developmental Biologythe Innovative Academy for Seed DesignChinese Academy of SciencesBeijing 100101China Department of Plant and Microbial Biology University of California at BerkeleyBerkeleyCA 94720USA

Nitrate-induced Ca^(2+) signaling is crucial for the primary nitrate response in ***,the molecular mechanism underlying the generation of the nitrate-specific calcium signature remains *** report here that a cyclic nucleotide-gated channel(CNGC)protein,CNGC15,and the nitrate transceptor(NRT1.1)constitute a molecular switch that controls calcium influx depending on nitrate *** expression of CNGC15 is induced by nitrate,and its protein is localized at the plasma membrane after establishment of young *** found that disruption of CNGC15 results in the loss of the nitrate-induced Ca^(2+) signature(primary nitrate response)and retards root growth,reminiscent of the phenotype observed in the nrt1.1 *** further showed that CNGC15 is an active Ca^(2+)-permeable channel that physically interacts with the NRT1.1 protein in the plasma ***,we discovered that CNGC15-NRT1.1 interaction silences the channel activity of the heterocomplex,which dissociates upon a rise in nitrate levels,leading to reactivation of the CNGC15 *** dynamic interactions between CNGC15 and NRT1.1 therefore control the channel activity and Ca^(2+) influx in a nitrate-dependent *** study reveals a new nutrient-sensing mechanism that utilizes a nutrient transceptor-channel complex assembly to couple nutrient status to a specific Ca^(2+) signature.

关键词： primary nitrate response nutrient sensing calcium signature nitrate transceptor calcium channel

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IC封装设备切片机电控系统设计

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微计算机信息 2007年第25期23卷 81-82,144页

作者：宋佳丽长春税务学院计算机系

为了高速、高精度切割半导体晶片,切片机的电控系统要求具备高精度及高稳定度。根据系统设计指标和可编程控制器(PLC)的特点,选用日本OMRON公司的CS1G型PLC构成主控系统,FC10/400型高速电机及其配套变频器构成高速主轴系统,Y、Z轴则用PD... 详细信息

为了高速、高精度切割半导体晶片,切片机的电控系统要求具备高精度及高稳定度。根据系统设计指标和可编程控制器(PLC)的特点,选用日本OMRON公司的CS1G型PLC构成主控系统,FC10/400型高速电机及其配套变频器构成高速主轴系统,Y、Z轴则用PD-0535M型步进电机驱动器驱动步进电机构成开环控制系统,X轴采用交流伺服电机及增量式编码器构成半闭环系统,?轴选用美国Parker公司DM1004B型转台交流伺服电机及DrvMⅡ型电机驱动器,供电系统采用隔离变压器等方法来屏蔽电磁干扰。通过多模块运动控制软件协调控制,该系统完全达到了设计要求。

关键词：运动控制可编程序控制器集成电路封装切片机

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高校图书馆用户科学数据素养能力与需求调查分析

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图书馆学研究 2019年第5期 56-70页

作者：宋甲丽宋春健程结晶淮安文化艺术学校不详扬州大学社会发展学院

在第四研究范式兴起、数据驱动科研的时代背景下,用户必须通过提高自身科学数据素养才能熟稔地运用各种科研数据,创新科技成果。选取在校本科生、硕士生及博士生,高等院校科研人员以及社会人员三类目标人群,采用问卷调查法,对用户个人... 详细信息

在第四研究范式兴起、数据驱动科研的时代背景下,用户必须通过提高自身科学数据素养才能熟稔地运用各种科研数据,创新科技成果。选取在校本科生、硕士生及博士生,高等院校科研人员以及社会人员三类目标人群,采用问卷调查法,对用户个人信息情况、科学数据素养能力情况、科学数据素养需求情况进行调查与分析,不同目标人群问卷侧重点不同。调查显示,在能力上用户数据意识和数据知识水平较高,共享意识偏低,具有一定数据处理能力和应用能力。在需求上用户对数据搜索获取、数据分析处理以及数据交流与共享、数据处理的基础设施有较高需求。

关键词：用户科学数据素养能力需求高校图书馆

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