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Effects of potassium channel blockage on inverse stochastic resonance in Hodgkin-Huxley neural systems

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2023年第8期24卷 735-748页

作者： Xueqing WANG Dong YU yong wu Qianming DING Tianyu LI Ya jia Department of Physics Central China Normal UniversityWuhan 430079China

Inverse stochastic resonance(ISR)is a phenomenon in which the firing activity of a neuron is inhibited at a certain noise *** this paper,the effects of potassium channel blockage on ISR in single Hodgkin-Huxley neurons and in small-world networks were *** the single neuron,the ion channel noise-induced ISR phenomenon can occur only in a certain small range of potassium channel blockage *** analysis showed that this small range is the bistable region regulated by the external bias *** small-world networks,the effect of non-homogeneous network blockage on ISR was *** network blockage ratio was used to represent the proportion of potassium-channel-blocked neurons to total network *** is found that an increase in network blockage ratio at small coupling strengths results in shorter ISR *** the coupling strength is increased,the ISR is more significant in the case of a large network blockage *** ISR phenomenon is determined by the network blockage ratio,the coupling strength,and the ion channel *** results will provide new perspectives on the observation of ISR in neuroscience experiments.

关键词： Inverse stochastic resonance(ISR) Small-world neuronal network Potassium channel blockage Network blockage ratio

Tree species classification in an extensive forest area using airborne hyperspectral data under varying light conditions

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Journal of Forestry Research 2023年第5期34卷 1359-1377页

作者： Wen jia yong Pang Institute of Forest Resource Information Techniques Chinese Academy of ForestryBeijing 100091People’s Republic of China Key Laboratory of Forestry Remote Sensing and Information System National Forestry and Grassland AdministrationBeijing 100091People’s Republic of China

Although airborne hyperspectral data with detailed spatial and spectral information has demonstrated significant potential for tree species classification,it has not been widely used over large areas.A comprehensive process based on multi-flightline airborne hyperspectral data is lacking over large,forested areas influenced by both the effects of bidirectional reflectance distribution function(BRDF)and cloud shadow *** this study,hyperspectral data were collected over the Mengjiagang Forest Farm in Northeast China in the summer of 2017 using the Chinese Academy of Forestry's LiDAR,CCD,and hyperspectral systems(CAF-LiCHy).After BRDF correction and cloud shadow detection processing,a tree species classification workflow was developed for sunlit and cloud-shaded forest areas with input features of minimum noise fraction reduced bands,spectral vegetation indices,and texture *** indicate that BRDF-corrected sunlit hyperspectral data can provide a stable and high classification accuracy based on representative training ***-shaded pixels also have good spectral separability for species *** red-edge spectral information and ratio-based spectral indices with high importance scores are recommended as input features for species classification under varying light *** to the classification accuracies through field survey data at multiple spatial scales,it was found that species classification within an extensive forest area using airborne hyperspectral data under various illuminations can be successfully carried out using the effective radiometric consistency process and feature selection strategy.

关键词： Tree species classification BRDF effects Cloud shadow Airborne hyperspectral data Random forest

Peanut-Like Hematite Prepared by a New Facile Hydrothermal Process for Removal of As(V)

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Transactions of Tianjin University 2019年第1期25卷 23-30页

作者： Chengjin Zhang Shaoyi jia Songhai wu yong Liu School of Chemical Engineering and Technology Tianjin University School of Chemistry and Chemical Engineering Tianjin University of Technology

Peanut-like hematite has been prepared by a new facile hydrothermal method and applied in the adsorption removal of As(V). The structural features of the as-prepared hematite were characterized systematically by X-ray diffraction, X-ray photoelectron spectroscopy, Brunauer–Emmett–Teller, scanning electron microscopy, energy-dispersive X-ray spectroscopy mapping, Fourier transform infrared spectroscopy, and transmission electron microscopy. Results showed that the morphologies of hematite could be tuned to spindle-like, oval-like, and cantaloupe-like shapes by adjusting the hydrothermal conditions. The peanut-like hematite formation followed a five-step route. At pH = 3, the adsorption amount of As(V) over peanut-like hematite reached 13.84 mg/g, and the adsorption kinetic process corresponded to the pseudo-second-order kinetic model. The peanut-like hematite also showed partial selectivity over As(V) in the hydrosphere. This method can be a reference for the preparation of other architectural metal oxide materials.

关键词： Peanut-like hematite Arsenic adsorbent Nanoparticle

Rapid, simple and selective determination of 2,4-dinitrophenol by molecularly imprinted spin column extraction coupled with fluorescence detection

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Chinese Chemical Letters 2014年第11期25卷 1492-1494页

作者： Min Fang Fang Lei jia Zhou yong-Ning wu Zhi-yong Gong Institute of Food Science and Engineering Wuhan Polytechnic University Hubei Collaborative Innovation Center for Processing of Agricultural Products Wuhan Polytechnic University China National Center for Food Safety Risk Assessment

A rapid, simple and selective method based on molecularly imprinted, spin column extraction coupled with fluorescence detection was successfully established for the determination of 2,4-dinitrophenol in serum samples. The 2,4-dinitrophenol imprinted polymers exhibited highly selective recognition for the template molecule and the maximum adsorption capacity was 138.9 mg/g. The results indicated that when water is used as the loading solution, only 2,4-dinitrophenol could be adsorbed on the spin column without the remaining structural analogs（2-nitrophenol, 4-nitrophenol and phenol）. After eluting with acetonitrile/acetic acid（9/1, v/v）, 2,4-dinitrophenol in serum samples could be determined by using the fluorescence spectrometer, based on the fluorescence enhancement of fluorescein by the template molecule. Under the optimal conditions, the spiked recovery ranged from 95.8% to 103.4% and the detection limit was 1 nmol/L. The results confirmed the reliability and practicality of the protocol and revealed a good perspective of this method for biological sample analysis.

关键词： Molecularly imprinted solid phase extraction Indirect fluorescence detection Spin column 2 4-Dinitrophenol

Improved expert selection model for forex trading

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Frontiers of Computer Science 2018年第3期12卷 518-527页

作者： jia ZHU Xingcheng wu Jing XIAO Changqin HUANG yong TANG Ke Deng School of Computer Science South China Normal University Guangzhou 510631 China School of Computer Science and Information Technology Royal Melbourne Institute of Technology Melbourne 3000 Australia

Online prediction is a process that repeatedly predicts the next element in the coming period from a sequence of given previous elements. This process has a broad range of applications in various areas, such as medical, streaming media, and finance. The greatest challenge for online prediction is that the sequence data may not have explicit features because the data is frequently updated, which means good predictions are difficult to maintain. One of the popular solutions is to make the prediction with expert advice, and the challenge is to pick the right experts with minimum cumulative loss. In this research, we use the forex trading prediction, which is a good example for online prediction, as a case study. We also propose an improved expert selection model to select a good set of forex experts by learning previously observed sequences. Our model considers not only the average mistakes made by experts, but also the average profit earned by experts, to achieve a better performance, particularly in terms of financial profit. We demonstrate the merits of our model on two real major currency pairs corpora with extensive experiments.

关键词： online learning expert selection forex prediction

数字赋能乡村教育现代化的实然困境与优化路径

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教学与管理 2025年第1期 6-11页

作者：王倩吴家华胡恒钊安徽大学马克思主义学院合肥230601 江西农业大学马克思主义学院南昌330045

以数字赋能为发展契机,推进乡村教育现代化是中国式教育现代化的必然要求,也是乡村全面振兴的重要依托。在教育领域,数字技术蕴含着驱动乡村教育现代化发展的重要价值,能够有效扩大优质教育资源的覆盖范围、变革乡村教育形态、推动乡土... 详细信息

以数字赋能为发展契机,推进乡村教育现代化是中国式教育现代化的必然要求,也是乡村全面振兴的重要依托。在教育领域,数字技术蕴含着驱动乡村教育现代化发展的重要价值,能够有效扩大优质教育资源的覆盖范围、变革乡村教育形态、推动乡土文化的交流传播。但在推动数字赋能乡村教育现代化的实践中,面临着数字教育观念淡薄、数字基础条件不足、师生数字素养薄弱等现实阻碍,迫切需要从重塑价值观念、完善数字设施、培养师生数字素养、加强体制建设入手,为数字赋能乡村教育现代化发展注入新动力,以适应中国式教育现代化发展的新生态。

关键词：数字赋能乡村教育中国式教育现代化乡土文化

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian jia jian Zhou Zhoule Zhu Yumin wu Xiaowu Lin Yiming Qian jiashu Lian Xin Hua jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

Study on synthesis and distribution in vivo of 5-Fu-cholic acid conjugate

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Chinese Chemical Letters 2009年第2期20卷 136-138页

作者： Jie Li Li Hai Wei jia Liu Xiao Chun wu yong wu Key Laboratory of Drug Targeting of Education Ministry West China School of Pharmacy Sichuan University Chengdu 610041 China Sichuan Normal University Chemistry and Material College Chengdu 610066 China

A series of hepatic targeting drugs, 5-Fu-cholic acid conjugate T1-T5, were synthesized. 5-Fu and cholic acid was selected as starting material, after N-hydroxymethylation, condensation, hydrogenolysis to obtain carboxylated 5-Fu 5a-e. Carboxylated 5-Fu 5a-e were condensated with intermediate 3-hydroxyethyl cholic acid benzyl ester 6 to get 7a-e, 7a-e were deprotected to get T1- T5.

关键词： Hepatic targeting drugs Cholic acid Synthesis

Searchlight trapping reveals seasonal cross-ocean migration of fall armyworm over the South China Sea

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Journal of Integrative Agriculture 2021年第3期20卷 673-684页

作者： ZHOU Xian-yong wu Qiu-lin jia Hui-ru wu Kong-ming College of Plant Protection Southwest UniversityChongqing 400716P.R.China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese

The fall armyworm(FAW),Spodoptera frugiperda,is a migratory noctuid pest that has recently invaded eastern *** 2017 up till 2020,searchlight trapping was used to assess the extent of FAW migration across the South China *** and morphology-based identification confirmed that FAW made its first appearance on yongxing Island on 11 April 2019,with most trapped individuals belonging to the ***"corn-strain".Carbon isotope analysis further showed that FAW moths originated from C4 host plants,while trajectory analyses revealed that migratory *** adults are able to cross the South China Sea and enter China's *** long-distance migration process plausibly results in frequent genetic mixing between domestic FAW populations and those of neighboring Southeast Asian ***,this work provides unique insights into FAW migration across eastern Asia and ultimately can help advance pest forecasting,risk assessment and area-wide pest management.

关键词： Spodoptera frugiperda host strain isotope trajectory analysis cross-ocean migration invasion biology