Effects of potassium channel blockage on inverse stochastic resonance in Hodgkin-Huxley neural systems
[钾离子通道阻塞对Hodgkin-Huxley神经系统中反随机共振的影响]作者机构：Department of PhysicsCentral China Normal UniversityWuhan 430079China
出 版 物：《浙江大学学报(英文版)A辑:应用物理与工程》 (Journal of Zhejiang University-Science A(Applied Physics & Engineering))
年 卷 期：2023年第24卷第8期
页 面：735-748页
核心收录：
学科分类：0810[工学-信息与通信工程] 12[管理学] 083002[工学-环境工程] 1204[管理学-公共管理] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 120402[管理学-社会医学与卫生事业管理(可授管理学、医学学位)] 08[工学] 0837[工学-安全科学与工程] 0805[工学-材料科学与工程（可授工学、理学学位）] 0812[工学-计算机科学与技术（可授工学、理学学位）]
基 金：the National Natural Science Foundation of China(No.12175080) the Fundamental Research Funds for the Central Universities(No.CCNU22JC009),China
主 题：Inverse stochastic resonance(ISR) Small-world neuronal network Potassium channel blockage Network blockage ratio
摘 要：Inverse stochastic resonance(ISR)is a phenomenon in which the firing activity of a neuron is inhibited at a certain noise *** this paper,the effects of potassium channel blockage on ISR in single Hodgkin-Huxley neurons and in small-world networks were *** the single neuron,the ion channel noise-induced ISR phenomenon can occur only in a certain small range of potassium channel blockage *** analysis showed that this small range is the bistable region regulated by the external bias *** small-world networks,the effect of non-homogeneous network blockage on ISR was *** network blockage ratio was used to represent the proportion of potassium-channel-blocked neurons to total network *** is found that an increase in network blockage ratio at small coupling strengths results in shorter ISR *** the coupling strength is increased,the ISR is more significant in the case of a large network blockage *** ISR phenomenon is determined by the network blockage ratio,the coupling strength,and the ion channel *** results will provide new perspectives on the observation of ISR in neuroscience experiments.
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