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Public auditing for real‑time medical sensor data in cloud‑assisted HealthIIoT system

Frontiers of Optoelectronics 2022年第3期15卷 1-14页

作者： Weiping Ye jia Wang Hui Tian Hanyu Quan College of Computer Science and Technology Huaqiao UniversityXiamen 361021China Wuhan National Laboratory for Optoelectronics Wuhan 430074China Xiamen Key Laboratory of Data Security and Blockchain Technology Xiamen 361021China Fujian Key Laboratory of Big Data Intelligence and Security Xiamen 361021China

With the advancement of industrial internet of things(IIoT),wireless medical sensor networks(WMSNs)have been widely introduced in modern healthcare systems to collect real-time medical data from patients,which is known as HealthIIoT.Considering the limited computing and storage capabilities of lightweight HealthIIoT devices,it is necessary to upload these data to remote cloud servers for storage and maintenance.However,there are still some serious security issues within outsourcing medical sensor data to the cloud.One of the most signifcant challenges is how to ensure the integrity of these data,which is a prerequisite for providing precise medical diagnosis and treatment.To meet this challenge,we propose a novel and efcient public auditing scheme,which is suitable for cloud-assisted HealthIIoT system.Specifcally,to address the contradiction between the high real-time requirement of medical sensor data and the limited computing power of HealthIIoT devices,a new online/ofine tag generation algorithm is designed to improve preprocessing efciency;to protect medical data privacy,a secure hash function is employed to blind the data proof.We formally prove the security of the presented scheme,and evaluate the performance through detailed experimental comparisons with the state-of-the-art ones.The results show that the presented scheme can greatly improve the efciency of tag generation,while achieving better auditing performance than previous schemes.

关键词： Healthcare industrial internet of things(HealthIIoT) Medical sensor data Online/ofine signature Public auditing

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张湛生平与养生思想

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中华中医药杂志 2022年第3期37卷 1609-1611页

作者：吕佳蔚王振国山东中医药大学中医文献与文化研究院济南250355

张湛是魏晋时期著名的玄学家,出身于名士家族,自幼受家庭熏陶形成了放达的性格。他发扬魏晋玄学,留下了许多有价值的思想,对《列子》的注解在玄学史上具有不可磨灭的功绩。同时他深研“经方”医学,尤其是其养生思想丰富了中医学的内容... 详细信息

张湛是魏晋时期著名的玄学家,出身于名士家族,自幼受家庭熏陶形成了放达的性格。他发扬魏晋玄学,留下了许多有价值的思想,对《列子》的注解在玄学史上具有不可磨灭的功绩。同时他深研“经方”医学,尤其是其养生思想丰富了中医学的内容。《养生要集》和《列子注》是集中体现张湛养生思想的两部著作,反映了时代思潮对张湛产生的影响,其中既有具体的养生方法,也有对生死观的阐发,以道家思想为主,又有佛教思想的渗透,对当代养生也有很好的借鉴意义。

关键词：张湛生平养生思想养生要集列子注

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The early days of structural biology at the Beijing Institute of Biophysics:In memory of Professor Zhengjiong Lin(1935-2022)

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Protein & Cell 2022年第12期13卷 869-872页

作者： jia-huai wang Dana-Farber Cancer Institute Harvard Medical SchoolBostonUnited States

At the end of 2017,while I was cleaning my apartment in Beijing,a thin journal caught my attention deep in one dusty cabinet.To my surprise,it was an old lab notebook I used 55 years ago!I could not help opening it.Written on the first page was my mentor Zhengjiong Lin's assignment for my first project:To determine the crystal structure of a di-pep-tide,Proline-Glycine.

关键词： journal assignment structural

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Perenniality:From model plants to applications in agriculture

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Molecular Plant 2024年第1期17卷 141-157页

作者： Bo Zhao jia-Wei wang National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant Sciences(CEMPS)Institute of Plant Physiology and Ecology(SIPPE)Chinese Academy of Sciences(CAS)Shanghai 200032China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory of Plant Carbon Capture CASShanghai 200032China New Cornerstone Science Laboratory Shanghai 200032China

To compensate for their sessile nature,plants have evolved sophisticated mechanisms enabling them to adapt to ever-changing environments.One such prominent feature is the evolution of diverse life history strategies,particularly such that annuals reproduce once followed by seasonal death,while perennials live longer by cycling growth seasonally.This intrinsic phenology is primarily genetic and can be altered by environmental factors.Although evolutionary transitions between annual and perennial life history strategies are common,perennials account for most species in nature because they survive well under year-round stresses.This proportion,however,is reversed in agriculture.Hence,perennial crops promise to likewise protect and enhance the resilience of agricultural ecosystems in response to climate change.Despite significant endeavors that have been made to generate perennial crops,progress is slow because of barriers in studying perennials,and many developed species await further improvement.Recent findings in model species have illustrated that simply rewiring existing genetic networks can lead to lifestyle variation.This implies that engineering plant life history strategy can be achieved by manipulating only a few key genes.In this review,we summarize our current understanding of genetic basis of perenniality and discuss major questions and challenges that remain to be addressed.

关键词： perenniality developmental plasticity flowering time poplar Arabis alpina perennial crops life history strategy

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National guidelines for diagnosis and treatment of lung cancer 2022 in China(English version)

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Chinese Journal of Cancer Research 2022年第3期34卷 176-206页

作者：无 Nan Wu jia Wang Quanne wang National Health Commission of the People’s Republic of China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Peking University Cancer Hospital&Institute Cheeloo College of Medicine Shandong University

Contents 1.Overview 2.Screening and diagnosis 2.1 Risk factors for lung cancer 2.1.1 Smoking and involuntary smoking 2.1.2 History of chronic obstructive pulmonary disease(COPD)2.1.3 Occupational exposures 2.1.4 Famil... 详细信息

关键词： diagnosis lung cancer

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Treating peripheral nerve injury-induced spinal cord degeneration and neuropathic pain with peripherally administrated stem cells

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Neural Regeneration Research 2023年第3期18卷 537-538页

作者： Zihui wang Xiaofeng jia Department of Neurosurgery University of Maryland School of Medicine Department of Orthopedics Anatomy and NeurobiologyUniversity of Maryland School of Medicine Department of Biomedical Engineering Anesthesiology and Critical Care MedicineJohns Hopkins University School of MedicineBaltimoreMDUSA

Peripheral nerve injury(PNI)causes sensory and motor deficits as well as neuropathic pain,which seriously impacts patient quality of life(jiang et al.,2017).Morphological and molecular changes in the spinal cord and dorsal root ganglia(DRG),such as neuronal cell death,nerve fiber degeneration,and glial activation,are strongly associated with PNI-induced pathological syndromes.

关键词： degeneration pain Morphological

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Synergistic utilization of carbon sources for efficient biosynthesis of N-acetylglucosamine

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Green Chemical Engineering 2023年第2期4卷 233-238页

作者： Yanni Pei Yuhan wang Xiaolin Shen jia Wang Xinxiao Sun Qipeng Yuan State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China

N-acetylglucosamine(GlcNAc)is an amino monosaccharide that has a variety of bioactivities and is widely used in pharmaceutical and food industries.Production of GlcNAc by chitin hydrolysis is limited by the supply of raw materials and encounters the risk of shellfish protein contamination.For efficient biosynthesis of GlcNAc,one challenge is to balance the carbon distribution between growth and production.Here,we applied the strategy of synergistic carbon utilization,in which glycerol supports cell growth and provides the acetyl group of GlcNAc while glucose serves as the precursor to glucosamine.The efficiency of GlcNAc production was stepwise improved by blocking the product re-uptake and degradation,strengthening the biosynthetic pathway and synergistically utilizing two carbon sources.With these efforts,the final strain produced 41.5 g/L GlcNAc with a yield of 0.49 g/g of total carbon sources.In addition,we also explored the feasibility of using acetate as a cheap carbon source to partly replace glycerol.This study provides a promising alternative strategy for sustainable and efficient pro-duction of GlcNAc.

关键词： N-Acetylglucosamine Synergistic carbon utilization Glucose facilitated diffusion system Acetate

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Mechanisms and strategies to overcome immunotherapy resistance in hepatobiliary malignancies

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 430-439页

作者： jia Xiong Qing-Qing wang Institute of Immunology Zhejiang University School of MedicineHangzhou 310058China The Key Laboratory for Immunity and Inflammatory Diseases of Zhejiang Province Hangzhou 310058China

Unprecedented advances have been achieved in hepatobiliary cancer treatment with immune checkpoint blockade(ICB).However,the efflcacy of ICB in patients with hepatobiliary malignancies is still limited.Resistance to immunotherapies is often orchestrated by complicated tumor-host-microenvironment interactions but could also occur after initial efflcacy,mostly when only partial responses are obtained.Clarification of cancer-resistance mechanisms will be beneficial to provide the rationale for the administration of personalized drugs.Here,we review the factors related to resistance to immune-targeted therapies in hepatobiliary malignancies and discuss the potential strategies for overcoming resistance and future directions of immunotherapy development.

关键词： Cancer immunotherapy Hepatobiliary malignancies Immune checkpoint blockade Drug resistance

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Nitric oxide assists nitrogen reduction reaction on 2D MBene: A theoretical study

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Chinese Chemical Letters 2024年第5期35卷 428-433页

作者： Chaozheng He jia Wang Ling Fu Wei Wei Henan Engineering Center of New Energy Battery Materials College of Chemistry and Chemical EngineeringShangqiu Normal UniversityShangqiu 476000China School of Chemistry and Chemical Engineering Shandong Provincial Key Laboratory/Collaborative Innovation Center of Chemical Energy Storage&Novel Cell TechnologyLiaocheng UniversityLiaocheng 252059China Institute of Environment and Energy Catalysis Shaanxi Key Laboratory of Optoelectronic Functional Materials and DevicesSchool of Materials Science and Chemical EngineeringXi’an Technological UniversityXi’an 710021China College of Resources and Environmental Engineering Tianshui Normal UniversityTianshui 741001China

Electrocatalytic synthesis of ammonia as an environment-friendly and sustainable development method has received widespread attention in recent years.Two-dimensional(2D)materials are a promising catalyst for ammonia synthesis due to their large surface area.In this work,we have constructed a series of 2D metal borides(MBenes)with transition metal(TM)defects(TMd-MBenes)and comprehensively calculated the reactivity of electrocatalytic synthesis of ammonia-based on density functional theory.The results have demonstrated that the TMd-MBenes can effectively activate nitrogen oxide(NO)and nitrogen(N2)molecules thermodynamically.Particularly interesting,the co-chemisorption of O atoms,dissociated from NO,can facilitate the spilled of the inert N2 molecules into single N atoms,which can further hydrogenate into ammonia easily with an ultralow limiting potential of 0.59 V on TMd-MnB.Our research has not only provided clues for catalyst design for experimental study but also paved the way for the industrial application of electrocatalytic ammonia synthesis.

关键词： 2D mbenes Nitrogen electro-reduction DFT N_(2)activation Ammonia synthesis

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Water-based lubrication of niobium nitride

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Friction 2022年第6期10卷 842-853页

作者： Kaifei MIAO jia Wang Qiang ZHAO Kaiwen wang Mao WEN Kan ZHANG State Key Laboratory of Superhard Materials Department of Materials ScienceKey Laboratory of Automobile MaterialsMOEJilin UniversityChangchun 130012China Department of Materials Science and Engineering Jilin Jianzhu UniversityChangchun 130118China

Water-based lubrication has attracted wide attention as an oil-free lubrication method owing to its greener and cleaner lubrication means.However,due to operating in the water environment,most moving parts would inevitably suffer from abrasion,rusting,and aging problems.Developing a novel solid-water composite system with ultra-low friction and wear will open new possibilities for innovative lubrication material research and development.Here,we first revealed the water-based lubrication behavior of a high-hardness niobium nitride coating(NbN).In a three-phase contact environment(water,air,and NbN),oxidation and hydrolytic reactions of NbN result in the formation of"colloidal solutions",containing Nb_(2)O_(5)colloidal particles between the tribo-pairs.Utilizing the double electric layer repulsion and weak shear action of the"colloidal solution",NbN achieves ultra-low friction and wear;the corresponding values are as low as 0.058 and 1.79×10^(-10)mm^(3)·N^(-1)·m^(-1),respectively.In addition,other VB transition metal nitrides(VB TMNs)exhibit the same low friction feature as NbN in the three-phase contact environment;the friction coefficients are even lower than those in an oil-based environment.The water-based lubrication of VB TMNs provides a new reliable scheme for optimizing solid-water composite lubrication systems without additives and is expected to be applied in environments with high humidity or insufficient water coverage.

关键词： NbN water-based lubrication ultra-low friction ultra-low wear

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