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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu jia Rui Mao Xiang cao Yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong Yan Ting Liang jia jia Shengjie Yuan Dongxing Kou Zhengji Zhou Wenhui Zhou Yafang qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： CIGS solar cells Solution-processed method Ag doping Crystal growth Defects engineering

塔里木盆地北缘盐土有机碳含量的贝叶斯地统计预测

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应用生态学报 2017年第2期28卷 439-448页

作者：伍维模王家强曹琦吴嘉平浙江大学环境与资源学院杭州310058 塔里木大学植物科学学院新疆阿拉尔843300 浙江大学海岛海岸带研究所浙江舟山316021

准确预测土壤有机碳的空间分布,对于土壤资源开发和保护、应对气候变化和生态系统健康都具有重要意义.本文以塔里木盆地北缘盐土1300 m×1700 m样地为试验区,采集5~10 cm深度土壤样品144个,构建土壤有机碳含量的贝叶斯地统计空间预测模... 详细信息

准确预测土壤有机碳的空间分布,对于土壤资源开发和保护、应对气候变化和生态系统健康都具有重要意义.本文以塔里木盆地北缘盐土1300 m×1700 m样地为试验区,采集5~10 cm深度土壤样品144个,构建土壤有机碳含量的贝叶斯地统计空间预测模型,并以普通克里格、序惯高斯模拟和逆距离加权方法为对照,评价贝叶斯地统计对土壤有机碳含量的预测性能.结果表明:研究区土壤有机碳含量处于1.59~9.30 g·kg^(-1),平均值为4.36 g·kg^(-1),标准偏差为1.62 g·kg^(-1);半方差函数符合指数模型,空间结构比参数值为0.57;利用贝叶斯地统计方法,获得了土壤有机碳含量的空间分布图以及评价预测不确定性的预测方差、上95%分位数、下95%分位数分布图;与普通克里格、序惯高斯模拟和逆距离加权方法相比,贝叶斯地统计方法具有更高的土壤有机碳含量空间预测精度,显示出该方法对土壤有机碳含量预测的优越性.

关键词：土壤有机碳空间预测贝叶斯地统计盐土

Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie Su Weicheng Feng Yaona Lai Kongli Huang Dandan cao qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

胶原-生长因子生物材料及其在骨和神经再生中的应用

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国际口腔医学杂志 2016年第6期43卷 729-733页

作者：朱宸佑曹钰彬邓佳亓文婷曹聪石冰口腔疾病研究国家重点实验室华西口腔医院唇腭裂外科(四川大学) 成都610041

胶原具有弱抗原性,良好的生物兼密性、生物降解能力以及生物力学性能,被广泛用于皮肤、肌腱、血管、骨和神经等部位的组织工程,而生长因子是生物体内一类微量高效调节细胞代谢和组织修复的小分产物质。胶原-生长因子生物材料(CGFB)在骨... 详细信息

胶原具有弱抗原性,良好的生物兼密性、生物降解能力以及生物力学性能,被广泛用于皮肤、肌腱、血管、骨和神经等部位的组织工程,而生长因子是生物体内一类微量高效调节细胞代谢和组织修复的小分产物质。胶原-生长因子生物材料(CGFB)在骨组织再生、神经组织修复、肌腱重建和慢性伤口修复中表现出优良的生物和生物力学性能。在骨组织修复中,CGFB合理地释放生长因子,有效地诱导了干细胞成骨向分化和促进受损骨组织修复。在神经组织修复中,根据修复对象采用的特异性的CGFB胶原设计,有效地促进了神经突的生成。在中枢神经系统修复中,胶原凝胶的注入为细胞生长提供了良好的微环境,有利于中枢神经系统的修复。本文回溯CGFB的基本性质及其近年来在骨和神经修复领域中的研究进展,以预测其未来可继续改进的方向。

关键词：胶原-生长因子组织工程骨再生神经再生

Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

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Neural Regeneration Research 2025年第6期20卷 1628-1643页

作者： Yimiao jiang Zengxin qi Huixian Zhu Kangli Shen Ruiqi Liu Chenxin Fang Weiwei Lou Yifan jiang Wangrui Yuan Xin cao Liang Chen qianxing Zhuang Department of Physiology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration ShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the comp

关键词： anxiety basal ganglia bradykinesia deep brain stimulation depression globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease

An all-round Al-Chemist with a scientific mind

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National Science Review 2022年第10期9卷 158-168页

作者： qing Zhu Fei Zhang Yan Huang Hengyu Xiao Lu Yuan Zhao Xu Chun Zhang Tao Song Xin Sheng Tang Xiang Li Guo He Bao Chen Chong Jun Yi Zhou Yi Han Zhang Baicheng Zhang jia qi cao Man Luo Song Wang Gui Lin Ye Wan Jun Zhang Xin Chen Shuang Cong Donglai Zhou Huirong Li jialei Li Gang Zou Wei Wei Shang Jun jiang Yi Luo Hefei National Research Center for Physical Sciences at the Microscale School of Chemistry and Materials Science University of Science and Technology of China School of Information Science and Technology University of Science and Technology of China Hefei Ji Shu Quantum Technology Co.Ltd Hefei National Laboratory University of Science and Technology of China

The realization of automated chemical experiments by robots unveiled the prelude to an artificial intelligence(AI) *** AI-based systems or robots with specific chemical skills have been demonstrated,but conducting all-round scientific research remains ***,we present an all-round AI-Chemist e quipped with scientific data intelligence that is capable of performing basic tasks generally re quired in chemical *** on a service platform,the AI-Chemist is able to automatically read the literatures from a cloud database and propose experimental plans *** can control a mobile robot in-house or online to automatically execute the complete experimental process on 14workstations,including synthesis,characterization and performance *** experimental data can be simultaneously analysed by the computational brain of the AI-Chemist through machine learning and Bayesian optimization,allowing a new hypothesis for the next iteration to be *** competence of the AI-Chemist has been scrutinized by three different chemical *** the future,the more advanced all-round AI-Chemists equipped with scientific data intelligence may cause changes to the landscape of the chemical laboratory.

关键词： AI-Chemist computational brain mobile robot machine reading all-round research

Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： Yi qi Xueying Chen Bowen Liu Xuliang Lin Xueqing qiu Yanlin qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving cao bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

Rare earth fluorescent nanoprobes with minimal side effects enable tumor microenvironment activation for chemotherapy

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Journal of Rare Earths 2024年第2期42卷 256-262,I0001页

作者： Tianqi cao Yuxin Liu qi jia Xiaolu Wang Shouqiang Zhang Jing Zhou Department of Chemistry Capital Normal UniversityBeijing100048China

Chemotherapy,the use of antitumor drugs to kill cancer cells,is currently one of the most effective treatments for ***,serious toxic side effects caused by long-term drug accumulation can cause significant damage to the body,which limits the clinical application of antitumor *** this study,a novel RENPs@DOX-Fe nanoprobe(NP) was constructed by coating the surface of rare earth nanomaterials(NaLuF_(4):Yb,Er) with a complex formed by doxorubicin(DOX) and iron ion(Ⅲ).Due to the low toxicity of anthracycline-metal complexes,the damage to normal cells is *** unique acidic microenvironment in tumor cells facilitates the decomposition and gradual release of DOX from the DOX-Fe *** addition,the DOX-Fe complex can convert near-infrared(NIR) light into heat energy,which promotes the decomposition of the complex,further enhancing the release of DOX in the tumor *** change of ratio fluorescence of rare earth nanomaterials at 660 and 1550 nm after DOX release enables visual monitoring of drug release,which can potentially improve the chemotherapeutic *** vitro experiments established that RENPs@DOX-Fe NPs with NIR illumination had good therapeutic efficacy in *** work provides new insights into designing tumor microenvironment-responsive nanoprobes for chemotherapy with minimal side effects.

关键词： Rare earth nanoprobes Fluorescence Ratiometric imaging DOX Chemotherapy