Rare earth fluorescent nanoprobes with minimal side effects enable tumor microenvironment activation for chemotherapy

作     者：Tianqi Cao Yuxin Liu Qi Jia Xiaolu Wang Shouqiang Zhang Jing Zhou Tianqi Cao;Yuxin Liu;Qi Jia;Xiaolu Wang;Shouqiang Zhang;Jing Zhou

作者机构：Department of ChemistryCapital Normal UniversityBeijing100048China 

出 版 物：《Journal of Rare Earths》 (稀土学报（英文版）)

年 卷 期：2024年第42卷第2期

页      面：256-262,I0001页

核心收录：

学科分类：081704[工学-应用化学] 1002[医学-临床医学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 100214[医学-肿瘤学] 0703[理学-化学] 10[医学] 

基　　金：Project supported by the National Natural Science Foundation of China(92159103) Beijing Municipal Education Commission Outstanding Young Individual Project(CIT&TCD201904082) Youth High-level Talent Project of Capital Normal University(20530810024) Yanjing Young Scholar Program of Capital Normal University 

主　　题：Rare earth nanoprobes Fluorescence Ratiometric imaging DOX Chemotherapy 

摘      要：Chemotherapy,the use of antitumor drugs to kill cancer cells,is currently one of the most effective treatments for ***,serious toxic side effects caused by long-term drug accumulation can cause significant damage to the body,which limits the clinical application of antitumor *** this study,a novel RENPs@DOX-Fe nanoprobe(NP) was constructed by coating the surface of rare earth nanomaterials(NaLuF_(4):Yb,Er) with a complex formed by doxorubicin(DOX) and iron ion(Ⅲ).Due to the low toxicity of anthracycline-metal complexes,the damage to normal cells is *** unique acidic microenvironment in tumor cells facilitates the decomposition and gradual release of DOX from the DOX-Fe *** addition,the DOX-Fe complex can convert near-infrared(NIR) light into heat energy,which promotes the decomposition of the complex,further enhancing the release of DOX in the tumor *** change of ratio fluorescence of rare earth nanomaterials at 660 and 1550 nm after DOX release enables visual monitoring of drug release,which can potentially improve the chemotherapeutic *** vitro experiments established that RENPs@DOX-Fe NPs with NIR illumination had good therapeutic efficacy in *** work provides new insights into designing tumor microenvironment-responsive nanoprobes for chemotherapy with minimal side effects.