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Involvement of Opioid Peptides in the Analgesic Effect of Spinal Cord Stimulation in a Rat Model of Neuropathic Pain

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Neuroscience Bulletin 2022年第4期38卷 403-416页

作者： Fu-Jun Zhai Song-Ping han Tian-jia Song Ran Huo Xing-Yu Lan Rong Zhang ji-sheng han Neuroscience Research Institute Peking UniversityBeijing 100191China Department of Neurobiology School of Basic Medical SciencesPeking UniversityBeijing 100191China Key Laboratory for Neuroscience Ministry of EducationNational Health CommissionPeking UniversityBeijing 100191China Wuxi hanS Health Medical Technology Co. Ltd.Wuxi 214122China Department of Integration of Chinese and Western Medicine School of Basic Medical SciencesPeking UniversityBeijing 100191China

Spinal cord stimulation(SCS)-induced analgesia was characterized,and its underlying mechanisms were examined in a spared nerve injury model of neuropathic pain in *** analgesic effect of SCS with moderate mechanical hypersensitivity was increased with increasing stimulation intensity between the 20%and 80%motor *** frequencies(2,15,50,100,10000 Hz,and 2/100 Hz dense-dispersed)of SCS were similarly ***-induced analgesia was maintained without tolerance within 24 h of continuous *** at 2 Hz significantly increased methionine enkephalin content in the cerebrospinal *** analgesic effect of 2 Hz was abolished byμorκopioid receptor *** effect of 100 Hz was prevented by aκantagonist,and that of 10 kHz was blocked by any of theμ,δ,orκreceptor antagonists,suggesting that the analgesic effect of SCS at different frequencies is mediated by different endorphins and opioid receptors.

关键词： SCS Analgesia Opioid receptors Methionine-Enkephalin Dynorphin Endorphins

Plasma Oxytocin and Arginine-Vasopressin Levels in Children with Autism Spectrum Disorder in China: Associations with Symptoms

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Neuroscience Bulletin 2016年第5期32卷 423-432页

作者： Hong-Feng Zhang Yu-Chuan Dai jing Wu Mei-Xiang jia ji-Shui Zhang Xiao-jing Shou Song-Ping han Rong Zhang ji-sheng han Neuroscience Research Institute Peking University Department of Neurobiology School of Basic Medical Sciences Peking University Health Science Center Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning Commission Peking University Center of Medical and Health Analysis Peking University Mental Health Institute Peking University Department of Neurology and Center of Rehabilitation Beijing Children’s Hospital Capital University of Medical Sciences

Autism spectrum disorder（ASD） is defined by impairments of social interaction and the presence of obsessive behaviors. The ＇＇twin＇＇ nonapeptides oxytocin（OXT） and arginine-vasopressin（AVP） are known to play regulatory roles in social behaviors. However, the plasma levels and behavioral relevance of OXT and AVP in children with ASD have seldom been investigated. It is also unknown whether their mothers have abnormal plasma peptide levels. Here, using well-established methods of neuropeptide measurement and a relatively large sample size, we determined the plasma levels of the two neuropeptides in 85 normal children, 84 children with ASD, and 31 mothers from each group of *** expected, children with ASD had lower plasma OXT levels than gender-matched controls（P = 0.028）. No such difference was found for plasma AVP concentrations. Correlation analysis showed that ASD children with higher plasma OXT concentrations tended to have less impairment of verbal communication（Rho =-0.22,P = 0.076）, while those with higher plasma AVP levels tended to have lower levels of repetitive use of objects（Rho =-0.231, P = 0.079）. Unlike the findings in children, maternal plasma OXT levels showed no group difference. However, plasma AVP levels in the mothers of ASD children tended to be lower than in the mothers of normal children（P = 0.072）. In conclusion, our results suggest that the OXT system is dysregulated in children with ASD, and that OXT and AVP levels in plasma seem to be associated with specific autistic symptoms. The plasma levels of OXT or AVP in mothers and their ASD children did not seem to change in the same direction.

关键词： Autism spectrum disorder Oxytocin Vasopressin Behavioral relevance

Effect of ligand of peroxisome proliferator-activated receptor γ on the biological characters of hepatic stellate cells

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World Journal of Gastroenterology 2005年第30期11卷 4735-4739页

作者： Yan-Tong Guo Xi-sheng Leng Tao Li ji-Run Peng sheng-han Song Liang-Fa Xiong Zhi-Zhong Qin Department of General Surgery Peking University People's Hospital Beijing 100044 China

AIM： To study the effect of rosiglitazone, which is a ligand of peroxisome proliferator-activated receptor gamma （PPARy）, on the expression of PPARy in hepatic stellate cells （HSCs） and on the biological characteristics of HSCs. METHODS： The activated HSCs were divided into three groups： control group, 3 μmol/L rosiglitazone group, and 10 μmol/L rosiglitazone group. The expression of PPARγ, α-smooth muscle actin （α-SMA）, and type Ⅰ and Ⅲ collagen was detected by RT-PCR, Western blot and immunocytochemical staining, respectively. Cell proliferation was determined with methylthiazolyltetrazolium （MTT） colodmetric assay. Cell apoptosis was demonstrated with flow cytometry. RESULTS： The expression of PPARγ at mRNA and protein level markedly increased in HSCs of 10 μmol/L rosiglitazone group （tvalue was 10.870 and 4.627 respectively, P〈0.01 in both）. The proliferation of HSCs in 10 μmol/L rosiglitazone group decreased significantly （t = 5.542, P〈0.01）, α-SMA expression level and type Ⅰ collagen synthesis ability were also reduced VS controls （tvalue = 10.256 and 14.627 respectively, P〈0.01 in both）. The apoptotic rate of HSCs significantly increased in 10 μmol/L rosiglitazone group vs control （X^2= 16.682, P〈0.01）. CONCLUSION： By increasing expression of PPARγ in activated HSCs, rosiglitazone, an agonist of PPARγ, decreases α-SNA expression and type Ⅰ collagen synthesis, inhibits cell proliferation, and induces cell apoptosis.

关键词： Peroxisome proliferator-activated receptor gamma Hepatic stellate cell Rosiglitazone

Development of an Autism Subtyping Questionnaire Based on Social Behaviors

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Neuroscience Bulletin 2018年第5期34卷 789-800页

作者： Fan-Chao Meng Xin-jie Xu Tian-jia Song Xiao-jing Shou Xiao-Li Wang Song-Ping han ji-sheng han Rong Zhang Neuroscience Research Institute Peking University Key Laboratory for Neuroscience Ministry of Education of China Peking University Key Laboratory for Neuroscience National Committee of Health and Family Planning of China Peking University Department of Neurobiology School of Basic Medical Sciences Peking University Central Laboratory Research Center for Translational Medicine Department of Scientific Research Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Division of Maternal and Child Health School of Public Health Peking University Health Science Center Wuxi Shenpingxintai Medical Technology Co. Ltd.

Autism spectrum disorder can be differentiated into three subtypes （aloof, passive, and active-but-odd） based on social behaviors according to the Wing Subgroups Questionnaire （WSQ）. However, the correlations between the scores on some individual items and the total score are poor. In the present study, we translated the WSQ into Chinese, modified it, validated it in autistic and typically- developing Chinese children, and renamed it the Beijing Autism Subtyping Questionnaire （BASQ）. Our results demonstrated that the BASQ had improved validity and reliability, and differentiated autistic children into these three subtypes more precisely. We noted that the autistic symptoms tended to be severe in the aloof, moderate in the passive, and mild in the active-but-odd subtypes. The modified questionnaire may facilitate etiological studies and the selection of therapeutic regimes.

关键词： Autism spectrum disorder Subtypes Wing Subgroups Questionnaire Beijing Autism Subtyping Questionnaire

LOW- AND HIGH-FREQUENCY ELEC DIFFERENCE IN NEURAL PATHWAYS AND THERAPEUTIC EFFECTS

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神经解剖学杂志 2001年第B7期17卷 65-69页

作者： ji-sheng han, MD, ACAS Neuroscience Research Institute, Peking University

Acupuncture as an ancient healing technique has been used in China for at least three thousand years. Aside from its well-known pain-killing effects, it can also be used for the treatment of a series of ailments caused by functional disturbances of many physiological systems. In 1997, a "Consensus Development Conference for Acupuncture", sponsored by the National Institute of Health (NIH) was held in Bethesda, Maryland, to

关键词：低频电针高频电针神经传导途径电针疗法疗效差异

Responses of Primary Afferent Fibers to Acupuncture-Like Peripheral Stimulation at Different Frequencies:Characterization by Single-Unit Recording in Rats

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Neuroscience Bulletin 2020年第8期36卷 907-918页

作者： Ran Huo Song-Ping han Feng-Yu Liu Xiao-jing Shou Ling-Yu Liu Tian-jia Song Fu-Jun Zhai Rong Zhang Guo-Gang Xing ji-sheng han Neuroscience Research Institute Peking UniversityBeijing 100191China Department of Neurobiology Peking University School of Basic Medical SciencesBeijing 100191China Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning CommissionPeking UniversityBeijing 100191China Department of Radiology Peking University Third HospitalBeijing 100191China Department of Integration of Chinese and Western Medicine Peking University School of Basic Medical SciencesBeijing 100191China

The pain-relieving effect of acupuncture is known to involve primary afferent nerves(PANs) via their roles in signal transmission to the *** single-unit recording in rats,we characterized the generation and transmission of electrical signals in Aβ and Aδ fibers induced by acupuncture-like ***-like signals were elicited in PANs using three techniques:manual acupuncture(MAc),emulated acupuncture(EAc),and electro-acupuncture(EA)-like peripheral electrical stimulation(PES).The discharges evoked by MAc and EAc were mostly in a burst pattern with average intra-burst and inter-burst firing rates of 90 Hz and 2 Hz,*** frequency of discharges in PANs was correlated with the frequency of *** highest discharge frequency was 246 Hz in Aβ fibers and 180 Hz in Aδ ***,EA in a dense-disperse mode(at alternating frequency between 2 Hz and 15 Hz or between 2 Hz and 100 Hz) best mimics *** of EA output>250 Hz appear to be obsolete for pain relief.

关键词： Acupuncture Peripheral electrical stimulation Dorsal root Primary afferent fiber Electrophysiology Single unit recording

A Volumetric and Functional Connectivity MRI Study of Brain Arginine-Vasopressin Pathways in Autistic Children

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Neuroscience Bulletin 2017年第2期33卷 130-142页

作者： Xiao-jing Shou Xin-jie Xu Xiang-Zhu Zeng Ying Liu Hui-Shu Yuan Yan Xing Mei-Xiang jia Qing-Yun Wei Song-Ping han Rong Zhang ji-sheng han Neuroscience Research Institute Peking UniversityBeijing 100191China Department of Neurobiology School of Basic Medical SciencesPeking UniversityBeijing 100191China Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning CommissionPeking UniversityBeijing 100191China Radiology Department Peking University Third HospitalBeijing 100191China Department of Pediatrics Peking University Third HospitalBeijing 100191China Mental Health Institute Peking UniversityBeijing 100191China Key Laboratory of Ministry of National Health and Family Planning Commission Beijing 100191China Sunshine Friendship Rehabilitation Centre Beijing 100085China

Dysfunction of brain-derived arginine-vasopressin（AVP） systems may be involved in the etiology of autism spectrum disorder（ASD）. Certain regions such as the hypothalamus, amygdala, and hippocampus are known to contain either AVP neurons or terminals and may play an important role in regulating complex social *** present study was designed to investigate the concomitant changes in autistic behaviors, circulating AVP levels, and the structure and functional connectivity（FC） of speci？c brain regions in autistic children compared with typically developing children（TDC） aged from 3 to5 years. The results showed：（1） children with ASD had a signi？cantly increased volume in the left amygdala and left hippocampus, and a signi？cantly decreased volume in the bilateral hypothalamus compared to TDC, and these were positively correlated with plasma AVP level.（2） Autistic children had a negative FC between the left amygdala and the bilateral supramarginal gyri compared to TDC. The degree of the negative FC between amygdala and supramarginal gyrus was associated with a higher score on the clinical autism behavior checklist.（3） The degree of negative FC between left amygdala and left supramarginal gyrus was associated with a lowering of the circulating AVP concentration in boys with ASD.（4） Autistic children showed a higher FC between left hippocampus and right subcortical area compared to TDC.（5） The circulating AVP was negatively correlated with the visual and listening response score of the childhood autism rating *** results strongly suggest that changes in structure and FC in brain regions containing AVP may be involved in the etiology of autism.

关键词： Autism Children Arginine-vasopressin MRI Structure Connectivity Behavior

炒麦芽含药血清中α-溴隐停移行成分高效液相色谱法定性定量分析

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时珍国医国药 2007年第12期18卷 3024-3026页

作者：徐勇戢翰升湖北中医学院湖北省郧阳医学院附属十堰市人民医院 442000

目的对炒麦芽含药血清中α-溴隐停进行定性定量分析。方法以炒麦芽中已知含有的成分α-溴隐停作为对照品,通过对实验动物家兔灌胃饲服炒麦芽,应用高效液相色谱法分别比较了实验动物家兔炒麦芽含药血清、阳性对照药物溴隐停含药血清及空... 详细信息

目的对炒麦芽含药血清中α-溴隐停进行定性定量分析。方法以炒麦芽中已知含有的成分α-溴隐停作为对照品,通过对实验动物家兔灌胃饲服炒麦芽,应用高效液相色谱法分别比较了实验动物家兔炒麦芽含药血清、阳性对照药物溴隐停含药血清及空白不含药血清的高效液相色谱图,建立α-溴隐停定量检测的方法学。结果α-溴隐停和炒麦芽含药血清及含溴隐停血清成分一部分峰相同,而空白血清在相同保留时间并没有该峰形,HPLC法最终测得炒麦含药血清中α-溴隐停含量为(0.070 2±0.01)μg/g。结论家兔经炒麦芽灌胃后,血中有炒麦芽源性的α-溴隐停移行成分,性质并未发生改变,建立了该成分定量分析的方法学操作规范。

关键词：炒麦芽高效液相色谱 α-溴隐停

Peripheral sensitization:roles and mechanisms for cancer-induced bone pain

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Peripheral sensitization:roles and mechanisms for cancer-ind...