Responses of Primary Afferent Fibers to Acupuncture-Like Peripheral Stimulation at Different Frequencies:Characterization by Single-Unit Recording in Rats

作     者：Ran Huo Song-Ping Han Feng-Yu Liu Xiao-Jing Shou Ling-Yu Liu Tian-Jia Song Fu-Jun Zhai Rong Zhang Guo-Gang Xing Ji-Sheng Han Ran Huo;Song-Ping Han;Feng-Yu Liu;Xiao-Jing Shou;Ling-Yu Liu;Tian-Jia Song;Fu-Jun Zhai;Rong ghang;Guo-Gang Xing;Ji-Sheng Han

作者机构：Neuroscience Research InstitutePeking UniversityBeijing 100191China Department of NeurobiologyPeking University School of Basic Medical SciencesBeijing 100191China Key Laboratory for NeuroscienceMinistry of Education/National Health and Family Planning CommissionPeking UniversityBeijing 100191China Department of RadiologyPeking University Third HospitalBeijing 100191China Department of Integration of Chinese and Western MedicinePeking University School of Basic Medical SciencesBeijing 100191China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2020年第36卷第8期

页      面：907-918页

核心收录：

学科分类：0710[理学-生物学] 1005[医学-中医学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100512[医学-针灸推拿学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of the Ministry of Science and Technology,China (2016YFC0105501,2019YFC1712104 and 2016YFF0202802) the National Natural Science Foundation of China (81974169, 81671085 and 61527815) 

主　　题：Acupuncture Peripheral electrical stimulation Dorsal root Primary afferent fiber Electrophysiology Single unit recording 

摘      要：The pain-relieving effect of acupuncture is known to involve primary afferent nerves(PANs) via their roles in signal transmission to the *** single-unit recording in rats,we characterized the generation and transmission of electrical signals in Aβ and Aδ fibers induced by acupuncture-like ***-like signals were elicited in PANs using three techniques:manual acupuncture(MAc),emulated acupuncture(EAc),and electro-acupuncture(EA)-like peripheral electrical stimulation(PES).The discharges evoked by MAc and EAc were mostly in a burst pattern with average intra-burst and inter-burst firing rates of 90 Hz and 2 Hz,*** frequency of discharges in PANs was correlated with the frequency of *** highest discharge frequency was 246 Hz in Aβ fibers and 180 Hz in Aδ ***,EA in a dense-disperse mode(at alternating frequency between 2 Hz and 15 Hz or between 2 Hz and 100 Hz) best mimics *** of EA output250 Hz appear to be obsolete for pain relief.