A Volumetric and Functional Connectivity MRI Study of Brain Arginine-Vasopressin Pathways in Autistic Children

作     者：Xiao-Jing Shou Xin-Jie Xu Xiang-Zhu Zeng Ying Liu Hui-Shu Yuan Yan Xing Mei-Xiang Jia Qing-Yun Wei Song-Ping Han Rong Zhang Ji-Sheng Han 

作者机构：Neuroscience Research InstitutePeking UniversityBeijing 100191China Department of NeurobiologySchool of Basic Medical SciencesPeking UniversityBeijing 100191China Key Laboratory for NeuroscienceMinistry of Education/National Health and Family Planning CommissionPeking UniversityBeijing 100191China Radiology DepartmentPeking University Third HospitalBeijing 100191China Department of PediatricsPeking University Third HospitalBeijing 100191China Mental Health InstitutePeking UniversityBeijing 100191China Key Laboratory of Ministry of National Health and Family Planning CommissionBeijing 100191China Sunshine Friendship Rehabilitation CentreBeijing 100085China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2017年第33卷第2期

页      面：130-142页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：support provided by the Department of Radiology,Peking University Third Hospital and the Brainnetome Center,Institute of Automation,Chines Academy of Sciences are highly appreciated supported by the UULM-PUHSC Joint Center for Neuroscience Fund(BMU20160563) 

主　　题：Autism Children Arginine vasopressin MRI Structure Connectivity Behavior 

摘      要：Dysfunction of brain-derived arginine-vasopressin（AVP） systems may be involved in the etiology of autism spectrum disorder（ASD）. Certain regions such as the hypothalamus, amygdala, and hippocampus are known to contain either AVP neurons or terminals and may play an important role in regulating complex social *** present study was designed to investigate the concomitant changes in autistic behaviors, circulating AVP levels, and the structure and functional connectivity（FC） of speci？c brain regions in autistic children compared with typically developing children（TDC） aged from 3 to5 years. The results showed：（1） children with ASD had a signi？cantly increased volume in the left amygdala and left hippocampus, and a signi？cantly decreased volume in the bilateral hypothalamus compared to TDC, and these were positively correlated with plasma AVP level.（2） Autistic children had a negative FC between the left amygdala and the bilateral supramarginal gyri compared to TDC. The degree of the negative FC between amygdala and supramarginal gyrus was associated with a higher score on the clinical autism behavior checklist.（3） The degree of negative FC between left amygdala and left supramarginal gyrus was associated with a lowering of the circulating AVP concentration in boys with ASD.（4） Autistic children showed a higher FC between left hippocampus and right subcortical area compared to TDC.（5） The circulating AVP was negatively correlated with the visual and listening response score of the childhood autism rating *** results strongly suggest that changes in structure and FC in brain regions containing AVP may be involved in the etiology of autism.