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Role of adjuvant chemoradiotherapy and chemotherapy in patients with resected gallbladder carcinoma: a multiinstitutional analysis (KROG 19-04)

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Cancer Biology & Medicine 2022年第6期19卷 931-944页

作者： Sung Uk Lee Jinsil Seong Tae Hyun kim Jung Ho Im Woo Chul kim Kyubo kim Hae Jin Park Tae Gyu kim Youngkyong kim Bae Kwon jeong Jin Hee kim Byoung Hyuck kim Taek-Keun Nam Center for Proton Therapy and Center for Liver and Pancreatobiliary Cancer National Cancer CenterGoyang 10408Korea Department of Radiation Oncology Yonsei Cancer CenterYonsei University College of MedicineSeoul 03722Korea Department of Radiation Oncology CHA Bundang Medical CenterCHA University School of MedicineSeongnam 13497Korea Department of Radiation Oncology Inha University HospitalInha University School of MedicineIncheon 22332Korea Department of Radiation Oncology Ewha Womans University Mokdong HospitalEwha Womans University College of MedicineSeoul 07985Korea Department of Radiation Oncology Hanyang University Medical CenterHanyang University College of MedicineSeoul 04763Korea Department of Radiation Oncology Samsung Changwon HospitalSungkyunkwan University School of MedicineChangwon 51353Korea Department of Radiation Oncology Kyung Hee University HospitalKyung Hee University College of MedicineSeoul 02447Korea Department of Radiation Oncology Gyeongsang National University HospitalGyeongsang National University College of MedicineJinju 52727Korea Department of Radiation Oncology Dongsan Medical CenterKeimyung University School of MedicineDaegu 41931Korea Department of Radiation Oncology Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 07061Korea Department of Radiation Oncology Chonnam National University Hwasun HospitalChonnam National University College of MedicineHwasun 58128Korea

Objective:The effectiveness of adjuvant treatments for resected gallbladder carcinoma(GBC)has remained unclear due to lack of randomized controlled trials;thus,the aim of present study was to evaluate the role of adjuvant treatments,including chemoradiotherapy(CRT)and/or chemotherapy(CTx),in patients with resected ***:A total of 733 GBC patients who received curative-intent surgical resection were identified in a multi-institutional *** 733 patients,372(50.8%)did not receive adjuvant treatment,whereas 215(29.3%)and 146(19.9%)received adjuvant CTx and CRT,*** locoregional recurrence-free survival(LRFS),recurrence-free survival(RFS),and overall survival(OS)of the adjuvant treatment groups were compared according to tumor stage(stage II *** III–IV).Results:In stage II disease(n=381),the 5-year LRFS,RFS,and OS were not significantly different among the no-adjuvant therapy,CTx,and CRT groups,and positive resection margin,presence of perineural invasion,and Nx classification were consistently associated with worse LRFS,RFS,and OS in the multivariate analysis(P<0.05).For stage III–IV(n=352),the CRT group had significantly higher 5-year LRFS,RFS,and OS than the no-adjuvant therapy and CTx groups(67.8%,45.2%,and 56.9%;37.9%,28.8%,and 35.4%;and 45.0%,30.0%,and 45.7%,respectively)(P<0.05).Conclusions:CRT has value as adjuvant treatment for resected GBC with stage III–IV *** study is needed for stage II disease with high-risk features.

关键词： Gallbladder cancer adjuvant treatment chemoradiotherapy locoregional recurrence-free survival overall survival

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Human periodontal ligament stem cells repair mental nerve injury

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Neural Regeneration Research 2013年第30期8卷 2827-2837页

作者： Bohan Li hun-Jong Jung Soung-Min kim Myung-Jin kim jeong Won Jahng Jong-Ho Lee Department of Oral and Maxillofacial Surgery School of Dentistry Binzhou Medical College Department of Occupation and Environment Konkuk Postgraduate Medical School Department of Oral and Maxillofacial Surgery School of Dentistry Seoul National University Dental Research Institute Seoul National University

Human periodontal ligament stem cells are easily accessible and can differentiate into Schwann cells. We hypothesized that human periodontal ligament stem cells can be used as an alternative source for the autologous Schwann cells in promoting the regeneration of injured peripheral nerve. To validate this hypothesis, human periodontal ligament stem cells （1 × 106） were injected into the crush-injured left mental nerve in rats. Simultaneously, autologous Schwann cells （1 × 106） and PBS were also injected as controls. Real-time reverse transcriptase polymerase chain reaction showed that at 5 days after injection, mRNA expression of low affinity nerve growth factor receptor was sig-nificantaly increased in the left trigeminal ganglion of rats with mental nerve injury. Sensory tests, histomorphometric evaluation and retrograde labeling demonstrated that at 2 and 4 weeks after in-jection, sensory function was significantly improved, the numbers of retrograde labeled sensory neurons and myelinated axons were significantly increased, and human periodontal ligament stem cells and autologous Schwann cells exhibited similar therapeutic effects. These findings suggest that transplantation of human periodontal ligament stem cells show a potential value in repair of mental nerve injury.

关键词： neural regeneration peripheral nerve injury stem cells periodontal ligament stem cells mentalnerve Schwann cells cell transplantation sensory nerve neurotrophic factor neuroregeneration

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Docurity: A New Cryptographic Primitive for Collaborative Cloud Systems

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Intelligent Automation & Soft Computing 2023年第6期36卷 3725-3742页

作者： Byeori kim Minseong Choi Taek-Young Youn jeong Hyun Yi Haehyun Cho Soongsil University Seoul06978Korea Dankook University Yongin16890Korea

Recently,there has been a sudden shift from using traditional office applications to the collaborative cloud-based office suite such as Microsoft Office *** cloud-based systems allow users to work together on the same docu-ment stored in a cloud server at once,by which users can effectively collaborate with each ***,there are security concerns unsolved in using cloud *** of the major concerns is the security of data stored in cloud ser-vers,which comes from the fact that data that multiple users are working together cannot be stored in encrypted form because of the dynamic characteristic of cloud *** this paper,we propose a novel mode of operation,DL-ECB,for AES by which we can modify,insert,and delete the ciphertext based on changes in ***,we can use encrypted data in collaborative cloud-based *** demonstrate that the DL-ECB mode can preserve the confidential-ity,integrity,and auditability of data used in collaborative cloud systems from adversaries,we implement and evaluate the prototype of the DL-ECB mode.

关键词： Cloud collaboration mode of operation auditability of ciphertext

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Corrugated surface microparticles with chitosan and levofloxacin for improved aerodynamic performance

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Asian Journal of Pharmaceutical Sciences 2023年第3期18卷 146-158页

作者： Chang-Soo Han Ji-Hyun Kang Eun hye Park Hyo-Jung Lee So-jeong jeong Dong-Wook kim Chun-Woong Park College of Pharmacy Chungbuk National UniversityCheongju 28160Republic of Korea School of Pharmacy Jeonbuk National UniversityJeonju 54896Republic of Korea College of Pharmacy Wonkwang UniversityIksan 54538Republic of Korea

Corrugated surface microparticles comprising levofloxacin(LEV),chitosan and organic acid were prepared using the 3-combo spray drying *** amount and the boiling point of the organic acid affected the degree of *** this study,we tried to improve the aerodynamic performance and increase aerosolization by corrugated surface microparticle for lung drug delivery efficiency as dry powder ***175 L20 prepared with 175 mmol propionic acid solution was corrugated more than HMF175 L20 prepared with 175 mmol formic acid *** ACI and PIV results showed a significant increase in aerodynamic performance of corrugated *** FPF value of HMP175 L20 was 41.3%±3.9%compared with 25.6%±7.7%of HMF175 *** microparticles also showed better aerosolization,decreased x-axial velocity,and variable *** dissolution of drug formulationswas observed in *** administered to the lungs achieved higher LEV concentrations in the lung fluid than high doses administered *** modification in the polymer-based formulation was achieved by controlling the evaporation rate and improving the inhalation efficiency of DPIs.

关键词： Chitosan Organic acid Levofloxacin Corrugated surface Aerodynamic performance

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Development of dilated cardiomyopathy with a long latent period followed by viral fulminant myocarditis:A case report

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World Journal of Clinical Cases 2022年第36期10卷 13451-13457页

作者： Seung Do Lee Hyo Jin Lee Hye Ree kim Min Gyu Kang Kyehwan kim jeong Rang Park Division of Cardiology Department of Internal MedicineGyeongsang National University School of Medicine and Gyeongsang National University HospitalJinju 52727South Korea

BACKGROUND The clinical course of acute myocarditis ranges from the occurrence of a few symptoms to the development of fatal fulminant ***,fulminant myocarditis causes clinical deterioration very rapidly and *** long-term prognosis of myocarditis is varied,and it fully recovers without leaving any special ***,even after recovery,heart failure may occur and eventually progress to dilated cardiomyopathy(DCM),which causes serious left ventricular *** the case of follow-up observation,no clear guidelines have been *** SUMMARY We report the case of a 21-year-old woman who presented with *** became hemodynamically unstable and showed sustained fatal arrhythmias with decreased heart *** was clinically diagnosed with fulminant myocarditis based on her echocardiogram and cardiac magnetic resonance *** 2 d,she was readmitted to the emergency department under cardiopulmonary resuscitation and received mechanical ventilation and extracorporeal membrane *** implantable cardioverter defibrillator was inserted for secondary *** recovered and was *** to being hospitalized for sudden cardiac function decline and arrhythmia,she had been well for 7 years without any *** was finally diagnosed with dilated *** DCM may develop unexpectedly in patients who have been cured of acute fulminant myocarditis and have been stable with a long period of ***,they should be carefully and regularly observed clinically throughout long-term follow-up.

关键词： Myocarditis Fulminant Dilated cardiomyopathy Outcome Remission Case report

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Development of acquired non-accommodative esotropia in a patient without a trochlear nerve

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International Journal of Ophthalmology(English edition) 2022年第6期15卷 1030-1031页

作者： Hee Kyung Yang Jae Hyoung kim jeong-Min Hwang Department of Ophthalmology Seoul National University College of MedicineSeoul National University Bundang HospitalSeongnam 13620Republic of Korea Department of Radiology Seoul National University College of MedicineSeoul National University Bundang HospitalSeongnam 13620Republic of Korea

Dear Editor,Congenital cranial dysinnervation disorders(CCDD) are neurodevelopmental diseases of the brainstem and cranial nerves;. Congenital superior oblique palsy(SOP) is one of the most representative CCDDs becaus... 详细信息

关键词： nerves diseases oblique

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Meta-analysis on the effectiveness of parent education for children with disabilities

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World Journal of Clinical Cases 2023年第29期11卷 7082-7090页

作者： JongSik Jang Geonwoo kim Hyewon jeong Narae Lee Seri Oh Department of Occupatioanl Therapy Kangwon National UniversityGangwondoSamcheok 25945South Korea Department of Occupational Therapy Kangwon National University Graduate SchoolGangwon-doSamcheok 25949South Korea

BACKGROUND Parents of children with disabilities often have difficulty understanding their child’s behavior and are unable to do it appropriately because they do not know what to *** more we properly understand children with disabilities,the more positive the importance of parent education becomes in various *** To demonstrate the effectiveness of parent education for children with disabilities in various aspects and present it as evidence that can be used *** For a meta-analysis on the effectiveness of parent education for children with disabilities,literature was collected from 2002 to 2022 using PubMed,Embase,Web of Science,Directory of Open Access Journals,and Europe *** terms were“disabled children,”“disabled children,”“parent education,”“parent training,”and“parent coaching.”The final searched literature included a total of 11 *** calculate the effect size,the mean,standard deviation,and sample size of the experimental and control groups were analyzed,and a meta-analysis was performed using RevMan version *** analyze statistical heterogeneity,a chi-square test was performed to evaluate the significance of Q statistics to indicate statistical *** The final literature totaled 11 articles,and a total of 4 items were *** were 5 studies on parental depression,the heterogeneity was 98%,and the effect size for parental depression was 0.35[confidence interval(CI:0.30-0.40)],indicating a small but statistically significant effect *** were 4 studies on parenting attitude,the heterogeneity was 100%,the effect size on parenting attitude was 0.41(CI:0.37-0.46),which was a medium effect size,and the P value showed a statistically significant ***,face-to-face parent education was found to have a larger effect size than non-face-to-face *** parent education methods,face-to-face parent education had a medium effect size[0.57(CI:0.52-0.61)],while non-face-to-face par

关键词： Children Children with disabilities Education Meta-analysis Parents Parent education

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Transcatheter embolization for hemorrhage from aberrant testicular artery after partial nephrectomy:A case report

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World Journal of Clinical Cases 2023年第32期11卷 7852-7857页

作者： Juyoun Youm Min-jeong Choi Bong Man kim Yumi Seo Department of Radiology Dankook University HospitalCheonan 31116South Korea Department of Urology Dankook University HospitalCheonan 31116South Korea

BACKGROUND Arterial bleeding typically involves the renal artery following partial nephrectomy;in this study,we present a case of bleeding originating from the testicular artery that has not been reported in previous *** SUMMARY A 52-year-old man suffered hemorrhage from a perinephric branch of the aberrant left testicular artery after an open nephron-sparing surgery for renal cell *** signs of bleeding were manifested by the patient,such as fresh blood drainage from the catheter,decreased hemoglobin levels,and significant vital sign *** computed tomography did not show evidence of active bleeding,transcatheter angiography was conducted to identify the bleeding *** spot images confirmed bleeding derived from a perinephric branch of the testicular artery originating from the segmental artery of the left renal *** n-butyl-2-cyanoacrylate,successful transcatheter arterial embolization of the affected branch was *** after the embolization procedure,the bleeding ceased,and the patient experienced complete recovery devoid of *** In patients with postoperative arterial hemorrhage after partial nephrectomy,the testicular artery can be a rare but notable source of *** bleeding site localization via angiographic evaluation,followed by transcatheter arterial embolization,can be instrumental for safe,prompt,and effective hemostasis.

关键词： Partial nephrectomy Hemorrhage Testicular artery Angiography Embolization Case report

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Metabolic signaling functions of the heme oxygenase/CO system in metabolic diseases

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Cellular & Molecular Immunology 2018年第12期15卷 1085-1087页

作者： Hyo jeong kim Yeonsoo Joe Young-Joon Surh hun Taeg Chung Department of Biological Sciences University of UlsanUlsanSouth Korea Tumor Microenvironment Global Core Research Center Research Institute of Pharmaceutical SciencesSeoul National UniversitySeoulSouth Korea

Immunometabolism is the intersection of immunology and *** heme oxygenase(HO)-1 and carbon monoxide(CO)(HO-1/CO)system can be induced by various stresses,including infection,and its function is to relieve stresses such as oxidative and inflammatory *** we demonstrate that the HO-1/CO system is intimately involved in the beneficial modulation of metabolic pathways via the production of ATF4 through an integrative stress response.

关键词： system monoxide oxidative

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Proxy-Based Hierarchical Distributed Mobility Management for Tactical Networks

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Computers, Materials & Continua 2022年第2期70卷 2381-2399页

作者： Myoung-hun Han Bong-Soo Roh Kyungwoo kim Dae-Hoon Kwon Jae-Hyun Ham KyungHyun Yoon Sanghyun Seo Agency for Defense Development Daejeon34186Korea Department of Computer Science and Engineering Chung-Ang UniversitySeoul06974Korea College of Art&Technology Chung-Ang UniversityAnseong17546Korea

An important requirement in a military domain is a highly reliable mobility management method,especially when components of the networks aremoving in tactical network *** increase reliability,themobility management technology of the tactical network should be able to reflect the characteristics of the tactical network,such as a limited environment,failure,and hierarchical unit *** this paper,we propose a proxy-based hierarchical distributedmobilitymanagement scheme,which is highly focused on tactical *** the characteristics of tactical networks,the proposed scheme is composed of the following:1)a proxy-based method,2)a distributed mobility management method that synchronizes a mobility database between entities,and 3)a method of managing mobility by dividing the tactical network into upper and lower *** analysis and modeling and simulation results demonstrate that the method outperforms the existing state-of-the-art method in overcoming entity failure,handover cost,and delay in tactical environments.

关键词： Mobility management tactical networks PMIP DMM

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