Human periodontal ligament stem cells repair mental nerve injury

作     者：Bohan Li Hun-Jong Jung Soung-Min Kim Myung-Jin Kim Jeong Won Jahng Jong-Ho Lee 

作者机构：Department of Oral and Maxillofacial Surgery School of Dentistry Binzhou Medical College Department of Occupation and Environment Konkuk Postgraduate Medical School Department of Oral and Maxillofacial Surgery School of Dentistry Seoul National University Dental Research Institute Seoul National University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2013年第8卷第30期

页      面：2827-2837页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

基　　金：supported by a grant of the Korea Healthcare Technology R&D Project Ministry for Health Welfare & Family Affairs Republic of Korea No.A101578 

主　　题：neural regeneration peripheral nerve injury stem cells periodontal ligament stem cells mentalnerve Schwann cells cell transplantation sensory nerve neurotrophic factor neuroregeneration 

摘      要：Human periodontal ligament stem cells are easily accessible and can differentiate into Schwann cells. We hypothesized that human periodontal ligament stem cells can be used as an alternative source for the autologous Schwann cells in promoting the regeneration of injured peripheral nerve. To validate this hypothesis, human periodontal ligament stem cells （1 × 106） were injected into the crush-injured left mental nerve in rats. Simultaneously, autologous Schwann cells （1 × 106） and PBS were also injected as controls. Real-time reverse transcriptase polymerase chain reaction showed that at 5 days after injection, mRNA expression of low affinity nerve growth factor receptor was sig-nificantaly increased in the left trigeminal ganglion of rats with mental nerve injury. Sensory tests, histomorphometric evaluation and retrograde labeling demonstrated that at 2 and 4 weeks after in-jection, sensory function was significantly improved, the numbers of retrograde labeled sensory neurons and myelinated axons were significantly increased, and human periodontal ligament stem cells and autologous Schwann cells exhibited similar therapeutic effects. These findings suggest that transplantation of human periodontal ligament stem cells show a potential value in repair of mental nerve injury.