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Avoiding heating interference and guided thermal conduction in stretchable devices using thermal conductive composite islands

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Nano Research 2021年第9期14卷 3253-3259页

作者： Seung Ji Kang Haeleen Hong Chanho jeong Ju Seung Lee Hyewon Ryu Jae-hun Yang Jong Uk Kim Yiel Jae shin Tae-il Kim School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Biomedical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Biomedical Institute for Convergence(BICS) Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea

The miniaturization and high integration of devices demand significant thermal management *** technologies for the thermal management of electronics show some limitations in the case of multiple chip arrays.A device in multiple chip array is affected by heat from adjacent devices,along with thermal conductive *** address this problem,we present a nano composite of aligned boron nitride(BN)nanosheet islands with porous polydimethylsiloxane(PDMS)foam to have mechanical stability and non-thermal *** islands of tetrahedrally-structured BN in the composite have a high thermal conductivity of 1.219 W·m^(-1)·K^(-1) in the through-plane direction(11.234W·m^(-1)·K^(-1)in the in-plane direction)with 16 wt.%loading of *** the other hand,porous PDMS foam has a low thermal conductivity of 0.0328W·m^(-1)·K^(-1) in the through-plane direction at 70%*** pathways are then formed only in the structured BN islands of the *** porous PDMS foam can be applied as a thermal barrier between structured BN islands to inhibit thermal interference in multiple device ***,this composite can maintain selective thermal dissipation performance with 70%tensile *** beauty of the work is that it could have guided heat dissipation by assembling of multiple layers which have high vertical thermal conductive islands,while inhibiting thermal *** selective heat dissipating composite can be applied as a heatsink for multiple chip arrays electronics.

关键词： selective thermal conduction non-thermal interference thermal conductive composite island stretchable electronics structured boron nitride nanosheet(s-BN) porous polydimethylsiloxane(p-PDMS)

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Short-term and long-term outcomes of laparoscopic vs open ileocolic resection in patients with Crohn's disease: Propensityscore matching analysis

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World Journal of Gastroenterology 2021年第41期27卷 7159-7172页

作者： shin jeong Pak Young Il Kim Yong Sik Yoon Jong Lyul Lee Jung Bok Lee Chang Sik Yu Department of Colon and Rectal Surgery University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Clinical Epidemiology and Biostatistics University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND Laparoscopic ileocolic resection(LICR)is the preferred surgical approach for primary ileocolic Crohn’s disease(CD)because it has greater recovery benefits than open ICR(OICR).AIM To compare short-and long-term outcomes in patients who underwent LICR and *** Patients who underwent ICR for primary CD from 2006 to 2017 at a single tertiary center specializing in CD were *** who underwent LICR and OICR were subjected to propensity-score matching *** were propensityscore matched 1:1 by factors potentially associated with 30-d perioperative *** included demographic characteristics and disease-and treatment-related *** were compared using univariate and multivariate ***-term surgical recurrence-free survival(SRFS)in the two groups was determined by the Kaplan-Meier method and compared by the log-rank *** During the study period,348 patients underwent ICR,211 by the open approach and 137 ***-score matching yielded 102 pairs of *** rate of postoperative complication was significantly lower(14%versus 32%,P=0.003),postoperative hospital stay significantly shorter(8 d versus 13 d,P=0.003),and postoperative pain on day 7 significantly lower(1.4 versus 2.3,P<0.001)in propensity-score matched patients who underwent LICR than in those who underwent *** analysis showed that postoperative complications were significantly associated with preoperative treatment with biologics[odds ratio(OR):3.14,P=0.01]and an open approach to surgery(OR:2.86,P=0.005).The 5-and 10-year SRFS rates in the matched pairs were 92.9%and 83.3%,respectively,with SRFS rates not differing significantly between the OICR and LICR *** performance of additional procedures was an independent risk factor for surgical recurrence[hazard ratio(HR):3.28,P=0.02].CONCLUSION LICR yielded better short-term outcomes and postoperative recovery than OICR,with no differences in long-ter

关键词： Crohn’s disease Laparoscopic Surgery Postoperative complications Recurrence Propensity score Retrospective study

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Antiinflammatory and analgesic effect of herbal cocktail Hongbaekjeong via inhibition of proinflammatory cytokines and prostaglandin E2 release

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Chinese Science Bulletin 2014年第25期59卷 3127-3133页

作者： Jinwon Lim Hyo-Jung Lee Bonglee Kim jeong-Un Choi Yoeok shin Eun Jung Sohn Sung-Hoon Kim Cancer Preventive Material Development Research Center College of Oriental Medicine Kyung Hee University

Though Hongbaekjeong(HBJ),a hebal mixture of three medicinal plants,has been traditionally used for arthritis and muscular pain,its scientific evidence still remains ***,in the present study,analgesic and anti-inflammatory mechanism of HBJ was evaluated in vitro and in *** significantly reduced NO production and prostaglandin E2(PGE2)release and also attenuated the expression of cyclooxygenase 2(COX-2)in lipopolysaccharides(LPS)and interferon(IFN)-c treated RAW 264.7 ***,HBJ abrogated the production of proinflammatory cytokines such as interleukin(IL)1b,IL-6,IL-8 and monocyte chemoattractant protein-1(MCP-1)in LPS and IFN-c treated RAW 264.7 *** addition,HBJ significantly decreased the number of writhing syndrome induced by acetic acid,and also increased latency in hot-plate method and tail flick test in ***,HBJ significantly reduced the edema volume in the hind paw of the rats with arthritis induced by Freund’s complete adjuvant(FCA)compared to untreated ***,our findings demonstrate the antiinflammatory and analgesic potential of HBJ via inhibition of proinflammatory cytokines and PGE2 release for treatment of arthritis and muscular pain.

关键词：前列腺素E2 炎性细胞因子和镇痛抗炎单核细胞趋化蛋白-1 鸡尾酒 IFN-γ

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How Do Phytochromes Transmit the Light Quality Information to the Circadian Clock in Arabidopsis？

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Molecular Plant 2014年第11期7卷 1701-1704页

作者： Miii Yeom Hyunmin Kim Junhyun Lim Ah- Young shin Sunghyun Hong jeong-II Kim Hong Gil Nam Division of Molecular and Life Sciences PohangUniversity of Science and Technology Hyojadong Pohang Gyeongbuk 790-784 Republic of Korea Integrative Biosciences & Biotechnology in POSTECH Hyojadong Pohang Gyeongbuk 790-784 Republic of Korea Department of Molecular Biotechnology and Kumho Life Science Laboratory Chonnam National University Gwangju 500-757 Republic of Korea Center for Plant Aging Research Institute for Basic Science Daegu 711-873 Republic of Korea Department of New Biology DGIST Hyeongpoong-Myun Dalsung-gun Daegu 711-873 Republic of Korea

Dear Editor, Plants use light as an environmental signal to coor- dinate diverse physiological and developmental processes, thereby increasing their fitness. Light quality, quantity, and photoperiod change periodically under natural condi- tions of daily and seasonal cycles. Plants have developed a circadian clock to respond to these predictable, periodic environmental changes, providing plants with the ability to anticipate daily and seasonal environmental changes.

关键词： STABILITY PROTEIN COP1

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MRI of gastric carcinoma:Results of T and N-staging in an in vitro study

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World Journal of Gastroenterology 2009年第32期15卷 3992-3998页

作者： Il Young Kim Sang Won Kim Hyeong Cheol shin Moon Soo Lee Dong Jun jeong Chang Jin Kim Young Tong Kim Department of Radiology Soonchunhyang University Cheonan Hospital23-20 BongmyungdongCheonanChoongnam 330-720South Korea Department of Surgery Soonchunhyang University Cheonan Hospital23-20 BongmyungdongCheonanChoongnam 330-720South Korea Department of Pathology Soonchunhyang University Cheonan Hospital23-20 BongmyungdongCheonanChoongnam 330-720South Korea

AIM:To determine the accuracy of 1.5-T magnetic resonance imaging (MRI) in the evaluation of gastric wall invasion and perigastric lymph node metastasis in gastric ***: Twenty resected gastric specimens containing 20 tumors were studied with a 1.5-T MR system using a commercial head surface coil. MR scanning was performed with a T1 weighted image (TR/TE = 500/20), and a T2 weighted image (TR/TE=2500/90). MR findings were compared with pathologic ***: A T1-weighted image demonstrated three layers in the normal gastric wall. All of the gastric tumors were well demonstrated by lesions and location. In a MRI findings of gastric wall invasion, there was 1 case of T1, 7 of T2, 11 of T3. Pathologic results of resected specimens included 3 cases of pT1, 4 of pT2, and 12 of pT3. The accuracy of T staging with MRI was 74% (14 of 19). MRI findings of lymph node me-tastasis included 6 cases of N0, 13 cases of N1. The accuracy of the N staging with MRI was 47% (9 of 19).CONCLUSION: MRI has a high diagnostic accuracy in the evaluation of the T staging of gastric cancer in vitro and thus potentially enables preoperative histo-pathologic staging.

关键词： MRI 胃癌体外图像显示磁共振成像评估精度共振系统手术切除

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Conservation and Diversification of the SHR-SCR- SCL23 Regulatory Network in the Development of the Functional Endodermis in Arabidopsis Shoots

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Molecular Plant 2016年第8期9卷 1197-1209页

作者： Eun Kyung Yoon Souvik Dhar Mi-Hyun Lee Jae Hyo Song shin Ae Lee Gyuree Kim Sejeong Jang Ji Won Choi jeong-Eun Choe jeong Hoe Kim Myeong Min Lee Jun Lim Department of Systems Biotechnology Konkuk University Seoul 05029 Korea Department of Systems Biology Yonsei University Seoul 03722 Korea Department of Biology Kyungpook National University Daegu 41566 Korea 4TheSe tlRors cotribCited equally/to ttats article Present address: Department of Agricultural Biotechnology National Institute of Agricultural Sciences Jeonju 54874 Korea Present address: Department of Agricultural Biology National Institute of Agricultural Sciences Wanju 55365 Korea

Development of the functional endodermis of Arabidopsis thaliana roots is controlled, in part, by GRAS transcription factors, namely SHORT-ROOT （SHR）, SCARECROW （SCR）, and SCARECROW-LIKE 23 （SCL23）. Recently, it has been shown that the SHR-SCR-SCL23 regulatory module is also essential for spec- ification of the endodermis （known as the bundle sheath） in leaves. Nevertheless, compared with what is known about the role of the SHR-SCR-SCL23 regulatory network in roots, the molecular interactions of SHR, SCR, and SCL23 are much less understood in shoots. Here, we show that SHR forms protein com- plexes with SCL23 to regulate transcription of SCL23 in shoots, similar to the regulation mode of SCR expression. Our results indicate that SHR acts as master regulator to directly activate the expression of SCR and SCL23. In the SHR-SCR-SCL23 network, we found a previously uncharacterized negative feed- back loop whereby SCL23 modulates SHR levels. Through molecular, genetic, physiological, and morpho- logical analyses, we also reveal that the SHR-SCR-SCL23 module plays a key role in the formation of the endodermis （known as the starch sheath） in hypocotyls. Taken together, our results provide new insights into the regulatory role of the SHR-SCR-SCL23 network in the endodermis development in both roots and shoots.

关键词： endodermis gene regulatory network SHORT-ROOT SCARECROW SCARECROW-LIKE 23,transcription factor

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Identification of Aristolactam Derivatives That Act as Inhibitors of Human Immunodeficiency Virus Type 1 Infection and Replication by Targeting Tat-Mediated Viral Transcription

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Virologica Sinica 2021年第2期36卷 254-263页

作者： Young Hyun shin Chul Min Park Hong Gi Kim Dong-Eun Kim Min Suk Choi jeong-ah Kim Byeong-Sun Choi Cheol-Hee Yoon Division of Viral Disease Research Center for Infectious Disease ResearchKorea National Institute of HealthHeungdeok-guCheongju-siShungbuk 28159Republic of Korea Center for Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyYuseong-guDaejeon 34114Republic of Korea

Despite the success of antiretroviral therapy(ART),efforts to develop new classes of antiviral agents have been hampered by the emergence of drug ***-indole-bearing aristolactams are compounds that have been isolated from various plants species and which show several clinically relevant effects,including anti-inflammatory,antiplatelet,and antimycobacterial ***,the effect of these compounds on human immunodeficiency virus type 1(HIV-1)infection has not yet been *** this study,we discovered an aristolactam derivative bearing dibenzo[cd,f]indol-4(5 H)-one that had a potent anti-HIV-1 effect.A structure-activity relationship(SAR)study using nine synthetic derivatives of aristolactam identified the differing effects of residue substitutions on the inhibition of HIV-1 infection and cell *** the compounds tested,1,2,8,9-tetramethoxy-5-(2-(piperidin-1-yl)ethyl)-dibenzo[cd,f]indol-4(5 H)-one(Compound 2)exhibited the most potent activity by inhibiting HIV-1 infection with a half-maximal inhibitory concentration(IC50)of 1.03 lmol/L and a half-maximal cytotoxic concentration(CC50)of 16.91 lmol/L(selectivity index,16.45).The inhibitory effect of the compounds on HIV-1 infection was linked to inhibition of the viral replication ***-of-action studies showed that the aristolactam derivatives did not affect reverse transcription or integration;instead,they specifically inhibited Tat-mediated viral *** together,these findings show that several aristolactam derivatives impaired HIV-1 infection by inhibiting the activity of Tat-mediated viral transcription,and suggest that these derivatives could be antiviral drug candidates.

关键词： Human immunodeficiency virus type 1(HIV-1) Aristolactam Antiviral activity HIV-1 transcription

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Magnetic resonance evaluation of human mesenchymal stem cells in corpus cavernosa of rats and rabbits

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Asian Journal of Andrology 2007年第3期9卷 361-367页

作者： Yun-seob Song Ja-Hyeon Ku Eun-Seop Song Jung-Hoon Kim Jin-Suck Jeon Kong-Hee Lee Sook-Ja Kim Hee-jeong Cheong Ik-Sung Lim Dongho Choi Jong-Ho Won Department of Urology Stem Cell therapy Center Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Urology Seoul National University Hospital Seoul 110-744 Korea Department of Obstetrics and Gynecology Inha University School of Medicine Incheon 400-103 Korea Department of Radiology Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Internal Medicine Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Urology Soonchunhyang School of Medicine Seoul 140-743 Korea Stem Cell therapy Center Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Industrial Management ＆ Engineering Namseoul University College of Engineering Cheonan 330-707 Korea Department of Surgery Stem Cell therapy Center Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Internal Medicine Stem Cell therapy Center Soonchunhyang School of Medicine Seoul 140-743 Korea

Aim： To investigate whether the biological process of superparamagnetic iron oxide （SPIO）-labeled human mesenchymal stem cells （hMSCs） may be monitored non-invasively by using in vivo magnetic resonance （MR） imaging with conventional 1.5-T system examinations in corpus cavernosa of rats and rabbits. Methods： The labeling efficiency and viability of SP10-labeled hMSCs were examined with Prussian blue and Tripan blue, respectively. After SPIO-labeled hMSCs were transplanted to the corpus cavernosa of rats and rabbits, serial T2-weighted MR images were taken and histological examinations were carried out over a 4-week period. Results： hMSCs loaded with SPIO compared to unlabeled cells had a similar viability. For SPIO-labeled hMSCs more than lx 105 concentration in vitro, MR images showed a decrease in signal intensity. MR signal intensity at the areas of SPIO-labeled hMSCs in the rat and rabbit corpus cavernosa decreased and was confined locally. After injection of SPIO-labeled hMSCs into the corpus cavernosum, MR imaging demonstrated that hMSCs could be seen for at least 12 weeks after injection. The presence of iron was confirmed with Prussian blue staining in histological sections. Conclusion： SP10-labeled hMSCs in corpus cavernosa of rats and rabbits can be evaluated non-invasively by molecular MR imaging. Our findings suggest that MR imaging has the ability to test the long-term therapeutic potential of hMSCs in animals in the setting of erectile dysfunction.

关键词： human mesenchymal stem cells magnetic resonance stem cells penis cell labeling corpus cavemosa

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Plasma Levels of Monocyte Chemotactic Protein 3 and Beta-Nerve Growth Factor Increase with Amnestic Mild Cognitive Impairment

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Cellular & Molecular Immunology 2009年第2期6卷 143-147页

作者： Kang Soo Lee Ji Hyung Chung Kyung Hye Lee Min-jeong shin Byoung Hoon Oh Soo Hyung Lee Chang Hyung Hong Department of Psychiatry Yonsei University College of Medicine Institution of Behavioral Science in Medicine Yonsei University College of Medicine Yonsei University Research Institute of Science for Aging Yonsei University Department of Food and Nutrition College of Health Science Korea University Department of Family Medicine Seoul Medical Center Department of Psychiatry Ajou University School of Medicine Memory Impairment Center Ajou University Hospital Ajou University School of Medicine

A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment （MCI）. In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 （MCP-3）, and beta-nerve growth factor （β-NGF） in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and β-NGF may be useful in differentiating subtypes of MCI.

关键词： mild cognitive impairment cytokine plasma inflammation biomarker

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果胶酶对苹果渣中多酚类物质的提取效果研究

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分析化学 2008年第3期36卷 306-310页

作者：郑虎哲 Hye-Ryun Lee Sang-Han Lee Chang-seob Kim shin-Kyo Chung 国立庆北大学校食品工学科浦项大学营养烹饪产业学院

具有多种生理活性的多酚类物质在苹果渣中主要以聚合体的形态存在。本研究利用果胶酶分解果胶质,把聚合态的多酚类物质转变为游离态,并提高多酚类物质的提取率。实验得出果胶酶释放总多酚类物质的最佳反应条件是温度为37℃,pH为3.6,酶/... 详细信息

具有多种生理活性的多酚类物质在苹果渣中主要以聚合体的形态存在。本研究利用果胶酶分解果胶质,把聚合态的多酚类物质转变为游离态,并提高多酚类物质的提取率。实验得出果胶酶释放总多酚类物质的最佳反应条件是温度为37℃,pH为3.6,酶/基质比例为12%,反应时间为11h。在此条件下,总多酚类物质(total phenolic compounds,TPC)和总黄酮类物质(total flavonoid compounds,TFC)含量分别达到9.08g/kg和1.38g/kg,比对照组的7.05g/kg和0.91g/kg分别提高1.3倍和1.5倍。果胶酶处理组比对照组多检出咖啡酸、香豆酸、阿魏酸、根皮素和未知物U3。以上结果表明,果胶酶具有较强的分解果胶质的功能,并能提高总多酚类物质的含量。

关键词：苹果渣果胶酶多酚类提取

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