Antiinflammatory and analgesic effect of herbal cocktail Hongbaekjeong via inhibition of proinflammatory cytokines and prostaglandin E2 release

作     者：Jinwon Lim Hyo-Jung Lee Bonglee Kim Jeong-Un Choi Yoeok Shin Eun Jung Sohn Sung-Hoon Kim 

作者机构：Cancer Preventive Material Development Research CenterCollege of Oriental Medicine Kyung Hee University 

出 版 物：《Chinese Science Bulletin》 (科学通报(英文版))

年 卷 期：2014年第59卷第25期

页      面：3127-3133页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by the National Research Foundation of Korea(NRF)grant funded by the Korean Ministry of Education Science and Technology(MEST](20120005755) 

主　　题：前列腺素E2 炎性细胞 因子和 镇痛 抗炎 单核细胞趋化蛋白-1 鸡尾酒 IFN-γ 

摘      要：Though Hongbaekjeong(HBJ),a hebal mixture of three medicinal plants,has been traditionally used for arthritis and muscular pain,its scientific evidence still remains ***,in the present study,analgesic and anti-inflammatory mechanism of HBJ was evaluated in vitro and in *** significantly reduced NO production and prostaglandin E2(PGE2)release and also attenuated the expression of cyclooxygenase 2(COX-2)in lipopolysaccharides(LPS)and interferon(IFN)-c treated RAW 264.7 ***,HBJ abrogated the production of proinflammatory cytokines such as interleukin(IL)1b,IL-6,IL-8 and monocyte chemoattractant protein-1(MCP-1)in LPS and IFN-c treated RAW 264.7 *** addition,HBJ significantly decreased the number of writhing syndrome induced by acetic acid,and also increased latency in hot-plate method and tail flick test in ***,HBJ significantly reduced the edema volume in the hind paw of the rats with arthritis induced by Freund’s complete adjuvant(FCA)compared to untreated ***,our findings demonstrate the antiinflammatory and analgesic potential of HBJ via inhibition of proinflammatory cytokines and PGE2 release for treatment of arthritis and muscular pain.