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Risk stratification for disease progression in pT3 prostate cancer after robot-assisted radical prostatectomy

Asian Journal of Andrology 2017年第6期19卷 700-706页

作者： jeong hee hong Young Suk Kwon Isaac Yi Kim Section of Urologic Oncology Rutgers Cancer Institute of New Jersey Division of Urology Rutgers Robert Wood Johnson Medical School Rutgers The State University of New Jersey New Brunswick NJ 08903 USA Department of Urology Dankook University College of Medicine Cheonan 31116 South Korea.

The aim of this study is to identify optimal patients for adjuvant radiation therapy （ART） in pT3 prostate cancer. The role of ART for patients with adverse pathologic features after radical prostatectomy （RP） has been demonstrated, but over- or under-treatment remains a significant concern. Two-hundred and five patients with pT3NOMO who underwent robot-assisted RP without ART were analyzed. Multivariate Cox proportional regression analyses were used to identify predictors of biochemical recurrence （BCR） and clinical progression （CP）. The estimated 5-year BCR-free survival （BCRFS） and CP-free survival （CPFS） were 52.8% and 85.6%, respectively. Preoperative prostate-specifc antigen （PSA）：〉10 ng m1-1 （hazard ratio [HR]： 3.288-6.027; P = 0.003）, pathologic Gleason score （pGS）：〉8 （HR： 4.146; P = 0.014）, and lymphovascular invasion （LVI）（HR： 2.167; P = 0.026） were associated with BCR. Based on these factors, a risk stratification tool was developed. Patients with no risk factors （PSA 〈10 ng m1-1, pGS 6, and absent LVI） showed excellent BCRFS and CPFS at 5 years （91.9% and 100.0%, respectively）, but those with two or more risk factors （PSA ：〉10 ng ml-1, pGS ≥8, or present LVI） had poor BCRFS and CPFS （12.1% and 54.6%, respectively）. In addition, the multivariate analysis revealed that pathologic stage pT3b （HR： 5.393; P = 0.025） was the only predictor of CP. Our study demonstrated the heterogeneity of oncologic outcomes in patients with pT3 prostate cancer. The proposed risk stratification can be used to identify patients who are at risk for disease progression and may aid in identifying the best patients for ART.

关键词： prostatectomy prostate-specific antigen recurrence survival

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Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer:a phase II trial of pembrolizumab

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Oncology Research 2025年第1期33卷 57-65页

作者： RYUL KIM JOO KYUNG PARK MINSUK KWON MINAE AN JUNG YONG hong JOON OH PARK SUNG hee LIM SEUNG TAE KIM Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Department of Hematology-Oncology Ajou University School of MedicineSuwon-siGyeonggi-doKorea Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of MedicineSeoulKorea

Background:Immune checkpoint inhibitors(ICIs)are effective in a subset of patients with metastatic solid ***,the patients who would benefit most from ICIs in biliary tract cancer(BTC)are still *** and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line ***:All patients had microsatellite stable(MSS)type *** of the 32 patients achieved partial response(PR),with an objective response rate(ORR)of 9.4%(95%confidence interval[CI],2.0–25.2)and nine showed stable disease(SD),exhibiting a disease control rate(DCR)of 37.5%(95%CI,21.1–56.3).For the 31 patients who had access to PD-1 ligand 1(PD-L1)combined positive score(CPS)testing(cut-off value≥1%),the ORR was not different between those who had PD-L1-positive(PD-L1+;1/11,9.1%)and PDL1-(2/20,10.0%)tumors(p=1.000).The tumor mutational burden(TMB)of PD-L1+BTC was comparable to that of PD-L1-BTC(p=0.630).TMB and any exonic somatic mutations were also not predictive of pembrolizumab *** analysis of blood and tumor samples demonstrated a relatively high natural killer(NK)cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor ***,the tumors of these patients presented high enrichment scores for NK cells,antitumor cytokines,and Th1 signatures,and a low enrichment score for cancer-associated ***:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing Biliary tract cancer

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Rice tissue-specific promoters and conditiondependent promoters for effective translational application

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Journal of Integrative Plant Biology 2015年第11期57卷 913-924页

作者： hee-jeong jeong Ki-hong Jung Department of Plant Molecular Systems Biotechnology and Crop Biotech Institute Kyung Hee University Graduate School of Biotechnology Kyung Hee University

Rice （Oryza sativa） is one of the most important staple food crops for more than half of the world＇s population. The demand is increasing for food security because of population growth and environmental challenges triggered by climate changes. This scenario has led to more interest in developing crops with greater productivity and sustainability. The process of genetic transformation, a major tool for crop improvement, utilizes promoters as one of its key elements. Those promoters are generally divided into three types： constitutive, spatiotemporal, and condition-dependent. Tran- scriptional control of a constitutive promoter often leads to reduced plant growth, due to a negative effect of accumu- lated molecules during cellular functions or energy consump- tion. To maximize the effect of a transgene on transgenic plants, it is better to use condition-dependent or tissue- specific promoters. However, until now, those types have not been as widely applied in crop biotechnology. In this review, we introduce and discuss four groups of tissue-specific promoters （5o promoters in total） and six groups of condition-dependent promoters （27 promoters）. These pro- moters can be utilized to fine-tune desirable agronomic traits and develop crops with tolerance to various stresses, enhanced nutritional value, and advanced productivity.

关键词： Condition-dependent promoters crop biotechnologyapplication genetic transformation rice tissue-specific promoters

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Insights into the changes in the surface properties of goethite with Ni in the lattice in the presence of salicylhydroxamic acid:Experimental and density functional theory studies

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 665-677页

作者： Levie Mweene Gilsang hong hee-Eun jeong hee-won Kang Hyunjung Kim Department of Earth Resources and Environmental Engineering Hanyang University222 Wangsimni-roSeongdong-guSeoul 04763Republic of Korea

Comparative experiments and theoretical analysis of the surface chemistry changes of goethite(GT)and goethite containing Ni(GTN)in the lattice in the presence of salicylhydroxamic acid(SA)were *** was revealed that in the presence of 100 g·t^(-1)of SA,the flotation recovery of GTN and GT increased with increasing pH,achieving a maximum recovery of 98.9%for both minerals at p H 8.3 and decreasing beyond that pH,with GTN having a slightly higher recovery than GT,except at pH *** was further confirmed by the higher complexation energies of GTN···SA(-883.87 kJ·mol^(-1))compared with GT···SA(-604.23 kJ·mol^(-1))resulting from covalent,closed-shell,and conventional hydrogen *** higher adsorption of SA onto GTN relative to GT was due to the formation of aπ-hole in GTN,thereby promoting a higher interaction of the collector with the ***,the presence of Ni in the GT lattice improves and decreases the adsorption and desorption of SA onto and from the mineral,respectively,compared with those onto and from GT.

关键词： nickel goethite adsorption salicylhydroxamic acid recovery

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Extremely rare case of successful treatment of metastatic ovarian undifferentiated carcinoma with high-dose combination cytotoxic chemotherapy: A case report

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World Journal of Clinical Cases 2020年第19期8卷 4488-4493页

作者： hong Beum Kim hee jeong Lee Ran hong Sang-Gon Park Department of Premedical Course Chosun University School of MedicineGwngju 505717South Korea Department of Internal Medicine Hemato-oncologyChosun University HospitalGwangju 505717South Korea Department of Pathology Chosun University HospitalGwangju 505717South Korea

BACKGROUND Ovarian undifferentiated carcinomas are significantly rare and have an aggressive clinical *** resection is the only curative treatment in early-stage ovarian undifferentiated carcinomas that has a favorable *** case of recurrent and metastatic disease,palliative chemotherapy is the only available ***,the effectiveness of standard chemotherapy regimen is not well-known,specifically in the case of extra-ovarian *** report an ovarian undifferentiated carcinoma of recurrent and inoperable advanced stage that was successfully treated with high-dose combination *** SUMMARY A 52-year-old woman presented with a 1-mo history of right lower quadrant and epigastric pain.A computed tomography(CT)scan of the abdomen revealed a multicystic mass with extensive internal necrosis of the right ovary without evidence of metastatic disease.A total hysterectomy with bilateral salpingooophorectomy and omentectomy was performed,but the surgery had a positive resection ***,it was diagnosed as ovarian undifferentiated carcinoma with sarcomatoid *** adjuvant chemotherapy was planned,it was delayed for 6 wk because of postoperative recovery,and the patient complained of abdominal pain.A CT scan and positron emission tomography-CT revealed a huge mass with multiple nodules in the pelvic cavity and para-aortic lymph node *** of standard therapy such as paclitaxel and platinum,combined chemotherapy with etoposide,ifosfamide,and cisplatin was *** patient experienced no recurrence for 5 *** This is a case of metastatic ovarian undifferentiated carcinoma with sarcomatoid change that was successfully treated with high-dose combination cytotoxic chemotherapy.

关键词： Ovarian undifferentiated carcinoma Sarcomatoid change Chemotherapy Etoposide,ifosfamide,cisplatin Case report

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Bronchobiliary fistula after ramucirumab treatment for advanced gastric cancer: A case report

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World Journal of Clinical Cases 2019年第19期7卷 3039-3046页

作者： hong-Beum Kim Yong Sub Na hee-jeong Lee Sang-Gon Park Department of Premedical Course Chosun University School of MedicineDong-guGwangju 501-717South Korea Department of Internal Medicine PulomonologyChosun University HospitalDong-guGwangju 501-717South Korea Department of Internal Medicine Hemato-oncologyChosun University HospitalDong-guGwangju 501-717South Korea

BACKGROUND Bronchobiliary fistula(BBF)is a rare disease characterized by an abnormal connection between the biliary system and *** causes of BBF include trauma and infections,and more recent causes include malignancies and certain cancer *** is an antivascular endothelial growth factor receptor 2 monoclonal antibody,currently used as a second-line treatment for gastric *** SUMMARY A 43-year-old man visited our hospital with the complaint of *** was diagnosed with inoperable advanced gastric cancer owing to invasion of the hepatic hilum by the *** percutaneous transhepatic biliary drainage(PTBD)and stent placement,capecitabine and oxaliplatin were administered as first-line palliative *** tumor progressed,and paclitaxel and ramucirumab were administered as second-line ***,on the first day of the second cycle,the patient suddenly developed dyspnea and *** was diagnosed on the basis of the presence of bilious sputum and the results of computed tomography,and PTBD was *** This is the first report of BBF after administration of the new antiangiogenic agent ramucirumab.

关键词： Ramucirumab Liver Bronchobiliary fistula Advanced gastric cancer Case report

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Preconditioning process for dermal tissue decellularization using electroporation with sonication

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Regenerative Biomaterials 2022年第1期9卷 22-29页

作者： Mi hee Leeand Jong-Chul Park Min-Ah Koo HaKyeong jeong Seung hee hong Gyeung Mi Seon Mi hee Lee Jong-Chul Park Cellbiocontrol Laboratory Yonsei University College of Medicine50-1 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Department of Medical Engineering Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of Medicine50-1 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

Decellularization to produce bioscaffolds composed of the extracellular matrix(ECM)uses enzymatic,chemical and physical methods to remove antigens and cellular components from *** decellularization methods depend on the characteristics of tissues,and in particular,tissues with dense,complex structure and abundant lipid content are difficult to completely *** study enables future research on the development of methods and treatments for fabricating bioscaffolds via decellularization of complex and rigid skin tissues,which are not commonly considered for decellularization to date as their structural and functional characteristics could not be preserved after severe *** this study,decellularization of human dermal tissue was done by a combination of both chemical(0.05%trypsin-EDTA,2%SDS and 1%Triton X-100)and physical methods(electroporation and sonication).After decellularization,the content of DNA remaining in the tissue was quantitatively confirmed,and the structural change of the tissue and the retention and distribution of ECM components were evaluated through histological and histochemical analysis,*** of the chemical pretreatment that increase the efficiency of physical stimulation as well as decellularization,and conditions for electroporation and sonication without the use of detergents,unlike the methods performed in previous studies,were established to enable the complete decellularization of the skin *** combinatorial decellularization treatment formed micropores in the lipid bilayers of the skin tissues while removing all cell and cellular residues without affecting the ECM ***,this procedure can be widely used to fabricate bioscaffolds by decellularizing biological tissues with dense and complex structures.

关键词： decellularization electroporation sonication extracellular matrix

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Bimodal grain structures and tensile properties of a biomedical Co-20Cr-15W-10Ni alloy with different pre-strains

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Rare Metals 2021年第1期40卷 20-30页

作者： Cheng-Lin Li Seong-Woo Choi jeong Mok Oh Jae-Keun hong Jong-Taek Yeom Joo-hee Kang Qing-Song Mei Chan hee Park Department of Materials Engineering School of Power and Mechanical EngineeringWuhan UniversityWuhan 430072China Advanced Metals Division.Korea Institute of Materials Science Changwon 51508Republic of Korea Materials Testing&Reliability Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

The influence of pre-strain on the formation of bimodal grain structures and tensile properties of a Co-20 Cr-15 W-10 Ni alloy was *** bimodal grain structures consist of fine grains(FGs;2-3μm in diameter)and coarse grains(CGs;8-16μm in diameter),which can be manipulated by changing the pre-strain(ε=0.3-0.7)and annealing temperatures(1000-1100℃).High pre-strain applied in the samples can intensify the plasticity heterogeneity through increasing the total dislocation density and the local volumes of high-density *** can essentially result in finer FGs,a higher FG volume fraction,and overall grain refinement in the samples after ***-temperature essentially increases both the size and volume fraction of CGs,leading to an increase in the average grain *** tensile test suggests that the bimodal grain structured samples exhibited both high strength and ductility,yield strengths of621-877 MPa and ultimate tensile strengths of1187-1367 MPa with uniform elongations of 55.0%-71.4%.The superior strength-ductility combination of the samples arises from the specific deformation mechanisms of the bimodal grain *** tensile properties strongly depend on the size ratio and volume fraction of FGs/CGs in addition to the average grain size in the bimodal grain *** grain structures can be modified via changing the pre-strain and annealing temperature.

关键词： Biomaterials Bimodal grain structure Deformation heterogeneity Pinning High strength/ductility

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Antioxidant and anticancer activity of Artemisia princeps *** extract in HepG2 and Hep3B hepatocellular carcinoma cells

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Chinese Journal of Cancer Research 2013年第5期25卷 536-543页

作者： Eun-jeong Choi Gun-hee Kim Plant Resources Research Institute Duksung Women's University

Objective：The aim of the present study was to investigate antioxidant and the anticancerigen activity of a methanol extract from Artemisia princeps *** （APME）,a well-known traditional herbal medicine in Asia,in hepatocellular cancer ***：To evaluate the antioxidant activity of APME,reactive oxygen species （ROS） and the antioxidant enzymes,superoxide dismutase （SOD） and catalase were investigated in HepG2 cells exposed to APME （5,100,and 200 μg/mL） for 72 ***,to evaluate the anticancer activity of APME,we investigated the proliferation and apoptosis induction of HepG2 and Hep3B cells exposed to APME （1-200 μg/mL） for 24,48,and 72 ***：APME dose-dependently reduced the generation of ROS in the presence of H2O2 compared with control ***,it increased catalase and SOD ***,APME inhibited cell proliferation in a dose-and time-dependcnt manner,but at concentrations lower than 100 μg/mL,the inhibition was less dose-dependent than ***2 and Hep3B cells exposed to 5,100,and 200 μg/mL APME for 72 h underwent cell cycle arrest and *** to APME resulted in a significant increase in the number of cells in G1 phase and a decrease in the G2/M phase cell *** addition,APME induced P53 expression of HepG2 cells in a dose-dependent manner,and played a role in the downregulation of Bcl-2 and upregulation of Bax in both HepG2 and Hep3B ***：These results indicate the potential role of APME as an antioxidant and anticancerigen agent in hepatocarcinoma cell lines.

关键词： Artemisia princeps var.orientalis antioxidant anticancer hepatocellular carcinoma

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Isolated peritoneal lymphomatosis defined as post-transplant lymphoproliferative disorder after a liver transplant: A case report

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World Journal of Clinical Cases 2019年第24期7卷 4299-4306页

作者： hong Beum Kim Ran hong Yung Sub Na Woo Young Choi Sang Gon Park hee jeong Lee Department of Premedical Course Chosun University School of MedicineGwangju 501-717South Korea Department of Pathology Chosun University Hospital365 Pilmun-daeroDong-guGwangju 501-717South Korea Department of Internal Medicine PulomonologyChosun University HospitalGwangju 501-717South Korea Department of Plastic and Reconstructive Surgery Chosun University HospitalGwangju 501-717South Korea Department of Internal Medicine Hemato-oncologyChosun University HospitalGwangju 501-717South Korea MD PhDDepartment of HematoOncologyChosun University Hospital365 Pilmun-daeroDong-guGwangju 501-717South Korea

BACKGROUND Post-transplant lymphoproliferative disorder(PTLD) is a fatal complication of solid organ transplantation or allogenic hematopoietic stem cell transplantation that is associated with immunosuppressive therapy. Potential manifestations are diverse, ranging from reactive lymphoid hyperplasia to high-grade *** is usually of B-cell origin and associated with Epstein-Barr virus(EBV)infection. Herein, we describe a case of PTLD involving the peritoneal *** has been only case of PTLD as a diffuse large B-cell lymphoma(DLBCL) in the *** SUMMARY The patient was a 62-year-old man who had been receiving immunosuppressive therapy with tacrolimus since undergoing a liver transplant 15 years prior. He reported that he had experienced abdominal discomfort and anorexia 1 month prior to the current admission. Abdominal pelvic computed tomography(CT)revealed peritoneal and omental mass-like lesions without bowel ***-guided biopsy was performed, and he was histologically diagnosed with EBV-negative DLBCL. Positron emission tomography(PET)-CT depicted peritoneum and omentum involvement only, without any lymphadenopathy or organ masses, including in the gastrointestinal tract. Six cycles of chemotherapy with a "R-CHOP" regimen(rituximab-cyclophosphamide, doxorubicin, vincristine, prednisolone) were administered,and PET-CT performed thereafter indicated complete *** This is the first report of isolated peritoneal lymphomatosis defined as PTLD in a liver transplant recipient.

关键词： Case report Diffuse large B-cell lymphoma Epstein-Barr virus infection Posttransplant lymphoproliferative disorder R-CHOP Isolated peritoneal lymphomatosis

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