Bronchobiliary fistula after ramucirumab treatment for advanced gastric cancer: A case report

作     者：Hong-Beum Kim Yong Sub Na Hee-Jeong Lee Sang-Gon Park 

作者机构：Department of Premedical CourseChosun University School of MedicineDong-guGwangju 501-717South Korea Department of Internal MedicinePulomonologyChosun University HospitalDong-guGwangju 501-717South Korea Department of Internal MedicineHemato-oncologyChosun University HospitalDong-guGwangju 501-717South Korea 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2019年第7卷第19期

页      面：3039-3046页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by the National Research Foundation of Korea funded by the Ministry of Science ICT and Future Planning No.NRF-2015R1A5A2009070 

主　　题：Ramucirumab Liver Bronchobiliary fistula Advanced gastric cancer Case report 

摘      要：BACKGROUND Bronchobiliary fistula(BBF)is a rare disease characterized by an abnormal connection between the biliary system and *** causes of BBF include trauma and infections,and more recent causes include malignancies and certain cancer *** is an antivascular endothelial growth factor receptor 2 monoclonal antibody,currently used as a second-line treatment for gastric *** SUMMARY A 43-year-old man visited our hospital with the complaint of *** was diagnosed with inoperable advanced gastric cancer owing to invasion of the hepatic hilum by the *** percutaneous transhepatic biliary drainage(PTBD)and stent placement,capecitabine and oxaliplatin were administered as first-line palliative *** tumor progressed,and paclitaxel and ramucirumab were administered as second-line ***,on the first day of the second cycle,the patient suddenly developed dyspnea and *** was diagnosed on the basis of the presence of bilious sputum and the results of computed tomography,and PTBD was *** This is the first report of BBF after administration of the new antiangiogenic agent ramucirumab.