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Dyslipidemia in Adults with Type 2 Diabetes in a Rural Community in Ganadougou, Mali: A Cross-sectional study

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Journal of Diabetes Mellitus 2024年第2期14卷 133-152页

作者： Abdoulaye Diawara Djibril Mamadou Coulibaly Drissa Kone Mama A. Traore Drissa Konaté Dicko s. Bazi Oumar Kassogue Djeneba sylla Fatoumata Gniné Fofana Oudou Diabaté Mariam Traore Ibrahim Antoine Nieantao Kaly Keїta Mamadou Diarra Olivia smith Jian Li Cheickna Cisse Talib Yusuf Abbas Crystal Zheng segun Fatumo Kassim Traore Mamadou Wele Mahamadou Diakité seydou O. Doumbia jeffrey G. shaffer University of sciences Techniques and Technologies of Bamako Bamako Mali National Federation of Community Health Associations Bamako Mali Department of Tropical Medicine Medical Microbiology & Pharmacology John A. Burns School of Medicine University of Hawaii Manoa Honolulu USA Department Biostatistics and Data science School of Public Health and Tropical Medicine Tulane University New Orleans USA Department of Biotechnology and Computer science Burhani College Mazgaon Mumbai India school of Medicine Tulane University New Orleans USA Medical Research Council Uganda Virus Research Institute Entebbe Uganda London school of Hygiene and Tropical Medicine London UK Departement of Biochemistry and Genetics Duquesne University College of Medicine Pittsburgh USA

Dyslipidemia is a disorder where abnormally lipid concentrations circulate in the bloodstream. The disorder is common in type 2 diabetics (T2D) and is linked with T2D comorbidities, particularly cardiovascular disease. Dyslipidemia in T2D is typically characterized by elevated plasma triglyceride and low high-density lipoprotein cholesterol (HDL-C) levels. There is a significant gap in the literature regarding dyslipidemia in rural parts of Africa, where lipid profiles may not be captured through routine surveillance. This study aimed to characterize the prevalence and demo-graphic profile of dyslipidemia in T2D in the rural community of Ganadougou, Mali. We performed a cross-sectional study of 104 subjects with T2D in Ganadougou between November 2021 and March 2022. Demographic and lipid profiles were collected through cross-sectional surveys and serological analyses. The overall prevalence of dyslipidemia in T2D patients was 87.5% (91/104), which did not differ by sex (P = .368). High low-density lipoprotein cholesterol (LDL-C) was the most common lipid abnormality (78.9%, [82/104]). Dyslipidemia was associated with age and hypertension status (P = .013 and.036, respectively). High total and high LDL-C parameters were significantly associated with hypertension (P = .029 and .006, respectively). In low-resource settings such as rural Mali, there is a critical need to improve infrastructure for routine dyslipidemia screening to guide its prevention and intervention approaches. The high rates of dyslipidemia observed in Gandadougou, consistent with concomitant increases in cardiovascular diseases in Africa suggest that lipid profile assessments should be incorporated into routine medical care for T2D patients in African rural settings.

关键词： Cholesterol Cross-sectional study Dyslipidemia Lipids Mali Type 2 Diabetes

Temporal and spatial comparisons of angiosperm diversity between eastern Asia and North America

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National science Review 2022年第6期9卷 38-42页

作者： Haihua Hu Jianfei Ye Bing Liu Lingfeng Mao stephen A.smith Russell L.barrett Pamela s.soltis Douglas E.soltis Zhiduan Chen Limin Lu state Key Laboratory of systematic and Evolutionary Botany Institute of Botany Chinese Academy of Sciences University of Chinese Academy of sciences sino-Africa Joint Research Center Chinese Academy of Sciences Beijing Botanical Garden Institute of BotanyChinese Academy of Sciences Co-Innovation Center for sustainable Forestry in southern China College of Biology and the Environment Nanjing Forestry University Department of Ecology and Evolutionary Biology University of Michigan National Herbarium of New south Wales Royal Botanic Gardens and Domain Trust Florida Museum of Natural History University of Florida Department of Biology University of Florida

Comparative approaches that examine floras with similar environments, but different diversity patterns, provide good opportunities to elucidate how uneven distributions of biodiversity were assembled. Eastern Asia(EA) and North America north of Mexico(NA; see definitions of EA and NA in Fig. s1 A) share similar geographical environments with comparable latitude, land area and climate,

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Relationships between Gene structure and Genome Instability in Flowering Plants

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Molecular Plant 2018年第3期11卷 407-413页

作者： jeffrey L. Bennetzen Xuewen Wang state Key Laboratory of Tea Plant Biology and Utilization/Key Laboratory of Tea Biology and Processing Ministry of Agriculture Anhui Agricultural University HefeiAnhui 230036 People's Republic of China Department of Genetics University of Georgia Athens GA 30602 USA

Flowering plant （angiosperm） genomes are exceptional in their variability with respect to genome size, ploidy, chromosome number, gene content, and gene arrangement. Gene movement, although observed in some of the earliest plant genome comparisons, has been relatively underinvestigated. We present here- in a description of several interesting properties of plant gene and genome structure that are pertinent to the successful movement of a gene to a new location. These considerations lead us to propose a model that can explain the frequent success of plant gene mobility, namely that small Insulated Genes Move Around （slGMAR）. The sIGMAR model is then compared with known processes for gene mobilization, and predic- tions of the sIGMAR model are formulated to encourage future experimentation. The overall results indicate that the frequent gene movement in angiosperm genomes is partly an outcome of the unusual properties of angiosperm genes, especially their small size and insulation from epigenetic silencing.

关键词： epigenetic silencing gene insulators gene movement illegitimate recombination inaccurate DNA break repair transposon mobilization

Business Continuity Management,Operational Resilience,and Organizational Resilience:Commonalities,Distinctions,and synthesis

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International Journal of Disaster Risk science 2023年第5期14卷 713-721页

作者： s.E.Galaitsi Elizaveta Pinigina jeffrey M.Keisler Gianluca Pescaroli Jesse M.Keenan Igor Linkov Us Army Engineer Research and Development Center VicksburgMS39180USA College of Management University of Massachusetts BostonBostonMA02125USA Institute for Risk and Disaster Reduction University College LondonLondonWC1E 6BTUK school of Architecture Tulane UniversityNew OrleansLA70118USA

The concepts of business continuity management,operational resilience,and organizational resilience each refer to actions that businesses and organizations can take in anticipating and responding to ***,the existing definitions and usages are difficult to differentiate due to overlapping objectives,implementation processes,and *** article examines definitions and approaches for these three concepts and suggest a framework to operationalize methods and tools relevant to *** definitions emphasize three dyads:risk versus resilience;organizational processes versus assets;and normal operating conditions versus crisis *** these dyads to differentiate the concepts of business continuity management,operational resilience,and organizational resilience can support planners in clarifying objectives and identifying which approach will be most beneficial as businesses or organizations plan for and encounter *** article evaluates these concepts by examining illustrative examples of disruptions and responses.

关键词： Business continuity management Disruptions Operational resilience Organizational resilience

Graph theory approach to determine configurations of multidentate and high coverage adsorbates for heterogeneous catalysis

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npj Computational Materials 2020年第1期6卷 998-1003页

作者： siddharth Deshpande Tristan Maxson jeffrey Greeley Davidson school of Chemical Engineering Purdue University480 W Stadium Mall DriveWest LafayetteIN 47907USA

Heterogeneous catalysts constitute a crucial component of many industrial processes,and to gain an understanding of the atomicscale features of such catalysts,ab initio density functional theory is widely ***,growing computational power has permitted the extension of such studies to complex reaction networks involving either high adsorbate coverages or multidentate adsorbates,which bind to the surface through multiple *** all possible adsorbate configurations for such systems,however,is often not possible based on chemical intuition *** systematically treat such complexities,we present a generalized Python-based graph theory approach to convert atomic scale models into undirected graph *** representations,when combined with workflows such as evolutionary algorithms,can systematically generate high coverage adsorbate models and classify unique minimum energy multidentate adsorbate configurations for surfaces of low symmetry,including multi-elemental alloy surfaces,steps,and kinks.

关键词： configuration theory catalysis

sizing up feature descriptors for macromolecular machine learning with polymeric biomaterials

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npj Computational Materials 2023年第1期9卷 1287-1296页

作者： samantha stuart jeffrey Watchorn Frank X.Gu Institute of Biomedical Engineering University of TorontoTorontoOntarioCanada Department of Chemical Engineering and Applied Chemistry University of TorontoTorontoOntarioCanada

It has proved challenging to represent the behavior of polymeric macromolecules as machine learning features for biomaterial interaction *** are several approaches to this representation,yet no consensus for a universal representational framework,in part due to the sensitivity of biomacromolecular interactions to polymer *** help navigate the process of feature engineering,we provide an overview of popular classes of data representations for polymeric biomaterial machine learning while discussing their merits and ***,increasing the accessibility of polymeric biomaterial feature engineering knowledge will contribute to the goal of accelerating clinical translation from biomaterials discovery.

关键词： properties prediction biomaterials

Understanding celiac disease monitoring patterns and outcomes after diagnosis:A multinational,retrospective chart review study

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World Journal of Gastroenterology 2021年第20期27卷 2603-2614页

作者： Knut EA Lundin Ciaran P Kelly David s sanders Kristina Chen sheena Kayaniyil sisi Wang Rajvi J Wani Caitlin barrett shakira Yoosuf Ellen s Pettersen Robert sambrook Daniel A Leffler K.G.Jebsen Coeliac Disease Research Centre University of OsloOslo 0450Norway Department of Gastroenterology Oslo University Hospital RikshospitaletOslo 0372Norway Celiac Center Beth Israel Deaconess Medical Center Celiac Research Program Harvard Medical SchoolBostonMA 02115United States Royal Hallamshire Hospital University of SheffieldSheffield S102TNUnited Kingdom Takeda Pharmaceuticals International Co. CambridgeMA 02139United States Real World Evidence strategy and Analytics ICON plc.TorontoON L7N 3G2Canada Real World Evidence strategy and Analytics ICON plc.VancouverBC V6B 1P1Canada

BACKGROUND Long-term outcomes and monitoring patterns in real-world practice are largely unknown among patients with celiac *** To understand patterns of follow-up and management of patients with celiac disease,and to characterize symptoms and villous atrophy after *** A retrospective chart review study was performed using medical chart data of patients diagnosed with celiac *** gastroenterology referral centers,with substantial expertise in celiac disease,participated in the United Kingdom,United states,and *** and clinical data were collected from medical *** analyses were conducted on patients with biopsyconfirmed celiac disease,diagnosed between 2008 and 2012,with at least one follow-up visit before December 31,*** demographic and clinical characteristics,biopsy/serology tests and results,symptoms,and comorbidities were captured at diagnosis and for each clinic visit occurring within the study period(i.e.,before the study end date of December 31,2017).REsULTs A total of 300 patients were included in this study[72%female;mean age at diagnosis:38.9 years,standard deviation(sD)17.2].Patients were followed-up for a mean of 29.9 mo(sD 22.1)and there were,on average,three follow-up visits per patient during the study *** two-thirds(68.4%)of patients were recorded as having ongoing gastrointestinal symptoms and 11.0%had ongoing symptoms and enteropathy during *** 80%of patients were referred to a dietician at least once during the follow-up ***(50.0%)of the patients underwent at least one follow-up duodenal biopsy and 36.6%had continued villous *** of monitoring varied between *** were conducted more frequently in Norway and patients in the United states had a longer follow-up *** This real-world study demonstrates variable follow-up of patients with celiac disease despite most patients continuing to have abnormal histology

关键词： Celiac disease Outcomes research Endoscopy Real-world General practice Villous atrophy

Formidable females redux:male social integration into female networks and the value of dynamic multilayer networks

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Current Zoology 2021年第1期67卷 49-57页

作者： Tyler R.BONNELL ChloéVILETTE Christopher YOUNG stephanus Peter HENZI ouise barrett Department of Psychology University of Lethbridge4401 University DriveLethbridgeT1K 3M4Canada Applied Behavioural Ecology and Ecosystems Research Unit University of South AfricaFloridaGautengSouth Africa Endocrine Research Laboratory Mammal Research InstituteFaculty of Natural and Agricultural ScienceUniversity of PretoriaPretoriaSouth Africa

The development of multilayer network techniques is a boon for researchers who wish to understand how different interaction layers might influence each other,and how these in turn might influence group ***,we investigate how integration between male and female grooming and aggression interaction networks influences male power trajectories in vervet monkeys Chlorocebus *** previous analyses of this phenomenon used a monolayer approach,and our aim here is to extend these analyses using a dynamic multilayer *** do so,we constructed a temporal series of male and female interaction *** then used a multivariate multilevel autoregression model to compare cross-lagged associations between a male's centrality in the female grooming layer and changes in male Elo *** results confirmed our original findings:changes in male centrality within the female grooming network were weakly but positively tied to changes in their Elo ***,the multilayer network approach offered additional insights into this social process,identifying how changes in a male's centrality cascade through the other network *** dynamic view indicates that the changes in Elo ratings are likely to be short-lived,but that male centrality within the female network had a much stronger impact throughout the multilayer network as a whole,especially on reducing intermale aggression(i.e.,aggression directed by males toward other males).We suggest that multilayer social network approaches can take advantage of increased amounts of social data that are more commonly collected these days,using a variety of *** data are inherently multilevel and multilayered,and thus offer the ability to quantify more precisely the dynamics of animal social behaviors.

关键词： multilayer networks multilevel multivariate autoregressive model primate social dynamics social networks sociality time-aggregated networks vervet monkeys

Effect of Artificial Intelligence on social Trust in American Institutions

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Journal of social Computing 2023年第3期4卷 221-231页

作者： Andrew Collins Jason jeffrey Jones the Department of sociology Stony Brook UniversityStony BrookNY 11790USA

In recent decades,social scientists have debated declining levels of trust in American *** the same time,many American institutions are coming under scrutiny for their use of artificial intelligence(AI)*** paper analyzes the results of a survey experiment over a nationally representative sample to gauge the effect that the use of AI has on the American public’s trust in their social institutions,including government,private corporations,police precincts,and *** find that artificial intelligence systems were associated with significant trust penalties when used by American police precincts,companies,and *** penalties were especially strong for American police precincts and,in most cases,were notably stronger than the trust penalties associated with the use of smartphone apps,implicit bias training,machine learning,and mindfulness ***’trust in institutions tends to be negatively impacted by the use of new *** there are significant variations in trust between different pairings of institutions and tools,generally speaking,institutions which use AI suffer the most significant loss of *** government agencies are a notable exception here,receiving a small but puzzling boost in trust when associated with the use of AI systems.

关键词： social trust artificial intelligence(AI) algorithm aversion