检索结果-南通市图书馆

Exploring the molecular mechanism of Suoquan pill in the treatment of diabetic kidney disease based on network pharmacology,molecular docking,in vitro experiment

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2024年第11期9卷 27-37页

作者： Zi-jie Yan Yu kang Shu-Man Liu Fang-Yu Wang Man Xiao Yi-qiang Xie College of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571199China Graduate School Heilongjiang Academy of Traditional Chinese MedicineHarbin 150001China Department of Pharmacology College of PharmacyHainan Medical UniversityHaikou 571199China Key Laboratory of Biochemistry and Molecular Biology Hainan Medical UniversityHaikou 571199China.

Background:Diabetic kidney disease(DKD)is a microvascular complication of diabetes mellitus and is the main cause of end-stage renal *** pills(SQP)has a variety of pharmacological activities and multiple therapeutic effects,and it is used clinically as a basic formula for the treatment of ***:Public databases were used to identify SQP compounds and the potential targets of SQP and DKD.A drug-component-therapeutic target network was ***-protein interaction network analysis,Gene Ontology functional analysis,and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were used to analyse the potential molecular mechanisms of SQP based on common targets of drugs and *** docking simulations were conducted to confirm the binding abity of the core compounds to key *** efficacy and predicted molecular mechanisms of SQP were validated using cell counting kit-8 assay,flow cytometry,and western blotting with HK-2 cells as a ***:Network pharmacology analysis showed that 26 compounds and 207 potential targets of SQP were involved in the treatment of DKD;boldine,denudatin B,pinocembrin,kaempferoid,and quercetin were considered core compounds,and epidermal growth factor receptor(EGFR)and proto-oncogene,non-receptor tyrosine kinase(SRC)were considered key *** Ontology enrichment analysis indicated that protein phosphorylation and negative regulation of apoptotic processes are important biological processes in the treatment of DKD by *** docking confirmed the excellent binding abilities of boldine,denudatin B,kaempferide,and quercetin to EGFR and *** results of in vitro experiments showed that treatment with an ethanolic extract of SQP significantly protected HK-2 cells from high glucose-induced cell *** addition,the SQP ethanol extract inhibited the phosphorylation of EGFR and SRC,suppressed the apoptosis rate,and regulated apoptosis-related proteins in HK-2 cells under hig

关键词： traditional Chinese medicine diabetic kidney disease Suoquan pill network analysis molecular docking

Fine mapping and characterization of stripe rust resistance gene YrAYH in near-isogenic lines derived from a cross involving wheat landrace Anyuehong

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Crop journal 2024年第3期12卷 826-835页

作者： Li Long jue Li Linyu Huang Huiling jin Fangnian Guan Haipeng Zhang Sasa Zhao Hao Li Zhien Pu Wei Li Qiantao jiang Yuming Wei jian Ma Houyang kang Shoufen Dai Pengfei Qi qiang Xu Mei Deng Youliang Zheng Yunfeng jiang Matthew james Moscou Guoyue Chen State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130SichuanChina Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina College of Resources Sichuan Agricultural UniversityChengdu 611130SichuanChina The Sainsbury Laboratory Norwich Research ParkNorwich NR47UHEnglandUK United States Department of Agriculture-Agricultural Research Service Cereal Disease LaboratorySt.PaulMN 55108USA

Stripe rust,caused by Puccinia striiformis ***(Pst),is a devastating disease in wheat *** and characterizing new resistance genes/QTL is crucial for wheat breeding *** this study,we fine-mapped and characterized a stripe rust resistance gene,YRAYH,on chromosome arm 5BL in the Chinese wheat landrace Anyuehong(AYH).Evaluations of stripe rust response to prevalent Chinese Pst races in near-isogenic lines derived from a cross of Anyuehong and Taichung 29 showed that YrAYH conferred a high level of resistance at all growth *** mapping using a large segregating population of 9748 plants,narrowed the YRAYH locus to a 3.7 Mb interval on chromosome arm 5BL that included 61 annotated *** analysis of two NIL pairs identified 64 upregulated differentially expressed genes(DEGs)in the resistant NILs(NILs-R).Annotations indicated that many of these genes have roles in plant disease resistance *** a combined approach of fine-mapping and transcriptome sequencing,we identified a serine/threonine-protein kinase SRPK as a candidate gene underlying YrAYH.A unique 25 bp insertion was identified in the NILs-R compared to the NILs-S and previously published wheat *** InDel marker was developed and co-segregated with *** trait evaluation of the NILs suggested that YrAYH not only reduces the impact of stripe rust but was also associated with a gene that increases plant height and spike length.

关键词： Candidate gene analysis Crop protection Puccinia striiformis Transcriptome analyses

Liquid crystal-integrated metasurfaces for an active photonic platform

在线全文

学校读者我要写书评

暂无评论

Opto-Electronic Advances 2024年第6期7卷 5-29页

作者： Dohyun kang Hyeonsu Heo Younghwan Yang junhwa Seong Hongyoon Kim joohoon Kim junsuk Rho Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Electrical Engineering Pohang University of Science and Technology(POSTECH)Pohang 36763Republic of Korea POSCOPOSTECH-RIST Convergence Research Center for Flat Optics and Metaphotonics Pohang 37673Republic of Korea National Institute of Nanomaterials Technology(NINT) Pohang 37673Republic of Korea

Metasurfaces have opened the door to next-generation optical devices due to their ability to dramatically modulate electromagnetic waves at will using periodically arranged ***,metasurfaces typically have static optical responses with fixed geometries of nanostructures,which poses challenges for implementing transition to technology by replacing conventional optical *** solve this problem,liquid crystals(LCs)have been actively employed for designing tunable metasurfaces using their adjustable birefringent in real ***,we review recent studies on LCpowered tunable metasurfaces,which are categorized as wavefront tuning and spectral *** to numerous reviews on tunable metasurfaces,this review intensively explores recent development of LC-integrated *** the end of this review,we briefly introduce the latest research trends on LC-powered metasurfaces and suggest further directions for improving *** hope that this review will accelerate the development of new and innovative LC-powered devices.

关键词： tunable metasurface liquid crystal active metasurface electrically tunable optical system

Unraveling engineering disturbance effects on deformation in red-bed mudstone railway cuttings:incorporating crack-facilitated moisture diffusion

在线全文

学校读者我要写书评

暂无评论

journal of Mountain Science 2024年第5期21卷 1663-1682页

作者： HUANG kang DAI Zhangjun YAN Chengzeng YAO junkai CHI Zecheng CHEN Shanxiong State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Faculty of Engineering China University of GeosciencesWuhan 430074China International joint Research Center for Deep Earth Drilling and Resource Development China University of GeosciencesWuhan 430074China China Academy of Railway Sciences Corporation Limited Beijing 100081China

Red-bed mudstone, prevalent in southwest China, poses a formidable challenge due to its hydrophilic clay minerals, resulting in expansion, deformation, and cracking upon exposure to moisture. This study addresses uplift deformation disasters in high-speed railways by employing a moisture diffusion-deformation-fracture coupling model based on the finite-discrete element method(FDEM). The model integrates the influence of cracks on moisture diffusion. The investigation into various excavation depths reveals a direct correlation between depth and the formation of tensile cracks at the bottom of the railway cutting. These cracks expedite moisture migration, significantly impacting the temporal and spatial evolution of the moisture field. Additionally, crack expansion dominates hygroscopic deformation, with the lateral coordinate of the crack zone determining peak vertical displacement. Furthermore, key factors influencing deformation in railway cuttings, including the swelling factor and initial moisture content at the bottom of the cutting, are explored. The number of tensile and shear cracks increases with greater excavation depth, particularly concerning shear cracks. Higher swelling factors and initial moisture contents result in an increased total number of cracks, predominantly shear cracks. Numerical calculations provide valuable insights, offering a scientific foundation and directional guidance for the precise prevention, control, prediction, and comprehensive treatment of mudstone-related issues in high-speed railways.

关键词： Red-bed mudstone Railway cutting FDEM Moisture diffusion Deformation Crack

Application of deep learning methods combined with physical background in wide field of view imaging atmospheric Cherenkov telescopes

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第4期35卷 208-220页

作者： Ao-Yan Cheng Hao Cai Shi Chen Tian-Lu Chen Xiang Dong You-Liang Feng Qi Gao Quan-Bu Gou Yi-Qing Guo Hong-Bo Hu Ming-Ming kang Hai-jin Li Chen Liu Mao-Yuan Liu Wei Liu Fang-Sheng Min Chu-Cheng Pan Bing-qiang Qiao Xiang-Li Qian Hui-Ying Sun Yu-Chang Sun Ao-Bo Wang Xu Wang Zhen Wang Guang-Guang Xin Yu-Hua Yao qiang Yuan Yi Zhang School of Physics and Technology Wuhan UniversityWuhan 430072China School of Physics and Astronomy Yunnan UniversityKunming 650091China Ministry of Education The Key Laboratory of Cosmic Rays(Tibet University)Lhasa 850000China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences 19 A Yuquan RoadShijingshan DistrictBeijing 100049China College of Physics Sichuan UniversityChengdu 610064China School of Intelligent Engineering Shandong Management UniversityJinan 250357China Tsung‑Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China Suzhou Aerospace Information Research Institute Suzhou 215123China College of Physics Chongqing UniversityNo.55 Daxuecheng South RoadHigh‑tech DistrictChongqing 401331China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210008China

The High Altitude Detection of Astronomical Radiation(HADAR)experiment,which was constructed in Tibet,China,combines the wide-angle advantages of traditional EAS array detectors with the high-sensitivity advantages of focused Cherenkov *** objective is to observe transient sources such as gamma-ray bursts and the counterparts of gravitational *** study aims to utilize the latest AI technology to enhance the sensitivity of HADAR *** datasets and models with distinctive creativity were constructed by incorporating the relevant physical theories for various *** models can determine the type,energy,and direction of the incident particles after careful *** obtained a background identification accuracy of 98.6%,a relative energy reconstruction error of 10.0%,and an angular resolution of 0.22°in a test dataset at 10 *** findings demonstrate the significant potential for enhancing the precision and dependability of detector data analysis in astrophysical *** using deep learning techniques,the HADAR experiment’s observational sensitivity to the Crab Nebula has surpassed that of MAGIC and *** energies below 0.5 TeV and remains competitive with conventional narrow-field Cherenkov telescopes at higher *** addition,our experiment offers a new approach for dealing with strongly connected,scattered data.

关键词： VHE gamma-ray astronomy HADAR Deep learning Convolutional neural networks

Fixed Subgroups are not Compressed in Direct Products of Surface Groups

在线全文

学校读者我要写书评

暂无评论

Chinese Annals of Mathematics,Series B 2024年第5期45卷 703-708页

作者： qiang ZHANG jianchun WU Fanling GU School of Mathematics and Statistics Xi'an Jiaotong University Department of Mathematics Soochow University School of Mathematics and Statistics Xi'an Jiaotong University School of General Education Guangzhou College of Technology and Business

By constructing counterexamples, the authors show that the fixed subgroups are not compressed in direct products of free and surface groups, and hence negate a conjecture in [Zhang, Q., Ventura, E. and j. Wu, Fixed su... 详细信息

关键词： 20F34 20F65 57M07 Compression Direct product Fixed subgroup Free group Inertia Surface group

Exact Convergence Rate of the Local Limit Theorem for a Branching Random Walk in Zd with a Random Environment in Time

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Annals of Mathematics,Series B 2024年第5期45卷 805-822页

作者： jian-xin LIU Zhi-qiang GAO School of Mathematical Sciences Beijing Normal University Laboratory of Mathematics and Complex Systems (Ministry of Education) School of Mathematical Sciences Beijing Normal University

Abstract Consider a branching random walk with a random environment in time in the d-dimensional integer *** branching mechanism is governed by a supercritical branching process,and the particles perform a lazy random walk with an independent,non-identical increment *** A?Zd,let Z_n（A） be the number of offsprings of generation n located in *** exact convergence rate of the local limit theorem for the counting measure Zn（·） is *** partially extends the previous results for a simple branching random walk derived by Gao （2017,*** Appl.）.

关键词： 60F05 60G50 60j10 60j80 Branching random walk Exact convergence rate Local limit theorems Random environment

Effect of Small Needle Knife on Autophagy and TGF-β in Synovial Fluid of KOA Rats

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese journal of Biomedical Engineering(English Edition) 2024年第1期33卷 33-39页

作者： ZHENG kang-hua LIN Zeng-ping CHEN Yong Fujian Provincial 2nd People's Hospital Affiliated Hospital of Fujian University of Traditional Chinese MedicineFuzhou Fujian 350003China College of Integrative Chinese and Western Medicine Fujian University of Traditional Chinese MedicineFuzhou Fujian 350122China

Objective:To explore the effects of small needle knife on the autophagy function of synovium and the expression of TGF-βin synovial fluid of KOA rats,so as to provide a new theoretical basis for the treatment of ***:48 SD rats were randomly divided into blank control group,model group,drug group and acupotomy *** blank control group maintained the original feeding without any intervention,the model group adopted the sodium monoiodoacetate injection method to prepare the KOA rat model without any intervention,the drug group prepared the KOA rat model and then treated with tripterine by gavage,and the needle knife group treated the KOA rat model with small needle *** expression levels of autophagy-related proteins in synovial tissues were detected by immunohistochemistry and Western blotting,and the content of TGF-βin synovial fluid was measured by ***:Compared with the blank control group,Beclin-1,Caspase-3 and Bax were up-regulated and m TOR was down-regulated in the model ***-1,m TOR,Caspase-3 and Bax were up-regulated in the drug *** was no significant difference in the expression of autophagy-related proteins Beclin-1(0.28±0.09)and m TOR(0.45±0.12)between the acupotomy group and the blank control group,while Caspase-3(0.17±0.03)and Bax(0.30±0.01)were *** expression level of TGF-βin synovial fluid in the small needle knife group was(0.29±0.09),which was similar to that in the blank control group,and was significantly higher than that in the model ***:Small needle knife treatment can promote the recovery of synovial autophagy in KOA rats,and reduce the level of TGF-βin synovial fluid,and can play a clinical role in the treatment of KOA by regulating the expression of synovial autophagy and TGF-β.

关键词： small needle knife knee osteoarthritis(KOA) synovium autophagy transforming growth factorβ(TGF-β)

On-chip stimulated Brillouin scattering[Invited]

在线全文

学校读者我要写书评

暂无评论

Chinese Optics Letters 2024年第2期22卷 28-41页

作者：余林峰黄楚坤程铭王康石浩天黄强孙军强 Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China

On-chip stimulated Brillouin scattering(SBS)has attracted extensive attention by introducing acousto-optic coupling interactions in all-optical signal processing systems.A series of chip-level applications such as Brillouin lasers,amplifiers,gyroscopes,filters,and nonreciprocal devices are realized based on Brillouin acousto-optic ***,we first introduce the fundamental principle of SBS in integrated photonics and a method for calculating Brillouin gain;then we illustrate the Brillouin effect on different material platforms with diverse ***,we make a concise conclusion and offer prospects on the future developments of on-chip SBS.

关键词： stimulated Brillouin scattering integrated photonics silicon-on-insulator