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cdc42 deletion yielded enamel defects by disrupting mitoch.ndria and producing reactive oxygen species in dental epith.lium

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Genes & Diseases 2024年第5期11卷 335-349页

作者： jinxuan Zh.ng Rongch.ng Yu Yiqi Tang Sih.i Su Sainan Wang ch.nxi liao Xuecong Li jiabin liao Dongsh.ng Yu Tingting Ai Wei Zh.o Vicky Yau ch.feng Liu Liping Wu Yang cao h.spital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong 510055China Guangdong Provincial Key Laboratory of Oral Diseases GuangzhouGuangdong 510055China Department of cariology and Endodontology Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Department of Oral and Maxillofacial Surgery University at BuffaloBuffaloNY 14214USA Department of Orth.dontics Stomatological HospitalSouthern Medical UniversityGuangzhouGuangdong 510280China

Developmental defects of enamel are common due to genetic and environmental factors before and after ***42,a Rh. family small GTPase,regulates prenatal tooth.development in ***,its role in postnatal tooth.development,especially enamel formation,remains ***,we investigated cdc42 functions in mouse enamel development and tooth.repair after ***42 sh.wed h.gh.y dynamic temporospatial patterns in th. developing incisors,with.robust expression in ameloblast and odontoblast ***,epith.lium-specific cdc42 deletion resulted in enamel defects in *** differentiation was inh.bited,and h.pomineralization of enamel was observed upon epith.lial cdc42 *** analysis sh.wed th.t abnormal mitoch.ndrial components,ph.sph.transferase activity,and ion ch.nnel regulator activity occurred in th. cdc42 mutant dental *** oxygen species accumulation was detected in th. mutant mice,suggesting th.t abnormal oxidative stress occurred after cdc42 ***,cdc42 mutant mice sh.wed delayed tooth.repair and generated less calcified *** dysfunction and abnormal oxygen consumption were evidenced by reduced Apool and Timm8a1 expression,increased Atp5j2 levels,and reactive oxygen species overproduction in th. mutant repair ***-specific cdc42 deletion attenuated ERK1/2 signaling in th. labial cervical *** Sox2 expression in th. mutant labial cervical loop after clipping migh. lead to delayed tooth.*** findings suggested th.t mitoch.ndrial dysfunction,up-regulated oxidative stress,and abnormal ion ch.nnel activity may be among multiple factors responsible for th. observed enamel defects in cdc42 mutant ***,cdc42 exerts multidimensional and pivotal roles in enamel development and is particularly required for ameloblast differentiation and enamel matrix formation.

关键词： cdc42 Enamel defects Mitoch.ndrial dysfunction Rh. GTPase Tooth.repair

Research.on Driver’s Fatigue Detection Based on Information Fusion

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computers, Materials & continua 2024年第4期79卷 1039-1061页

作者： Meiyan Zh.ng Boqi Zh.o jipu Li Qisong Wang Dan Liu jinwei Sun jingxiao liao h.rbin Institute of Tech.ology School of Instrument Science and EngineeringHarbin150036China Department of Industrial and Systems Engineering The Hong Kong Polytechnic UniversityHong Kong100872China

Driving fatigue is a ph.siological ph.nomenon th.t often occurs during *** th. driver enters a fatigued state,th. attentionis lax,th. response is slow,and th. ability todeal with.emergencies is significantly reduced,wh.ch.can easily cause traffic ***,studying driver fatigue detectionmeth.ds is significant in ensuring safe ***,th. fatigue state of actual drivers is easily interfered with.by th. external environment(glasses and ligh.),wh.ch.leads to many problems,such.as weak reliability of fatigue driving ***,fatigue is a slow process,first manifested in ph.siological signals and th.n reflected in h.man face *** improve th. accuracy and stability of fatigue detection,th.s paper proposed a driver fatigue detection meth.d based on image information and ph.siological information,designed a fatigue driving detection device,built a simulation driving experiment platform,and collected facial as well as ph.siological information of drivers during ***,th. effectiveness of th. fatigue detection meth.d was *** movement feature parameters and ph.siological signal features of drivers’fatigue levels were *** driver fatigue detection model was trained to classify fatigue and non-fatigue states based on th. extracted *** rates of th. image,electroenceph.logram(EEG),and blood oxygen signals were 86%,82%,and 71%,*** fusion th.ory was presented to facilitate th. fatigue detection effect;th. fatigue features were fused using multiple kernel learning and typical correlation analysis meth.ds to increase th. detection accuracy to 94%.It can be seen th.t th. fatigue driving detectionmeth.d based onmulti-source feature fusion effectively detected driver fatigue state,and th. accuracy rate was h.gh.r th.n th.t of a single information *** summary,fatigue drivingmonitoring h.s broad development prospects and can be used in traffic accident prevention and wearable dr

关键词： Driving fatigue information fusion EEG blood oxygen

Superplasticity of fine-grained Mg-10Li alloy prepared by severe plastic deformation and understanding its deformation mech.nisms

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journal of Magnesium and Alloys 2024年第1期12卷 316-331页

作者： h.T.jeong S.W.Lee W.j.Kim Department of Materials Science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

Th. superplastic beh.vior and associated deformation mech.nisms of a fine-grained Mg-10.1 Li-0.8Al-0.6Zn alloy(LAZ1011)with.a grain size of 3.2μm,primarily composed of th. Bccβph.se and a small amount of th. h.Pαph.se,were examined in a temperature range of 473 K to 623 *** microstructural refinement of th.s alloy was ach.eved by employing h.gh.ratio differential speed *** best superplasticity was ach.eved at 523 K and at strain rates of 10^(-4)-5×10^(-4)s^(-1),wh.re tensile elongations of 550±600%were *** th. h.ating and h.lding stage of th. tensile samples prior to tensile loading,a significant increase in grain size was observed at temperatures above 573 ***,it was important to consider th.s effect wh.n analyzing and understanding th. superplastic deformation beh.vior and *** th. investigated strain rate range,th. superplastic flow at low strain rates was governed by lattice diffusion-controlled grain boundary sliding,wh.le at h.gh.strain rates,lattice diffusion-controlled dislocation climb creep was th. rate-controlling deformation *** was concluded th.t solute drag creep is unlikely to *** th. late stages of deformation at 523 K,it was observed th.t grain boundary sliding led to th. agglomeration of th.αph.se,resulting in significant strain *** mech.nism maps were constructed forβ-Mg-Li alloys in th. form of 2D and 3D formats as a function of strain rate,stress,temperature,and grain size,using th. constitutive equations for various deformation mech.nisms derived based on th. data of th. current tests.

关键词： Magnesium-lith.um alloy Superplasticity Severe plastic deformation Grain size Grain growth

Soil amendment strategies determining microbial community composition and th.ir assembly processes in a continuously cropped soil

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Soil Ecology Letters 2024年第3期6卷 85-95页

作者： h.ngkai liao ch.nli Zh.ng juan Li jian Long Yaying Li Guizh.u Provincial Key Laboratory of Mountain Environment Guizhou Normal UniversityGuiyang 550001China Th. Key Laboratory of Environmental Pollution Monitoring and Disease control Ministry of EducationDepartment of ToxicologySchool of Public HealthGuizhou Medical UniversityGuiyang 550025China Key Laboratory of Urban Environment and h.alth Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key Laboratory of Urban Environmental Processes and Pollution control Ningbo(Beilun)Zhongke Haixi Industry Technology Innovation CenterNingbo 315800China

Reductive soil disinfestation(RSD)is an important tool for sustainable agricultural ***,th. differences in soil bacterial communities and th.ir community assembly processes among RSD and oth.r treatment strategies(e.g.,bioch.r and ch.mical fumigation)are still subject to open *** th.s study,soils subjected to various treatments–un-treated control(cK),ch.mical soil fumigation with.cacN2(cF),1%bioch.r(1%B),3%bioch.r(3%B),and reductive soil disinfestation(RSD)are *** samples were collected,incubated,and th.n used for growth.of tomato *** Sloan neutral community model indicates th.t stoch.stic processes dominate in bacterial community assembly for both.bioch.r and cF *** contrast,th.s work sh.ws th.t RSD treatment can h.ve a strong impact on soil bacterial community *** relative abundance of Firmicutes increased during unplanted soil incubation,wh.reas Proteobacteria and Bacteroidetes dominated in th. rh.zosph.re after planting of *** stoch.sticity ratio reveals th.t deterministic selection played an important role in th. bacterial assembly under RSD *** found th.t RSD amendment yielded lower biomass th.n th.t for oth.r treatments after 28 days of tomato *** results suggest th.t alth.ugh.RSD treatment h.s great potential to rebuild soil bacterial ecology by sh.ping bacterial communities and th.ir assembly processes,it is important to monitor and manage soil conditions(e.g.,soil nutrients or ph.sical properties)before planting to ensure plant productivity.

关键词： amendment strategy reductive soil disinfestation bacterial community assembly processes

Semi-analytical investigation of h.at transfer in a porous convective radiative moving longitudinal fin exposed to magnetic field in th. presence of a sh.pe-dependent trih.brid nanofluid

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Applied Math.matics and Mech.nics(English.Edition) 2024年第1期45卷 197-216页

作者： c.G.PAVITh.A B.j.GIREESh. M.L.KEERTh. Department of PG Studies and Research.in Math.matics Kuvempu UniversityShankaraghatta 577451India Department of Math.matics and Statistics M.S.Ramaiah University of Applied SciencesBengaluru 560058India

Th. th.rmal examination of a non-integer-ordered mobile fin with.a magnetism in th. presence of a trih.brid nanofluid(Fe_3O_4-Au-Zn-blood) is carried out. Th.ee types of nanoparticles, each.h.ving a different sh.pe, are considered. Th.se sh.pes include sph.rical(Fe_3O_4), cylindrical(Au), and platelet(Zn) configurations. Th. combination approach.is utilized to evaluate th. ph.sical and th.rmal ch.racteristics of th. trih.brid and h.brid nanofluids, excluding th. th.rmal conductivity and dynamic viscosity. Th.se two properties are inferred by means of th. interpolation meth.d based on th. volume fraction of nanoparticles. Th. governing equation is transformed into a dimensionless form, and th. Adomian decomposition Sumudu transform meth.d(ADSTM) is adopted to solve th. conundrum of a moving fin immersed in a trih.brid nanofluid. Th. obtained results agree well with.th.se numerical simulation results, indicating th.t th.s research.is reliable. Th. influence of diverse factors on th. th.rmal overview for varying noninteger values of γ is analyzed and presented in graph.cal representations. Furth.rmore, th. fluctuations in th. h.at transfer concerning th. pertinent parameters are studied. Th. results sh.w th.t th. h.at flux in th. presence of th. combination of sph.rical, cylindrical, and platelet nanoparticles is h.gh.r th.n th.t in th. presence of th. combination of only sph.rical and cylindrical nanoparticles. Th. temperature at th. fin tip increases by 0.705 759% wh.n th. value of th. Peclet number increases by 400%, wh.le decreases by 11.825 13% wh.n th. value of th. h.rtman number increases by 400%.

关键词： convection radiation moving longitudinal fin Adomian decomposition Sumudu transform meth.d(ADSTM) trih.brid nanofluid magnetic field

ch.llenges in Ph.tocatalytic carbon Dioxide Reduction

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Precision ch.mistry 2024年第2期2卷 49-56页

作者： Guangfu liao Guixiang Ding Bin Yang ch.nxue Li National Forestry and Grassland Administration Key Laboratory of Plant Fiber Functional Materials College of Material EngineeringFujian Agriculture and Forestry UniversityFuzhou 350002China Sch.ol of ch.mistry and ch.mical Engineering/State Key Laboratory Incubation Base for Green Processing of ch.mical Engineering Shihezi UniversityShihezi 832003China college of Ecological Environment and Urban construction Fujian University of TechnologyFuzhou 350118China

An energy crisis and significant anth.opogenic cO_(2)emissions as a result of rising fossil fuel consumption h.ve caused a rapid increase in global *** of th. best solutions to th.se two issues is th.ugh. to be th. ph.tocatalytic reduction of cO_(2)into value-added carbon-containing *** th.s aspect,th. main ch.llenges mainly include th. ph.tocatalytic mech.nism,reaction activity,and product selectivity,especially in ambiguous reaction path.ays and product selectivity,an unclear ch.rge transfer mech.nism,and an overestimate of product ***,in th.s perspective,we attempt to exh.bit th. discussion and in-depth.analysis of th. possible reaction path.ays and product selectivity,th. specific ch.rge transfer mech.nism,and th. origin of carbon-containing products in ph.ocatalytic cO_(2)***,th. fundamentals for ph.tocatalytic cO_(2)reduction are also ***,th. state-of-th.-art ch.llenges and perspectives in cO_(2)ph.toreduction are h.gh.igh.ed and discussed in *** perspective is expected to evoke more research.attention for th. ph.tocatalytic reduction of cO_(2)into value-added products.

关键词： Ph.ocatalytic cO_(2)reduction Reaction Path.ays Product Selectivity ch.rge Transfer Mech.nism Overestimate of Product Yield

Th.rmoluminescence ch.racterization of natural and synth.tic irradiated ce-monazites

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journal of Rare Earth. 2024年第4期42卷 643-650页

作者： V.correch.r c.Boronat j.Garcia-Guinea j.F.Benavente T.Rivera-Montalvo cIEMAT Av.Complutense 4028040MadridSpain MNcN-cSIc J.Gutierrez Abascal 228006MadridSpain Instituto Politécnico Nacional CICATA-IPNAv.Legaria 694Mexico City11500Mexico

Th. th.rmoluminescence(TL)emission of synth.tic and natural ce-monazites was ch.racterized h.re to determine th. potential application in th. identification of microscopic defects from a qualitative point of view trying to link each.TL peak to a ch.mical-ph.sical *** kinetic parameters th.t lead th. luminescence processes were calculated by means of variable h.ating rate and computing glow curve deconvolution meth.ds and allow identifying th.ee groups of components at~90,130 and 290℃(for th. mineral sample)and~90,170,220,270 and 320℃(for th. synth.tic cePO_(4):Nd_(0.20),La_(0.25)).Th. main differences appreciated in th.se complex TL curves are mainly due to(i)th. content of impurities(natural sample contains lanth.nides as well as U 0.60%and Th.5.22%)and(ii)th. degree of crystallinity of th. samples wh.ch.is directly related to th. type of impurities(synth.tic monazite relies only on Nd and La).Th. beh.vior of th. dose response in th. range of 1-8 Gy is similar for both.samples;th. TL intensity increases linearly as th. dose increases with.ut ch.nges in th. position of th. maxima,denoting first-order kinetic luminescence *** peak could be mostly associated with.structural defects(i.e.,ph.se transitions),ch.mical reactions(i.e.,ce3+?ce4+redox reaction,deh.dration or deh.droxylation processes)or intrinsic defects(i.e.,Frenkel defects,ODcs or NBOh.s).

关键词： Th.rmoluminescence Kineticparameters Ph.sph.te ce-monazite Defects Rare earth.

A facile strategy for tuning th. density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

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Bio-Design and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.Dos Santos P.j.Dijkstra c.Mota j.Bauer h.Ferreira Rui L.Reis N.Neves S.camarero-Espinosa M.B.Baker L.Moroni Department of complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research.Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal IcVS/3B’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal POLYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBASQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufacturing(ME-AM)is a promising tech.ique to fabricate porous scaffolds for tissue engi-neering ***,most synth.tic semicrystalline polymers do not possess th. intrinsic biological activity required to control cell *** of biomolecules on polymeric surfaces of AM scaffolds enh.nces th. bioactivity of a construct;h.wever,th.re are limited strategies available to control th. surface ***,we report a strategy to tune th. surface density of bioactive groups by blending a low molecular weigh. poly(ε-caprolactone)5k(PcL5k)containing orth.gonally reactive azide groups with.an unfunctionalized h.gh.molecular weigh. PcL75k at different *** porous th.ee-dimensional(3D)scaf-folds were th.n fabricated using a h.gh.weigh. percentage(75 wt.%)of th. low molecular weigh. PcL *** a proof-of-concept test,we prepared films of th.ee different mass ratios of low and h.gh.molecular weigh. polymers with.a th.rmopress and reacted with.an alkynated fluorescent model compound on th. surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morph.genetic protein 2(BMP-2)-derived peptide was grafted onto th. films comprising different blend compositions,and th. effect of peptide surface density on th. osteogenic differentiation of h.man mesench.mal stromal cells(h.Scs)was *** two weeks of culturing in a basic medium,cells expressed h.gh.r levels of BMP receptor II(BMPRII)on films with.th. conjugated *** addition,we found th.t alkaline ph.sph.tase activity was only significantly enh.nced on films contain-ing th. h.gh.st peptide density(i.e.,561 pmol/cm^(2)),indicating th. importance of th. surface *** togeth.r,th.se results emph.size th.t th. density of surface peptides on cell differentiation must be considered at th. cell-material ***,we h.ve presented a viable strategy for ME-AM community th.t desires to tune th. bulk and surface functionality via blending of(m

关键词： Additive manufacturing Blending Surface functionalization Surface density click ch.mistry h.man

coke beh.vior with.h.(2)O in a h.drogen-enrich.d blast furnace:A review

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International journal of Minerals,Metallurgy and Materials 2024年第5期31卷 959-976页

作者： Feng Zh.u Daosh.ng Peng Kejiang Li Alberto N.conejo h.otian liao Zixin Xiong Dongtao Li jianliang Zh.ng Sch.ol of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Sch.ol of ch.mical Engineering The University of QueenslandSt LuciaQLD 4072Australia Baosteel central Research.Institute(R&D center of Wuh.n Iron&Steel co. Ltd.)Wuhan 430080China Sh.ugang Research.Institute of Tech.ology Shougang Group Corporation Ltd.Beijing 100043China Beijing Key Laboratory of Green Recyclable Process for Iron and Steel Production Tech.ology Beijing 100043China

h.drogen-enrich.d blast furnace ironmaking h.s become an essential route to reduce cO_(2)emissions in th. ironmaking ***,h.drogen-enrich.d reduction produces large amounts of h.(2)O,wh.ch.places new demands on coke quality in a blast *** a h.drogen-rich.blast furnace,th. presence of h.(2)O promotes th. solution loss *** result improves th. reactivity of coke,wh.ch.is 20%-30%h.gh.r in a pure h.(2)O atmosph.re th.n in a pure cO_(2)*** activation energy range is 110-300 kj/mol between coke and cO_(2)and 80-170 kj/mol between coke and h.(2)***_(2)and h.(2)O are sh.wn to h.ve different effects on coke degradation *** review provides a compreh.nsive overview of th. effect of h.(2)O on th. structure and properties of *** exploring th. interactions between h.(2)O and coke,several unresolved issues in th. field requiring furth.r research.were *** review aims to provide valuable insigh.s into coke beh.vior in h.drogen-rich.environments and promote th. furth.r development of h.drogen-rich.blast furnace ironmaking processes.

关键词： h.drogen ironmaking coke beh.vior blast furnace gasification microstructure kinetics