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Dietary fatty acids and bioactive fatty acid metabolites in alcoholic liver disease

Liver Research 2019年第3期3卷 206-217页

作者： Kara H.Zirnheld Dennis R.Warner jeffrey B.Warner josiah E.Hardesty craig j.McClain Irina A.Kirpich Division of Gastroenterology Hepatologyand NutritionDepartment of MedicineUniversity of Louisville School of MedicineLouisvilleKYUSA Department of Pharmacology and Toxicology University of Louisville School of MedicineLouisvilleKYUSA University of Louisville Alcohol Center University of Louisville School of MedicineLouisvilleKYUSA Robley Rex Veterans Medical Center LouisvilleKYUSA

Alcoholic liver disease(ALD)comprises a spectrum of liver pathology,including steatosis,steatohepatitis,and *** work from our group and others suggests that dietary fat,both the amount and composition,plays a pivotal role in ALD development and progression;however,the impact of specific dietary fatty acids on ALD pathogenesis is not fully *** rodent models of ALD revealed the deleterious effects of omega-6 polyunsaturated fatty acids(n-6 PUFAs),specifically linoleic acid(LA),and this may be partially attributed to the increased levels of pro-inflammatory oxidized LA *** is limited understanding regarding the role of omega-3 polyunsaturated fatty acids(n-3 PUFAs,such as alpha-linolenic acid,eicosapentaenoic acid,and docosahexaenoic acid),and bioactive n-3 PUFAderived lipid molecules in *** that majority of n-6 and n-3 PUFAs-derived metabolites are potent endogenous signaling molecules,knowledge regarding the changes in these lipid mediators may shed new light on the mechanisms contributing to ALD pathogenesis and reveal novel therapeutic targets and biomarkers of this *** current review summarizes relevant scientific literature regarding the role of dietary fat,distinct fatty acids,and bioactive fatty acid metabolites in ALD,and highlights recent advances in the field.

关键词： Dietary fatty acids Bioactive fatty acid metabolites Alcoholic liver disease(ALD) Omega-6 polyunsaturated fatty acids(n-6 PUFAs) Omega-3 polyunsaturated fatty acids(n-3 PUFAs)

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Collective Perspective on Advances in Dyson–Schwinger Equation QCD

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Communications in Theoretical Physics 2012年第7期58卷 79-134页

作者： Adnan Bashir Ian C.Clet Bruno El-Bennich craig D.Roberts Peter C.Tandy Instituto de Física y Matemticas Universidad Michoacana de San Nicols de Hidalgo Edificio C-3Ciudad UniversitariaMoreliaMichoacn 58040Mxico Physics Division Argonne National Laboratory ArgonneIllinois 60439USA Center for Nuclear Research Department of PhysicsKent State UniversityKent OH 44242USA CSSM and CoEPP School of Chemistry and Physics University of AdelaideAdelaide SA 5005Australia Laboratorio de Física Teórica e Computao Científica Universidade Cruzeiro do Sul01506-000 So PauloSPBrazil Instituto de Física Torica Universidade Estadual Paulista01140-070 So PauloSPBrazil Department of Physics Center for High Energy Physics and State Key Laboratory of Nuclear Physics and TechnologyPeking University Institut für Kernphysik Forschungszentrum JülichD-52425 JülichGermany Department of Physics Illinois Institute of TechnologyChicagoIllinois 60616-3793USA

We survey contemporary studies of hadrons and strongly interacting quarks using QCD's Dyson-Schwinger equations, addressing the following aspects: confinement and dynamical chiral symmetry breaking; the hadron spectrum; hadron elastic and transition form factors, from small-to large-Q2; parton distribution functions; the physics of hadrons containing one or more heavy quarks; and properties of the quark gluon plasma.

关键词： confinement dynamical chiral symmetry breaking Dyson-Schwinger equations hadron spectrum hadron elastic and transition form factors heavy mesons in-hadron condensates parton distribution functions quark gluon plasma UA(1)-problem

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Distinct mechanisms of FAK mechanoactivation by different extracellular matrix proteins

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医用生物力学 2013年第S1期28卷 69-71页

作者： jihye Seong Arash Tajik jie Sun jun-Lin Guan Martin j.Humphries Susan E.craig Asha Shekaran Andrs j.García Ning Wang Yingxiao Wang Neuroscience Program University of Illinois Department of Mechanical Science and Engineering University of Illinois Department of Bioengineering & Beckman Institute for Advanced Science and Technology University of Illinois Division of Molecular Medicine and Genetics Departments of Internal Medicine and Cell & DevelopmentalBiologyUniversity of Michigan Medical School Wellcome Trust Centre for Cell-Matrix Research Faculty of Life SciencesUniversity of Manchester Woodruff School of Mechanical Engineering and Petit Institute for Bioengineering and Bioscience Georgia Institute of Technology Department of Biomedical Engineering School of Life Science and TechnologyHuazhong University of Science and Technology Department of Integrative and Molecular Physiology Center for Biophysics and Computational BiologyInstitute for Genomic BiologyUniversity of Illinois Department of Bioengineering University of California

Introduction Cells can sense and respond to the mechanical microenvironment by converting forces into biochemical signals inside the cells,***[1-3].Focal adhesions are the major sites of interaction between a cell and its extracellular matrix（ECM）microenvironment,thus outside mechanical signals can be sensed at focal adhesions through transmembrane receptor *** particular,it has been shown that matrix elasticity can control the cell fate[4]by modulating the interactions between ECM proteins and their receptor integrins[5,6].For example,different rigidity of polyacrylamide（PA）gels can lead to different density of ECM ancho-

关键词： integrin converting transmembrane biochemical modulating elasticity rigidity polyacrylamide outside purchased

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听性稳态反应测试的发展

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听力学及言语疾病杂志 2010年第6期18卷 603-605页

作者：闻雨婷 Beck D Speidel D craig j 奥迪康国际贸易(上海)有限公司上海201203

听性稳态反应(ASSR)测试在很多方面与听性脑干反应(ABR)测试相似. 此外,ASSR还能同时测试双耳各4个频率(500、1 000、2 000和4 000 Hz)的听觉反应,且有助于分辨重度和极重度听力损失. 后一点在进行听觉康复、选择大功率助听器和人工耳... 详细信息

听性稳态反应(ASSR)测试在很多方面与听性脑干反应(ABR)测试相似. 此外,ASSR还能同时测试双耳各4个频率(500、1 000、2 000和4 000 Hz)的听觉反应,且有助于分辨重度和极重度听力损失. 后一点在进行听觉康复、选择大功率助听器和人工耳蜗时具有非常重要的意义

关键词：听性稳态反应测试重度听力损失统计学方法听性脑干反应大功率助听器听觉反应听觉康复

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Impact of colorectal cancer screening participation in remote northern Canada:A retrospective cohort study

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World journal of Gastroenterology 2020年第48期26卷 7652-7663页

作者： Heather A Smith Andrew D Scarffe Nicole Brunet Cait Champion Kami Kandola Alisha Tessier Robin Boushey craig Kuziemsky Department of Surgery University of OttawaOttawa K1Y4E9OntarioCanada Telfer School of Management University of OttawaOttawa K1N6N5OntarioCanada Faculty of Medicine University of OttawaOttawa K1Y4E9OntarioCanada Department of Surgery Northern Ontario School of MedicineSudbury P3E2C6OntarioCanada Department of Health and Social Services Government of the Northwest TerritoriesYellowknife X1A1P5Northwest TerritoriesCanada Department of Surgery Stanton Territorial Health AuthorityYellowknife X1A0H1Northwest TerritoriesCanada Division of General Surgery University of OttawaOttawa K1H 8L6OntarioCanada Office of Research Services MacEwan UniversityEdmonton T5J4S2AlbertaCanada

BACKGROUND Screening provides earlier colorectal cancer(CRC)detection and improves *** remains poorly understood if these benefits are realized with screening guidelines in remote northern populations of Canada where CRC rates are nearly twice the national average and access to colonoscopy is *** To evaluate the participation and impact of CRC screening guidelines in a remote northern *** This retrospective cohort study included residents of the Northwest Territories,a northern region of Canada,age 50-74 who underwent CRC screening by a fecal immunohistochemical test(FIT)between january 1,2014 to March 30,*** assess impact,individuals with a screen-detected CRC were compared to clinically-detected CRC cases for stage and location of CRC between *** assess participation,we conducted subgroup analyses of FIT positive individuals exploring the relationships between signs and symptoms of CRC at the time of screening,wait-times for colonoscopy,and screening *** sample Welch t-test was used for normally distributed continuous variables,Mann-Whitney-Wilcoxon Tests for data without normal distribution,and Chi-square goodness of fit test for categorical variables.A P value of<0.05 was considered to be statistically *** 6817 fecal tests were completed,meaning an annual average screening rate of 25.04%,843(12.37%)were positive,629 individuals underwent a follow-up colonoscopy,of which,24.48%had advanced neoplasia(AN),5.41%had *** were no significant differences in stage,pathology,or location between screen-detected cancers and clinically-detected *** assessing participation and screening outcomes,we observed 49.51%of individuals referred for colonoscopy after FIT were ineligible for CRC screening,most often due to signs and symptoms of *** were more likely to have AN if they had signs and symptoms of cancer at the time of screening,waited over 180 d for colonoscopy,or were indigenous[

关键词： Gastroenterology Rural health services Public health Colorectal neoplasms Early detection of cancer Northwest Territories

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Zinc Finger Protein ZBTB20 is a Key Repressor of Alpha-Fetoprotein Transcription in Liver

Zinc Finger Protein ZBTB20 is a Key Repressor of Alpha-Fetop...

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2008年中国病理生理学会第十一届肿瘤和第十二届免疫专业委员会学术会议

作者： Wenwei Tsai Claude Szpirer Michelle craig Barton Michael j. Grusby Department of Biochemistry and Molecular Biology University of TexasMD Anderson Cancer CenterHoustonUSA Université Libre de Bruxelles Institut de Biologie et de Médecine Moléculaires12 Rue Profs Jeneer & BrachetB-6041 GosseliesBelgium Department of Immunology and Infectious Diseases Harvard School of Public Health671 Huntington AvenueBostonMA02115USA.

Alpha-fetoprotein (AFP) gene is highly activated in fetal liver,but is dramatically repressed shortly after *** mechanisms that underlie AFP transcriptional repression in postpartum liver are not well *** enhancer,rep...

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Fish vaccines:current state and future trends

Fish vaccines:current state and future trends

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中国工程院第77场工程科技论坛·2008水产科技论坛——渔业现代化与可持续发展

作者： Phillip H.Klesius craig A.Shoemaker joyce j.Evans Aquatic Animal Health Research Laboratory Agricultural Research ServiceU.S.Department of AgricultureAuburnAlabama 36832 and ChestertownMaryland 21620U.S.A.

A vaccine is a preventive tool used in a health management strategy for the control of infectious diseases in *** more than 100 years,vaccines have proved to be an effective tool for preventing infectious disease outbreaks in humans,poultry and other food *** aquaculture, the development and use of vaccines is now making rapid progress to achieve its full potential as effective disease prevention *** objective of vaccination is to provide a strong immune response to an administered antigen able to provide acquired long-term protection against a *** achieve this objective either a killed or modified live vaccine needs to be developed and licensed for use in fresh or marine water *** type of immunity needed,antibody and/or cell-mediated against,a particular pathogen is among the deciding factors in the development of a *** with a killed bacterial vaccine produces an antibody-mediated protection,but not cell-mediated *** and/or antibody-mediated immunity can be provided only by immunization with a modified live ***,antibody-mediated immunity provided by killed vaccines is relatively short lived in terms of protection(3-5 months).Longer protection(≥12 months)is provided by modified live *** duration of protection may be increased by the addition of an adjuvant to the killed *** adjuvant is a substance that increases specific immune responses against the co-inoculated *** vaccines are usually administered by intraperitonal and/or intramuscular injection of individual *** is the least cost effective in terms of labor and time. Modified live vaccines may be administered by bath immersion to large numbers of fish(fry and/or eggs)which is a more cost effective method of mass vaccination in both labor and *** vaccines are considered to be safer than modified live vaccines which may revert to ***, future trends include oral del

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Radiation-induced oral mucositis hamster model using a linear accelerator enhances clinical relevance of preclinical studies for treatment strategy investigation

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Animal Models and Experimental Medicine 2021年第1期4卷 47-53页

作者： Carolyn T.jordan Emily M.Bradford Dennis C.Cheek Mahesh Kudrimoti craig S.Miller Molly H.Smith j.Zach Hilt Thomas D.Dziubla Department of Chemical and Materials Engineering University of KentuckyLexingtonKYUSA Department of Internal Medicine University of KentuckyLexingtonKYUSA Department of Radiation Medicine University of KentuckyLexingtonKYUSA Department of Oral Health Practice University of KentuckyLexingtonKYUSA Department of Oral and Maxillofacial Pathology University of KentuckyLexingtonKYUSA

Translational animal models for oral mucositis(OM)are necessary to simulate and assess the bioclinical effects and response in *** models should simulate high levels of radiation exposure that leads to oxidative stress and inflammatoryinitiated tissue *** models have been extensively studied to observe pathological effects of radiation exposure and help in the development of effective *** successfully evaluate the potential for treatment regimens with consistency and relevance,a radiation-induced OM hamster model was developed using a clinical linear accelerator utilized by cancer patients *** dose exposure to the isolated,everted cheek pouch of a hamster,as well as the progression of injury,proinflammatory marker,histological,and elasticity analyses of the buccal pouch were conducted to verify replicability and reproducibility of the injury *** findings from this model demonstrated its ability to consistently induce injury and resolution over 28 days using an acute dose of 60 *** model was developed to enhance clinical relevance when evaluating potential efficacious treatments and can now be utilized in efficacy studies to better evaluate developed therapeutics in a preclinical model that is easy to translate to clinical studies..

关键词： animal models radiotherapy stomatitis

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Paleoproterozoic juvenile magmatism within the northeastern sector of the Sao Francisco paleocontinent:Insights from the shoshonitic high Ba-Sr Montezuma granitoids

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Geoscience Frontiers 2020年第5期11卷 1821-1840页

作者： Samuel Moreira Bersan Alice Fernanda de Oliveira Costa Andre Danderfer Francisco Roberio de Abreu Cristiano Lana Glaucia Queiroga craig Storey Hugo Moreira Universidade Federal de Ouro Preto Programa de Pos-graduacaoDepartamento de GeologiaCampus Morro do CruzeiroOuro PretoMGCEP 35400-000Brazil Universidade Federal de Ouro Preto Departamento de GeologiaCampus Morro do CruzeiroOuro PretoMGCEP 35400-000Brazil Sustain Geologia Ltda Teresa M.Valadares 503/502Belo HorizonteMGCEP 30575-160Brazil University of Portsmouth School of Earth and Environmental SciencesBurnaby BuildingBurnaby RoadPortsmouthPO13QLUK

New,integrated petrographic,mineral chemistry,whole rock geochemical,zircon and titanite UPb geochronology,and zircon Hf isotopic data from the Montezuma granitoids,as well as new geochemical results for its host rocks represented by the Corrego Tingui Complex,provides new insights into the late-to post-collisional evolution of the northeastern Sao Francisco paleocontinent.U-Pb zircon dates from the Montezuma granitoids spread along the Concordia between ca.2.2 Ga to 1.8 Ga and comprise distinct *** I have crystallization ages between ca.2.15 Ga and 2.05 Ga and are interpreted as inherited *** II zircon dates vary from 2.04 Ga to1.9 Ga and corresponds to the crystallization of the Montezuma granitoids,which were constrained at ca.2.03 Ga by the titanite U-Pb *** age zoning is common within the ca.1.8 Ga Group III zircon ages,being related to fluid isotopic re-setting during the Espinhaco rifiting ***εHf(t)analysis show dominantly positive values for both Group I(-4 to+9)andⅡ(-3 to+8)zircons and TDM2 model ages of 2.7-2.1 Ga and 2.5-1.95 Ga,***,the Montezuma granitoids are weakly peraluminous to metaluminous magnesian granitoids,enriched in LILES and LREE,with high to moderate Mg#and depleted in some of the *** lithochemical signature,added to the juvenile signature of both inherited and crystallized zircons,allowed its classification as a shoshonitic high Ba-Sr granitoid related to a late-to post-collisional lithosphere delamination followed by asthenospheric *** this scenario,the partial melting of the lithospheric mantle interacted with the roots of an accreted juvenile intra-oceanic arc,being these hybrid magma interpreted as the source of the Montezuma *** Corrego Tingui Complex host rocks are akin to a syn-to late-collisional volcanic arc granitoids originated from the partial melting of ancient crustal *** results presented in this study have revealed the occurrence of j

关键词： Zircon U–Pb-Hf Titanite U–Pb High Ba–Sr Late-to post-collisional Sao Francisco paleocontinent

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An acute naproxen dose does not affect core temperature or Interleukin-6 during cycling in a hot environment

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Sports Medicine and Health Science 2021年第4期3卷 243-251页

作者： Dawn M.Emerson Stephen CL.Chen Toni M.Torres-McGehee craig E.Pfeifer Charles C.Emerson j.Mark Davis Department of Physical Therapy Rehabilitation Scienceand Athletic TrainingSchool of Health ProfessionsUniversity of Kansas Medical Center3901 Rainbow BlvdMS 2002Kansas CityKansas66160USA. Division of Exercise and Sport Science Bob Jones University1700 Wade Hampton BlvdGreenvilleSouth Carolina29614USA. Department of Exercise Science Arnold School of Public HealthUniversity of South Carolina921 Assembly StreetColumbiaSC29208USA Applied Sport and Exercise Sciences The ParkUniversity of GloucestershireCheltenham GL502RHUnited Kingdom. Department of Athletics 5100 Rockhill Rd SRC 201University of Missouri-Kansas CityKansas CityMissouri64110USA.

Non-steroidal anti-inflammatory drugs’anti-pyretic and anti-inflammatory effects has led some individuals to theorize these medications may blunt core body temperature(Tc)increases during *** utilized a double-blind,randomized,and counterbalanced cross-over design to examine the effects of a 24-h naproxen dose(3–220 mg naproxen pills)and placebo(0 mg naproxen)on Tc and plasma interleukin-6(IL-6)concentrations during cycling in a hot or ambient ***(n=11;6 male,5 female;age=27.8±6.5 years,weight=79.1±17.9 kg,height=177±9.5 cm)completed 4 conditions:1)placebo and ambient(Control);2)placebo and heat(Heat);3)naproxen and ambient(Npx);and 4)naproxen and heat(NpxHeat).Dependent measures were taken before,during,and immediately after 90 min of cycling and then 3 h after ***,Tc significantly increased pre-(37.1±0.4℃)to post-cycling(38.2±0.3℃,F_(1.7,67.3)=150.5,p<0.001)and decreased during rest(37.0±0.3℃,F_(2.0,81.5)=201.6,p<0.001).Rate of change or maximum Tc were not significantly different between ***-6 increased pre-(0.54±0.06 pg/ml)to post-exercise(2.46±0.28 pg/ml,p<0.001)and remained significantly higher than pre-at 3 h post-(1.17±0.14 pg/ml,95%CI=-1.01 to-0.23,p=0.001).No significant IL-6 differences occurred between conditions.A 24-h,over-the-counter naproxen dose did not significantly affect Tc or IL-6 among males and females cycling in hot or ambient environments.

关键词： Cytokine Exertional heat illness NSAIDs Thermoregulation Exercise

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