Radiation-induced oral mucositis hamster model using a linear accelerator enhances clinical relevance of preclinical studies for treatment strategy investigation

作     者：Carolyn T.Jordan Emily M.Bradford Dennis C.Cheek Mahesh Kudrimoti Craig S.Miller Molly H.Smith J.Zach Hilt Thomas D.Dziubla Carolyn T.Jordan;Emily M.Bradford;Dennis C.Cheek;Mahesh Kudrimoti;Craig S.Miller;Molly H.Smith;J.Zach Hilt;Thomas D.Dziubla

作者机构：Department of Chemical and Materials EngineeringUniversity of KentuckyLexingtonKYUSA Department of Internal MedicineUniversity of KentuckyLexingtonKYUSA Department of Radiation MedicineUniversity of KentuckyLexingtonKYUSA Department of Oral Health PracticeUniversity of KentuckyLexingtonKYUSA Department of Oral and Maxillofacial PathologyUniversity of KentuckyLexingtonKYUSA 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2021年第4卷第1期

页      面：47-53页

核心收录：

学科分类：1003[医学-口腔医学] 100302[医学-口腔临床医学] 10[医学] 

基　　金：National Institute of Dental and Craniofacial Research Grant/Award Number:R44DE023523 

主　　题：animal models radiotherapy stomatitis 

摘      要：Translational animal models for oral mucositis(OM)are necessary to simulate and assess the bioclinical effects and response in *** models should simulate high levels of radiation exposure that leads to oxidative stress and inflammatoryinitiated tissue *** models have been extensively studied to observe pathological effects of radiation exposure and help in the development of effective *** successfully evaluate the potential for treatment regimens with consistency and relevance,a radiation-induced OM hamster model was developed using a clinical linear accelerator utilized by cancer patients *** dose exposure to the isolated,everted cheek pouch of a hamster,as well as the progression of injury,proinflammatory marker,histological,and elasticity analyses of the buccal pouch were conducted to verify replicability and reproducibility of the injury *** findings from this model demonstrated its ability to consistently induce injury and resolution over 28 days using an acute dose of 60 *** model was developed to enhance clinical relevance when evaluating potential efficacious treatments and can now be utilized in efficacy studies to better evaluate developed therapeutics in a preclinical model that is easy to translate to clinical studies..