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国际医学放射学杂志 2024年第3期 373-374页

作者： S.Lee Y.Y.Kim j.shin Y.H.Roh j.Y.Choi V.Chernyak 吴玉平

摘要目的该项更新的Meta分析旨在确定使用肝脏影像报告和数据系统（LI-RADS）2018版本（v2018）的LI-RADS LR-5类对肝细胞癌（HCC）的诊断能力，并通过评估成像方

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Spin synthesis of monolayer of SiO_2 thin films

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journal of Semiconductors 2015年第4期36卷 16-25页

作者： S.S.shinde S.Park j.shin Korea Research Institute of Standards and Science

The highly ordered monolayer of submicron size silica （SiO2） particles （235 nm） is developed on p-silicon by using three-step spin-coating in colloidal suspension, which has significant potential in various applications. The influence of three-step spin speeds, spinning time, acceleration time between different steps, concentration of SiO2 particles in the solution, solution quantity, and the ambient humidity （relative humidity） on the properties ofmonolayer SiO2 are studied in order to achieve a large area monolayer film. A relatively high surface coverage and uniform monolayer film of SiO2 particles in the range of 85%-90% are achieved by appropriate control of the preparative parameters. We conclude that this method can be useful in industrial applications, because of the fabrication speed, surface coverage and cost of the process.

关键词： thin films spin synthesis electron microscopy

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混纺聚酯纤维织物染色的染料分布

国外纺织技术（纺织针织服装化纤染整） 2002年第3期 20-25页

作者： j.shin 肖敏

微纤维聚酯有时与较高旦尼尔的纤维混纺,使织物在较低成本下具有很好的美感.1.4 D和0.7 D的聚酯纱线单独染色和共同用一系列不同深度的CI分散蓝79染色,检验染色过程中染料分布情况.染色初期,染料对微纤维的上染量较高,但随染料进一步上... 详细信息

微纤维聚酯有时与较高旦尼尔的纤维混纺,使织物在较低成本下具有很好的美感.1.4 D和0.7 D的聚酯纱线单独染色和共同用一系列不同深度的CI分散蓝79染色,检验染色过程中染料分布情况.染色初期,染料对微纤维的上染量较高,但随染料进一步上染纤维,染料分布变均匀,最终两种纤维上染料浓度相等.根据观察,给定染料浓度,微纤维上染的颜色较浅,即使染浴竭染稳定,染色过程发生的染料重新分配也会使织物上颜色不断发生改变.使用三种染料的混合物可以在固定染色温度下20 min后在1.0 D的聚酯纤维织物上产生稳定的颜色,但染1.0 D和0.5 D纤维的织物,色泽变化的持续时间长于1 h.

关键词：混纺聚酯纤维织物染色染料分布

Uncoupling Oligodendrocyte Differentiation and Myelination: Dynamic Neuronal Signaling Not Required

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Uncoupling Oligodendrocyte Differentiation and Myelination: ...

A pipeline to characterize p53 effectors by integrative cistrome and transcriptome analysis in a genetically-defined organoid model

中国神经科学学会第十二届全国学术会议

作者： Sonia R.Mayoral Ainhoa Etxeberria Chin j.shin Chew S.Yian jonah R.Chan Department of Neurology University of California School of Chemical and Biomedical Engineering Lee Kong Chian School of Medicine Nanyang Technological University

Myelination in the CNS is thought to occur via two distinct, but coupled processes. First, highly proliferative and migratory oligodendrocyte precursor cells（OPCs） differentiate into mature oligodendrocytes（OLs）. Second, OL processes concentrically wrap around selected axons forming myelin. These processes occur in a spatially and temporally stereotyped manner throughout development, which implies that environmental cues are at play in the regulation of OL differentiation and myelination. It is thought that dynamic neuronal signaling involving transcriptional control and neuronal activity plays a major role in regulating these processes, but it is unclear whether this is the case in the early development of white matter tracts, such as the optic nerve, where there is synchronous and robust differentiation and myelination within a short timeframe. By eliminating dynamic neuronal signaling in the optic nerve our findings indicate that（1） OL differentiation and myelination are indeed coupled processes where myelination will occur upon differentiation if provided with a permissive substrate, and（2） dynamic neuronal signaling is not required for the majority of OL differentiation during early white matter development. We propose a model in which OL differentiation is largely regulated by extrinsic, non-neuronal factors during development, but myelination is sensitive to the biophysical properties of axonal diameter.

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Genes & Diseases 2024年第2期11卷 512-515页

作者： june-Ha shin Hwa-Ryeon Kim jae-Seok Roe Department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 120-749Republic of Korea

Tumor-protein 53(p53)is a transcription factor(TF)encoded by TP53(Trp53 in mice)and is a master regulator of tumor-suppressive programs'.Importantly,TP53 is the most frequently mutated gene in human cancer,and its loss of function contributes to tumor development,exemplified by variable p53 mutations detected in 50%-75%of pancreatic cancers.2 From these perceptions,a number of targets transcribed by p53 that confer tumor suppression have been ***,our understanding of how p53 prevents normal cells from initiating tumorigenesis is still *** complement this limitation,herein,we established a new approach to identify underlying effectors transcribed by p53 in normal physiology.

关键词： incomplete initiating herein

LI-RADS分类中的CT和MRI算法评估肝细胞癌的百分比：系统综述和Meta分析

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国际医学放射学杂志 2023年第3期 358-358页

作者： S.Lee Y.Y.Kim j.shin W.j.Son Y.H.Roh j.Y.Choi 杨思雨

摘要肝脏成像报告和数据系统（LI-RADS）中的CT和MRI算法同样适用于CT、使用细胞外对比剂的MRI (ECAMRI)和使用钆对比剂的MRI(Gx-MRI)的检查。目的通过

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MRI影像组学模型预测放化疗后直肠癌的病理完全缓解

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国际医学放射学杂志 2022年第4期 478-478页

作者： j.shin N.Seo S.E.Baek N.H.Son j.S.Lim N.K.Kim 陈佳乐

摘要为了保存器官，越来越需要术前评估局部晚期直肠癌（LARC）新辅助放化疗（n CRT）后的病理完全缓解（p CR），但MRI影像组学模型仍然缺乏大规模验证。目的评

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Effects of mesenchymal stem cell on dopaminergic neurons,motor and memory functions in animal models of Parkinson's disease:a systematic review and meta-analysis

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Neural Regeneration Research 2024年第7期19卷 1584-1592页

作者： jong Mi Park Masoud Rahmati Sang Chul Lee jae Il shin Yong Wook Kim Department and Research Institute of Rehabilitation Medicine Yonsei University College of MedicineSeoulSouth Korea Department of Physical Education and Sport Sciences Faculty of Literature and Human SciencesLorestan UniversityKhoramabadIran Department of Pediatrics Yonsei University College of MedicineSeoulSouth Korea

Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease *** cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s *** stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of *** performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal *** searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through j une 28,*** study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control *** use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the *** with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational *** the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a

关键词： animal animal experimentation mesenchymal stem cells models Parkinson’s disease stem cell transplantation

Tetramic acid-motif natural products from a marine fungus Tolypocladium cylindrosporum FB06 and their anti-Parkinson activities

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Marine Life Science & Technology 2024年第1期6卷 84-92页

作者： Yuna jung Chaesun Kwon Taeyeon Kim jin Woo Lee Min-Kyoo shin Sang Hee Shim Natural Products Research Institute College of PharmacySeoul National UniversitySeoul 08826Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 08826Republic of Korea College of Pharmacy Duksung Women’s UniversitySeoul 01369Republic of Korea

Tetramic acid-containing natural products are attracting significantly increasing attention from biologists and chemists due to their intriguing structures and biological *** the present study,two new tetramic acid alkaloids tolypyridone I(1)and tolypyridone j(2),together with five known ones(3–7),were isolated from cultures of a marine fungus Tolypocladium cylindrosporum FB06 isolate obtained from a marine sediment in Beaufort sea of North *** structures were elucidated using 1D,2D NMR,and *** configurations were established on the basis of 1H coupling constants,ROESY correlations and DP4 *** 2 was isolated as mixtures of rotational isomers with C-3 to C-7 axis between 4-hydroxy-2-pyridone and 1-ethyl-3,5-dimethylcyclohexane,hindering *** our unbiased screening to discover neuroprotective compounds in an in vitro Parkinson’s disease(PD)model,SH-SY5Y dopaminergic cells were treated with isolated compounds followed by treatment with 1-methyl-4-phenylpyridinium(MPP^(+)),a parkinsonian *** tested compounds,F-14329(7)significantly protected cells from MPP^(+)-induced ***^(+)-mediated cell death is known to be related to the regulation of Bcl-2 family proteins,specifically the down-regulation of anti-apoptotic Bcl-2 and the up-regulation of pro-apoptotic Bax *** with 2 mmol/L of MPP^(+)for 24 h significantly reduced Bcl-2 levels compared to control treated with ***,treatment with F-14329(7)attenuated such *** study demonstrates that tetramic acid-motif compounds could be potential lead compounds for treating PD.

关键词： Tolypocladium cylindrosporum Tetramic acid Tolypyridone Parkinson’s disease

Highly Elastic,Bioresorbable Polymeric Materials for Stretchable,Transient Electronic Systems

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Nano-Micro Letters 2024年第6期16卷 1-13页

作者： jeong‑Woong shin Dong‑je Kim Tae‑Min jang Won Bae Han joong Hoon Lee Gwan‑jin Ko Seung Min Yang Kaveti Rajaram Sungkeun Han Heeseok Kang jun Hyeon Lim Chan‑Hwi Eom Amay j.Bandodkar Hanul Min Suk‑Won Hwang KU‑KIST Graduate School of Converging Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea SK Hynix 2091Gyeongchung‑daeroBubal‑eupIcheon‑siGyeonggi‑do 17336Republic of Korea Hanwha Systems Co. Ltd.188Pangyoyeok‑roBundang‑guSeongnam‑siGyeonggi‑do 13524Republic of Korea Department of Electrical and Computer Engineering North Carolina State UniversityRaleighNC 27606USA Center for Advanced Self‑Powered Systems of Integrated Sensors and Technologies(ASSIST) North Carolina State UniversityRaleighNC 27606USA Department of Integrative Energy Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea Biomaterials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang‑ro 14‑gilSeongbuk‑guSeoul 02792Republic of Korea Semiconductor R&D Center Samsung Electronics Co.Ltd.Hwaseong‑siGyeonggi‑do 18448Republic of Korea Center for Advanced Biomolecular Recognition Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Substrates or encapsulants in soft and stretchable formats are key components for transient,bioresorbable electronic systems;however,elastomeric polymers with desired mechanical and biochemical properties are very limited compared to nontransient ***,we introduce a bioresorbable elastomer,poly(glycolide-co-ε-caprolactone)(PGCL),that contains excellent material properties including high elongation-at-break(<1300%),resilience and toughness,and tunable dissolution *** of PGCLs as polymer matrices,in combination with conducing polymers,yields stretchable,conductive composites for degradable interconnects,sensors,and actuators,which can reliably function under external *** of device components with wireless modules demonstrates elastic,transient electronic suture system with on-demand drug delivery for rapid recovery of postsurgical wounds in soft,time-dynamic tissues.

关键词： Biodegradable elastomer Conductive polymer composites Biomedical device Transient electronics