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Lancet N：卒中二级预防长期双联抗血小板的突破

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中国卒中杂志 2020年第2期15卷 167-168页

作者：杨中华 tOYODA k UCHIYAMA S yamaguchi t 首都医科大学附属北京天坛医院神经病学中心脑血管病中心神经重症医学科北京100070 不详

合并颈动脉和颅内动脉狭窄或多重血管危险因素的非心源性缺血性卒中患者复发风险很高。对于这一部分患者,综合预防治疗,包括抗血小板治疗,已经被证明是有益的。不过,新型抗血小板药物,比如替格瑞洛和普拉格雷,是治疗冠心病很有前景的药... 详细信息

合并颈动脉和颅内动脉狭窄或多重血管危险因素的非心源性缺血性卒中患者复发风险很高。对于这一部分患者,综合预防治疗,包括抗血小板治疗,已经被证明是有益的。不过,新型抗血小板药物,比如替格瑞洛和普拉格雷,是治疗冠心病很有前景的药物,在临床应用大约10年了,但是在卒中患者的随机对照试验中并未发现它们优于传统的抗血小板药物。不同的抗血小板药物通过不同的机制发挥作用,联合用药比单药能更加有效地预防卒中。

关键词：抗血小板药物血管危险因素替格瑞洛普拉格雷颅内动脉狭窄抗血小板治疗双联抗血小板联合用药

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Correlation between 99mtcO4-thyroid Scintigraphy and Blood test in Primary Hyperthyroidism

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Open Journal of Endocrine and Metabolic Diseases 2021年第3期11卷 71-78页

作者： Yukinori Okada Shoichiro Matsushita keiichiro yamaguchi Department of Radiology School of Medicine St. Marianna University Kawasaki Japan Department of Proton therapy and tumor Imaging School of Medicine St. Marianna University Kawasaki Japan

Background: the 99mtcO4- thyroid scintigraphy is commonly used for hyperthyroidism diagnosis. Uptake value of 99mtcO4- on thyroid scintigraphy is an indicator of hyperthyroidism activity. Although, the correlation be... 详细信息

tyle="text-align:justify;"> Background: The 99mTcO4- thyroid scintigraphy is commonly used for hyperthyroidism diagnosis. Uptake value of 99mTcO4- on thyroid scintigraphy is an indicator of hyperthyroidism activity. Although, the correlation between free T3 value and free T4 value is not necessary clear in primary hyperthyroidism. Introduction: This study investigated the correlation between results of blood test and uptake of 99mTcO4- on thyroid scintigraphy in primary hyperthyroidism. Methodlogy: In this retrspective study, uptake was calculated in patients diagnosed with primary hyperthyroidism (Graves’ disease/Basedow’s disease) based on clinical findings, blood tests, thyroid ultrasound, and 99mtcO4tyle="margin-left:-7px;">- thyroid scintigraphy (uptake ≥3%) at St. Marianna University School of Medicine Hospital between 1 January 2010 and 31 December 2019. this uptake of 99mtcO4tyle="margin-left:-7px;">- was compared with results of blood tests. trong>Results:trong> Fifty-four consecutively arriving patients at the hospital (12 men, 42 women;mean age 43.0 ± 14.0 years) were selected. Free t3 (n = 54) was 14.6 ± 6.8 pg/mL, free t4 (n = 53) was 5.0 ± 2.3 ng/mL, and uptake on thyroid scintigraphy was 10.0% ± 7.1%. the correlation coefficients were 0.60 (p tween free t4 (all case), 0.39 (p tween free t4 (under 7 ng/mL), 0.12 (p = 0.70) between free t4 (above 7 ng/mL) and 99mtcO4tyle="margin-left:-7px;">- thyroid scintigraphy uptake. trong>Conclusion:trong> In primary hyperthyroidism (Graves’ disease), there is a correlation between free t4 value and 99mtcO

关键词： Graves’ Disease/Basedow’s Disease 99mtcO4- thyroid Scintigraphy Free t3 Free t4 tSH

Induction of CXC chemokines in human mesenchymal stem cells by stimulation with secreted frizzled-related proteins through non-canonical Wnt signaling

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World Journal of Stem Cells 2015年第11期7卷 1262-1273页

作者： David S Bischoff Jian-Hua Zhu Nalini S Makhijani Dean t.yamaguchi Research Service VA Greater Los Angeles Healthcare System Department of Medicine David Geffen School of Medicine at UCLA

AIM: to investigate the effect of secreted frizzledrelated proteins(s FRPs) on CXC chemokine expression in human mesenchymal stem cells(h MSCs).MEtHODS: CXC chemokines such as CXCL5 and CXCL8 are induced in h MSCs during differentiation with osteogenic differentiation medium(OGM) and may be involved in angiogenic stimulation during bone repair. h MSCs were treated with conditioned medium(CM) from L-cells expressing non-canonical Wnt5 a protein, or with control CM from wild type L-cells, or directly with s FRPs for up to 10 d in culture. m RNA expression levels of both CXCL5 and CXCL8 were quantitated by real-time reverse transcriptase-polymerase chain reaction and secreted protein levels of these proteins determined by ELISA. Dose-(0-500 ng/m L) and time-response curves were generated for treatment with s FRP1. Signal transduction pathways were explored by western blot analysis with pan- or phosphorylation-specific antibodies, through use of specific pathway inhibitors, and through use of si RNAs targeting specific frizzled receptors(Fzd)-2 and 5 or thereceptor tyrosine kinase-like orphan receptor-2(Ro R2) prior to treatment with s FRPs. RESULtS: CM from L-cells expressing Wnt5 a, a noncanonical Wnt, stimulated an increase in CXCL5 m RNA expression and protein secretion in comparison to control L-cell CM. s FRP1, which should inhibit both canonical and non-canonical Wnt signaling, surprisingly enhanced the expression of CXCL5 at 7 and 10 d. Dickkopf1, an inhibitor of canonical Wnt signaling prevented the s FRPstimulated induction of CXCL5 and actually inhibited basal levels of CXCL5 expression at 7 but not at 10 d post treatment. In addition, all four s FRPs isoforms induced CXCL8 expression in a dose- and time-dependent manner with maximum expression at 7 d with treatment at 150 ng/m L. the largest increases in CXCL5 expression were seen from stimulation with s FRP1 or s FRP2. Analysis of mitogen-activated protein kinase signaling pathways in the presence of OGM sh

关键词： CXC chemokines Mesenchymal stem cell Osteogenesis Differentiation Wnt signaling pathway Frizzled-related protein Frizzled receptors

Die Motions of New Forging Process Using Intermediate Die Assembly

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Journal of Materials Science & technology 2001年第1期17卷 127-128页

作者： t. Umemura, Y.Zhou and S.kamimura Dept. Mech. Eng., Nagaoka Unly. of technology, Nagaoka, Japan N.Motoi and Y Ohta Johetsu industries Co. Ltd., Ogunimachi, Niigata, Japan N. yamaguchi COMAC, Ltd. Sanjyo, Niigata, Japan Dep. of Mech. Eng. Nagaoka Univ. of Technol. Nagaoka Japan

the die motions of a new forging process for automation with an intermediate die assembly called hamburger were analyzed through high-speed video pictures. the results showed that the upper die that is assembled in the hamburger and retained over the lower die collides few times . with the ram and workpiece, but sound products can be obtained with less sticking in spite of the lowered impacts of hit.

关键词： L

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Fluid Vibration Induced in t-Junction with Double Side Branches

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World Journal of Mechanics 2016年第4期6卷 169-179页

作者： Ryuhei yamaguchi Gaku tanaka Hao Liu toshiyuki Hayase Graduate School of Engineering Chiba University Chiba Japan Institute of Fluid Science Tohoku University Sendai Japan

A t-junction is a fundamental fluid element prevalent in pipe networks of water supplies and power plants. In the present study, a double t-junction was investigated for flow instability and fluid vibration. Both axi-aligned and skewed double t-junctions are examined from viewpoint of flow instability. With single-phase flow in an open-ended double t-junction, fluid vibration is induced in both side branches because of a high shear rate with a point of inflection. the frequency of vibration in the downstream branch is higher than that in the upstream branch. Except for the upstream branch in the skewed double t-junction, the frequency is higher than that in a single t-junction. the fluid vibrations are closely associated with the fluid interference created by the presence of the two side branches.

关键词： Fluid Vibration Flow Instability Shear Rate Double t-Junction Particle Image Velocimetry Laser Doppler Anemometry

Accelerated chondrogenesis in nanofiber polymeric scaffolds embedded with BMP-2 genetically engineered chondrocytes

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Journal of Biomedical Science and Engineering 2010年第9期3卷 908-916页

作者： Robert t. Gorsline Prasam tangkawattana John J. Lannutti Mamoru yamaguchi Christopher C. kaeding Alicia L. Bertone 不详

this study evaluated chondrogenesis within a nanofiber polymeric scaffold seeded with isolated untreated chondrocytes, isolated chondrocytes genetically engineered with adenoviral (Ad) bone morphogenetic protein (BMP)-2, or isolated chondrocytes genetically engineered with green fluorescent protein (Ad-GFP). Electrospun polycaprolactone scaffolds (150-200 m thickness, 700 m fiber diameter, 30 m pore size) were optimally seeded with 1 x 107 isolated chondrocytes by using a 20% serum gradient culture system. Chondrocyte-scaffold constructs (untreated, Ad-B- MP-2 and Ad-GFP) were generated from 5 adult horses, cultured in triplicate for 7 or 14 days, and quantitatively analyzed for cell proliferation (DNA content;Hoechst assay), viability, morphology (confocal microscopy), matrix production (proteoglycan content;DMMB assay), and mRNA expression of collagen I, collagen II, and aggrecan. Chondrocytes transduced with Ad-BMP-2 demonstrated greater cell numbers and significantly greater expression of chondrogenic markers including aggrecan, collagen II, and proteoglycan through 14 days of culture as compared to untransduced or Ad-GFP controls. this study demons- trated that chondrocytes can be driven to seed a polycaprolactone nanofiber scaffold by serum gradient and a polycaprolactone nanofiber scaffold containing Ad-BMP2 transduced chondrocytes resulted in grea- ter and accelerated chondrogenesis than controls. this cell engineered construct has potential use in one-step cartilage repair in vivo.

关键词： Nanofiber Scaffold Chondrogenesis BMP- 2 Adenovirus

Isolation and Expression Profiling of a CONStANS-Like Gene and two FLOWERING LOCUS t-Like Genes from Spinacia oleracea L.

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American Journal of Plant Sciences 2014年第26期5卷 4018-4028页

作者： Erika Abe kaien Fujino kiyoshi Masuda Yube yamaguchi Graduate School of Agriculture Hokkaido University Sapporo Japan Research Faculty of Agriculture Hokkaido University Sapporo Japan Graduate School of Life and Environmental Sciences Osaka Prefecture University Sakai Japan

Spinach (Spinacia oleracea L.) develops leaf rosettes under short-day conditions, and starts reproductive growth including bolting and flowering under long-day conditions. Japanese people prefer Oriental spinach that bolts easily with a shorter photoperiod than European spinach. this is one of the main reasons that Oriental spinach is difficult to grow year-round. In order to understand spinach flowering mechanisms and obtain knowledge for spinach breeding, we isolated one CONStANS-like (COL) and two FLOWERING LOCUS t (Ft) homologs, which are key components of photoperiodic regulation of flowering time, from a Japanese cultivar. the expression of SoCOL1 showed diurnal rhythm with the highest expression at the end of the dark cycle. this diurnal rhythm is similar to the expression of BvCOL1 from sugar beet (Beta vulgaris), whose flower-promoting effect was observed when overexpressed in Arabidopsis. Phylogenetic analysis showed that SoCOL1 is the closest homolog of BvCOL1, suggesting that SoCOL1 is an ortholog of BvCOL1. SoFt1 and SoFt2 are closely related to BvFt1 and BvFt2, respectively. the expression of SoFt1 and SoFt2 were induced in advance of flower bud formation after changing the photoperiod, but the expression level of SoFt1 was much lower than SoFt2. Currently, we are speculating that SoFt2 is a flower-promoting factor of spinach, and that SoFt1 has a role in light signaling because the expression of SoFt1 showed a diurnal rhythm.

关键词： CONStANS FLOWERING LOCUS t Spinacia oleracea L. Flower Bud Formation Photoperiod

HsfAld, a Protein Identified via FOX Hunting Using thellungiella salsuginea cDNAs Improves Heat tolerance by Regulating Heat-Stress-Responsive Gene Expression

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Molecular Plant 2013年第2期6卷 411-422页

作者： Yukari Higashi Naohiko Ohama tomoko Ishikawa taku katori Ayaka Shimura kazuya kusakabe kazuko yamaguchi-Shinozaki Junko Ishida Maho tanaka Motoaki Seki kazuo Shinozaki Yoichi Sakata takahisa Hayashi teruaki taji Department of Bio-Science Tokyo University of Agriculture 1-1-1 Sakuragaoka Setagaya Tokyo 156-8502 Japan Graduate School of Agriculture and Life Sciences University of Tokyo Tokyo 113-8657 Japan RIkEN Yokohama Institute 1-7-22 Suehiro-cho Tsururni-ku Yokohama 230-0045 Japan

thellungiella salsuginea （formerly t. halophila）, a species closely related to Arabidopsis （Arabidopsis thali-ana）, is tolerant not only to high salt levels, but also to chilling, freezing, and ozone. Here, we report that t. salsuginea also shows greater heat tolerance than Arabidopsis. We identified t. salsuginea HsfAld （tsHsfAld） as a gene that can confer marked heat tolerance on Arabidopsis. tsHsfAld was identified via Full-length cDNA Over-eXpressing gene （FOX） hunt-ing from among a collection of heat-stress-related t. salsuginea cDNAs. transgenic Arabidopsis overexpressing tsHsfAld showed constitutive up-regulation of many genes in the Arabidopsis AtHsfA1 regulon under normal growth tempera-ture. in Arabidopsis mesophyll protoplasts, tsHsfAld was localized in both the nucleus and the cytoplasm. tsHsfAld also interacted with AtHSP90, which negatively regulates AtHsfAls by forming HsfA1-HSP90 complexes in the cytoplasm. It is likely that the partial nuclear localization of tsHsfAld induced the expression of the AtHsfAld regulon in the transgenic plants at normal temperature. We also discovered that transgenic Arabidopsis plants overexpressing AtHsfAldwere more heat-tolerant than wild-type plants and up-regulated the expression of the HsfAld regulon, as was observed in tsHsfAld-overexpressing plants. We propose that the products of both tsHsfAld and AtHsfAld function as positive regulators of Arabidopsis heat-stress response and would be useful for the improvement of heat-stress tolerance in other plants.

关键词： thellungiella salsuginea heat-stress tolerance HsfA1 FOX hunting.

Neutron and Alpha Structure in Neutron Deficient Nuclei in Astrophysics

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原子核物理评论 2016年第2期33卷 212-216页

作者： S.kubono 何建军 H.yamaguchi D.M.kahl S.Hayakawa t.teranishi S.Cheribini M.Gulino Y.k.kwon t.Hashimoto Y.Wakabayashi N.Iwasa S.kato t.komatsubara D.N.Binh L.H.khiem N.N.Duy t.kawabata C.Spitaleri G.G.Rapisarda M.La Cognata L.Lamia R.G.Pizzone S.Romano A.Coc N.de Sereville F.Hammache G.kiss S.Bishop Institute of Modern Physics Chinese Academy of Sciences RIkEN Nishina Center Center for Nuclear Study University of Tokyo Department of Physics Kyushu University Laboratori Nazionali del Sud Istituto Nazionale di Fisica Nucleare Institute for Basic Science 70Yuseong-daero 1689-gil RIkEN Nishina Center 2-1 Hirosawa Department of Physics Tohoku University Department of Physics Yamagata University Institute of Physics Vietnam Academy for Science and Technology Department of Physics Kyoto University IN2P3 Institute for Nuclear Research (MtA-AtOMkI) tUM

the paper includes discussions on the important role of neutron and alpha configurations in proton-rich nuclei in nuclear astrophysics in terms of nucleosynthesis under extremely high-temperature hydrogenburning conditions. the νp-process, which is supposed to take place at the very early epoch of type II supernovae, has considerable neutrons and alphas together with protons. the alpha-induced reactions on proton-rich unstable nuclei in the light mass regions is expected to play a crucial role, but very few of them were investigated well yet because of the experimental difficulties. Specifically, I report our recent experimental effort for the breakout process from the pp-chain region,~7Be(α, γ)^(11)C(α,p)^(14)N under the νp-process. the neutron-induced reactions on proton-rich nuclei, which is even more a challenging subject, were investigated previously for very few nuclei. One possible experimental method is the trojan Horse Method(tHM). We successfully have applied tHM to the ^(18)F(n,α)^(14)N reaction study with an unstable beam of ^(18)F.

关键词： alpha-and neutron-induced stellar reactions in proton-rich nuclear region νp-process pp-chain breakout nuclear cluster structures in astrophysics low-energy RI beam

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