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QUANTIFYING NANOP ARTICLE TRANSPORT IN VIVO USING HYP ERSPECTRAL IMA GING WITH A DORSAL SKINFOLD WINDOW CHAMBER

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Journal of Innovative Optical Health Sciences 2012年第4期5卷 8-17页

作者： TREVOR D.MCKEE JUAN CHEN ian corbin GANG ZHENG RAMA KHOKHA Ontario Cancer Institute University Health Network TorontoOntario STTARR Innovation Center University Health Network TorontoCanada Department of Medical Biophysics University of Toronto TorontoCanada Advanced Imaging Research Center University of Texas Southwestern Medical Center at Dallas Dallas USA

We have developed a noninv asive imaging method to quantify in viwo drug delivery pharmaco-kinetics without the need for blood or tissue collection to determine drug *** combining the techniques of hy perspectral imaging and a dorsal skinfold window chamber,this method enabled the real-time monitoring of vascular transport and tissue deposition of nano-particles labeled with near infrared(NIR)*** this imaging method,we quantified the delivery pharmacokinetics of the native high-density lipoprotein(HDL)and epidermal growth factor receptor(EGFR)-targeted HDL nanoparticles and demonstrated these HDLs had long circulation time in blood stream(half-life>12h).These HDL nanoparticles could eficiently carry cargo DiR-BOA to extravasate from blood vesels,difuse through extr acellular matrix,and penetrate and be retained in the tumor *** EGFR targeting specificity of EGFR-targeted HDL(EGFR-specific peptide conjugated HDL)was also visualized in vivo by competitive inhi bition with excess EGFR specifc *** summary,this imaging technology may help point the way toward the development of novel imaging based pharmacokinetic assays for preclinical drugs and evaluation of drug delivery eficiency,providing a dynamic window into the devel opment and application of novel drug delivery systems.

关键词： specificity kinetics competitive

Conceptual physical education: A course for the future

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Journal of Sport and Health Science 2021年第3期10卷 308-322页

作者： Charles B.corbin College of Health Solutions Arizona State UniversityPhoenixAZ 85004USA

The conceptual physical education(CPE)innovation began in the mid-20th century as an alternative approach to college-level,activity-only basic instruction *** addition to physical activity sessions,CPE courses(classes)use text material and classroom sessions to teach kinesiology concepts and principles of health-related fitness and health-enhancing physical *** courses are now offered in nearly all college programs as either required or electives *** decades later,the high school CPE innovation began,and Kindergarten-8 programs *** this commentary,I argue that historian Roberta Park was correct in her assessment that physical education has the potential to be the renaissance field of the 21st *** contributions of researchers in kinesiology will lead the way,but science-based CPE and companion fitness education programs that align with physical education content standards and fitness education benchmarks will play a significant *** courses have been shown to be effective in promoting knowledge,attitudes,and out-of-school physical activity and have the potential to elevate physical education as we chart the course of our future.

关键词： Conceptual physical education Fitness education Secondary school physical education

Heterogeneous molecular catalysts for electrocatalytic CO2 reduction

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Nano Research 2019年第9期12卷 2093-2125页

作者： Nathan corbin Joy Zeng Kindle Williams Karthish Manthiram Department of Chemical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

This review provides an overview of the literature regarding heterogeneous molecular catalysts for electrochemical CO2 reduction (ECR).Fundamental aspects of the science,including aggregation,electrochemical rate laws,and electrode-catalyst electronic coupling,are discussed to provide a solid foundation on which to design experiments and interpret *** aspects of ECR are presented based on electrokinetic and spectroscopic measurements as well as density functional theory (DFT) *** is improving for electrokinetic measurements,but the redox state of the metal center under reaction conditions and DFT reaction pathways lack agreement in the *** the tunable aspects of the molecular catalyst,the impacts of the metal center,ligand substituents,and electrode support on the activity and selectivity toward ECR are presented with an emphasis on those studies that controlled for aggregation and minimized mass-transport *** three-dimensional (3D) structures such as polymers,metal-organic frameworks (MOFs),and covalent-organic frameworks (COFs) are discussed as highly tunable architectures that begin to mimic the catalytic pockets of enzyme active *** achieve the full potential of these catalysts,design principles must emerge based on a combination of deconvoluting measurements to extract intrinsic catalyst properties and more reliable theoretical calculations to predict reaction pathways.

关键词： CO2 reduction electrocatalysis porphyrins phthalocyanines molecular complexes heterogeneous catalysis

Involvement of glycated albumin in adipose-derived-stem cellmediated interleukin 17 secreting T helper cell activation

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World Journal of Stem Cells 2020年第7期12卷 621-632页

作者： Julien Pestel Maud Robert Sara corbin Hubert Vidal Assia Eljaafari INSERM U1060 CarMen Batiment CENS-ELICentre Hospitalier Lyon SudPierre Bénite 69310France Faculty of Medicine UniversitéClaude Bernard Lyon 1Batiment CENS-ELICentre Hospitalier Lyon SudPierre Bénite 69310France Department of Surgery in Gastro-enterology Edouard Herriot HospitalLyon 69003France Public Health Department Hospices Civils de Lyon1 quai des célestins Lyon 69002France DO-IT Research Team Hospices Civils de Lyon1 quai des célestinsLyon 69002France

BACKGROUND Advanced glycation end products(AGE)are a marker of various diseases including diabetes,in which they participate to vascular damages such as retinopathy,nephropathy and *** those vascular complications,AGE are involved in altered metabolism in many tissues,including adipose tissue(AT)where they contribute to reduced glucose uptake and attenuation of insulin *** are known to contribute to type 1 diabetes(T1D)through promotion of interleukin(IL)-17 secreting T helper(Th17)*** To investigate whether lean adipose-derived stem cells(ASC)could be able to induce IL-17A secretion,with the help of *** As we have recently demonstrated that ASC are involved in Th17 cell promotion when they are harvested from obese AT,we used the same co-culture model to measure the impact of glycated human serum albumin(G-HSA)on human lean ASC interacting with blood mononuclear ***-17A and pro-inflammatory cytokine secretion were measured by *** of AGE(RAGE)together with intercellular adhesion molecule 1(ICAM-1),human leukocyte Antigen(HLA)-DR,cluster of differentiation(CD)41,and CD62P surface expressions were measured by ***-RAGE specific monoclonal antibody was added to co-cultures in order to evaluate the role of RAGE in IL-17A *** Results showed that whereas 1%G-HSA only weakly potentiated the production of IL-17A by T cells interacting with ASC harvested from obese subjects,it markedly increased IL-17A,but also interferon gamma and tumor necrosis factor alpha production in the presence of ASC harvested from lean *** was associated with increased expression of RAGE and HLA-DR molecule by cocultured ***,RAGE blockade experiments demonstrated RAGE specific involvement in lean ASC-mediated Th-17 cell ***,platelet aggregation and ICAM-1,which are known to be induced by AGE,were not involved in these *** Thus,our results demonstrated tha

关键词： Interleukin 17 secreting T helper cells Lean adipose tissue Type 1 diabetes Advanced glycation end products Adipose-derived stem cells

Use of riboflavin for photoinactivation of pathogens in blood components

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中国输血杂志 2001年第S1期14卷 295-296页

作者： Frank corbinⅢ

Use of riboflavin for photoinactivation of pathogens in blood components

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Use of riboflavin for photoinactivation of pathogens in bloo...

Depression,suicidality and associated risk factors among police officers in urban Tanzania:a cross-sectional study

国际输血协会第十一届西太地区大会

作者： Frank corbin Ⅲ Ph.D Vice PresidentResearch ＆ DevelopmentGambro BCTInc.USA

＜正＞Riboflavin is a naturally occurring compound and an essential human *** in the 1960s and 70s showed that it could be effective,when exposed to visible or UV light,in inactivating viruses and *** studies showed that the principal mode of action is through electron transfer reactions,most importantly in nucleic acids,and not through the production of active oxygen *** suggested to us that it could act as a photosensitizer useful in the inactiva- tion of pathogens found in blood products,because of its nucleic acid specificity and its limited tendency toward indiserim-

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General Psychiatry 2021年第3期34卷 135-142页

作者： Belinda Jackson Njiro Harrieth Peter Ndumwa Charles Joseph Msenga Thomas Kawala Ezekiel Matola Juhudi Mhonda Hillary corbin Omary Ubuguyu Samuel Likindikoki School of Medicine Muhimbili University of Health and Allied SciencesDar es SalaamTanzaniaUnited Republic of Medical Unit Tanzania Police ForceDar es SalaamTanzaniaUnited Republic of National NCD Prevention and Control Program Ministry of HealthCommunityDevelopmentGenderElderly and ChildrenDodomaTanzaniaUnited Republic of

Background The WHO has classified depression as a disease of public *** officers are a particular subpopulation group that is at an increased risk for mental health *** study examined the prevalence of depression,suicidality and associated risk factors among police officers in urban *** The aim of this study was to examine the prevalence of depression,suicidality and associated risk factors among police officers in *** A cross-sectional study was conducted between April 2019 and October 2020 among 550 participants in Dar es Salaam recruited using a multistage cluster sampling *** Patient Health Questionnaire-9 was used to screen for depression and *** Interpersonal Support Evaluation List-12 tool was used to measure perceived social *** statistics were summarised using frequencies and *** and multivariate analyses were used to establish associations between predictors of interest,depression and *** There were 497 participants in the *** these,76.6%(376 of 491)were men,and the median(IQR)age was 37.0(17)*** 19.8%(96 of 486)of the police officers screened positive for depression and 15.4%(75 of 413)for suicidality.A significant proportion was either moderately(29 of 96,30.2%)or severely depressed(8 of 75,10.7%).Of those who experienced suicidal thoughts,10.7%(8 of 75)reported having daily suicidal *** low social support was associated with an increased risk of reporting depression(adjusted OR(aOR):28.04,95%CI:8.42 to 93.37,p<0.001)and suicidality(aOR:10.85,95%CI:3.56 to 33.08,p<0.001)as compared with those with high perceived social *** The magnitude of depression and suicidality among police officers in urban Tanzania is alarmingly *** study findings indicate the need for routine screening for depression and suicidality among police officers and design appropriate mental health responsive services in thi

关键词： routine sectional urban

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新技术为会议推波助澜

中国会展 2011年第8期 46-48页

作者： corbin Ball

在过去6年中，会议技术行业一直不断发展。包括计算机技术在内的应用于会议活动的新技术，无论是信息的索引还是处理，其发展速度每年都在成倍地增长。人们正处于会议技术高速发展的时期，这个行业未来的发展趋势将会越来越趋于成熟和... 详细信息

在过去6年中，会议技术行业一直不断发展。包括计算机技术在内的应用于会议活动的新技术，无论是信息的索引还是处理，其发展速度每年都在成倍地增长。人们正处于会议技术高速发展的时期，这个行业未来的发展趋势将会越来越趋于成熟和快速。可以想见在10～15年以后，这个行业的变化将与现在有巨大的差别。这是会议技术行业的最显著的发展趋势。

关键词：新技术技术行业发展趋势计算机技术会议活动

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勃起功能障碍的药物疗法

中华男科学杂志 2010年第3期16卷 285-286页

作者： Eardlev I Donatucci C corbin J 赵永平不详北京大学人民医院生殖中心 100044

药物疗法是大多数勃起功能障碍的男性患者常用的初始治疗手段。对男性勃起功能障碍治疗药物的有效性、耐受性和安全性相关资料进行回顾与分析。由来自5个国家的8名专家组成的研究小组根据以往的回顾性研究负责处理与药物疗法相关的文献... 详细信息

药物疗法是大多数勃起功能障碍的男性患者常用的初始治疗手段。对男性勃起功能障碍治疗药物的有效性、耐受性和安全性相关资料进行回顾与分析。由来自5个国家的8名专家组成的研究小组根据以往的回顾性研究负责处理与药物疗法相关的文献回顾和分析。主要的参考依据:本研究中专家意见和建议基于循证依据的文献分级、小组内讨论、开放式评论和辩论等。目前几乎所有可收集到的资料均与西地那非、他达拉非和伐地那非有关。在无明确禁忌症的情况下,5型磷酸二酯酶(PDE5)抑制剂是大多数男性勃起功能障碍患者的首选治疗。没有证据显示各种PDE5抑制剂和阿扑吗啡在有效性、安全性和耐受性等方面存在显著差异。阴茎海绵体内注射前列腺素E1可作

关键词：男性勃起功能障碍药物疗法文献回顾专家意见初始治疗男性患者治疗药物有效性