检索结果-南通市图书馆

神经解剖学杂志 2001年第B7期17卷 105-105页

作者： hui-li li and jun chen department of anatomy and k.k. leung brain research centre, the fourth military medical university, xi’an 710032

Aim: To study the roles of nitric oxide (NO) of spinal cord in induction and maintenance of the bee venom (BV)-induced persistent spontaneous nociception (PSN) and hyperalgesia to heat and mechanical stimulation. Methods: Chronic intrathecal (i.t.) catheterization was performed and effects of i.t. pre- and post-application of NO synthase inhibitor, N^G-nitro-L-arginine-methyl-ester hydrochloride (L-NAME), at does of 0.01, 0.1, 1 and

关键词：大白鼠足底皮注蜂毒热痛觉过敏机械性痛觉过敏脊髓一氧化氮 NO 作用

ROLES OF SPINAL PROTEIN kINASES IN BEE VENOM-INDUCED PERSISTENT SPONTANEOUS NOCICEPTION AND HYPERALGESIA

在线全文

学校读者我要写书评

暂无评论

神经解剖学杂志 2001年第B7期17卷 104-105页

作者： kai-cheng li and jun chen department of anatomy and k.k. leung brain research centre, the fourth military medical university, xi’an, 710032

Aim: It has been shown that spinal protein kinases (Pigs) such as PkC and PkA may play important roles in induction or maintenance of persistent nociception and hyperagesia. In the present study, we examined the spinal roles of PkC and cAMP-dependent PkA in development and maintenance of the bee venom(BV)-induced persistent spontaneous nociception and hyperalgesia in conscious rats with chronically intrathecal catheterization.

关键词：蜂毒诱发持续性自发性损伤感受痛觉过敏脊髓蛋白激酶作用 PkC PkA

TEMPORAL ENCODING CHARACTERISTICS OF BV-INDUCED PERSISTENT FIRING OF SPINAL DORSAL HORN WDR NEURONS IDENTIFIED BY UPO DETECTION METHOD

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

神经解剖学杂志 2001年第B7期17卷 100-101页

作者： Ji-Hong ZHENG, jun chen department of anatomy and k.k. leung brain research centre, the fourth military medical university, xi’an 710032

Aim: Spinal wide-dynamic-range (WDR) neuron has been generally accepted to mediate the transmission of nociceptive information derived from peripheral tissues. The firing frequency of WDR neuron has long been used as a reliable index in measuring the intensity of nociceptive stimulation, while the nociceptive information generated by different sources of pain stimuli may be contained in the distinct firing pattern of WDR neuron with different ISI series. The temporal encoding features have not been revealed so far due to the lack

关键词：疼痛蜂毒诱发持续性点燃脊髓背角神经元 WDR 瞬态解码特性 UPO检测法

DIVERSITY OF PATHOLOGICAL PAIN: NEW EVIDENCE FROM THE BEE VENOM MODEL

在线全文

学校读者我要写书评

暂无评论

神经解剖学杂志 2001年第B7期17卷 28-34页

作者： jun chen, MD, PhD department of anatomy and k.k. leung brain research centre, the fourth military medical university , xi’an 710032 and Center for Sensory and Motor Interaction, Aalborg university, Aalborg 9220, Denmark

There has been increasing experimental evidence showing that the clinical pathological pain differs greatly from physiological pain. The former is characterized by its clinical diversity in manifestations referred to as: (1) persistent spontaneous pain (pain lasts without external stimulation); (2)hyperalgsia (enhanced pain sensation following normally noxious heat or mechanical stimuli);(3) allodynia (abnormal pain evoked by normally non-painful stimulation or touch-evoked pain). Moreover, hyperalgesia or allodynia can be further classified

关键词：病理性疼痛蜂毒试验动物模型

THE BEE VENOM-INDUCED PERSISTENT SPONTANEOUS NOCICEPTION AND HYPERALGESIA IN ELDERLY RATS

在线全文

学校读者我要写书评

暂无评论

神经解剖学杂志 2001年第B7期17卷 107-108页

作者： Wei GE~2, hui-Sheng chen~1, Yuan li~2, jun chen~1 ~1 department of anatomy and k.k. leung brain research centre, ~2 department of Geriatrics, the fourth military medical university, xi’an 710032

Aim: The bee venom (BV) model in adult rats has been well established. However, the BV-induced multiple aspects of pathological pain have not been studied in elderly (age >22 months) rats. The present study was designed to investigate: (1) response pattern and time course of the BV-indueed persistent spontaneous nociception (PSN) and hyperalgesia in elderly rats; (2) Laminar distribution and time course of the

关键词：老龄大白鼠蜂毒诱发持续性自发性损伤感受痛觉过敏

Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain

在线全文

学校读者我要写书评

暂无评论

Science China(life Sciences) 2024年第1期67卷 67-82页

作者： Chun-kui Zhang Pan Wang Yuan-Yuan Ji Jian-Shuai Zhao jun-xiang Gu xian-xia Yan Hong-Wei Fan Ming-Ming Zhang Yu Qiao xiao-Die liu Bao-Juan li Ming-hui Wang Hai-Long Dong Hao-Hong li Peng-cheng Huang Yun-Qing li Wu-Gang Hou Jin-lian li Tao chen department of anatomy and k.k.leung brain research centre Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Basic medical Sciences Beijing 100850China key Laboratory of Ministry of Public Health for Forensic Science Xi’an Jiaotong UniversityXi’an 710061China department of Anesthesiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China department of Neurosurgery the Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China School of Biomedical Engineering Fourth Military Medical UniversityXi’an 710032China Affiliated Mental Health centre and Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhou 310013China The MOE Frontier research Center of brain&brain-machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou 310058China department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China department of anatomy School of MedicineNorthwest UniversityXi’an 710069China

Chronic pain often develops severe mood changes such as ***,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely *** we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1%of mice with depression *** determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA ***,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic *** of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic *** study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.

关键词： chronic pain depression lateral habenula ventral tegmental area dopamine susceptibility

THE ROLES OF SPINAL N- AND L-TYPE VOLTAGE-DEPENDENT CALCIUM CHANNELS IN DEVELOPING AND MAINTAINING PROCESSES OF BEE VENOM-INDUCED PERSISTENT SPONTANEOUS NOCICEPTION AND HYPERALGESIA IN RATS

在线全文

学校读者我要写书评

暂无评论

神经解剖学杂志 2001年第B7期17卷 102-102页

作者： Zheng li and jun chen department of anatomy and k.k. leung brain research centre, the fourth military medical university, xi’an, 710032

Aim: To further study the roles of spinal N-or L-type voltage-dependent calcium channel (VDCC) in induction and maintenance of both persistent spontaneous nociception (PSN) and hyperalgesia induced by subcutaneous (s.c.) bee venom injection, the effects of intrathecal (i.t.) pre- or post-treatment with VDCC blockers of N-type (ω-Conotoxin-GVIA) and L-type (verapamil) were evaluated in conscious rats.

关键词：大鼠蜂毒诱导持续性自发性损伤感受痛觉过敏脊髓钙通道 N型 T型电位依赖性

CONTRIBUTION OF CAPSAICIN-SENSITIVE PRIMARY AFFERENT-MEDIATED NEUROGENIC RESPONSES TO THE BEE VENOM-INDUCED INFLAMMATION IN RATS

在线全文

学校读者我要写书评

暂无评论

神经解剖学杂志 2001年第B7期17卷 99-99页

作者： hui-sheng chen, Zhen li and jun chen department of anatomy & k.k. leung brain research centre, the fourth military medical university, xi’an 710032

Aim: The bee venom (BV) model has been proved to be a good one to study the inflammatory pain, because subcutaneous injection of BV into one hind paw in rats could produce typical inflammatory responses such as rednes... 详细信息

关键词：大白鼠蜂毒诱发炎症辣椒素敏感性神经性反应初级传入调制

ROLES OF SPINAL PROTEIN kINASES IN BEE VENOM-INDUCED PERSISTENT SPONTANEOUS NOCICEPTION AND HYPERALGESIA

在线全文

学校读者我要写书评

暂无评论

神经解剖学杂志 2001年第S1期 104-104页

作者： kai-cheng li and jun chen department of anatomy and k.k. leung brain research centre, the fourth military medical university, xi’an, 710032

关键词： BV PkC heat ROLES OF SPINAL PROTEIN kINASES IN BEE VENOM-INDUCED PERSISTENT SPONTANEOUS NOCICEPTION AND HYPERALGESIA

MECHANISMS OF CONTRALATERAL HEAT HYPERALGESIA INDUCED BY SUBCUTANEOUS INTRAPLANTAR BEE VENOM INJECTION IN RATS

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

神经解剖学杂志 2001年第B7期17卷 98-98页

作者： hui-Sheng chen and jun chen department of anatomy & k.k. leung brain research centre, the fourth military medical university, xi’an 710032

Aim: It has been found that subcutaneous intraplantar injection of bee venom (BV) unilaterally could produce contralateral heat hyperalgesia as well as primary heat and mechanical hyperalgesia in adult rats. The aim of the present study is to investigate: (1) whether contralateral heat hyperalgesia is a consequence of central sensitization, and whether, if it is the case, establishment of central sensitization is dependent upon a

关键词：足底皮下注射蜂毒对侧热痛觉过敏大白鼠神经传导