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THERMAL AND MECHANICAL PROPERTIES OF POLYLACTIDE TOUGHENED WITH A BUTYL ACRYLATE-ETHYL ACRYLATE-GLYCIDYL METHACRYLATE COPOLYMER

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Chinese Journal of Polymer Science 2013年第11期31卷 1519-1527页

作者： Yan-ping Hao huan-huan ge Li-jing Han 张会良 Li-song Dong Shu-lin Sun Key Laboratory of Polymer Ecomaterials Chinese Academy of SciencesChangchun Institute of Applied Chemistry Changchun University of Technology

In this work, a specific polylactide （PLA） 4032D was melt-mixed with a new toughener： butyl acrylate （BA）, ethyl acrylate （EA） and glycidyl methacrylate （GMA） copolymer （BA-EA-GMA）. DMA tests showed that PLA/BA-EA-GMA blends were partially miscible. The degree of crystallinity of PLA increased while the cold crystallization temperature shifted to higher temperatures with increasing BA-EA-GMA content. The SEM micrographs showed that PLA/BA-EA-GMA blends had a good dispersion and this phenomenon was in good agreement with their higher impact strength. The result showed that the adding of BA-EA-GMA has enhanced the flexibility of PLA/BA-EA-GMA blends as compared with pure PLA. The impact strength was changed from 3.4 kJ/m2 for pure PLA to 29.6 kJ/m2 for 80/20 PLA/BA-EA-GMA blend.

关键词： Polylactide Thermal properties Mechanical properties.

Design and Synthesis of a Series of Novel Macrocycle Janus Kinase 2 Inhibitors

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Chinese Journal of Chemistry 2019年第12期37卷 1259-1263页

作者： Yanling Wang huan ge Disha Wang huan He Lu Li Yanyan Diao Zihao Shen Lili Zhu Shiliang Li Zhenjiang Zhao Honglin Li Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and Technology130 Meilong RoadShanghai 200237China

Summary of main observation and conclusion Macrocycle has attracted the attention of many researchers in the field of medicinal chemistry due to its unique advantages and good prospects,but the difficulties in drug design and synthesis of macrocycle limit its *** this study,a series of macrocyclic derivatives designed from anaplastic lymphoma kinase(ALK)inhibitor lorlatinib were synthesized as Janus kinase 2(JAK2)selective *** them,17f had the best inhibitory activity(IC50=0.177μmol·L^-1)and selectivity for JAK2 over JAK1 and JAK3,which indicated that design of the macrocyclic derivatives might be a feasible strategy for the discovery of novel selective JAK2 inhihitors.

关键词： cycle macrocyclic conclusion

Design,synthesis and SAR study of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors

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Chinese Chemical Letters 2022年第6期33卷 2969-2974页

作者： Dandan Liu huan ge Fangling Xu Yufang Xu Wenjun Liu Honglin Li Lili Zhu Yanyan Diao Zhenjiang Zhao Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and TechnologyShanghai 200237China Research and Development Department Jiangzhong Pharmaceutical Co.Ltd.Nanchang 330096China

The abnormal activation of JAK2 kinase is closely related to the occurrence and progression of myeloproliferative neoplasms(MPNs).At present,there is still an obvious unmet medical need for selective JAK2 inhibitors in *** this paper,a class of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors was obtained by combining drug design,synthesis and structure-activity relationship studies based on the previously identified lead *** them,21 b exhibited high inhibitory activity against JAK2 with an IC_(50)of 9 nmol/L,moreover,it showed 276-and 184-fold selectivity over JAK1 and JAK3,***,21 b had a significant antiproliferative activity against HEL cells,and also inhibited the phosphorylation of JAK2 and its down-stream signaling *** results indicated that2-aminopyridine compound 21 b had the potential to be developed as a selective JAK2 inhibitor for further study.

关键词： JAK2 Selectivity Inhibitors Cancer Structure-activity relationships

A Combinatorial Approach Based on Nucleic Acid Assembly and Electrostatic Compression for siRNA Delivery

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Chemical Research in Chinese Universities 2021年第4期37卷 906-913页

作者： REN Yiqing LIU Xinlong ge huan GUO Yuanyuan ZHANG Qiushuang XIE Miao WANG Ping ZHU Xinyuan ZHANG Chuan School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai200240P.R.China Weigao Research Center Shanghai201203P.R.China

A combinatorial strategy based on nucleic acid assembly and electrostatic complexation is developed for efficient small interfering ribonucleic acid(siRNA)*** this approach,siRNAs are first loaded into a well-defined nanotube through programmable nucleic acid *** to small rigid siRNA duplex,the obtained siRNA-bearing nanotube with large architecture is more readily to complex with cationic and ionizable poly(β-amino ester),resulting in the formation of a novel platform for efficient siRNA delivery.

关键词： Nucleic acid nanogel Electrostatic compression siRNA delivery Self-assembly

Engineering a Floxuridine-integrated RNA Prism as Precise Nanomedicine for Drug Delivery

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Chemical Research in Chinese Universities 2020年第2期36卷 274-280页

作者： PAN Gaifang MA Yuan ZHANG Jiao GUO Yuanyuan DING Fei ge huan LI Qifeng ZHU Xinyuan ZHANG Chian School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix CompositesShanghai Key Laboratory of Electrical Insulation and Thermal AgeingShanghai Jiao Tong UniversityShanghai 200240P.R.China Department of Paediatric Neurosurgery Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092P.R.China

Herein,we report a geometrically well-defined prism assembled by two floxuridine(F)integrated RNA strands as a precise nanomedicine for chemodrug *** to the similarity between chemotherapeutic F and uridine(U),all uridines in the component RNA strands are replaced by F during their in vitro transcription *** specifically designing their sequences,F-containing S-shape tiles with the single-stranded loops are constructed and then further assemble into the RNA prism through T-junction interactions and sticky-end *** present study demonstrates that the F-integrated RNA prism can serve as an efficient platform for chemodrug delivery and anticancer *** believe that the study would help the future development of RNA-based nanomedicine in various applications.

关键词： Self-assembly Floxuridine RNA prism Precise nanodrug Drug delivery

A review of the etched terminal structure of a 4H-SiC PiN diode

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Journal of Semiconductors 2023年第11期44卷 69-78页

作者： Hang Zhou Jingrong Yan Jialin Li huan ge Tao Zhu Bingke Zhang Shucheng Chang Junmin Sun Xue Bai Xiaoguang Wei Fei Yang State Key Laboratory of Advanced Power Transmission Technology Beijing Institute of Smart EnergyBeijing 102209China

The comparison of domestic and foreign studies has been utilized to extensively employ junction termination extension(JTE)structures for power ***,achieving a gradual doping concentration change in the lateral direction is difficult for SiC devices since the diffusion constants of the implanted aluminum ions in SiC are much less than *** previously reported studies adopted many new structures to solve this ***,the JTE structure is strongly sensitive to the ion implantation ***,GA-JTE,double-zone etched JTE structures,and SM-JTE with modulation spacing were reported to overcome the above shortcomings of the JTE structure and effectively increase the breakdown *** provided a theoretical basis for fabricating terminal structures of 4H-SiC PiN *** paper summarized the effects of different terminal structures on the electrical properties of SiC devices at home and ***,the continuous development and breakthrough of terminal technology have significantly improved the breakdown voltage and terminal efficiency of 4H-SiC PiN power diodes.

关键词： PiN diode terminal structure mesa-JTE reverse breakdown voltage etching process

Clinical study on the related markers of blood coagulation in the patients with ANFH after SARS

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Frontiers of Medicine 2007年第4期1卷 410-412页

作者： WU Lianhua GAO Chunjin WANG Guozhong YANG Lin HOU Xiaomin ge huan XIA Chengqing QI Man Department of Hyperbaric Oxygen Chaoyang HospitalCapital University of Medical SciencesBeijing 100020China Department of Pathology Chaoyang HospitalCapital University of Medical SciencesBeijing 100020China

The aim of this research was to investigate the blood coagulation function in the patients with avascular necrosis of the femoral head(ANFH)after severe acute respiratory syndrome(SARS).The expression of CD31,CD61,CD62p,CD63 and PAC-1 on platelet membrane was measured respectively by flowcytometry,and the plasma prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT)and fibrinogen(Fbg)were mea-sured by blood clotting instrument in 26 patients with ANFH after SARS and in 17 healthy *** expression of CD31,CD61,CD 62p,CD63 and PAC-1 on platelet membrane in 26 patients was all lower than that in 17 healthy subjects(P0.05)in those markers between patients and 17 healthy *** blood may not be in hypercoagulable state in patients with ANFH after SARS.

关键词： severe acute respiratory syndrome femur head necrosis blood coagulation

Evaluation of Intersection Performance Under Atc System in Wuhan

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Intelligent Information Management 2011年第4期3卷 105-111页

作者： huan ge Zhiyun Zou Zhihao Zhou 不详

In order to accurately evaluate the implementation of Area Traffic Control (ATC) system, two situations were compared in this paper, i.e., comparison of intersection performance under two different operation conditions before and after the application of ATC system. Based on floating car theorem, this paper investigated the average intersection delay and the average vehicle stop times. During the traffic investigation, ArcGIS, GPS, VC++ and other technologies have been applied. In addition, the evaluation indices of intersection performance average intersection delay and average vehicle stop times (Guiyan Jiang et al., 2006) were selected and compared. The results showed that both average intersection delay and average vehicle stop times have been reduced after the implementation of ATC system. Improvement of traffic condition is more obvious under cooperative control status. This paper provided a reference for testing the performance of intersections under ATC system.

关键词： ATC System Intersection Performance Performance Evaluation Intersection Delay Vehicle Stop Times

论啖助、赵匡和陆淳《春秋》学的学术转型意义

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文史哲 2005年第5期 40-45页

作者：葛焕礼山东大学宗教科学与社会问题研究所山东济南250100

啖助、赵匡和陆淳《春秋》学的学术转型意义,除却人所熟知的尊经排传,而又兼采三传、变专门为通学外,更有着理念层面上的内容:独特的《春秋》宗旨说建立了经文义说的主体性;记实书法原则的运用开启了“汉”、“宋”经学义理依据的转化;... 详细信息

啖助、赵匡和陆淳《春秋》学的学术转型意义,除却人所熟知的尊经排传,而又兼采三传、变专门为通学外,更有着理念层面上的内容:独特的《春秋》宗旨说建立了经文义说的主体性;记实书法原则的运用开启了“汉”、“宋”经学义理依据的转化;重以义例解经极大地加强了经文解说的自主性;重以“讥贬之义”解经暗含着其论说立场的转变;强烈的现实关怀再建了《春秋》经世学统。

关键词：中唐《春秋》学学术转型