Engineering a Floxuridine-integrated RNA Prism as Precise Nanomedicine for Drug Delivery

作     者：PAN Gaifang MA Yuan ZHANG Jiao GUO Yuanyuan DING Fei GE Huan LI Qifeng ZHU Xinyuan ZHANG Chian 

作者机构：School of Chemistry and Chemical EngineeringState Key Laboratory of Metal Matrix CompositesShanghai Key Laboratory of Electrical Insulation and Thermal AgeingShanghai Jiao Tong UniversityShanghai 200240P.R.China Department of Paediatric NeurosurgeryXinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092P.R.China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2020年第36卷第2期

页      面：274-280页

核心收录：

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：Supported by the National Key Research and Development Program of China(Nos.2018YFC1106100,2018YFC1106102) the National Natural Science Foundation of China(Nos.21661162001,21673139,51690151,51473093,51973112) the Special Program for Collaborative Innovation in Shanghai University of Medicine&Health Sciences,China(No.SPCI-17-15-001) the Program of Shanghai Medical Professionals Across Subject Funds,China(No.YG2016MS74) 

主　　题：Self-assembly Floxuridine RNA prism Precise nanodrug Drug delivery 

摘      要：Herein,we report a geometrically well-defined prism assembled by two floxuridine(F)integrated RNA strands as a precise nanomedicine for chemodrug *** to the similarity between chemotherapeutic F and uridine(U),all uridines in the component RNA strands are replaced by F during their in vitro transcription *** specifically designing their sequences,F-containing S-shape tiles with the single-stranded loops are constructed and then further assemble into the RNA prism through T-junction interactions and sticky-end *** present study demonstrates that the F-integrated RNA prism can serve as an efficient platform for chemodrug delivery and anticancer *** believe that the study would help the future development of RNA-based nanomedicine in various applications.