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Human embryonic stem cell-derived mesenchymal stem cells improved premature ovarian failure

World Journal of Stem Cells 2020年第8期12卷 857-878页

作者： Khadijeh Bahrehbar Mojtaba Rezazadeh Valojerdi Fereshteh Esfandiari Rouhollah Fathi Seyedeh-NafisehHassani hossein baharvand Department of Stem Cells and Developmental Biology Cell Science Research CenterRoyan Institute for Stem Cell Biology and TechnologyTehran ***Iran Department of Developmental Biology University of Science and CultureTehran ***Iran Department of Embryology Reproductive Biomedicine Research CenterRoyan Institute for Reproductive BiomedicineTehran ***Iran Department of Anatomy Faculty of Medical ScienceTarbiat Modares UniversityTehran ***Iran

BACKGROUND Premature ovarian failure(POF)affects many adult women less than 40 years of age and leads to *** to previous reports,various tissue-specific stem cells can restore ovarian function and folliculogenesis in mice with chemotherapy-induced *** embryonic stem cells(ES)provide an alternative source for mesenchymal stem cells(MSCs)because of their similarities in phenotype and immunomodulatory and anti-inflammatory *** stem cell-derived mesenchymal stem cells(ES-MSCs)are attractive candidates for regenerative medicine because of their high proliferation and lack of barriers for harvesting tissue-specific ***,possible therapeutic effects and underlying mechanisms of transplanted ES-MSCs on cyclophosphamide and busulfan-induced mouse ovarian damage have not been *** To evaluate ES-MSCs vs bone marrow-derived mesenchymal stem cells(BMMSCs)in restoring ovarian function in a mouse model of chemotherapy-induced premature ovarian *** Female mice received intraperitoneal injections of different doses of cyclophosphamide and busulfan to induce *** human ES-MSCs or BMMSCs were transplanted into these *** days after the mice were injected with cyclophosphamide and busulfan and 4 wk after transplantation of the ESMSCs and/or BM-MSCs,we evaluated body weight,estrous cyclicity,folliclestimulating hormone and estradiol hormone concentrations and follicle count were used to evaluate the POF model and cell ***,terminal deoxynucleotidyl transferase mediated 2-deoxyuridine 5-triphosphate nick end labeling,real-time PCR,Western blot analysis and immunohistochemistry and mating was used to evaluate cell ***-linked immunosorbent assay was used to analyze vascular endothelial growth factor,insulin-like growth factor 2 and hepatocyte growth factor levels in ES-MSC condition medium in order to investigate the mechanisms that underlie their *** Th

关键词： Premature ovarian failure Human embryonic stem cells Chemotherapy drugs Mesenchymal stem cell Bone marrow Apoptosis

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Organoids: a novel modality in disease modeling

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Bio-Design and Manufacturing 2021年第4期4卷 689-716页

作者： Zahra Heydari Farideh Moeinvaziri Tarun Agarwal Paria Pooyan Anastasia Shpichka Tapas KMaiti Peter Timashev hossein baharvand Massoud Vosough Department of Stem Cells and Developmental Biology Cell Science Research CenterRoyan Institute for Stem Cell Biology and TechnologyACECRTehran 14155-4364Iran Department of Developmental Biology University of Science and CultureTehran 14155-4364Iran Department of Biotechnology Indian Institute of TechnologyKharagpurWest Bengal 721302India World-Class Research Center“Digital Biodesign and Personalized Healthcare” Sechenov First Moscow State Medical University19991 MoscowRussia Institute for Regenerative Medicine Sechenov University119991 MoscowRussia Chemistry Department Lomonosov Moscow State University119991 MoscowRussia Department of Polymers and Composites N.N.Semenov Federal Research Center for Chemical PhysicsRussian Academy of Sciences119991 MoscowRussia Department of Regenerative Medicine Cell Science Research CentreRoyan Institute for Stem Cell Biology and TechnologyACECRTehran 14155-4364Iran

Limitations of monolayer culture conditions have motivated scientists to explore new models that can recapitulate the architecture and function of human organs more *** advances in the improvement of protocols have resulted in establishing three-dimensional(3D)organ-like architectures called‘organoids’that can display the characteristics of their corresponding real organs,including morphological features,functional activities,and personalized responses to specific *** discuss different organoid-based 3D models herein,which are classified based on their original germinal *** of organoids simulating the complexity of real tissues could provide novel platforms and opportunities for generating practical knowledge along with preclinical studies,including drug screening,toxicology,and molecular pathophysiology of *** paper also outlines the key challenges,advantages,and prospects of current organoid systems.

关键词： Organoid Germ layer Disease modeling Drug screening

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Phase 1 human trial of autologous bone marrow-hematopoietic stem cell transplantation in patients with decompensated cirrhosis

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World Journal of Gastroenterology 2007年第24期13卷 3359-3363页

作者： Mehdi Mohamadnejad Mehrnaz Namiri Mohamad Bagheri Seyed Masiha Hashemi hossein Ghanaati Narges Zare Mehrjardi Saeed Kazemi Ashtiani Reza Malekzadeh hossein baharvand Digestive Disease Research Center Shariati Hospital Medical Sciences/ University of Tehran Tehran Iran Gastrointestinal and Liver Disease Research Center Iran University of Medical Sciences Tehran Iran Department of Stem Cells Royan Institute Tehran Iran Digestive Disease Research Center Shariati Hospital Medical Sciences/ University of Tehran Tehran Iran

AIM: To evaluate safety and feasibility of autologous bone marrow-enriched CD34+ hematopoietic stem cell Tx through the hepatic artery in patients with decompensated ***: Four patients with decompensated cirrhosis were included. Approximately 200 mL of the bone marrow of the patients was aspirated, and CD34+ stem cells were selected. Between 3 to 10 million CD34+ cells were isolated. The cells were slowly infused through the hepatic artery of the ***: Patient 1 showed marginal improvement in serum albumin and no significant changes in other test results. In patient 2 prothrombin time was decreased; however, her total bilirubin, serum creatinine, and Model of End-Stage Liver Disease (MELD) score worsened at the end of follow up. In patient 3 there was improvement in serum albumin, porthrombin time (PT), and MELD score. Patient 4 developed radiocontrast nephropathy after the procedure, and progressed to type 1 hepatorenal syndrome and died of liver failure a few days later. Because of the major side effects seen in the last patient, the trial was prematurely ***: Infusion of CD34+ stem cells through the hepatic artery is not safe in decompensated cirrhosis. Radiocontrast nephropathy and hepatorenal syndrome could be major side effects. However, this study doesnot preclude infusion of CD34+ stem cells through other routes.

关键词： Cirrhosis Bone marrow Stem cell Transplantation Quality of life Model of End-Stage Liver Disease score

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Biofabrication of size-controlled liver microtissues incorporated with ECM-derived microparticles to prolong hepatocyte function

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Bio-Design and Manufacturing 2021年第4期4卷 790-805页

作者： Zahra Heydari Ibrahim Zarkesh Mohammad-hossein Ghanian Mahdokht HAghdaei Svetlana Kotova Ensieh Zahmatkesh Zahra Farzaneh Abbas Piryaei Iman Akbarzadeh Anastasia Shpichka Roberto Gramignoli Peter Timashev hossein baharvand Massoud Vosough Department of Developmental Biology University of Science and CultureACECR14155-4364 TehranIran Department of Regenerative Medicine Cell Science Research CentreRoyan Institute for Stem Cell Biology and TechnologyACECR14155-4364 TehranIran Department of Stem Cells and Developmental Biology Cell Science Research CenterRoyan Institute for Stem Cell Biology and TechnologyACECR14155-4364 TehranIran Department of Cell Engineering Cell Science Research CenterRoyan Institute for Stem Cell Biology and TechnologyACECR14155-4364 TehranIran Transplant Research Center Shiraz University of Medical Sciences71936-13311 ShirazIran N.N.Semenov Federal Research Center for Chemical Physics Russian Academy of SciencesMoscow 117977Russia Department of Biology and Anatomical Sciences School of MedicineShahid Beheshti University of Medical Sciences14155-4364 TehranIran Department of Tissue Engineering and Applied Cell Sciences School of Advanced Technologies in MedicineShahid Beheshti University of Medical Sciences14155-4364 TehranIran Institute for Regenerative Medicine Sechenov UniversityMoscow 117977Russia Division of Pathology Department of Laboratory MedicineKarolinska Institute17177 StockholmSweden

Multicellular microtissues of primary human hepatocytes(PHHs)co-cultured with other supporting cell types are a promis-ing model for drug screening and toxicological ***,these liver microtissues(LMs)rapidly lose their functions during ex vivo ***,in order to mimic the cellular and structural hepatic microenvironment,we co-cultured PHHs with human mesenchymal stromal cells(MSCs)and human umbilical vein endothelial cells(HUVECs)in the presence of cell-sized microparticles(MPs)derived from liver extracellular matrix(LEMPs).The microwell culture platform enabled biofabrication of size-controlled multicellular microtissues(PHH:HUVEC:MSC=3:2:1)with efficient LEMP incorporation(about 70%at a 2:1 ratio of cells:MP).The biofabricated liver microtissues(BLMs)were cultured ex vivo for 14 days and compared to the cell-only LM in terms of gene and protein expression,functional activity,cytochrome P450(CYP450)enzyme inducibility,and drug *** results supported superior hepatic-related gene expression,functional activity,and polarity for PHH in BLM compared to ***450 enzyme inducibility and dose-responsive sensitivity to toxic drugs were significantly higher in the BLM *** conclusion,microtissue engineering by incorporation of tissue-specific microparticles within a multicellular microtissue can offer some advantages for drug discovery studies and cell transplantation *** the near future,this approach could generate a scalable platform of several functional biofabricated microtissues representing different organs.

关键词： Liver microtissue Hepatocyte maintenance Microparticles Decellularized tissue Drug screening

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NIR-II live imaging study on the degradation pattern of collagen in the mouse model

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Regenerative Biomaterials 2023年第1期10卷 271-279页

作者： Huizhu Li Xinxian Meng Huaixuan Sheng Sijia Feng Yuzhou Chen Dandan Sheng Liman Sai Yueming Wang Mo Chen Yan Wo Shaoqing Feng hossein baharvand Yanglai Gao Yunxia Li Jun Chen Department of Sports Medicine Sports Medicine Institute of Fudan UniversityHuashan HospitalFudan UniversityShanghai 200040China Department of Plastic and Reconstructive Surgery School of MedicineShanghai Jiao Tong UniversityShanghai Ninth People’s HospitalShanghai 200011China Department of Physics Shanghai Normal UniversityShanghai 200234China Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Stem Cells and Developmental Biology Cell Science Research CenterRoyan Institute for Stem Cell Biology and TechnologyACECRTehran ***Iran Department of Developmental Biology School of Basic Sciences and Advanced Technologies in BiologyUniversity of Science and CultureTehran ***Iran Hexi College ZhangyeGansu 73400China

The degradation of collagen in different body parts is a critical point for designing collagen-based biomedical ***,three kinds of collagens labeled by second near-infrared(NIR-II)quantum dots(QDs),including collagen with low crosslinking degree(LC),middle crosslinking degree(MC)and high crosslinking degree(HC),were injected into the subcutaneous tissue,muscle and joints of the mouse model,respectively,in order to investigate the in vivo degradation pattern of collagen by NIR-II live *** results of NIR-II imaging indicated that all tested collagens could be fully degraded after 35 days in the subcutaneous tissue,muscle and joints of the mouse ***,the average degradation rate of subcutaneous tissue(k=0.13)and muscle(k=0.23)was slower than that of the joints(shoulder:k=0.42,knee:k=0.55).Specifically,the degradation rate of HC(k=0.13)was slower than LC(k=0.30)in muscle,while HC showed the fastest degradation rate in the shoulder and knee *** summary,NIR-II imaging could precisely identify the in vivo degradation rate of ***,the degradation rate of collagen was more closely related to the implanted body parts rather than the crosslinking degree of collagen,which was slower in the subcutaneous tissue and muscle compared to the joints in the mouse model.

关键词： collagen degradation rate NIR-II live imaging in vivo crosslinking degree

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CSRWA:Covert and Severe Attacks Resistant Watermarking Algorithm

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Computers, Materials & Continua 2025年第1期82卷 1027-1047页

作者： Balsam Dhyia Majeed Amir hossein Taherinia Hadi Sadoghi Yazdi Ahad Harati Faculty of Engineering Ferdowsi University of MashhadMashhad***Iran Department of Computer Techniques Engineering Imam Al-Kadhum CollegeBaghdad10087Iraq

Watermarking is embedding visible or invisible data within media to verify its authenticity or protect *** watermark is embedded in significant spatial or frequency features of the media to make it more resistant to intentional or unintentional *** of these features are important perceptual features according to the human visual system(HVS),which means that the embedded watermark should be imperceptible in these ***,both the designers of watermarking algorithms and potential attackers must consider these perceptual features when carrying out their *** two roles will be considered in this paper when designing a robust watermarking algorithm against the most harmful attacks,like volumetric scaling,histogram equalization,and non-conventional watermarking attacks like the Denoising Convolution Neural Network(DnCNN),which must be considered in watermarking algorithm design due to its rising role in the state-of-the-art *** DnCNN is initialized and trained using watermarked image samples created by our proposed Covert and Severe Attacks Resistant Watermarking Algorithm(CSRWA)to prove its *** this algorithm to satisfy the robustness and imperceptibility tradeoff,implementing the Dither Modulation(DM)algorithm is boosted by utilizing the Just Noticeable Distortion(JND)principle to get an improved performance in this ***,luminance,inter and intra-block contrast are used to adjust the JND values.

关键词： Covert attack digital watermarking DnCNN JND perceptual model robustness

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Discrete time multiple spacecraft formation flying attitude optimal control in presence of relative state constraints

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Chinese Journal of Aeronautics 2021年第4期34卷 293-305页

作者： hossein MORADI PARI hossein BOLANDI Department of Electrical Engineering Iran University of Science and TechnologyTehran 009821Iran

This paper addresses the challenge of synchronized multiple spacecraft attitude reorientation in presence of pointing and boundary constraints with limited inter-spacecraft communication *** attitude pointing constraint among the fleet of spacecraft has also been modeled and considered during the attitude maneuvers toward the desired *** fling control structure that consists of decentralized path planners based on virtual structure approach joint with discrete time optimal local controller is designed to achieve the mission's *** to digital computing of spacecraft's onboard computer,local optimal controller based on discrete time prediction and correction algorithm has been *** time step of local optimal algorithm execution is designed so that the spacecraft track their desired attitudes with appropriate error *** convergence of the proposed architecture and stability of local controller's tracking error within appropriate upper bound are ***,a numerical simulation of a stereo imaging scenario is presented to verify the performance of the proposed architecture and the effectiveness of the algorithm.

关键词： Decentralized Discrete time Formation flying Optimal control Spacecraft Virtual structure approach

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Effect of different treatments on electrokinetic remediation of Zn, Pb and Cd from a contaminated calcareous soil

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Chinese Journal of Chemical Engineering 2021年第10期34卷 255-265页

作者： hossein Beyrami National Salinity Research Center Agricultural ResearchEducation and Extension OrganizationYazdIran

Electrokinetic remediation is a promising method to decontamination of the heavy metals from *** this paper,the remediation of a contaminated calcareous soil with Zn,Cd and Pb sampled from around Zanjan province of Iran,was investigated using electrokinetic *** this paper,the soil contain a high concentration of Zn(1400 mg·kg^(-1)),Cd(15 mg·kg^(-1))and Pb(250 mg·kg^(-1)).Electrokinetic decontamination consists of two series of experiments as follows:(1)the effect of five treatments including the use of distilled water,acetic acid and EDTA electrolyte solutions,and approaching anodes systems,and the circulation flow of electrolyte at two different voltage gradient(i.e.1.33 and 2.66 V·cm^(-1)),and(2)the effect of moisture content(saturated,FC and 0.7 FC,FC indicated soil moisture at "Field Capacity")with a voltage gradient of 1.33 V·cm^(-1).After applying electric current for 5 days,the results of experiments indicated that the removal efficiency of heavy metals can be increased by raising the voltage *** this matter,the highest remediation can be observed among different treatments in EDTA(Ethylene diamine tetra acetic acid)treatment(40.11%,43.10%and 24.7%for Zn,Cd and Pb,respectively).Moreover,the heavy metals removal at the saturated moisture was at the highest level so that 32.62%cadmium,31.33%zinc and 18.82%lead being removed after 120 h of electric current *** decreasing moisture to 0.7 FC,the removal percentage for the three heavy metals obtained 20.97%,18.44%and 12.25%,***,Cd had the highest removal,and Zn and Pb were next among the three heavy metals in question.

关键词： Decontamination Soil moisture Voltage gradient Cadmium Lead Zinc

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Effects of Location,Size and Number of Wind Turbine Receptors on Blade Lightning Protection

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电力系统自动化 2012年第8期36卷 122-127页

作者： hossein Kazemi KAREGAR hossein BAGHERIAN Faculty of Electrical &Computer Engineering Shahid Beheshti University

Electric and magnetic fields generated by lightning cause a serious hazard to various *** wind turbine installations with higher power capacity are *** power capacity requires higher height and so there is more probability of lightning *** are the most probable components to be struck by *** most common lightning protection system for the blades consists of several metallic receptors on the blade *** are connected to the ground by metallic down-conductors placed inside the blade *** paper studies effects of the receptor configurations on protecting the blade against lightning *** this purpose,an analysis procedure based on finite element method(FEM)in COMSOL Multiphysics software environment is *** voltage distribution around the blade is simulated for various configurations of *** best configuration is *** are performed on the blade model of a special wind turbine,which isVESTAS V47".

关键词：风力发电机组受体刀片防雷叶片表面位置最佳配置发电能力

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REMOVAL OF MERCURY FROM WATER USING POLYPYRROLE AND ITS COMPOSITES

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Chinese Journal of Polymer Science 2007年第4期25卷 393-397页

作者： hossein Eisazadeh Faculty of Chemical Engineering University of MazandaranP.O.Box 484BabolIran

One of the suitable methods for removing heavy metals from water is by using surface adsorption process. In this paper, the preparation of polypyrrole and its composites as adsorbents are discussed and the capability of separating mercury from water is investigated. The results indicated that the polypyrrole and its composites are able to remove mercury from aqueous media. Furthermore the adsorption percentage is related to the surface morphology, type of additives and its concentration.

关键词： Polypyrrole and its composites Mercury removal Additives Surface morphology.

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