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Causal effects of circulating vitamin levels on the risk of heart failure:a Mendelian randomization study

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Journal of Geriatric Cardiology 2023年第3期20卷 195-204页

作者： Bo GUAN Xiao-Qiang CHEN Yan LIU Hui ZHOU Ming-Yan YANG hong-wei zheng Shi-Jun LI Jian CAO Medical School of Chinese PLA General Hospital BeijingChina Department of Cardiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Xiangya School of Nursing Central South UniversityChangshaHunanChina Department of Cardiology Tangshan Gongren Hospital Affiliated to Hebei Medical UniversityTangshanChina Geriatric Cardiology Department of the Second Medical Center and National Clinical Research Center for Geriatric Diseases Chinese PLA General HospitalBeijingChina

BACKGROUND Observational studies suggest inverse associations between serum vitamin levels and the risk of heart failure(HF). However, the causal effects of vitamins on HF have not been fully elucidated. Here, we conducted a Mendelian randomization(MR) study to investigate the causal associations between genetically determined vitamin levels and *** Genetic instrumental variables for circulating vitamin levels, including vitamins A, B, C, D, and E, which were assessed as either absolute or metabolite levels were obtained from public genome-wide association studies. Summary statistics for single-nucleotide-polymorphisms and HF associations were retrieved from the HERMES Consortium(47,309 cases and 930,014controls) and FinnGen Study(30,098 cases and 229,612 controls). Two-sample MR analyses were implemented to assess the causality between vitamin levels and HF per outcome database, and the results were subsequently combined by *** Our MR study did not find significant associations between genetically determined circulating vitamin levels and HF risk. For absolute vitamin levels, the odds ratio for HF ranged from 0.97(95% confidence interval [CI]: 0.85–1.09, P = 0.41) for vitamin C to 1.05(95% CI: 0.61–1.82, P = 0.85) for vitamin A. For vitamin metabolites, the odds ratio ranged between 0.94(95% CI:0.75–1.19, P = 0.62) for α-tocopherol and 1.11(95% CI: 0.98–1.26, P = 0.09) for γ-*** Evidence from our study does not support the causal effects of circulating vitamin levels on HF. Therefore,there may be no direct beneficial effects of vitamin intake on the prevention of primary HF.

关键词： vitamin prevention absolute

Recycle Adsorption of Cu2＋ on Amine-functionalized Mesoporous Silica Monolithic

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Chemical Research in Chinese Universities 2013年第4期29卷 793-797页

作者： ZHAO Da-zhou JING Shu-bo XU Jia-ning YANG hong zheng wei SONG Tian-you ZHANG Ping State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Changchun 130012 P. R. China

3-Aminopropyltriethoxysilane functionalized worm-like mesoporous silica monolithic（WMSM-NH2） was prepared and used as a new regenerable adsorbent for the removal of Cu2＋ ions. The analysis results show that the WMSM-NH2 monolithic had a high efficiency value of 99.3% for Cu2＋ remediation when the Cu2＋ solution was at an initial concentration of 10.32 mg/L. The regeneration study of the WMSM-NH2 monolithic presented that the adsorp- tion efficiency of 89.0% was remained and a mass of 92.0% was left after seven adsorption-desorption cycles were executed. The monolithic material with high resistance to the acid and good mechanical stability can facilitate the operations of adsorption and regeneration of the adsorbent.

关键词： Amine-functionalized mesoporous silica monolithic(WMSM-NH2) Cu2+ removal Multiple cycle Adsorp- tion Easy operation

Long non-coding RNA plasmacytoma variant translocation 1 linked to hypoxia-induced cardiomyocyte injury of H9c2 cells by targeting miR-135a-5p/forkhead box O1 axis

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Chinese Medical Journal 2020年第24期133卷 2953-2962页

作者： Jin-Juan Xu wei-hong zheng Jun Wang Yuan-Yuan Chen Department of General Practice Medicine The Fifth People’s Hospital of Yuhang DistrictHangzhouZhejiang 311100China School of Life Sciences Huzhou UniversityHuzhouZhejiang 313000China Binjiang Clinic Zhejiang Chinese Medical UniversityHangzhouZhejiang 310053China Department of Geriatrics Hangzhou Hospital of Traditional Chinese MedicineHangzhouZhejiang 310007China

Background:Myocardial infarction occurs due to insufficient(ischemia)blood supply to heart for long time;plasmacytoma variant translocation 1(PVT1)is a long non-coding RNAs(lncRNAs)involved in the pathogenesis of various diseases,including heart disease;However,few studies have explored its *** present study evaluated the effects of lncRNA PVT1 on hypoxic rat H9c2 ***:Hypoxic injury was examined by measuring cell viability and apoptosis by using cell counting kit-8 activity and flow cytometry *** expressions after hypoxia were estimated by quantitative real time polymerase chain reaction and the signaling pathway were explored by Western blot *** immunoprecipitation and luciferase reporter assays were applied to examine the interactions among *** were analyzed using t-test with one-way or two-way analysis of ***:The lncRNA PVT1 is up-regulated in hypoxia-stressed H9c2 cells and knockdown of PVT1 mitigates hypoxia-induced injury in H9c2 ***1 acts as a sponge for miR-135a-5p and knockdown of PVT1 attenuated the increased hypoxia-induced injury by up-regulating *** box O1(FOXO1)was identified as a target of miR-135a-5p,and the expression was negatively regulated by *** exploration of the underlying mechanism demonstrated that knockdown of FOXO1 reversed PVT1/miR-135a-5p mediated hypoxia-induced injury in H9c2 ***:PVT1 plays a crucial role in hypoxia-injured H9c2 cells through sponging miR-135a-5p and then positively regulating FOXO1.

关键词： Acute myocardial infarction PVT1 miR-135a-5p FOXO1

Interspecific variation of thermoregulation between small migratory and resident passerines in Wenzhou

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Zoological Research 2016年第3期37卷 167-175页

作者： Qing-Gang QIAO hong-Ji LIANG Min-Lan BAI wei-hong zheng Jin-Song LIU School of Life and Environmental Sciences Wenzhou UniversityWenzhou 325035China Zhejiang Provincial Key Lab for Subtropical Water Environment and Marine Biological Resources Protection Wenzhou 325035China

Physiological adaptation arises from several fundamental sources of phenotypic variation. Most analyses of metabolic adaptation in birds have focused on the basal metabolic rate （BMR）, the lower limit of avian metabolic heat production. In this study, we investigated thermoregulation in three passerine species; the yellow-billed grosbeak Eophona migratoria, white-rumped munia Lonchura striata and black-throated bushtit Aegithalos concinnus, in Wenzhou, China. Metabolic rate was measured using the closed-circuit respirometer containing 3.5 L animal chambers. Body temperature （Tb） was measured during metabolic measurements using a lubricated thermocouple. The minimum thermal conductance of these species was calculated by measuring their Tb and metabolic rates. The yellow-billed grosbeak remained largely normothermic, and the white-rumped munia and black-throated bushtit exhibited variable Tb at ambient temperatures （Ta）. Mean metabolic rates within thermal neutral zone were 2.48±0.09 02 （mL）/g/h for yellow-billed grosbeaks, 3.44±0.16 02 （mL）/g/h for white-rumped munias, and 3.55±0.20 O2 （mL）/g/h for black-throated bushtits, respectively. Minimum thermal conductance of yellow-billed grosbeak, white-rumped munia and black-throated bushtit were 0.13±0.00, 0.36±0.01, and 0.37±0.01 02 （mL）/g/h/℃, respectively. The ecophysiological characteristics of these species were：（1） the yellowbilled grosbeak had relatively high Tb and BMR, a low lower critical temperature and thermal conductance, and a metabolic rate that was relatively insensitive to variation in Ta; all of which are typical of cold adapted species and explain its broader geographic distribution; （2） the white-rumped munia and black- throated bushtit had high thermal conductance, lower critical temperature, and relatively low BMR, all which are adapted to warm environments where there is little selection pressure for metabolic thermogenesis. Taken together, these data illustrate small migratory and resident passeri

关键词： Basal metabolic rate Body temperature Thermal conductance Eophona migratoria Lonchurastriata Aegithalos concinnus

Development and validation of a web-based calculator to predict individualized conditional risk of site-specific recurrence in nasopharyngeal carcinoma: Analysis of 10,058 endemic cases

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Cancer Communications 2021年第1期41卷 37-50页

作者： Chen-Fei Wu Jia-wei Lv Li Lin Yan-Ping Mao Bin Deng wei-hong zheng Dan-Wan Wen Yue Chen Jia Kou Fo-Ping Chen Xing-Li Yang Zi-Qi zheng Zhi-Xuan Li Si-Si Xu Jun Ma Ying Sun Department of Radiation Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhouGuangdong 510060P.R.China Department of Radiation Oncology Wuzhou Red Cross HospitalWuzhouGuangxi 543002P.R.China

Background:Conditional survival(CS)provides dynamic prognostic estimates by considering the patients existing survival *** CS for endemic nasopharyngeal carcinoma(NPC)is lacking,we aimed to assess the CS of endemic NPC and establish a web-based calculator to predict individualized,conditional sitespecific recurrence ***:Using an NPC-specific database with a big-data intelligence platform,10,058 endemic patients with non-metastatic stage I–IVA NPC receiving intensity-modulated radiotherapy with or without chemotherapy between April 2009 and December 2015 were *** CS estimates of conditional overall survival(COS),conditional disease-free survival(CDFS),conditional locoregional relapse-free survival(CLRRFS),conditional distant metastasis-free survival(CDMFS),and conditional NPC-specific survival(CNPC-SS)were ***-adjusted CS estimates were generated using inverse probability weighting.A prediction model was established using competing risk models and was externally validated with an independent,non-metastatic stage I–IVA NPC cohort undergoing intensity-modulated radiotherapy with or without chemotherapy(n=601)at another ***:The median follow-up of the primary cohort was 67.2 *** 5-year COS,CDFS,CLRRFS,CDMFS,and CNPC-SS increased from 86.2%,78.1%,89.8%,87.3%,and 87.6%at diagnosis to 87.3%,87.7%,94.4%,96.0%,and 90.1%,respectively,for an existing survival time of 3 years since *** in CS estimates between prognostic factor subgroups of each endpoint were noticeable at diagnosis but diminished with time,whereas an ever-increasing disparity in CS between different age subgroups was observed over ***,the prognoses of patients that were poor at diagnosis improved greatly as patients survived *** individualized CS predictions,we developed a web-based model to estimate the conditional risk of local(C-index,0.656),regional(0.667),bone(0.742),lung(0.681),and liver(0.711)recurren

关键词： endemic nasopharyngeal carcinoma conditional survival big data web-based individualized prediction model overall survival disease-free survival locoregional relapse-free survival distant metastasis-free survival NPC-specific survival

Energy intake, oxidative stress and antioxidant in mice during lactation

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Zoological Research 2015年第2期36卷 95-102页

作者： Guo-Xiao zheng Jiang-Tao LIN wei-hong zheng Jing CAO Zhi-Jun ZHAO College of Life and Environmental Science Wenzhou University

Reproduction is the highest energy demand period for small mammals, during which both energy intake and expenditure are increased to cope with elevated energy requirements of offspring growth and somatic protection. Oxidative stress life history theory proposed that reactive oxygen species（ROS） were produced in direct proportion to metabolic rate, resulting in oxidative stress and damage to macromolecules. In the present study, several markers of oxidative stress and antioxidants activities were examined in brain, liver, kidneys, skeletal muscle and small intestine in non-lactating（Non-Lac） and lactating（Lac） KM mice. Uncoupling protein（ucps） gene expression was examined in brain, liver and muscle. During peak lactation, gross energy intake was 254% higher in Lac mice than in Non-Lac mice. Levels of H2O2 of Lac mice were 17.7% higher in brain（P〈0.05）, but 21.1%（P〈0.01） and 14.5%（P〈0.05） lower in liver and small intestine than that of Non-Lac mice. Malonadialdehyde（MDA） levels of Lac mice were significantly higher in brain, but lower in liver, kidneys, muscle and small intestine than that of Non-Lac mice. Activity of glutathione peroxidase（GSH-PX） was significantly decreased in brain and liver in the Lac group compared with that in the Non-Lac group. Total antioxidant capacity（TAOC） activity of Lac mice was significantly higher in muscle, but lower in kidneys than Non-Lac mice. Ucp4 and ucp5 gene expression of brain was 394% and 577% higher in Lac mice than in Non-Lac mice. These findings suggest that KM mice show tissuedependent changes in both oxidative stress and antioxidants. Activities of antioxidants may be regulated physiologically in response to the elevated ROS production in several tissues during peak lactation. Regulations of brain ucp4 and ucp5 gene expression may be involved in the prevention of oxidative damage to the tissue.

关键词： Antioxidant Energy intake Lactation Metabolic rate Oxidative stress Uncoupling protein

Short photoperiod increases energy intake, metabolic thermogenesis and organ mass in silky starlings Sturnus sericeus

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Zoological Research 2016年第2期37卷 75-83页

作者： Jia-Qi WANG Jia-Jia WANG Xu-Jian WU wei-hong zheng Jin-Song LIU School of Life and Environmental Sciences Wenzhou University Zhejiang Provincial Key Lab for Subtropical Water Environment and Marine Biological Resources Protection

Environmental cues play important roles in the regulation of an animal＇s physiology and behavior. One such cue, photoperiod, plays an important role in the seasonal acclimatization of birds. It has been demonstrated that an animal＇s body mass, basal metabolic rate （BMR）, and energy intake, are all affected by photoperiod. The present study was designed to examine photoperiod induced changes in the body mass, metabolism and metabolic organs of the silky starling, Stumus sericeus. Captive silky starlings increased their body mass and BMR during four weeks of acclimation to a short photoperiod. Birds acclimated to a short photopedod also increased the mass of certain organs （liver, gizzard and small intestine）, and both gross energy intake （GEl） and digestible energy intake （DEI）, relative to those acclimated to a long photoperiod. Furthermore, BMR was positively correlated with body mass, liver mass, GEl and DEI. These results suggest that silky starlings increase metabolic thermogenesis when exposed to a short photoperiod by increasing their body and metabolic organ mass, and their GEl and DEI. These findings support the hypothesis that bird species from temperate climates typically display high phenotypic flexibility in thermogenic capacity.

关键词： Basal metabolic rate (BMR) Body mass Energy budget Organ mass Photoperiod Silkystarling Sturnus sericeus.

Metabolic rate and evaporative water loss in the silky starling （Sturnus sericeus）

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Zoological Research 2014年第4期35卷 280-286页

作者： Huan-Huan BAO Qing-Jian LIANG hong-Lei ZHU Xiao-Qiu ZHOU wei-hong zheng Jin-Song LIU College of Chemistry and Life Sciences Zhejiang Normal University Jinhua 321004 China College of Life and Environmental Sciences Wenzhou University Wenzhou 325035 China

To better understand the physiological characteristics of the silky starling（Sturnus sericeus）, its body temperature（Tb）, basal metabolic rate（BMR）, evaporative water loss（EWL） and thermal conductance（C） elicited by different ambient temperatures（Ta）（5-30 ℃） were determined in the present study. Our results showed that they have a high Tb（41.6±0.1 ℃）, a wide thermal neutral zone（TNZ）（20-27.5 ℃） and a relatively low BMR within the TNZ（3.37±0.17 mL O2/g·h）. The EWL was nearly stable below the TNZ（0.91±0.07 mg H2O/g·h） but increased remarkably within and above the TNZ. The C was constant below the TNZ, with a minimum value of 0.14±0.01 mL O2/g·h·℃. These findings indicate that the BMR, Tb and EWL of the silky starling were all affected by Ta, especially when Ta was below 20℃ and the EWL plays an important role in thermal regulation.

关键词： Silky starling (Sturnus sericeus) Basal metabolic rate Body temperature Evaporative water loss

Relationship between transforming growth factorβ1 and antifibrotic effect of interleukin-10

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World Journal of Gastroenterology 2006年第15期12卷 2357-2362页

作者： Mei-Na Shi Yue-hong Huang wei-Da zheng Li-Juan Zhang Zhi-Xin Chen Xiao-Zhong Wang Department of Gastroenterology Union Hospital of Fujian Medical UniversityFuzhou 350001 Fujian Province China

AIM： To study the effect of interleukin-10 （IL-10） on the expression of transforming growth factor β1 （TGF-β1） in hepatic fibrosis rats and the anti-fibrotic role of exogenous IL-10. METHODS： Hepatic fibrosis was induced by carbon tetrachloride administered （CCh） intraperitoneally. The experiment was performed in two stages. In the first stage, 60 SD rats were divided randomly into normal control group I（GNI, n = 8）, hepatic fibrosis group（GC, n = 28）and IL-10 intervened group（GI, n = 24）. At the beginning of the 7^th and 11^th wk, hepatic stellate cells （HSCs） were isolated, reverse transcription-polymerase chain reation （RT-PCR） and immunocytochemistry were performed to detect the expression of TGF-β1 in HSCs. Histological examination was used to determine the degree of hepatic fibrosis. In the second stage, 47 SD rats were divided randomly into normal control group 2 （GN2, n = 6）and CCh group（GZ, n = 41）. At the end of the 9th week, rats in GZ group were allocated randomly into model group（GM, n = 9）, IL-10 treatment group（GT, n = 9） and recovered group （GR, n = 9）. At the end of the 12^th week, all rats were sacrificed. RT-PCR and immuno- histochemistry were performed to detect the expression of TGF-β1 in liver tissue. ELISA was used to assay serum TGF-β1 levels. RESULTS： Hepatic fibrosis developed in rats with the increase of the injection frequency of CCI4. In the first stage, hepatic fibrosis developed and HSCs were isolated successfully. At the 7^th and 11^th week, TGF-β1 mRNA in GC group increased significantly compared with that in GN1（P = 0.001/0.042） and GI groups（P = 0.001/0.007）, whereas there was no significant difference between the two groups. The levels of TGF-β1 at the beginning of the 7^th wk was higher than that of the 11^th wk （P = 0.049）.Immunocytochemistry results of TGF-β1 were consistent with the above findings. In the second stage, TGF-β1 increased significantly in GM group compared to GN2. Alter treatment with IL-10, TGF-β1 declined obvio

关键词： Hepatic fibrosis Hepatic stellate cells Interleukin-10 Transforming growth factor-β1