Causal effects of circulating vitamin levels on the risk of heart failure:a Mendelian randomization study

作     者：Bo GUAN Xiao-Qiang CHEN Yan LIU Hui ZHOU Ming-Yan YANG Hong-Wei ZHENG Shi-Jun LI Jian CAO Bo GUAN;Xiao-Qiang CHEN;Yan LIU;Hui ZHOU;Ming-Yan YANG;Hong-Wei ZHENG;Shi-Jun LI;Jian CAO

作者机构：Medical School of Chinese PLA General HospitalBeijingChina Department of CardiologyShanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Xiangya School of NursingCentral South UniversityChangshaHunanChina Department of CardiologyTangshan Gongren Hospital Affiliated to Hebei Medical UniversityTangshanChina Geriatric Cardiology Department of the Second Medical Center and National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijingChina 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2023年第20卷第3期

页      面：195-204页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Grant No.81970341) Beijing Natural Science Foundation(Grant No.7232157) 

主　　题：vitamin prevention absolute 

摘      要：BACKGROUND Observational studies suggest inverse associations between serum vitamin levels and the risk of heart failure(HF). However, the causal effects of vitamins on HF have not been fully elucidated. Here, we conducted a Mendelian randomization(MR) study to investigate the causal associations between genetically determined vitamin levels and *** Genetic instrumental variables for circulating vitamin levels, including vitamins A, B, C, D, and E, which were assessed as either absolute or metabolite levels were obtained from public genome-wide association studies. Summary statistics for single-nucleotide-polymorphisms and HF associations were retrieved from the HERMES Consortium(47,309 cases and 930,014controls) and FinnGen Study(30,098 cases and 229,612 controls). Two-sample MR analyses were implemented to assess the causality between vitamin levels and HF per outcome database, and the results were subsequently combined by *** Our MR study did not find significant associations between genetically determined circulating vitamin levels and HF risk. For absolute vitamin levels, the odds ratio for HF ranged from 0.97(95% confidence interval [CI]: 0.85–1.09, P = 0.41) for vitamin C to 1.05(95% CI: 0.61–1.82, P = 0.85) for vitamin A. For vitamin metabolites, the odds ratio ranged between 0.94(95% CI:0.75–1.19, P = 0.62) for α-tocopherol and 1.11(95% CI: 0.98–1.26, P = 0.09) for γ-*** Evidence from our study does not support the causal effects of circulating vitamin levels on HF. Therefore,there may be no direct beneficial effects of vitamin intake on the prevention of primary HF.