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Comparative effectiveness of combined antiplatelet treatments in acute minor ischaemic stroke

Stroke & Vascular Neurology 2022年第1期7卷 13-21页

作者： Shina Kim joon-Tae Kim Ji Sung Lee Beom joon Kim Jong-Moo Park Kyusik Kang Soo Joo Lee Jae Guk Kim Jae-Kwan Cha Dae-Hyun Kim Tai Hwan Park Sang-Soon Park Kyung Bok Lee Jun Lee Keun-Sik Hong Yong-Jin Cho Hong-Kyun Park Byung-Chul Lee Kyung-Ho Yu Mi Sun Oh Dong-Eog Kim Wi-Sun Ryu Jay Chol Choi Jee-Hyun Kwon Wook-Joo Kim Dong-Ick Shin Sung-Il Sohn Jeong-Ho Hong Man-Seok Park Kang-Ho Choi Ki-Hyun Cho Juneyoung Lee hee-joon bae Department of Neurology Chonnam National University HospitalChonnam National University Medical SchoolGwangjuKorea Clinical Research Center Asan Institute for Life SciencesAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Neurology Cerebrovascular CenterSeoul National University Bundang HospitalSeongnamKorea Department of Neurology Uijeongbu Eulji Medical CenterEulji University School of MedicineUijeongbu-siKorea Department of Neurology Nowon Eulji Medical CenterEulji UniversitySeoulKorea Department of Neurology Eulji University HospitalEulji UniversityDaejeonKorea Department of Neurology Dong-a UniversityBusanKorea Department of Neurology Seoul Medical CenterSeoulKorea Department of Neurology Soonchunhyang University HospitalSeoulKorea Department of Neurology Yeungnam University HospitalDaeguKorea Department of Neurology Inje University Ilsan Paik HospitalInje University College of MedicineGoyangKorea Department of Neurology Hallym University Sacred Heart HospitalAnyangKorea Department of Neurology Dongguk University Ilsan HospitalGoyangKorea Department of Neurology Jeju National University HospitalJeju National University School of MedicineJejuKorea Department of Neurology University of Ulsan College of MedicineUlsanKorea Department of Neurology Chungbuk National University HospitalCheongjuKorea Department of Neurology Keimyung University Dongsan Medical CenterDaeguKorea Department of Biostatistics Korea University College of MedicineSeoulKorea

Background No study has thoroughly compared the effectiveness of combined antiplatelet treatments(other than clopidogrel–aspirin)versus clopidogrel–aspirin or aspirin alone for early secondary prevention in acute ischaemic *** We identified patients with acute,minor,non-cardiogenic ischaemic stroke treated with aspirin alone,clopidogrel–aspirin or other combination *** scores considering the inverse probability of treatment weighting were used to adjust for baseline *** primary outcome was the composite of all strokes(ischaemic or haemorrhagic),myocardial infarction and all-cause mortality at 3 *** Among 12234 patients(male:61.9%;age:65.5±13 years)who met the eligibility criteria,aspirin,clopidogrel–aspirin and other combination treatments were administered in 52.2%,42.9%and 4.9%of patients,*** the crude analysis,the primary outcome event at 3 months occurred in 14.5%of the other combination group,14.4%of the aspirin group and 13.0%of the clopidogrel–aspirin *** the weighted Cox proportional hazards analysis,the 3-month primary outcome event occurred less frequently in the clopidogrel–aspirin group than in the other combination group(weighted HR:0.82(0.59–1.13)),while no association was found between the aspirin group(weighted HR:1.04(0.76–1.44))or other combination group and the 3-month primary *** Other combined antiplatelet treatment,compared with aspirin alone or clopidogrel–aspirin,was not associated with reduced risks of primary composite vascular events or recurrent stroke during the first 3 months after ***,the results suggest that other combination treatments,particularly the cilostazol-based combination,may not be effective alternatives for clopidogrel–aspirin to prevent early vascular events in patients with acute minor *** exploration in clinical trials will be needed.

关键词： prevention treatment alone

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Multi-faceted small molecule for Alzheimer’s disease

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Neural Regeneration Research 2023年第10期18卷 2198-2199页

作者： Min hee Park hee Kyung Jin Jae-sung bae KNU Alzheimer’s Disease Research Institute Department of PhysiologySchool of MedicineKyungpook National UniversityDaeguSouth Korea KNU Alzheimer’s Disease Research Institute Department of Laboratory Animal MedicineCollege of Veterinary MedicineKyungpook National UniversityDaeguSouth Korea

The main pathologies of Alzheimer’s disease(AD)are the accumulation of amyloid-B(AB)and tau ta ngles,and these two fundamental pathologies accompany the va rious neuropathological features,such as neuroinfla mmation,... 详细信息

关键词： Alzheimer tau amyloid

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Primary large cell neuroendocrine carcinoma in the common bile duct:First Asian case report

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World Journal of Gastroenterology 2014年第47期20卷 18048-18052页

作者： Sung bae Park Suk bae Moon Young joon Ryu Jeana Hong Yang hee Kim Gi Bong Chae Seong Kweon Hong Department of Surgery Kangwon National University HospitalKangwon National University School of MedicineChuncheon 200-947South Korea Department of Pathology Kangwon National University HospitalKangwon National University School of MedicineChuncheon 200-947South Korea Department of Pediatrics Kangwon National University HospitalKangwon National University School of MedicineChuncheon 200-947South Korea

Large cell neuroendocrine carcinoma (LCNEC) in the biliary system is a poorly differentiated, high-grade neuroendocrine tumor. These tumors exhibit aggressive behavior and an increased tendency for early nodal and distant metastases. Herein, we report an unusual case of a pure primary LCNEC of the common bile duct (CBD). A 75-year-old female presented with nausea and jaundice. The patient underwent a CBD excision with lymph node dissection. Upon histological and immunohistochemical examination, the tumor exhibited pure large cell-type neuroendocrine features. Metastases were noted in two of the eight lymph nodes. The patient was administered adjuvant chemotherapy. The patient’s cancer recurred 7 mo after surgery, and the patient died from liver failure 5 mo after recurrence. The prognosis of LCNEC of CBD remains poor despite curative resection and adjuvant chemotherapy. The role of additional therapies, such as multimodal treatment including radiation therapy, must be further studied to improve the prognoses of patients.

关键词： Neuro endocrine tumor Large cell neuroendocrine carcinoma Metastases Multimodal treatment Common bile duct

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Uncertainty analysis of flow rate measurement for multiphase flow using CFD

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Acta Mechanica Sinica 2015年第5期31卷 698-707页

作者： joon-Hyung Kim Uk-hee Jung Sung Kim joon-Yong Yoon Young-Seok Choi Department of Mechanical Design Engineering Hanyang University Thermal & Fluid System R&BD Group Korea Institute of Industrial Technology Energy System Engineering University of Science and Technology

The venturi meter has an advantage in its use,because it can measure flow without being much affected by the type of the measured fluid or flow ***,it has excellent versatility and is being widely applied in many *** flow of a liquid containing air is a representative example of a multiphase flow and exhibits complex flow *** particular,the greater the gas volume fraction（GVF）,the more inhomogeneous the flow *** a result,using a venturi meter to measure the rate of a flow that has a high GVF generates an *** this study,the cause of the error occurred in measuring the flow rate for the multiphase flow when using the venturi meter for analysis by *** ensure the reliability of this study,the accuracy of the multiphase flow models for numerical analysis was verified through comparison between the calculated results of numerical analysis and the experimental *** a result,the Grace model,which is a multiphase flow model established by an experiment with water and air,was confirmed to have the highest ***,the characteristics of the internal flow Held about the multiphase flow analysis result generated by applying the Grace model were analyzed to find the cause of the uncertainty occurring when measuring the flow rate of the multiphase flow using the venturi meter.A phase separation phenomenon occurred due to a density difference of water and air inside the venturi,and flow inhomogeneity happened according to the flow velocity difference of each *** was confirmed that this flow inhomogeneity increased as the GVF increased due to the uncertainty of the flow measurement.

关键词： Multiphase flow Measurement Numerical analysis Venturi meter Gas volume fraction(GVF) Uncertainty Multiphase flow model Grace model

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Prospective comparison of prophylactic antibiotic use between intravenous moxifloxacin and ceftriaxone for high-risk patients with post-ERCP cholangitis

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Hepatobiliary & Pancreatic Diseases International 2017年第5期16卷 512-518页

作者： Nam hee Kim Hong Joo Kim Ki bae Bang Department of Internal Medicine Sungkyunkwan University Kangbuk Samsung Hospital Department of Internal Medicine Dankook University Hospital

BACKGROUND: The use of prophylactic antibiotics before endoscopic retrograde cholangiopancreatography(ERCP) is recommended by all major international gastroenterological societies, especially in the presence of an obstructed biliary system. This study compared the occurrence rate of post-procedural complications, including cholangitis and septicemia between prophylactic intravenous moxifloxacin and ceftriaxone in patients with bile duct obstruction scheduled for therapeutic ***: From November 2013 to July 2015, 86 consecutive patients with biliary obstruction with one or more factors predicting benefits of antibiotic prophylaxis prior to ERCP were included in the current randomized open-label non-inferiority trial(Clinical *** identifier NCT02098486). Intravenous moxifloxacin(400 mg/day) or ceftriaxone(2 g/day)were given 90 minutes before ERCP, and were administered for more than 3 days if the patient developed symptoms and signs of cholangitis or septicemia. Recalcitrant cholangitis was defined as persistence of cholangitis for more than 5 days after ERCP or recurrence of cholangitis within 30 days after ***: Recalcitrant cholangitis occurred in 1(2.3%) and 2(4.8%) patients receiving intravenous moxifloxacin and ceftriaxone group, respectively(P=0.612). Septicemia was noted in1(2.3%) and 1(2.4%) patient in intravenous moxifloxacin and ceftriaxone group, respectively(P=1.0). The mean hospital stay was also not significantly different between the moxifloxacin and ceftriaxone groups(8.8±7.2 vs 9.1±9.4 days, P=0.867). Antibiotic resistance of the isolated pathogens by in vitro activity assay was noted in 1(2.3%) and 2(4.8%) patients in the moxifloxacin and ceftriaxone group, respectively(P=0.612). CONCLUSION: Intravenous moxifloxacin is not inferior to intravenous ceftriaxone for the prophylactic treatment of post-ERCP cholangitis and cholangitis-associated morbidity.

关键词： endoscopic retrograde cholangiopancreatography cholangitis moxifloxacin ceftriaxone recalcitrant cholangitis

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Surgical excision of a large retroperitoneal lymphangioma: A case report

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World Journal of Clinical Cases 2022年第31期10卷 11561-11566页

作者： John hee Park Donghyoun Lee Young hee Maeng Won-bae Chang Department of Surgery Samsung Medical CenterSeoul 06351South Korea Department of Surgery Jeju National University HospitalJeju-si 63241JejudoSouth Korea Department of Pathology Jeju National University Medical CenterJeju-si 63241Jeju-doSouth Korea Department of Surgery Jeju National University Medical CenterJeju-si 63241Jeju-doSouth Korea

BACKGROUND Lymphangiomas are rare benign tumors most commonly found in children under 2 years of age;adult cases are extremely *** lymphangiomas represent less than 1%of all *** of their benign nature and possibility of spontaneous resolution,lymphangiomas are sometimes left untreated for long periods of ***,if they grow large enough to compress surrounding structures,retroperitoneal lymphangiomas may cause symptoms such as abdominal pain,nausea or *** report a case of a rapidly growing retroperitoneal lymphangioma in an adult,treated with complete surgical *** SUMMARY A 60-year-old female who was diagnosed with an intra-abdominal cystic mass(11 cm×9.5 cm)seven years ago presented to our hospital with symptoms of early satiety,nausea,and intermittent abdominal *** tomography(CT)scan confirmed interval enlargement to a 24 cm×22 cm-sized huge left retroperitoneal mass,causing left hydronephrosis by external *** was done via long midline *** to severe adhesion between the aorta and the medial border of the mass,the cyst was intentionally opened for fluid aspiration and size *** suture closure of the opening,we proceeded carefully with *** showed light yellowish serous *** mass was excised completely,and the pathology was consistent with cystic *** post-operative period was uneventful,and the patient was discharged without ***-up CT scan one month after surgery confirmed complete removal of the mass and decreased left *** Excision of the huge retroperitoneal cystic mass resulted in relief of the patient’s symptoms,originally caused by external compression,and also ruled out the possibility of malignancy.

关键词： Retroperitoneum Lymphangioma Hydronephrosis Case report

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Callus proliferation-induced hypoxic microenvironment decreases shoot regeneration competence in Arabidopsis

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Molecular Plant 2024年第3期17卷 395-408页

作者： Dohee Koo Hong Gil Lee Soon Hyung bae Kyounghee Lee Pil joon Seo Department of Chemistry Seoul National UniversitySeoul 08826Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Research Institute of Basic Sciences Seoul National UniversitySeoul 08826Korea

Plants are aerobic organisms that rely on molecular oxygen for respiratory energy *** conditions,with oxygen levels ranging between 1%and 5%,usually limit aerobic respiration and affect plant growth and ***,we demonstrate that the hypoxic microenvironment induced by active cell proliferation during the two-step plant regeneration process intrinsically represses the regener-ation competence of the callus in Arabidopsis *** showed that hypoxia-repressed plant regener-ation is mediated by the RELATED TO APETALA2.12(RAP2.12)protein,a memberof the Ethylene Response Factor VIl(ERF-Vll)*** found that the hypoxia-activated RAP2.12 protein promotes salicylic acid(SA)biosynthesis and defense responses,thereby inhibiting pluripotency acquisition and de novo shoot regeneration in *** and genetic analyses revealed that RAP2.12 could bind directly to the SALICYLIC ACID INDUCTION DEFICIENT 2(SID2)gene promoter and activate SA biosynthesis,repressing plant regeneration possibly via a PLETHORA(PLT)-dependent ***,the rap2.12 mutant calli exhibits enhanced shoot regeneration,which is impaired by SA *** together,these find-ings uncover that the cell proliferation-dependent hypoxic microenvironment reduces cellular pluripotency and plant regeneration through the RAP2.12-SID2 module.

关键词： callus cell proliferation-induced hypoxia SID2 plant regeneration salicylic acid RAP2.12

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Temperature Distribution and Thermal Stresses in Various Conditions of Moving Heating Source during Line Heating Process

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Journal of Thermal Science 2012年第1期21卷 82-87页

作者： Yoon Hwan Choi Yeon Won Lee Kwang Choi Deog hee Doh Kyoung joon Kim Department of Mechanical and Automotive Engineering Pukyong National University Steel Structure Research Division Research Institute of Industrial Science & Technology Division of Mechanical and information Engineering Korea Maritime University

Line heating method is widely used to manufacture curved surfaces in ship building. The main factors governing the quality of the manufactured products are the moving velocity of the heating source, heating strength, and heating ways. In this study, the temperature distributions of the heated plate were investigated with the condition that the line heating process was automatic. The temperature variations were also investigated with the changes of those three variables. The numerical results showed that the peak temperature decreased as the moving velocity of the heating source increased. It also revealed that the peak temperatures changed linearly with the changes of the heating source.

关键词： Moving heat source Line heating Thermal stress Residual deformation Conductive heat transfer

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Development of tenofovir disoproxil fumarate resistance after complete viral suppression in a patient with treatment-na?ve chronic hepatitis B: A case report and review of the literature

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World Journal of Gastroenterology 2018年第17期24卷 1919-1924页

作者： Woo hee Cho Hyun Jae Lee Ki bae Bang Seok bae Kim Il Han Song Department of Internal Medicine Dankook University College of MedicineCheonan 31116South Korea

Tenofovir disoproxil fumarate(TDF) is a potent nucleo-tide analogue that is recommended as first-line therapy for patients with chronic hepatitis B. The results of a longitudinal study of TDF treatment demonstrated no development of resistance. We observed one treatment-na?ve chronic hepatitis B(CHB) patient who developed TDF resistance after complete viral suppression during long-term TDF treatment. A 37-year-old HBe Ag-positive man received TDF 300 mg/d for 43 mo. The hepatitis B virus(HBV) DNA titer was 8 log_(10) copies/m L at baseline and became undetectable at 16 mo after treatment. However, the HBV DNA titer rebounded to 7.5 log_(10) copies/m L at 43 mo after treatment. We performed full sequencing to find mutation sites associated with virologic breakthrough. The results showed 9 mutation sites, most of which had not been well-known as mutation sites. We changed the therapy from tenofovir to entecavir with a regimen of 0.5 mg once daily. After 4 mo, the HBV DNA titer decreased to 267 copies/m L, and the liver enzyme levels were normalized.

关键词： Chronic hepatitis B Tenofovir Resistance Mutation

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Role of debris flow on the change of^10Be concentration in rapidly eroding watersheds:a case study on the Seti River,central Nepal

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Journal of Mountain Science 2017年第4期14卷 716-730页

作者： KIM Dong Eun SEONG Yeong bae CHOI Kwang hee YU Byung Yong Dept.of Geography Korea UniversitySeoul 02841Korea Yeongsan River Basin Environmental Office Ministry of EnvironmentGwangju 61945Korea Korea Institute of Science and Technology Seoul 02792Korea

The concentration of cosmogenic loBe in riverine sediments has been widely used as a proxy for catchment-wide denudation rate （CWDR）. One of the key assumptions of this approach is that sediments originating from sub-basins with different erosional histories are well mixed. A tragic debris flow occurred in the Seti River watershed, central Nepal, on May 5, 2012. This catastrophic debris flow was triggered by slope failure on the peak of Annapurna IV and resulted in many casualties in the lower Seti Khola. However, it provided an opportunity to test the assumption of equal mixing of sediments in an understudied rapidly eroding watershed. This study documents the CWDR of ^10Be to evaluate the extent of the influence of episodic erosional processes such as debris flow on the spatio-temporal redistribution of loBe concentrations. Our data show that the debris flow caused little change in CWDR across the debris flow event. In addition to isotopic measurement, we calculated denudation rates by using the modeled concentrations in pre- and post-landslide sediments based on the local ^10Be production rate. The modeled result showed little change across the event, indicating that the debris flow in May 2012 played a minor role in sediment evacuation, despite the rapid erosion in the catchment. Our study concludes that although the 2012 event caused many casualties and severe damage, it was a low-magnitude, high frequency event.

关键词： Seti River Beryllium-10 (^10Be) Catchment-wide denudation rate (CWDR) Debrisflow Episodic erosional processes

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