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Pathologic Q Waves and Prolonged QTc Time in Preoperative ECG Are Predictive for Perioperative Cardiovascular Events

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World Journal of Cardiovascular Diseases 2014年第10期4卷 498-509页

作者： Thomas Wolters Michael Weber Thomas Neumann hans-georg strauß Andreas Luchner Manfred Seeberger Christian Mueller Christoph Liebetrau Svetlana Apostolovic Radmilo Jankovic Dragic Bankovic Marina Jovic Vesselin Mitrovic Holger Nef Helge Mollmann Karl Werdan Christian W. Hamm Axel Schlitt Department of Medicine III University Clinic Halle (Saale) Halle Germany Department of Medicine Clinic Grabs Grabs Switzerland Department of Cardiology Kerckhoff Heart and Thorax Center Bad Nauheim Germany Department of Medicine II Clinic Gro&szlig -Umstadt Gro&szlig -Umstadt Germany Department of Medicine II University of Regensburg Regensburg Germany Department of Cardiology University of Basel Basel Switzerland University Cardiology Clinic Ni&scaron Serbia Department of Mathematical Sciences University of Kragujevac Kragujevac Serbia Department of Medicine I University Clinic of Gie&szlig en and Marburg Gie&szlig en Germany Department of Medicine I Paracelsus-Harz-Clinic Bad Suderode Quedlinburg Germany

Aims: The value of ECG in the perioperative risk stratification under modern treatment options is uncertain. The main objective of the present analysis was to determine the usefulness of a pre-operative ECG derivation for evaluating the risk of perioperative morbidity and mortality. Methods: We performed a secondary analysis of the prospective, international, multicenter, observational “No-Risk” Study (N-terminal B-type natriuretic peptide [NT-proBNP] for the assessment of the perioperative cardiac risk after major noncardiac surgery) to determine the prognostic value of 12-lead ECG. Inclusion criteria were age >55 years and at least one of the following cardiovascular risk factors: arterial hypertension, diabetes mellitus, dyslipidemia, active smoking, and family history positive for coronary heart disease. The combined primary endpoint included total mortality, acute myocardial infarction (NSTEMI and STEMI), cardiopulmonary resuscitation, heart failure, and asystole or ventricular fibrillation during hospitalization. ECGs from 616 patients enrolled from 2006 to 2009 prior to noncardiac surgery in the No-Risk Study were analyzed. Results: The mean age was 67.6 (±8.1) years;300 (48.7%) patients were male. Fourteen (2.3%) patients suffered from the combined primary endpoint while in the hospital. In Kaplan-Meier analyses, a pathologic Q wave and QTc > 500 ms were significantly related to the incidence of the primary endpoint (p p = 0.042, respectively), whereas other ECG parameters such as LBBB, RBBB, PQ interval, QRS interval, and others were not related to worse in-hospital outcome. Conclusion: The 12-lead ECG is still an important diagnostic tool for perioperative risk assessment of cardiovascular events in noncardiac surgery in patients at risk.

关键词： ECG Perioperative Risk Cardiovascular Risk

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Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： Daniel Adam Felix Langerscheidt hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al Kabbani Christoph Köhler hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

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Synthetic demand data generation for individual electricity consumers:Inpainting

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Energy and AI 2024年第1期15卷 36-43页

作者： Dascha Dobrovolskij hans-georg Stark Universität Bremen Bibliothekstraβe 528359 BremenGermany Technische Hochschule Aschaffenburg Würzburger Straβe4563743 AschaffenburgGermany

In this contribution we deal with the problem of producing“reasonable”data,when considering recorded energy consumption data,which are at certain sections incomplete and/or *** task is important,when energy providers employ prediction models for expected energy consumption,which are based on past recorded consumption data,which then of course should be reliable and *** a related contribution Yilmaz(2022),GAN-based methods for producing such“artificial data”have been *** this contribution,we describe an alternative and complementary method based on signal inpainting,which has been successfully applied to audio processing Lieb and Stark(2018).After giving a short overview of the theory of proximity-based convex optimization,we describe and adapt an iterative inpainting scheme to our *** usefulness of this approach is demonstrated by analyzing real-world-data provided by a German energy supplier.

关键词： Time series Missing data points Time-frequency analysis Convex optimization Douglas-Rachford-algorithm Gabor transform

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Necessity and Memory in Hegel's Phenomenology of Spurut A Reconstruction

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Frontiers of Philosophy in China 2018年第4期13卷 505-517页

作者： hans-georg Moeller Philosophy and Religious Studies Program University of MacaoMacaoChina

This paper discusses two core concepts in Hegel’s Phenomenology of Spirit: necessity (Notwendigkeit) and memory (Erinnerung). The analysis is based on an investigation of the connotations and linguistic components of the two terms as they are used in the German language. Occurrences of the terms in decisive passages in the Phenomenology of Spirit are investigated and seen as a key to an understanding of Hegel’s overall project of constructing a “scientific” (wissenschaftlich) philosophy in the form of a conceptual system. The paper aims at showing that this project can in part be understood as an attempt to transform the contingency of all moments of the path of the self-cultivation, maturation, and growth (Bildung) of spirit (Geist)—understood both in terms of its personal dimension and as “world spirit”—into necessity. It is argued that memory plays a decisive role in this endeavor, not only in the sense of a recalling of the past, but also as a prerequisite for a future that opens up room for further cultivation, maturation, and growth.

关键词： Hegel Phenomenology of Spirit necessity memory system

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Study of the degradation behavior and the biocompatibility of Mg-0.8Ca alloy for orthopedic implant applications

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Journal of Magnesium and Alloys 2019年第2期7卷 249-257页

作者： Aya Mohamed Ahmed MEl-Aziz hans-georg Breitinger Materials Engineering Department German University in Cairo(GUC)11835 New CairoEgypt Department of Biochemistry German University in Cairo(GUC)11835 New CairoEgypt

Mg-Ca alloys have recently attracted great attention towards the research in the field of orthopedic biodegradable *** study presents an in vitro degradation assessment of Mg-0.8Ca(0.8 wt.%of Ca)alloy in Hank’s balanced salt solution(HBSS).Immersion,hydrogen evolution and electrochemical behavior was studied as well as the cytotoxicity of the degradation *** and phase composition of the corrosion products were studied using SEM,EDX and XRD *** in HBSS resulted in the formation of the needle-shaped carbonated hydroxyapatite which was similar to the biological apatite in the human *** kinetics showed that Mg-0.8Ca alloy had approximately 3-fold faster degradation rate than the pure Mg(1.08±0.38 mm/year for Mg-0.8Ca and 0.35±0.17 mm/year for pure Mg),as observed in two independent ***,pure Mg and Mg-0.8Ca alloy were biocompatible,generating no cytotoxic degradation products against human-derived HEK 293 ***,the Mg-0.8Ca alloy was found to be a promising biodegradable implant in terms of bioactivity and compatibility with human cell *** on the application of the implant and the estimated healing time of the bone,the desired degradation rate of an implant can be controlled by the Mg-Ca composition of such alloys.

关键词： Mg-Ca alloys Biodegradability Orthopedic implants Biocompatibility Toxicity Hydroxyapatite

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Numerical study of novel OME_(1-6) combustion mechanism and spray combustion at changed ambient environments

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Frontiers in Energy 2024年第4期18卷 483-505页

作者： Frederik WIESMANN Zeyan QIU Dong HAN Lukas strauβ Sebastian RIEβ Michael WENSING Thomas LAUER Institute of Powertrains and Automotive Technology TU Wien1060 ViennaAustria Key Laboratory for Power Machinery and Engineering of Ministry of Education Shanghai Jiao Tong UniversityShanghai 200240China Professorship for Fluid Systems Technology Friedrich-AlexanderUniversität Erlangen-Nürnberg91058 ErlangenGermany

For a climate-neutral future mobility,the socalled e-fuels can play an essential ***,oxygenated e-fuels containing oxygen in their chemical formula have the additional potential to burn with significantly lower soot *** particular,polyoxymethylene dimethyl ethers or oxymethylene ethers(PODEs or OMEs)do not contain carbon-carbon bonds,prohibiting the production of soot precursors like acetylene(C_(2)H_(2)).These properties make OMEs a highly interesting candidate for future climate-neutral compression-ignition ***,to fully leverage their potential,the auto-ignition process,flame propagation,and mixing regimes of the combustion need to be *** achieve this,efficient oxidation mechanisms suitable for computational fluid dynamics(CFD)calculations must be developed and *** present work aims to highlight the improvements made by developing an adapted oxidation mechanism for OME1-6 and introducing it into a validated spray combustion CFD model for *** simulations were conducted for single-and multi-injection patterns,changing ambient temperatures,and oxygen *** results were validated against high-pressure and high-temperature constantpressure chamber ****-chemiluminescence measurements accomplished the characterization of the auto-ignition *** experiments and simulations were conducted for two different *** improvements concerning the prediction of the ignition delay time were accomplished while also retaining an excellent agreement for the flame lift-off *** spatial zones of high-temperature reaction activity were also affected by the adaption of the reaction *** showed a greater tendency to form OH^(*) radicals within the center of the spray in accordance with the experiments.

关键词： oxygenated fuels reaction kinetics oxidation mechanisms computational fluid dynamics(CFD) oxymethylene ethers(OME) e-fuels multiinjection spray-combustion

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Towards a business model for second-life batteries: Barriers,opportunities, uncertainties, and technologies

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Journal of Energy Chemistry 2023年第3期78卷 507-525,I0014页

作者： Carlos Antônio Rufino Júnior Eleonora Riva Sanseverino Pierluigi Gallo Daniel Koch Yash Kotak hans-georg Schweiger Hudson Zanin Advanced Energy Storage Division New Energy Innovation CenterUniversity of Campinas(UNICAMP)Campinas 13083-852Brazil Engineering Department University of Palermo(UNIPA)Palermo 90128Italy Consorzio Nazionale Interuniversitario per le Telecomunicazioni(CNIT) Parma 43124Italy Technische Hochschule Ingolstadt Institute for ElectricConnected and Safe Mobility(C-ECOS)Ingolstadt 85049Germany

Electric vehicles(EVs) and the recent pandemic outbreak give cities a new trend to primarily private and shared mobility with low noise and less air *** factors for the widespread of EVs are the electrical charging infrastructure,driving range,and the reduction of the cost of battery *** this reason,there is a massive effort from manufacturers,governments,and the scientific community to reduce battery costs and boost sustainable electrical production and *** reuse is an alternative to reduce batteries’ costs and environmental ***-life batteries can be used in a wide variety of secondary ***-life batteries can be connected with off-grid or on-grid photovoltaic and wind systems,vehicle charging stations,forklifts,and frequency *** present work aims to analyze the main challenges imposed on the reuse of batteries,the leading technologies for their reuse,and the different types of batteries in terms of their feasibility for second-life *** main novelty of this work is the discussion about the barriers,opportunities,uncertainties,and technologies for the second life *** we summarize the present state of the art in reusing lithium-ion batteries discussing technical and economic feasibility,environmental impacts,and *** results show five business models that have been proposed in the literature,three types of markets for trading second-life batteries,and the main opportunities and barriers for each actor in the battery supply chain.

关键词： Business models Batteries Sustainability Electric vehicles Challenges Opportunities Lithium-ion batteries Reuse

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Synthesis, Crystal Structure and Magnetic Property of Disodium Biscarbonato cobaltate(Ⅱ) Tetrahydrate, Na_2Co(CO_3)_2·4H_2O

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Chemical Research in Chinese Universities 1999年第4期15卷 311-316页

作者： ZHENG Yue-Qing YE Yu-Han HU Fu-Tao PETERS Karl and von SCHNERING hans georg Chemistry Department Ningbo UniversityNingbo 315211P.R.China Max Planck Institut für Festkrperforschung D 70569 StuttgartGermany

The title compound, Na 2Co(CO 3) 2·4H 2O, was synthesized by dropwise addition of 1.0 mL of 1 mol/L Co(CH 3COO) 2 to 50 mL of aqueous solution containing 7.0 g(66.0 mmol) of Na 2CO 3 and 2.5 g(29.8 mmol) of NaHCO 3 under stirring. A rose colored rhombohedral crystal grew by the slow evaporation of the solution of the title compoud at room temperature. The crystal structure was established on the basis of the single crystal X ray diffraction data. Na 2Co(CO 3) 2·4H 2O crystallizes in the monoclinic space group C2/c with a =0.856 6(1) nm, b =0.714 6(1) nm, c = 1 438 7(2) nm, β =97.59(1)° , V =0.873 0(2) nm 3 , D x=2.260 g/cm 3, F (000)=596, M r=296 99, μ (Mo K α)=21.06 cm -1 , Z =4 and the final R(F) =0.032 and wR(F 2) =0.068 on the basis of 947 reflections ( F 2 ≥ 2σ(F 0 2)). The crystal consists of H 2O molecules, Na + ions and 2D 2 ∞[Co(CO 3) 2] 2- layers extending parallel to (001). H 2O molecules and Na + cations are located between the 2D layers. Each Co atom is tetrahedrally coordinated by four O atoms from four CO 2- 3 groups with d (Co\_O)=0.206 5(2) nm, 0.207 6(2) nm and the angle of O\_Co\_O is in the range of 97.7(1)°—128.5(1)°. The CO 2- 3 group bridging two Co atoms via two O atoms deviates from D 3h symmetry with d (C\_O)=0.127 2(3)\_0.129 9(3) nm and the angle of O\_C\_O is in the range of 119.5(2)°\_123.4(2)°. Each Na atom, with two close Na neighbours at 0.338 4(2) nm and 0 346 7(2) nm, respectively, is octahedrally coordinated by six O atoms from four H 2O molecules and two carbonate groups belonging to two layers with d (Na\_O)=0.232 7(2)\_0.241 1(2) nm. Of two crystallographically different H 2O molecules, one forms hydrogen bonds to two CO 3 2- groups of one 2D layer, and the other to those from two different 2D layers. Na 2Co(CO 3) 2·4H 2O is antiferromagnetic below 16 K, and between 30\_300

关键词： Synthesis Disodium biscarbonatocobaltate(Ⅱ) tetrahydrate Crystal structure Complex carbonate Magnetic property

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Surgical approach affecting long-term urinary continence status after robot-assisted laparoscopic prostatectomy prospectively evaluated using self-reported functional status(Expanded Prostate Cancer Index Composite,EPIC-26)

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Current Urology 2024年第1期18卷 61-65页

作者： Mathias Reichert Ame strauß Joost Wilhelm Voß hans Christoph von Knobloch Hannah Maria Neuenhofer Annemarie Uhlig Lutz Trojan Mirjam Naomi Mohr Department of Urology University Medical CenterGoettingenGermany Department of Pediatrics University HospitalBonnGermany

Purpose:The aim of the study was to examine the influence of the surgical approach for robot-assisted laparoscopic prostatectomy(RALP)on long-term urinary continence status in the era of self-reported functional status measures using the Expanded Prostate Cancer Index Composite *** and methods:This is a prospective evaluation of 232 patients undergoing RALP between September,2019 and September,*** continence status and postoperative incontinence(pad usage)were evaluated 12 months after RALP using Expanded Prostate Cancer Index Composite 26 *** were categorized according to their surgical approach and outcome into the following groups:successful nerve sparing(NS),primarily without nerve sparing(***),and no nerve sparing by secondary resection(NNS by SR).The median levels of their questionnaire outcomes were evaluated and compared using the Wilcoxon rank sum test with continuity ***:Urinary continence status 12 months after RALP differed significantly between the NS and ***(p=0.0071)and the NS and NNS by SR(p=0.0076)*** was no significant difference between the *** and NNS by SR(p=0.53)*** usage 12 months after RALP had no significant difference with regard to SR of the neurovascular bundle(p=0.14).Conclusions:Patient-reported outcomes of long-term urinary continence status seem to show no difference in postoperative continence,regardless of whether a non-nerve-sparing result was planned or reached through ***,preservation of neurovascular bundle seems to lead to better long-term continence rates.

关键词： Prostate cancer Robot-assisted radical prostatectomy Expanded Prostate Cancer Index Composite 26 Urinary incontinence Surgical approach Nerve sparing

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