Study of the degradation behavior and the biocompatibility of Mg-0.8Ca alloy for orthopedic implant applications

作     者：Aya Mohamed Ahmed MEl-Aziz Hans-Georg Breitinger 

作者机构：Materials Engineering DepartmentGerman University in Cairo(GUC)11835 New CairoEgypt Department of BiochemistryGerman University in Cairo(GUC)11835 New CairoEgypt 

出 版 物：《Journal of Magnesium and Alloys》 (镁合金学报（英文）)

年 卷 期：2019年第7卷第2期

页      面：249-257页

核心收录：

学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：The authors would like to thank the Helmholtz-Zentrum Geesthacht and Fesil Company(Germany)for the alloys syn-thesis and casting 

主　　题：Mg-Ca alloys Biodegradability Orthopedic implants Biocompatibility Toxicity Hydroxyapatite 

摘      要：Mg-Ca alloys have recently attracted great attention towards the research in the field of orthopedic biodegradable *** study presents an in vitro degradation assessment of Mg-0.8Ca(0.8 wt.%of Ca)alloy in Hank’s balanced salt solution(HBSS).Immersion,hydrogen evolution and electrochemical behavior was studied as well as the cytotoxicity of the degradation *** and phase composition of the corrosion products were studied using SEM,EDX and XRD *** in HBSS resulted in the formation of the needle-shaped carbonated hydroxyapatite which was similar to the biological apatite in the human *** kinetics showed that Mg-0.8Ca alloy had approximately 3-fold faster degradation rate than the pure Mg(1.08±0.38 mm/year for Mg-0.8Ca and 0.35±0.17 mm/year for pure Mg),as observed in two independent ***,pure Mg and Mg-0.8Ca alloy were biocompatible,generating no cytotoxic degradation products against human-derived HEK 293 ***,the Mg-0.8Ca alloy was found to be a promising biodegradable implant in terms of bioactivity and compatibility with human cell *** on the application of the implant and the estimated healing time of the bone,the desired degradation rate of an implant can be controlled by the Mg-Ca composition of such alloys.