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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： Daniel Adam Felix Langerscheidt hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

Cellular models of stress resistance may pave ways to fight neurodegenerative diseases

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Neural Regeneration Research 2025年第9期20卷 2579-2580页

作者： Thu Nguyen Minh Pham christian Behl Institute of Pathobiochemistry University Medical Center of the Johannes Gutenberg UniversityMainzGermany

Alzheimer's disease(AD),the most common form of neurodegeneration,is characterized by selective neuronal vulnerability and brain regionselective neuron *** entorhinal cortex and hippoc,ampal CA1 projection neurons are at greater risk in AD whereas other regions display resistance to ***,the cerebellum,a phylogenetically very old region,is affected only very late in the disease progression.

关键词： cortex resistance Alzheimer

Many faces of neuronal activity manipulation in Drosophila

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Neural Regeneration Research 2025年第9期20卷 2574-2576页

作者： Amber Krebs Steffen Kautzmann christian Klämbt Institut für Neuro-und Verhaltensbiologie MünsterGermany

Animals exhibit complex responses to external and internal *** information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane *** can neuronal activity orchestrate complex motor patterns or allow learning from previous experience?To answer such questions,we need the ability not only to record,but also to modulate neuronal activity in both space(e.g.,neuronal subsets)and time.

关键词： manipulation potential. neuronal

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al Kabbani Christoph Köhler hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Why Open Government Data? The Case of a Swedish Municipality

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Journal of Data and Information Science 2021年第1期6卷 120-138页

作者： Koraljka Golub arwid Lund Linnaeus University 35195 VäxjöSweden Södertörn University 14189 HuddingeStockholmSweden

Purpose: The purpose of this exploratory study is to provide modern local governments with potential use cases for their open data, in order to help inform related future policies and decision-making. The concrete context was that of the Vaxjo municipality located in southeastern ***/methodology/approach: The methodology was two-fold: 1) a survey of potential end users(n=151) from a local university;and, 2) analysis of survey results using a theoretical model regarding local strategies for implementing open government ***: Most datasets predicted to be useful were on: sustainability and environment;preschool and school;municipality and politics. The use context given is primarily research and development, informing policies and decision making;but also education, informing personal choices, informing citizens and creating services based on open data. Not the least, the need for educating target user groups on data literacy emerged. A tentative pattern comprising a technical perspective on open data and a social perspective on open government was identified. Research limitations: In line with available funding, the nature of the study was exploratory and implemented as an anonymous web-based survey of employees and students at the local university. Further research involving(qualitative) surveys with all stakeholders would allow for creating a more complete picture of the matter. Practical implications: The study determines potential use cases and use contexts for open government data, in order to help inform related future policies and ***/value: Modern local governments, and especially in Sweden, are faced with a challenge of how to make their data open, how to learn about which types of data will be most relevant for their end users and what will be different societal purposes. The paper contributes to knowledge that modern local governments can resort to when it comes to attitudes of local citizens to open government da

关键词： Open data E-government Open government

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仔猪球虫病的诊断

国外畜牧学（猪与禽） 2001年第5期21卷 44-45页

作者：刘理林 hans-christian.arwid daugschies Valeria Letkova 德国拜耳动物保健品公司德国Ludwig-Maximilians大学比较热带医学和寄生虫学研究所斯洛伐克共和国兽医大学寄生虫学系

上一篇文章“Don’tforgetpigletcoccidiosis”(见本刊 2 0 0 1年第三期 52～ 53页──《猪与禽》杂志编者注 )是关于猪等孢球虫病系列文章的导言。猪等孢球虫病越来越被人们承认是仔猪腹泻的重要病因。要对此病进行治疗。

关键词：仔猪球虫病猪群病原体病原物猪等孢球虫病仔猪腹泻

Impact of renewable energies on the operation and economicsituation of coal fired power stations： Actual situation of coalfired power stations in Germany

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Frontiers in Energy 2017年第2期11卷 119-125页

作者： hans-Joachim KRAUTZ Alexander LISK Joachim POSSELT christian KATZER Department for Power Plant Technology Brandenburg University of Technology Cottbus-Senftenberg 03046 Cottbus Gemany

Due to the fluctuating character of the renewable energy sources the demand of conventional power plants for flexibility is increasing. In the recent years, in Germany there has been a fast rise of production capacity of renewable energies, especially from wind turbines, photovoltaic installations, and biomass plants. The installed nominal power of wind turbines is actually (December 2016) 42 GW and of photovoltaic installations 40?GW. The renewable electric energy production in Germany is about 190?TWh/a, which represents a share of 33% of the yearly demand. The increased need for flexibility affects both the power gradients as well as the minimum load of conventional power plants. Due to this flexibility behaviour, conventional power plants are faced with problems concerning the durability of power plant components, corrosion, more maintenance effort and consequently the overall life expectancy. Another consequence of the increasing share of renewable energies is the decreasing full load operating hours, especially of coal fired and gas power plants. Along with decreasing revenues from the energy exchange market, coal fired power plants are faced with new economically challenges.

关键词： flexible load operation minimal load power gradients power plant maintenance corrosion life expectancy

Investigation of the Flow in the Impeller Side Clearances of a Centrifugal Pump with Volute Casing

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Journal of Thermal Science 2012年第3期21卷 197-208页

作者： Bjrn-christian Will Friedrich-Karl Benra hans-Josef Dohmen Institute of Energy and Environmental Engineering TurbomachineryUniversity Duisburg-Essen

The paper is concerned with the fluid flow in the impeller side clearances of a centrifugal pump with volute *** flow conditions in these small axial gaps are of significant importance for a number of effects such as disk friction,leakage losses or hydraulic axial thrust to name but a *** the investigated single stage pump,the flow pattern in the volute turns out to be asymmetric even at design flow *** gain a detailed insight into the flow structure,numerical simulations of the complete pump including the impeller side clearances are ***,the hydraulic head and the radial pressure distributions in the impeller side clearances are measured and compared with the numerical *** configurations of the impeller,either with or without balancing holes,are ***,three different operating points,i.e.:design point,part load or overload conditions are *** addition,analytical calculations are accomplished to determine the pressure distri-butions in the impeller side *** accurate boundary conditions are available,the 1D flow models used in this paper can provide reasonable results for the radial static pressure distribution in the impeller side ***,a counter rotating wake region develops in the rear impeller side clearances in absence of balancing holes which severely affects the inflow and outflow conditions of the cavity in circumferential direction.

关键词： Cavity Rotor-Stator Cavities Side Chambers Centrifugal Pump

Colorectal carcinogenesis-update and perspectives

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World Journal of Gastroenterology 2014年第48期20卷 18151-18164页

作者： hans Raskov hans-christian Pommergaard Jakob Burcharth Jacob Rosenberg Speciall?gecentret ved Diakonissestiftelsen 2000 Frederiksberg Denmark Department of Surgery Herlev Hospital University of Copenhagen DK-2730 Herlev Denmark

Colorectal cancer(CRC)is a very common malignancy in the Western World and despite advances in surgery,chemotherapy and screening,it is still the second leading cause of cancer deaths in this part of the *** factors are found important in the development of CRC including colonocyte metbolism,high risk luminal environment,inflammation,as well as lifestyle factors such as diet,tobacco,and alchohol *** recent years focus has turned towards the genetics and molecular biology of CRC and several interesting and promising correlations and pathways have been *** major genetic pathways of CRC are the Chromosome Instability Pathway representing the pathway of sporadic CRC through the K-ras,APC,and P53 mutations,and the Microsatellite Instability Pathway representing the pathway of he re di t ar y non-polyposis c olon c anc e r t hrough mutations in mismatch repair *** identify early cancers,screening programs have been initiated,and the leading strategy has been the use of faecal occult blood testing followed by colonoscopy in positive *** the treatment of colorectal cancer,significant advances have been made in the recent *** molecular targets of CRC include at least two important cell surface receptors:the epidermal growth factorreceptor and the vascular endothelial growth factor *** genetic and molecular knowledge of CRC has widen the scientific and clinical perspectives of diagnosing and ***,despite significant advances in the understanding and treatment of CRC,results from targeted therapy are still not *** studies will determine the role for this new treatment modality.

关键词： Colorectal carcinogenesis Risk factors Microbiology Genetics Diet Microbiome Inflammation

Numerical Analysis of a System of Singularly Perturbed Convection-Diffusion Equations Related to Optimal Control

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Numerical Mathematics(Theory,Methods and Applications) 2011年第4期4卷 562-575页

作者： hans-Görg Roos christian Reibiger Technische Universität Dresden Institut für Numerische Mathematik01062 DresdenGermany

We consider an optimal control problem with an 1D singularly perturbed differential state *** solving such problems one uses the enhanced system of the state equation and its adjoint ***,we obtain a system of two convectiondiffusion *** linear finite elements on adapted grids we treat the effects of two layers arising at different boundaries of the *** proof uniform error estimates for this method on meshes of Shishkin *** present numerical results supporting our analysis.

关键词： Convection-diffusion linear finite elements a priori analysis layer-adapted meshes singular perturbed optimal control