检索结果-南通市图书馆

Alternative polyadenylation events in epithelial cells sense endometritis progression in dairy cows

j.urnal of Integrative Agriculture 2023年第6期22卷 1820-1832页

作者： Meagan j.STOTTS Yangzi ZHANG Shuwen ZHANG j.nnifer j.MICHAL j.an VELEZ Bothe hans Martin MAQUIVAR Zhihua j.ANG Department of Animal Sciences and Center for Reproductive Biology Washington State UniversityPullmanWA 99164-7620USA Aurora Organic Farms PlattevilleCO 80651USA

Endometritis(inflammation of the endometrial lining) is one of the most devastating reproductive diseases in dairy cattle, resulting in substantial production loss and causing more than $650 million in lost revenue annually in the *** hypothesize that alternative polyadenylation(APA) sites serve as decisive sensors for endometrium health and disease in dairy cows. Endometrial cells collected from 18 cows with purulent vaginal discharge scored 0 to 2 were used for APA profiling with our whole transcriptome termini site sequencing(WTTS-seq) method. Overall, pathogens trigger hosts to use more differentially expressed APA(DE-APA), more intronic DE-APA, more DE-APA sites per gene and more DE-genes associated with inflammation. Host CD59 molecule(CD59), Fc fragment of IgG receptor IIa(FCGR2A), lymphocyte antigen 75(LY75) and plasminogen(PLG) may serve as initial contacts or combats with pathogens on cell surface, followed by activation of nuclear receptor subfamily 1 group H member 4(NR1H4) to regulate AXL receptor tyrosine kinase(AXL), FGR proto-oncogene, Src family tyrosine kinase(FGR), HCK protooncogene, Src family tyrosine kinase(HCK) and integrin subunit beta 2(ITGB2) for anti-inflammation. This study is the first to show significance of cilium pathways in endometrium health and animal reproduction. MIR21 and MIR30A would be perfect antagonistic biomarkers for diagnosis of either inflammation or anti-inflammation. These novel findings will set precedent for future genomic studies to aid the dairy industry develop new strategies to reduce endometritis incidence and improve fertility.

关键词： organic dairy endometritis alternative polyadenylation infection progression antagonistic biomarkers

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ileo-right hemi-colonic cervical pull-up on a non-supercharged ileocolic arterial pedicle: A technical and case report

引用

World j.urnal of Gastroenterology 2016年第14期22卷 3869-3874页

作者： Andreas RR Weiss Christina Hackl Yorick Soeder hans j.Schlitt Marc-H Dahlke Department of Surgery University Medical Center Regensburg

Esophageal reconstruction can be challenging when stomach and colon are not anatomically intact and their use as esophageal substitutes is therefore limited. Innovative individual approaches are then necessary to restore the intestinal passage. We describe a technique in which a short stump of the right hemicolon and 25 cm of ileum on a long, non-supercharged, fully mobilized ileocolic arterial pedicle were used for esophageal reconstruction to the neck. In this case, a 65 year-old male patient had accidentally indigested hydrochloric acid which caused necrosis of his upper digestive tract. An emergency esophagectomy, gastrectomy, duodenectomy, pancreatectomy and splenectomy had been performed in an outside hospital. A cervical esophagostomy and a biliodigestive anastomosis had been created and a j.j.nal catheter for enteral feeding had been placed. After the patient had recovered, a reconstruction of his food passage via the left and transverse colon failed for technical reasons due to an intraoperative necrotic demarcation of the colon. Our team then faced the situation that only a short stump of the right hemi-colon was left in situ when the patient was referred to our center. After intensified nutritional therapy, we reconstructed this patient's food passage with the right hemicolonapproach described herein. After treatment of a postoperative pneumonia, the patient was discharged from hospital on the 26 th postoperative day in a good clinical condition on an oral-only diet. In conclusion, individual approaches for long-segment reconstruction of the esophagus can be technically feasible in experienced hands. They do not always require arterial supercharging or free intestinal transplantation.

关键词： Esophageal cancer Esophageal trauma Esophageal reconstruction Gastric pull-up Colonic interposition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

First-line endoscopic treatment with over-the-scope clips significantly improves the primary failure and rebleeding rates in high-risk gastrointestinal bleeding: A single-center experience with 100 cases

引用

World j.urnal of Gastroenterology 2016年第41期22卷 9162-9171页

作者： hans-j.rgen Richter-Schrag Torben Glatz Christine Walker Andreas Fischer Robert Thimme Center of Interdisciplinary Gastrointestinal Endoscopy Department of Medicine II Medical Center-University of Freiburg Faculty of Medicine University of Freiburg Department of General and Visceral Surgery Medical Center-University of Freiburg Faculty of Medicine University of Freiburg

AIM To evaluate rebleeding, primary failure(PF) and mortality of patients in whom over-the-scope clips(OTSCs) were used as first-line and second-line endoscopic treatment(FLET, SLET) of upper and lower gastrointestinal bleeding(UGIB, LGIB).METHODS A retrospective analysis of a prospectively collected database identified all patients with UGIB and LGIB in a tertiary endoscopic referral center of the University of Freiburg, Germany, from 04-2012 to 05-2016(n= 93) who underwent FLET and SLET with OTSCs. The complete Rockall risk scores were calculated from patients with UGIB. The scores were categorized as < or ≥ 7 and were compared with the original Rockall data. Differences between FLET and SLET were calculated. Univariate and multivariate analysis were performed to evaluate the factors that influenced rebleeding after OTSC *** Primary hemostasis and clinical success of bleeding lesions(without rebleeding) was achieved in 88/100(88%) and 78/100(78%), respectively. PF was significantly lower when OTSCs were applied as FLET compared to SLET(4.9% vs 23%, P = 0.008). In multivariate analysis, patients who had OTSC placement as SLET had a significantly higher rebleeding risk compared to those who had FLET(OR 5.3; P = 0.008). Patients with Rockall risk scores ≥ 7 had a significantly higher in-hospital mortality compared to those with scores < 7(35% vs 10%, P = 0.034). No significant differences were observed in patients with scores < or ≥ 7 in rebleeding and rebleeding-associated *** Our data show for the first time that FLET with OTSC might be the best predictor to successfully prevent rebleeding of gastrointestinal bleeding compared to SLET. The type of treatment determines the success of primary hemostasis or primary failure.

关键词： Gastrointestinal bleeding Rockall risk score Over-the-scope clip First-line endoscopic treatment Second-line endoscopic treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

被动与自调Q激光脉冲重复频率的理论和实验(英文)

引用

光电子．激光 2001年第8期12卷 802-805页

作者：朱长虹李正佳周海丘军林朱奇刘百宁 H.j.eichler 华中科技大学武汉430074 柏林技术大学光学研究所德国柏林d10623

对被动或自调 Q激光器的速率方程运用绝热近似方法和 Hopf分岔条件进行分析 ,导出光学参量与脉冲重复频率之间的解析表达式。针对 Cr:Nd:YAG调 Q激光器的实验数据进行了计算。

关键词：自调Q激光器脉冲重复频率绝热近似激光脉冲

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

EXCEPTIONALLY HIGH AND DIVERSE MUTATION RATES IN INSECTS SMALL rRNA

引用

Science China Chemistry 1985年第10期28卷 1060-1063页

作者：冯亚雄 KRUPP GUIDO GROSS j.hans Academia Siaica Institut für Biochemie der Universitt Würzburg Shanghai Institute of Biochemistry D-8700 Würzburg FRG Rontgenring 11

The nucleotide sequence of 5S rRNA from the posterior silk gland of the silk worm Philosamia cynthia ricini has been determined. The comparison with other insect 5S rRNAs revealed an exceptionally conserved secondary structure, in spite of an extremely high mutation rate: Thirteen nucleotides are different in Philosamia and Drosophila 5S rRNA, but all substitutions are either compensatory or occur in loops or introduce G:U base pairs. The rates of base substitution per site per year of several insect species (diptera and lepidoptera) 5S and 5.8S rRNAs are compared with those occurring in vertebrate rRNAs. In the latter cases the rates are remarkably constant, whereas their value is not only about twofold higher in insect rRNAs, but is found to be extremely large in the 5S rRNA of the silkworm Bombyx mori. These data demonstrate that phylogcnetic conclusions derived from small rRNA sequence comparisons are only of limited value.

关键词： EXCEPTIONALLY HIGH AND DIVERSE MUTATION RATES IN INSECTS SMALL rRNA rate

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Persistent astrocytic IL-3 stimulation of microglia slows disease in Alzheimer’s:treatment perspectives for Alzheimer’s

引用

Signal Transduction and Targeted Therapy 2021年第12期6卷 3369-3370页

作者： Natj. Haag hans Zempel Institute of Human Genetics Medical FacultyRWTH Aachen UniversityAachenGermany Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany

In their new paper,McAlpine and colleagues provide compelling evidence that astrocyte dependent microglial stimulation is crucial for fighting off one of the most prominent Alzheimer disease(AD)pathological hallmarks,namelyβ-amyloid(Aβ)plaque *** find that(i)a subpopulation of astrocytes secrete the classical cytokine interleukin-3(IL-3),(ii)microglia are responsive to this cytokine,(iii)responsiveness(not so much secretion of IL-3)is increased in patients with AD and model systems of AD,and(iv)presence of IL-3 is necessary to allow microglia to counteract some of the detrimental effects of AD:if IL-3 is missing,AD pathology worsens(see Fig.1 for graphical depiction).1 AD and related tauopathies,e.g.,frontotemporal dementia(FTD)or frontotemporal lobar degeneration with tauopathy(FTLDTAU),are detrimental diseases,impose a huge burden on patients and caregivers,and are the scourge of modern healthcare *** recent advances in(immuno-)therapies,a causative cure seems out of range.

关键词： stimulation Alzheimer degeneration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development and application of phase diagrams for Li-ion batteries using CALPHAD approach

引用

Progress in Natural Science:Materials International 2019年第3期29卷 265-276页

作者： Na Li Daj.an Li Weibin Zhang Keke Chang Feng Dang Yong Du hans j.Seifert Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) Shandong University Institute for Applied Materials–Applied Materials Physics (IAM-AWP) Karlsruhe Institute of Technology (KIT) Engineering Laboratory of Advanced Energy Materials Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences State Key Laboratory of Powder Metallurgy Central South University

Phase diagrams provide fundamental knowledge about design map of new electrode materials for Li-ion batteries. The CALPHAD (CALculation of PHAse Diagrams) approach is widely applied to the development of phase diagrams and property diagrams in a thermodynamic language. Within the CALPHAD framework, the theoretical modeling can be performed to predict phase equilibria, thermodynamics, electrochemical and physical properties of electrodes. This review provides the successful application of high quality calculated phase diagrams and thermodynamic property diagrams in CALPHAD investigation to both cathodes and anodes of Li-ion batteries, including Li–Co–O, Li–Ni–O, Li–Co–Ni–O, Li–Mn–O, Li–Cu–O, Li–Si, Li–Sb and Li–Sn systems with. The intensive CALPHAD-type research may also predict electrochemical properties, cell performance of the Li-ion batteries to achieve more efficient development of electrode materials.

关键词： Li-Ion battery Phase diagram CALPHAD Thermodynamic property Electrochemical behavior

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Magnetically actuated glaucoma drainage devicefor regulating intraocular pressure afterimplantation

引用

Microsystems & Nanoengineering 2023年第4期9卷 91-105页

作者： Inês C.F.Pereira Ralph j.S.van Mechelen hans M.Wyss Leonard Pinchuk Henny j.M.Beckers j.ap M.j.den Toonder Microsystems Department of Mechanical EngineeringEindhoven University of Technology5600MB EindhovenThe Netherlands Institute for Complex Molecular Systems(ICMS) Eindhoven University of Technology5600MB EindhovenThe Netherlands University Eye Clinic Maastricht Maastricht University Medical Centre+(MUMC+)6202AZ MaastrichtThe Netherlands InnFocus Inc.a Santen CompanyMiamiFlorida 33186USA Ophthalmic Biophysics Center Bascom Palmer Eye InstituteUniversity of Miami Miller School of MedicineMiamiFlorida 33136USA

The key risk factor for glaucoma is increased intraocular pressure (IOP). Glaucoma drainage devices implanted in theeye can reduce IOP and thus stop disease progression. However, most devices currently used in clinical practice arepassive and do not allow for postsurgical IOP control, which may result in serious complications such as hypotony (i.e.,excessively low IOP). To enable noninvasive IOP control, we demonstrate a novel, miniature glaucoma implant that willenable the repeated adj.stment of the hydrodynamic resistance after implantation. This is achieved by integrating amagnetic microvalve containing a micropencil-shaped plug that is moved using an external magnet, thereby openingor closing fluidic channels. The microplug is made from biocompatible poly(styrene-block-isobutylene-block-styrene)(SIBS) containing iron microparticles. The complete implant consists of an SIBS drainage tube and a housing elementcontaining the microvalve and fabricated with hot embossing using femtosecond laser-machined glass molds. Usingin vitro and ex vivo microfluidic experiments, we demonstrate that when the microvalve is closed, it can providesufficient hydrodynamic resistance to overcome hypotony. Valve function is repeatable and stable over time. Due to itssmall size, our implant is a promising, safe, easy-to-implant, minimally invasive glaucoma surgery device.

关键词： enable implantation overcome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Models and Neural Bases of the Believing Process

引用

j.urnal of Behavioral and Brain Science 2015年第1期5卷 12-23页

作者： Motoaki Sugiura Rüdiger j. Seitz hans-Ferdinand Angel Institute of Development Aging and Cancer Tohoku University Sendai Japan International Research Institute of Disaster Science Tohoku University Sendai Japan Centre for Neurology and Neuropsychiatry LVR-Klinikum Düsseldorf Heinrich-Heine-University Düsseldorf Düsseldorf Germany Institute of Catechetics and Religious Education Karl-Franzens-University Graz Graz Austria

Departing from the long debates on the role of faith/belief, recent interdisciplinary research has turned to characterize the features of the psychophysical processes underlying believing. Here we review recent cognitive neuroscience models of the believing process and propose a conceptual framework that integrates current theoretical and empiric knowledge about the processes of believing. There are theories that elegantly explain believing as a self-organization process of cognitive and emotional elements. Adding to the component of self-organized belief representation, dual-component models assume a belief evaluation component, which is probably supported by the right dorsolateral prefrontal cortex (DLPFC) and explains the stability of the belief despite the changing environment. Borrowing an idea from the neural models for the mental representation of action or situation, inclusion of both perceptive and action informations as the construct of belief representation allows the intimate relationship between a specific belief and a specific range of behaviour. Furthermore, inclusion of the personal value or affective information in the representation explains the deep impact of one’s emotional and physical state on the believing process. For associating perception, action, and value in a representation, the medial frontal cortex (MFC) may play a key role. Recent neuro-cognitive models of self-cognition explain the developmental origin of such a representation and the hierarchically nested structure of three levels of complexity in the representations: basic physical level, interpersonal level, and higher social level. The integrated model provides a comprehensive perspective of the believing process which suggests the importance and future directions of this interdisciplinary approach.

关键词： Association Learning Believing Credition Delusion Frontal Cortex Self Value

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

关于倍频绿光问题的研究(英文)

引用

激光技术 2001年第6期25卷 425-429页

作者：朱长虹刘百宁李正佳王英丘军林李德华张治国 Volker Gabler hans j.achim eichler 华中科技大学国家激光技术重点实验室武汉430074 Optisches Institute TU-Berlin 中国科学院物理研究所北京100080

采用双波片晶体的物理模型和j.nes矩阵方法 ,得到了在连续多纵模腔内倍频激光器中压缩噪声的必要条件 ,推导出与Ⅱ类和Ⅰ类相位匹配方式相对应的消除和频效应的公式 ,并推广为往返j.nes矩阵元所应满足的关系 ,以及相应的腔内本征矢。

关键词：和频效应 Ⅰ类相位匹配方式倍频效应 Ⅱ类相位匹配方式倍频绿光问题腔内倍频激光器腔内本征矢

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：