Persistent astrocytic IL-3 stimulation of microglia slows disease in Alzheimer’s:treatment perspectives for Alzheimer’s

作     者：Natja Haag Hans Zempel Natja Haag;Hans Zempel

作者机构：Institute of Human GeneticsMedical FacultyRWTH Aachen UniversityAachenGermany Institute of Human GeneticsFaculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC)Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第12期

页      面：3369-3370页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：This research was funded by the Else-Kröner-Fresenius Stiftung(2019_A41) the Jürgen-Manchot-Stiftung and was supported by the Koeln Fortune Program/Faculty of Medicine,University of Cologne(assigned to HZ) a START-grant from the RWTH/University Hospital Aachen assigned to NH 

主　　题：stimulation Alzheimer degeneration 

摘      要：In their new paper,McAlpine and colleagues provide compelling evidence that astrocyte dependent microglial stimulation is crucial for fighting off one of the most prominent Alzheimer disease(AD)pathological hallmarks,namelyβ-amyloid(Aβ)plaque *** find that(i)a subpopulation of astrocytes secrete the classical cytokine interleukin-3(IL-3),(ii)microglia are responsive to this cytokine,(iii)responsiveness(not so much secretion of IL-3)is increased in patients with AD and model systems of AD,and(iv)presence of IL-3 is necessary to allow microglia to counteract some of the detrimental effects of AD:if IL-3 is missing,AD pathology worsens(see Fig.1 for graphical depiction).1 AD and related tauopathies,e.g.,frontotemporal dementia(FTD)or frontotemporal lobar degeneration with tauopathy(FTLDTAU),are detrimental diseases,impose a huge burden on patients and caregivers,and are the scourge of modern healthcare *** recent advances in(immuno-)therapies,a causative cure seems out of range.