Magnetically actuated glaucoma drainage devicefor regulating intraocular pressure afterimplantation

作     者：Inês C.F.Pereira Ralph J.S.van Mechelen Hans M.Wyss Leonard Pinchuk Henny J.M.Beckers Jaap M.J.den Toonder 

作者机构：MicrosystemsDepartment of Mechanical EngineeringEindhoven University of Technology5600MB EindhovenThe Netherlands Institute for Complex Molecular Systems(ICMS)Eindhoven University of Technology5600MB EindhovenThe Netherlands University Eye Clinic MaastrichtMaastricht University Medical Centre+(MUMC+)6202AZ MaastrichtThe Netherlands InnFocusInc.a Santen CompanyMiamiFlorida 33186USA Ophthalmic Biophysics CenterBascom Palmer Eye InstituteUniversity of Miami Miller School of MedicineMiamiFlorida 33136USA 

出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)

年 卷 期：2023年第9卷第4期

页      面：91-105页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 100212[医学-眼科学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学] 10[医学] 

基　　金：This research was financially supported by the Chemelot Institute for Science&Technology(InSciTe)under grant agreement BM3.03 SEAMS 

主　　题：enable implantation overcome 

摘      要：The key risk factor for glaucoma is increased intraocular pressure (IOP). Glaucoma drainage devices implanted in theeye can reduce IOP and thus stop disease progression. However, most devices currently used in clinical practice arepassive and do not allow for postsurgical IOP control, which may result in serious complications such as hypotony (i.e.,excessively low IOP). To enable noninvasive IOP control, we demonstrate a novel, miniature glaucoma implant that willenable the repeated adjustment of the hydrodynamic resistance after implantation. This is achieved by integrating amagnetic microvalve containing a micropencil-shaped plug that is moved using an external magnet, thereby openingor closing fluidic channels. The microplug is made from biocompatible poly(styrene-block-isobutylene-block-styrene)(SIBS) containing iron microparticles. The complete implant consists of an SIBS drainage tube and a housing elementcontaining the microvalve and fabricated with hot embossing using femtosecond laser-machined glass molds. Usingin vitro and ex vivo microfluidic experiments, we demonstrate that when the microvalve is closed, it can providesufficient hydrodynamic resistance to overcome hypotony. Valve function is repeatable and stable over time. Due to itssmall size, our implant is a promising, safe, easy-to-implant, minimally invasive glaucoma surgery device.