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Prevalence, Grades and Management of Prostate Cancer among Men Attending Oncology Unit at Bugando Medical Centre Mwanza, Tanzania

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Open journal of Epidemiology 2022年第2期12卷 146-157页

作者： Deogratias M. Katabalo joyce josephat Winfrida Minja Stanley Mwita Karol j. Marwa Peter Rambau Department of Pharmaceutics and Pharmacy Practice School of Pharmacy Catholic University of Health and Allied Sciences Mwanza Tanzania Department of Pharmacology School of Medicine Catholic University of Health and Allied Sciences Mwanza Tanzania Department of Pathology School of Medicine Catholic University of Health and Allied Sciences Mwanza Tanzania

Background: Prostate cancer is the second most frequent cancer in men after lung cancer, it accounts for 3.8% of all deaths caused by cancer in men worldwide. This study aimed at determining the prevalence, grades and management of prostate cancer among male patients admitted with cancer at Oncology Department of Bugando Medical Centre. Methodology: This was a hospital-based retrospective cross-section study that retrieved data from 384 medical files of male patients admitted with cancer in Oncology wards at Bugando Medical Centre from january 2017 to December 2020. Results: The prevalence of prostate cancer was 39.84% (153 of 384 male patients). The mean age of patients with prostate cancer was 64.85 years ± 14.59 years. Two third of the patients’ prostate cancer were graded at presentation and of these, 52.58% (51 of 97) were having a high grade prostate cancer of Gleason scores 8, 9 or 10. Treatment involved hormonal therapy, chemotherapy and Radiotherapy whereby 49.48% (n = 190) were treated with hormonal therapy (Goserelin and Bicalutamide), 32.03% (n = 123) with combination of hormonal and chemotherapy, (Goserelin, bicalutamide and docetaxel or paclitaxel), 15.69% (n = 60) with combination of radiotherapy and hormonal therapy and 2.6% (n = 11) with chemotherapy alone (Docetaxel). Conclusion: The study found high prevalence of prostate cancer among male patients, majority with high grade form and limited options of treatment. Frequent screening and awareness programs should be conducted to enable early detection to reduce its morbidity and mortality. Patient on treatment should be followed up to determine their response to treatments.

关键词： Prostate Cancer Prevalence Management Tanzania

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Fish vaccines:current state and future trends

Fish vaccines:current state and future trends

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中国工程院第77场工程科技论坛·2008水产科技论坛——渔业现代化与可持续发展

作者： Phillip H.Klesius Craig A.Shoemaker joyce j.Evans Aquatic Animal Health Research Laboratory Agricultural Research ServiceU.S.Department of AgricultureAuburnAlabama 36832 and ChestertownMaryland 21620U.S.A.

A vaccine is a preventive tool used in a health management strategy for the control of infectious diseases in *** more than 100 years,vaccines have proved to be an effective tool for preventing infectious disease outbreaks in humans,poultry and other food *** aquaculture, the development and use of vaccines is now making rapid progress to achieve its full potential as effective disease prevention *** objective of vaccination is to provide a strong immune response to an administered antigen able to provide acquired long-term protection against a *** achieve this objective either a killed or modified live vaccine needs to be developed and licensed for use in fresh or marine water *** type of immunity needed,antibody and/or cell-mediated against,a particular pathogen is among the deciding factors in the development of a *** with a killed bacterial vaccine produces an antibody-mediated protection,but not cell-mediated *** and/or antibody-mediated immunity can be provided only by immunization with a modified live ***,antibody-mediated immunity provided by killed vaccines is relatively short lived in terms of protection(3-5 months).Longer protection(≥12 months)is provided by modified live *** duration of protection may be increased by the addition of an adjuvant to the killed *** adjuvant is a substance that increases specific immune responses against the co-inoculated *** vaccines are usually administered by intraperitonal and/or intramuscular injection of individual *** is the least cost effective in terms of labor and time. Modified live vaccines may be administered by bath immersion to large numbers of fish(fry and/or eggs)which is a more cost effective method of mass vaccination in both labor and *** vaccines are considered to be safer than modified live vaccines which may revert to ***, future trends include oral del

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Development of a modular, biocompatible thiolated gelatin microparticle platform for drug delivery and tissue engineering applications

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Regenerative Biomaterials 2021年第3期8卷 45-56页

作者： hannah A.Pearce Yu Seon Kim Emma Watson Kiana Bahrami Mollie M.Smoak Emily Y.jiang Michael Elder Tate Shannon Antonios G.Mikos Department of Bioengineering Rice University6500 Main StreetHoustonTX 77030USA

The field of biomaterials has advanced significantly in the past *** the growing need for high-throughput manufacturing and screening,the need for modular materials that enable streamlined fabrication and analysis of tissue engineering and drug delivery schema has *** are a powerful platform that have demonstrated promise in enabling these technologies without the need to modify a bulk *** building block paradigm of using microparticles within larger scaffolds to control cell ratios,growth factors and drug release holds *** microparticles(GMPs)are a well-established platform for cell,drug and growth factor *** of the challenges in using GMPs though is the limited ability to modify the gelatin *** the present work,we hypothesized that by thiolating gelatin before microparticle formation,a versatile platform would be created that preserves the cytocompatibility of gelatin,while enabling post-fabrication *** thiols were not found to significantly impact the physicochemical properties of the ***,the thiolated GMPs were demonstrated to be a biocompatible and robust platform for mesenchymal stem cell ***,the thiolated particles were able to be covalently modified with a maleimide-bearing fluorescent dye and a peptide,demonstrating their promise as a modular platform for tissue engineering and drug delivery applications.

关键词： gelatin microparticles thiolated gelatin microparticles click chemistry cell delivery drug delivery tissue engineering biomaterials

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Effects of Resistant Starch on Symptoms,Fecal Markers,and Gut Microbiota in Parkinson’s Disease—The RESISTA-PD Trial

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Genomics, Proteomics & Bioinformatics 2022年第2期20卷 274-287页

作者： Anouck Becker Georges Pierre Schmartz Laura Groger Nadja Grammes Valentina Galata hannah Philippeit jacqueline Weiland Nicole Ludwig Eckart Meese Sascha Tierling jorn Walter Andreas Schwiertz jorg Spiegel Gudrun Wagenpfeil Klaus Faßbender Andreas Keller Marcus M.Unger Department of Neurology Saarland UniversityD-66421 HomburgGermany Chair for Clinical Bioinformatics Saarland UniversityD-66123 SaarbruckenGermany Department of Human Genetics Saarland UniversityD-66421 HomburgGermany Department of Genetics/Epigenetics Saarland UniversityD-66123 SaarbruckenGermany Institute of Microecology D-35745 HerbornGermany Institute of Medical Biometry Epidemiology and Medical InformaticsSaarland UniversityD-66421 HomburgGermany Department of Neurology Stanford UniversityPalo AltoCA 94305USA

The composition of the gut microbiota is linked to multiple diseases,including Parkinson’s disease(PD).Abundance of bacteria producing short-chain fatty acids(SCFAs)and fecal SCFA concentrations are reduced in *** exert various beneficial functions in *** the interventional,monocentric,open-label clinical trial “Effects of Resistant Starch on Bowel Habits,Short Chain Fatty Acids and Gut Microbiota in Parkinson’s Disease”(RESISTA-PD;ID:NCT02784145),we aimed at altering fecal SCFAs by an 8-week prebiotic intervention with resistant starch(RS).We enrolled 87 subjects in three study-arms:32 PD patients received RS(PD+RS),30 control subjects received RS,and 25 PD patients received solely dietary *** performed paired-end 100 bp length metagenomic sequencing of fecal samples using the BGISEQ platform at an average of 9.9 *** was *** the PD+RS group,fecal butyrate concentrations increased significantly,and fecal calprotectin concentrations dropped significantly after 8 weeks of RS ***,we observed a reduction in non-motor symptom load in the PD+RS *** reference-based analysis of metagenomes highlighted stable alpha-diversity and beta-diversity across the three groups,including bacteria producing ***-free analysis suggested punctual,yet pronounced differences in the metagenomic signature in the PD+RS ***-PD highlights that a prebiotic treatment with RS is safe and well-tolerated in *** stable alpha-diversity and beta-diversity alongside altered fecal butyrate and calprotectin concentrations call for long-term studies,also investigating whether RS is able to modify the clinical course of PD.

关键词： Parkinson’s disease Short-chain fatty acid Microbiota Metagenomics Intestinal inflammation

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Plasma-polymerized pericyte patches improve healing of murine wounds through increased angiogenesis and reduced inflammation

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Regenerative Biomaterials 2021年第4期8卷 21-32页

作者： hannah M.Thomas Parinaz Ahangar Robert Fitridge Giles T.S.Kirby Stuart j.Mills Allison j.Cowin Future Industries Institute University of South AustraliaMawson Lakes SA 5095Australia Cell Therapy Manufacturing Cooperative Research Centre Adelaide SA 5000Australia Faculty of Health and Medical Sciences University of AdelaideAdelaide SA 5005Australia

Pericytes have the potential to be developed as a cell therapy for the treatment of wounds;however,the efficacy of any cell therapy relies on the successful delivery of intact and functioning ***,the effect of delivering pericytes on wound repair was assessed alongside the development of a surface-functionalized pericyte *** polymerization(PP)was used to functionalize the surface of silicone patches with heptylamine(HA)or acrylic acid(AA)*** pericytes were subsequently delivered to murine excisional wounds by intradermal injection or using the pericyte-laden patches and the comparative effects on wound healing,inflammation and revascularization *** AA surface provided the superior transfer of the cells to de-epidermized *** murine wounds treated either with pericytes injected directly into the wound or with the pericyte-laden AA patches showed improved healing with decreased neutrophil infiltration and reduced numbers of macrophages in the *** delivery also enhanced angiogenesis through a mechanism independent of VEGF ***,when delivered to wounds,improved healing responses by dampening inflammation and promoting *** of pericytes using PP-AA-functionalized patches was equally as effective as direct injection of pericytes into ***-functionalized dressings may therefore be a clinically relevant approach for the treatment of wounds.

关键词： pericytes cell therapy wound healing plasma polymerization advanced surfaces

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The Case for Integrative Sustainable Development Practice Based on the Minas Conga Gold-Mining Experience in Peru

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journal of Geoscience and Environment Protection 2020年第5期8卷 17-40页

作者： Timothy j. Downs Andrea Cabrera Roa Katherine Chyna Dixon Phyllis Duff Eric Pasay hannah Silverfine International Development Community and Environment Department (IDCE) Clark University Worcester USA

Mining projects are among the most impactful development projects, and the most controversial. The Conga Mining Project, proposed by the U.S. based Newmont Mining Corporation, in partnership with Minas Buenaventura, was slated for the Cajamarca region of Peru. Since the Environmental Impact Assessment (EIA) was completed in 2010, controversy has escalated: public protests have precipitated a political crisis for President Humala, with several ministers resigning. The proposed project would have been made located approximately 73 km northeast of the city of Cajamarca, in the northern Peruvian Andes, in the district of Sorochuco, within an area defined by four major lakes, headwaters of rivers, and wetlands. Despite findings of “no significant impact” by the 2010 EIA, the project is currently postponed indefinitely due to the public backlash, international attention, and questions of integrity surrounding environmental and social concerns. We use the Conga Mining case to interrogate business-as-usual (BAU) design, assessment, planning, implementation and monitoring practices for extractive development in Peru, and suggest alternatives. Our analysis is based on an integrative framework that is empirically based (previously developed by the authors), one with a greater likelihood of improving sustainable development and the equity of positive and negative impacts among stakeholders. Suggestions are tailored to the setting: we pay special attention to the climate-change and socio-political contexts of Peru. We seek to exploit a shifting political landscape that is resisting BAU and countering the systematic disenfranchisement of vulnerable populations by extractive resource industries. These appear to be enabling conditions to promote the adoption of a capacity building, socio-technical enterprise approach to framing and designing sustainable development projects in Peru, with implications beyond.

关键词： Peru Mining Sustainable Development EIA Capacity Building

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教学模式 1版

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丛书名：基础教育改革与发展译丛i教学模式与方法系列

2002年

作者：（美）Bruce joyce等荆建华等译

本书共分6部分28章，详尽地阐述了社会型、信息加工型、个人型和行为系统型四种教学模式及其各自所包含的具体内容。

ISBN: (纸本)7501934401

本书共分6部分28章，详尽地阐述了社会型、信息加工型、个人型和行为系统型四种教学模式及其各自所包含的具体内容。

关键词：文化、科学、教育、体育教育教学理论

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Serological Targeted Analysis of an ITIH4 Peptide Isoform: A Preterm Birth Biomarker and Its Associated SNP Implications

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journal of Genetics and Genomics 2015年第9期42卷 507-510页

作者： Zhou Tan Zhongkai Hu Emily Y.Cai Cantas Alev Ting Yang Zhen Li joyce Sung Yasser Yehia El-Sayed Gary M.Shaw David K.Stevenson Atul j.Butte Guojun Sheng Karl G.Sylvester Harvey j.Cohen Xuefeng B.Ling Institute of Developmental and Regenerative Biology Hangzhou Normal University Department of Surgery Stanford University Lab for Early Embryogenesis RIKEN Center for Developmental Biology Department of Obstetrics and Gynecology Stanford University Department of Pediatrics Stanford University Stanford

Over 11% of all pregnancies in the US result in preterm birth, greatly contributing to perinatal morbidity and mortality （Goldenberg and Rouse, 1998）. Preterm birth etiologies remain largely unknown, and effective prevention methods have yet to be developed. The use of biofluid （e.g., serum or urine） for the analysis of the naturally occurring peptidome （MW 〈 4000） as a source of biomarkers has been reported for different diseases （Villanueva et al., 2006; Ling et al., 2010a, 2010b, 2010c, 2011）. Mass spectrometry-based profiling of naturally occurring peptides can provide an extensive in- ventory of serum peptides derived from either high-abundant endogenous circulating proteins or cell and tissue proteins （Liotta and Petricoin, 2006）.

关键词： Serological Targeted Analysis of an ITIH4 Peptide Isoform A Preterm Birth Biomarker and Its Associated SNP Implications SNP

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一个青年艺术家的画像

一个青年艺术家的画像

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作者： (爱尔兰)詹姆斯·乔伊斯(j. joyce)

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THE WEST IN THE WORLD 2nd

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2004年

作者： DENNIS SHERMAN joyce SALISBURY

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