Development of a modular, biocompatible thiolated gelatin microparticle platform for drug delivery and tissue engineering applications
作者机构：Department of BioengineeringRice University6500 Main StreetHoustonTX 77030USA
出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)
年 卷 期：2021年第8卷第3期
页 面：45-56页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程]
基 金：This work was supported by the National Institutes of Health(R01 AR068073 and P41 EB023833) H.A.P.,M.M.S.and E.Y.J.acknowledge support from the National Science Foundation Graduate Research Fellowship Program.M.M.S.also acknowledges support from the Ford Doctoral Fellowship Program.E.W.received support from Ruth L.Kirschstein Fellowship and the National Institute of Dental and Craniofacial Research(F31 DE027586)
主 题：gelatin microparticles thiolated gelatin microparticles click chemistry cell delivery drug delivery tissue engineering biomaterials
摘 要：The field of biomaterials has advanced significantly in the past *** the growing need for high-throughput manufacturing and screening,the need for modular materials that enable streamlined fabrication and analysis of tissue engineering and drug delivery schema has *** are a powerful platform that have demonstrated promise in enabling these technologies without the need to modify a bulk *** building block paradigm of using microparticles within larger scaffolds to control cell ratios,growth factors and drug release holds *** microparticles(GMPs)are a well-established platform for cell,drug and growth factor *** of the challenges in using GMPs though is the limited ability to modify the gelatin *** the present work,we hypothesized that by thiolating gelatin before microparticle formation,a versatile platform would be created that preserves the cytocompatibility of gelatin,while enabling post-fabrication *** thiols were not found to significantly impact the physicochemical properties of the ***,the thiolated GMPs were demonstrated to be a biocompatible and robust platform for mesenchymal stem cell ***,the thiolated particles were able to be covalently modified with a maleimide-bearing fluorescent dye and a peptide,demonstrating their promise as a modular platform for tissue engineering and drug delivery applications.
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