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Clinical benefit of COX-2 inhibitors in the adjuvant chemotherapy of advanced non-small cell lung cancer: A systematic review and metaanalysis

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World Journal of Clinical Cases 2021年第3期9卷 581-601页

作者： Yu-Qiong Xu Xiang Long ming han ming-Qiang Huang Jia-Fa Lu Xue-Dong Sun Wei han Department of Emergency Medicine Shenzhen University General HospitalShenzhen University Clinical Medical AcademyShenzhen 518000Guangdong ProvinceChina Department of Respiratory and Critical Care Medicine Peking University Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina

BACKGROUND Lung cancer is a major cause of death among patients,and non-small cell lung cancer(NSCLC)accounts for more than 80%of all lung cancers in many *** To evaluate the clinical benefit(CB)of COX-2 inhibitors in patients with advanced NSCLC using systematic *** We searched the six electronic databases up until December 9,2019 for studies that examined the efficacy and safety of the addition of COX-2 inhibitors to chemotherapy for *** survival(OS),progression free survival(PFS),1-year survival rate(SR),overall response rate(ORR),CB,complete response(CR),partial response(PR),stable disease(SD),and toxicities were measured with more than one outcome as their *** and random effects models were used to calculate risk estimates in a *** publication bias was calculated using Egger’s linear regression *** analysis was performed using R *** The COX-2 inhibitors combined with chemotherapy were not found to be more effective than chemotherapy alone in OS,progression free survival,1-year SR,CB,CR,and ***,there was a difference in overall response rate for patients with advanced *** a subgroup analysis,significantly increased ORR results were found for celecoxib,rofecoxib,first-line treatment,and *** adverse events,the increase in COX-2 inhibitor was positively correlated with the increase in grade 3 and 4 toxicity of leukopenia,thrombocytopenia,and cardiovascular *** COX-2 inhibitor combined with chemotherapy increased the total effective rate of advanced NSCLC with the possible increased risk of blood toxicity and cardiovascular events and had no effect on survival index.

关键词： Non-small cell lung cancer COX-2 Survival Progression free survival Systematic review Randomized controlled trials

Gastrointestinal and hepatic manifestations of COVID-19:A comprehensive review

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World Journal of Gastroenterology 2020年第19期26卷 2323-2332页

作者： ming han Cha Miguel Regueiro Dalbir S Sandhu Department of Internal Medicine Cleveland ClinicAkron GeneralAkronOH 44307United States Department of Gastroenterology Hepatology and NutritionDigestive Disease and Surgery InstituteCleveland ClinicClevelandOH 44307United States

The severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)that causes coronavirus disease-2019(COVID-19)is a global pandemic,manifested by an infectious *** patients primarily present with fever,cough and dyspnea,some patients also develop gastrointestinal(GI)and hepatic *** most common GI symptoms reported are diarrhea,nausea,vomiting,and abdominal *** chemistry abnormalities are common and include elevation of aspartate transferase,alanine transferase,and total *** have shown that SARS-CoV-2 infects the GI tract via its viral receptor angiotensin converting enzyme Ⅱ,which is expressed on enterocytes of the ileum and *** RNA has also been isolated from stool specimens of COVID-19 patients,which raised the concern for fecal-oral transmission in addition to droplet *** indirect evidence has suggested possible fecal-oral transmission of SARS-CoV-2,more effort is needed to establish the role of the fecal-oral transmission *** research will help elucidate the association between patients with underlying GI diseases,such as chronic liver disease and inflammatory bowel disease,and severity of *** this review,we summarize the data on GI involvement to date,as well as the impact of COVID-19 on underlying GI diseases.

关键词： COVID-19 SARS-CoV-2 Gastrointestinal Liver Diarrhea Inflammatory bowel disease

Application of SSOR-PCGM with improved iteration format in FEM simulation of massive concrete

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Water Science and Engineering 2011年第3期4卷 317-328页

作者： Lin han Zi-ming ZhanG Zhi-qiang NI College of Mechanics and Materials Hohai University Nanjing 210098 P. R. China

In this study, for the purpose of improving the efficiency and accuracy of numerical simulation of massive concrete, the symmetric successive over relaxation-preconditioned conjugate gradient method （SSOR-PCGM） with an improved iteration format was derived and applied to solution of large sparse symmetric positive definite linear equations in the computational process of the finite element analysis. A three-dimensional simulation program for massive concrete was developed based on SSOR-PCGM with an improved iteration format. Then, the programs based on the direct method and SSOR-PCGM with an improved iteration format were used for computation of the Guandi roller compacted concrete （RCC） gravity dam and an elastic cube under free expansion. The comparison and analysis of the computational results show that SSOR-PCGM with the improved iteration format occupies much less physical memory and can solve larger-scale problems with much less computing time and flexible control of accuracy.

关键词： massive concrete symmetric successive over relaxation-preconditioned conjugate gradient method (SSOR-PCGM) improved iteration Jbrmat .finite element method (FEM) numerical simulation

Gene expression profile in immunologically injured liver cell of mice

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Science China(Life Sciences) 2006年第5期49卷 454-459页

作者： han Fengmei CHENG ming XIA Qisong CHEN Yong Hubei Provincial Key Laboratory of Traditional Chinese Medicine & Biotechnology Faculty of Life Science Hubei University Wuhan 430062 China Hubei Provincial Key Laboratory of Traditional Chinese Medicine & Biotechnology Faculty of Life Science Hubei University Wuhan 430062 China Hubei Provincial Key Laboratory of Traditional Chinese Medicine & Biotechnology Faculty of Life Science Hubei University Wuhan 430062 China Hubei Provincial Key Laboratory of Traditional Chinese Medicine & Biotechnology Faculty of Life Science Hubei University Wuhan 430062 China

To study the gene expression profiles between immunologically injured liver cell and normal liver cell of mice and to screen on a large scale the differentially expressed genes associated with the formation of liver injury,the experimental mice were randomly divided into the normal group for controlling and the immunologically liver-injured group induced by BCG and *** liver mRNA of the two groups were extracted respectively and reversely-transcribed to cDNA with the incorpora-tion of different fluorescence(Cy3,Cy5) labeled dUTP as the hybridization *** mixed probes were hybridized to the cDNA microarray *** fluorescent signal results were acquired by scanner ScanArray 4000 and analyzed with software GenePix Pro *** the 14112 target genes,293 genes were found to be significantly differentially expressed,in which 188 genes were up-regulated and 105 genes were *** on the analysis of biological functions of those differentially expressed genes,it was indicated that the occurrence and development of mouse liver damage induced by BCG and LPS were highly correlated with the processes of immune reac-tions,cell synthesis,metabolism,apoptosis and transportation in liver cell,which might be quite im-portant for elucidating the regulatory network of gene expression associated with the liver damage,also important for finally discovering the pathogenic mechanisms of immunological liver damage.

关键词： mouse, immunological liver damage, cDNA microarray, gene expression profile.

EXTRACTION OF INTERNAL TIDE FROM CURRENT

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Journal of Hydrodynamics 2001年第3期13卷 138-142页

作者： Pan, Zeng-Di han, Chun-ming Yu, Wei-Dong Key Lab. of Mar. Sci. and Numl. Mode First Inst. of Oceanography State Oceanic Administration Qingdao 266061 China

In order to extract the internal tidal current from the current data which is not measured from the sea surface to the bottom, a data processing method is developed. It is based on the fact that the internal wave currents above and below the sharp thermocline are inverse in direction. This method is a practical extension to that proposed by Shu (1985) that can be only used to quite ideal current data. The ADCP data collected on the South China Sea is then processed by this method. The internal tidal current is successfully extracted.

关键词： Data processing Thermal gradients Tides

Progranulin:A promising biomarker and therapeutic target for fibrotic diseases

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3312-3326页

作者： Fan Yang ming-han Cheng Hai-Feng Pan Jian Gao Pediatric Translational Medicine Institute Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghai 200000China Department of Ophthalmology the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230022China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Hefei 230022China

Progranulin(PGRN),a multifunctional growth factor-like protein expressed by a variety of cell types,serves an important function in the physiologic and pathologic processes of fibrotic diseases,including wound healing and the inflammatory *** was discovered to inhibit proinflammation effect by competing with tumor necrosis factor-alpha(TNF-a)binding to TNF ***,excessive tissue repair in the development of inflammation causes tissue *** investigations have indicated the significance of PGRN in regulating inflammatory ***,multiple studies have shown that PGRN was linked to fibrogenesis,and was considered to monitor the formation of fibrosis in multiple organs,including liver,cardiovascular,lung and *** paper is a comprehensive review summarizing our current knowledge of PGRN,from its discovery to the role in *** is followed by an in-depth look at the characteristics of PGRN,consisting of its structure,basic function and intracellular ***,we will discuss the potential of PGRN in the diagnosis and treatment of fibrosis.

关键词： Progranulin Fibrotic disease Fibrosis Inflammation Biomarker Therapeutic target PGRN/TNFR interaction Signaling pathway

Propagation of surfactant and polymer flow in natural carbonate cores

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Petroleum 2022年第3期8卷 414-423页

作者： Dongqing Cao Jinxun Wang ming han Amar J.Alshehri Beijing Research Center Aramco AsiaBeijing100102PR China EXPEC Advanced Research Center Saudi AramcoDhahran31311Saudi Arabia

This paper presents an experimental and analytical study of comprehensive effects of surfactant and polymer in aqueous solutions on the propagation in ***-phase flow tests of surfactant,polymer and surfactant-polymer mixture were respectively conducted on natural carbonate core plugs at high temperature and high salinity reservoir *** effect of different factors on chemical propagation was taken into account by use of a convection-dispersion *** dynamic adsorptions of two amphoteric surfactants at 2000 mg/L concentration onto the carbonate rocks were 0.21 and 0.17 mg/g-rock,*** dynamic adsorptions of a sulfonated polymer at 2000 and 5000 mg/L were 0.11 and 0.17 mg/g-rock,***-polymer mixtures in aqueous solutions were coinjected to evaluate their competitive adsorption,showing the surfactant adsorption was reduced by approximately 50%.The dispersion coefficient of the chemicals in the carbonate cores was in the magnitude of 10^(-3) cm^(2)/*** by dispersion and adsorption,chemical concentration reduction occurred obviously during the propagation in carbonate porous *** separation took place in the surfactant-polymer co-injection scheme,which was estimated by modeling as well.

关键词： Natural carbonate core Chemical propagation Polymer Surfactant Competitive adsorption Convention-dispersion model

Resource allocation algorithm with cross-layer design for DiffServ-based OFDM systems

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The Journal of China Universities of Posts and Telecommunications 2007年第2期14卷 45-50页

作者： LI Xiao-hui han ming YI Ke-chu TIAN Bin Key Laboratory of Integrated Services Networks Xidian University Xi'an 710071 China

According to the quality of service （QoS） requirements of differentiated service （DiffServ）, a cross-layer resource allocation algorithm for multi-user orthogonal frequency division multiplexing （OFDM） systems is presented. The constant rate is maintained by adjusting the power dynamically for the voice traffics with high priority, whereas the fairness amongst the data traffics is guaranteed by weighted fairness queued （WFQ） algorithm. The two above-mentioned strategies are used for video traffics to realize variable data rate with the constraint of the minimum rate. Combing all these methods, both the throughput and the fairness are ensured when there are multiple users in the OFDM system. Simulation results indicate the validity of the proposed algorithm, which can work well even if the SNR is less than 0 dB.

关键词： OFDM cross-layer QoS DiffServ

TMEM251,a new player in lysosomal enzyme trafficking

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Life Metabolism 2023年第2期2卷 4-5页

作者： Liming Wang han-ming Shen School of Biomedical Sciences Hunan UniversityChangshaHunan 410082China Faculty of Health Sciences Ministry of Education Frontiers Science Center for Precision OncologyUniversity of MacaoMacao 999078China

In recent studies published in Science and Nature Communications,three independent groups identified TMEM251,one transmembrane protein in Golgi,as an indispensable factor for lysosomal enzyme *** or mutation of TMEM251 results in hypersecretion of lysosomal enzymes due to lack of mannose-6-phosphate(M6P)modification,leading to lysosomal dysfunction and eventually lysosome storage disorders(LSDs).The lysosome is a membrane-bound organelle discovered by Christian de Duve in the *** critical function of lysosome is to degrade and recycle intracellular materials via autophagy and extracellular materials via endocytosis as well as phagocytosis[1].

关键词： lysosomal eventually traffic