Progranulin:A promising biomarker and therapeutic target for fibrotic diseases
作者机构：Pediatric Translational Medicine InstituteShanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghai 200000China Department of Ophthalmologythe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Epidemiology and BiostatisticsSchool of Public HealthAnhui Medical UniversityHefei 230022China Inflammation and Immune Mediated Diseases Laboratory of Anhui ProvinceHefei 230022China
出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)
年 卷 期：2024年第14卷第8期
页 面：3312-3326页
核心收录：
学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学]
基 金：supported by the National Natural Science Foundation of China(Nos.81274172,81473267,81973637 and 82373933) The National Traditional Chinese Medicine Inheritance and Innovation“Hundreds and Thousands”Talent Project:Young Qihuang Scholar Support Project of the State Administration of Traditional Chinese Medicine in 2020(China)
主 题：Progranulin Fibrotic disease Fibrosis Inflammation Biomarker Therapeutic target PGRN/TNFR interaction Signaling pathway
摘 要：Progranulin(PGRN),a multifunctional growth factor-like protein expressed by a variety of cell types,serves an important function in the physiologic and pathologic processes of fibrotic diseases,including wound healing and the inflammatory *** was discovered to inhibit proinflammation effect by competing with tumor necrosis factor-alpha(TNF-a)binding to TNF ***,excessive tissue repair in the development of inflammation causes tissue *** investigations have indicated the significance of PGRN in regulating inflammatory ***,multiple studies have shown that PGRN was linked to fibrogenesis,and was considered to monitor the formation of fibrosis in multiple organs,including liver,cardiovascular,lung and *** paper is a comprehensive review summarizing our current knowledge of PGRN,from its discovery to the role in *** is followed by an in-depth look at the characteristics of PGRN,consisting of its structure,basic function and intracellular ***,we will discuss the potential of PGRN in the diagnosis and treatment of fibrosis.
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