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Proton radiation effects on high-speed silicon Mach-Zehnder modulators for space application

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Science China(Information Sciences) 2022年第12期65卷 301-312页

作者： changhao han Zhaoyi HU Yuansheng TAO Engang FU Yandong HE Fenghe YANG Jun QIN Xingjun WANG State Key Laboratory of Advanced Optical Communication Systems and Networks School of Electronics Peking University State Key Laboratory of Nuclear Physics and Technology School of Physics Peking University Institute of Microelectronics School of Integrated Circuits Peking University Peking University Yangtze Delta Institute of Optoelectronics Frontier Science Center for Nano-optoelectronics Peking University Peng Cheng Laboratory

In this paper, performance degradation effects on high-speed silicon Mach-Zehnder modulators under proton radiation were investigated for future space environment applications. The test devices were exposed to 3-MeV protons of three fluence levels(5×1013, 2×1014, and 5×1015ions/cm2), which is comparable to the radiation amount for operating in a harsh space environment after several decades. The performance of the silicon modulator after radiation was characterized in terms of modulation efficiency and eye *** results illustrate that the modulation efficiency is significantly reduced after proton radiation and shows an obvious decrease with increasing radiation fluence. The extinction ratios of the on-off keying(OOK) eye diagram are obviously dropped with increasing radiation fluence and correspond well to modulation efficiency degradation. Furthermore, three representative states for data transmission are demonstrated under three fluences, from still working to the critical state and eventually complete fail. Displacement damage and ionization damage are the two major mechanisms during proton radiation, which lead to the bulk defects and accumulating defect charges and cause performance degradation of silicon Mach-Zehnder modulators.

关键词： silicon Mach-Zehnder modulator proton radiation space application silicon photonics optical communication

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Interoceptive regulation of skeletal tissue homeostasis and repair

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Bone Research 2023年第3期11卷 481-496页

作者： Yao Xiao changhao han Yunhao Wang Xinshu Zhang Rong Bao Yuange Li Huajiang Chen Bo Hu Shen Liu Department of Orthopaedics Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233PR China Spine Center Department of OrthopedicsChangzheng HospitalNaval Medical UniversityShanghai 200003PR China

Recent studies have determined that the nervous system can sense and respond to signals from skeletal tissue,a process known as skeletal interoception,which is crucial for maintaining bone *** hypothalamus,located in the central nervous system(CNS),plays a key role in processing interoceptive signals and regulating bone homeostasis through the autonomic nervous system,neuropeptide release,and neuroendocrine *** mechanisms control the differentiation of mesenchymal stem cells into osteoblasts(OBs),the activation of osteoclasts(OCs),and the functional activities of bone *** nerves extensively innervate skeletal tissues,facilitating the transmission of interoceptive signals to the *** review provides a comprehensive overview of current research on the generation and coordination of skeletal interoceptive signals by the CNS to maintain bone homeostasis and their potential role in pathological *** findings expand our understanding of intersystem communication in bone biology and may have implications for developing novel therapeutic strategies for bone diseases.

关键词： system homeostasis maintain

Sprayed PAA-CaO_(2)nanoparticles combined with calcium ions and reactive oxygen species for antibacterial and wound healing

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Regenerative Biomaterials 2023年第1期10卷 1356-1371页

作者： Hong Yu Jiale Sun Kepeng She Mingqi Lv Yiqiao Zhang Yawen Xiao Yangkun Liu changhao han Xinyue Xu Shuqing Yang Guixue Wang Guangchao Zang Tissue and Cell Biology Lab Teaching&Management CenterChongqing Medical UniversityChongqing 400016China Chongqing University Central Hospital Chongqing Emergency Medical CenterChongqing 400030China Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing 400030China Jinfeng Laboratory Chongqing 401329China

The most common socioeconomic healthcare issues in clinical are burns,surgical incisions and other skin *** lesion healing can be achieved with nanomedicines and other drug application *** study developed a nano-spray based on cross-linked amorphous calcium peroxide(CaO_(2))nanoparticles of polyacrylic acid(PAA)for treating skin wounds(PAA-CaO_(2)nanoparticles).CaO_(2)serves as a‘drug’precursor,steadily and continuously releasing calcium ions(Ca^(2+))and hydrogen peroxide(H_(2)O_(2))under mildly acidic conditions,while PAA-CaO_(2)nanoparticles exhibited good spray behavior in aqueous *** demonstrated that PAA-CaO_(2)nanoparticles exhibited low cytotoxicity and allowed L929 cells proliferation and migration in *** effectiveness of PAA-CaO_(2)nanoparticles in promoting wound healing and inhibiting bacterial growth in vivo was assessed in SD rats using full-thickness skin defect and Staphylococcus aureus(***)-infected wound models based *** results revealed that PAA-CaO_(2)nanoparticles demonstrated significant advantages in both ***,the infected rats’skin defects healed in 12 *** benefits are linked to the functional role of Ca^(2+)coalesces with H_(2)O_(2)as known antibacterial and healing-promoted ***,we developed nanoscale PAA-CaO_(2)sprays to prevent bacterial development and heal skin lesions.

关键词： polyacrylic acid calcium peroxide nanomedicines antibacterial wound healing

Photocrosslinking silver nanoparticles–aloe vera–silk fibroin composite hydrogel for treatment of full-thickness cutaneous wounds

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Regenerative Biomaterials 2021年第6期8卷 46-58页

作者： Yangkun Liu JinChuan Fan MingQi Lv Kepeng She Jiale Sun Qingqing Lu changhao han SongTao Ding Shuang Zhao GuiXue Wang YuChan Zhang GuangChao Zang Institute of Life Science And Laboratory of Tissue and Cell BiologyLab Teaching&Management CenterChongqing Medical UniversityChongqing 400016China Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing 400030China

Damage to the skin causes physiological and functional *** most effective treatment approach is the use of wound *** fibroin(SF)is a promising candidate biomaterial for regulating wound healing;however,its antibacterial properties and biological activity must be further *** this study,a photocrosslinking hydrogel was developed to treat full-thickness cutaneous *** composite hydrogel(Ag-AV-SF hydrogel)was prepared by introducing the silver nanoparticles(AgNPs)and aloe vera(AV)as the *** vitro study exhibited great antibacterial ability,biocompatibility and cell-proliferation and-migration-promoting *** also showed the pH-response releasing properties which release more AgNPs in a simulated chronic infection *** healing effect evaluation in vivo showed the healing-promoting ability of the Ag-AV-SF hydrogel was stronger than the single-modifiers groups,and the healing rate of it reached 97.02%on Day 21,higher than the commercial wound dressing,silver sulfadiazine(SS)cream on ***,the histological and protein expression results showed that the Ag-AV-SF hydrogel has a greater effect on the pro-healing regenerative phenotype with M2 macrophages at the early stage,reconstructing the blood vessels networks and inhibiting the formation of *** summary,the Ag-AV-SF hydrogel developed in this study had good physical properties,overwhelming antibacterial properties,satisfactory biocompatibility and significantly promoting effect on cell proliferation,migration and wound ***,our results suggest that the Ag-AV-SF hydrogel we developed has great potential for improving the wound healing in clinical treatment.

关键词： silk fibroin silver nanoparticles aloe vera hydrogel wound healing

16-channel photonic–electric co-designed silicon transmitter with ultra-low power consumption

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Photonics Research 2023年第2期11卷 143-149页

作者： JINGBO SHI MING JIN TAO YANG HAOWEN SHU FENGHE YANG han LIU YUANSHENG TAO JIANGRUI DENG RUIXUAN CHEN changhao han NAN QI XINGJUN WANG State Key Laboratory of Advanced Optical Communication Systems and Networks School of ElectronicsPeking UniversityBeijing 100871China College of Engineering Peking UniversityBeijing 100871China Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Material Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Frontier Science Center for Nano-optoelectronics Peking UniversityBeijing 100871China

A hybrid integrated 16-channel silicon transmitter based on co-designed photonic integrated circuits(PICs) and electrical chiplets is demonstrated. The driver in the 65 nm CMOS process employs the combination of a distributed architecture, two-tap feedforward equalization(FFE), and a push–pull output stage, exhibiting an estimated differential output swing of 4.0V_(pp). The rms jitter of 2.0 ps is achieved at 50 Gb/s under nonreturnto-zero on–off keying(NRZ-OOK) modulation. The PICs are fabricated on a standard silicon-on-insulator platform and consist of 16 parallel silicon dual-drive Mach–Zehnder modulators on a single chip. The chip-on-board co-packaged Si transmitter is constituted by the multichannel chiplets without any off-chip bias control, which significantly simplifies the system complexity. Experimentally, the open and clear optical eye diagrams of selected channels up to 50 Gb/s OOK with extinction ratios exceeding 3 dB are obtained without any digital signal processing. The power consumption of the Si transmitter with a high integration density featuring a throughput up to 800 Gb/s is only 5.35 p J/bit, indicating a great potential for massively parallel terabit-scale optical interconnects for future hyperscale data centers and high-performance computing systems.

关键词： channel power return

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硅基调制器的最新研究进展(特邀)

光学学报 2024年第15期44卷 273-294页

作者：韩昌灏王皓玉舒浩文秦军王兴军北京大学电子学院区域光纤通信网与新型光通信系统国家重点实验室北京100871 美国加利福尼亚大学圣芭芭拉分校电子与计算机工程系加利福尼亚圣芭芭拉931063 北京大学集成电路学院北京100871 北京大学长三角光电科学研究院江苏南通226010 北京大学纳光电子前沿科学中心北京100871 北京信息科技大学信息与通信系统实验室北京100101 鹏城实验室广东深圳518055

随着新一代信息技术的大规模应用,全球数据总量呈现指数式增长趋势,光通信凭借其大带宽、大容量、低损耗、低串扰等优势成为信息通信网络的重要组成部分。硅基光电子技术作为光电子集成技术的重要分支,是实现光通信小型化、多功能化的... 详细信息

随着新一代信息技术的大规模应用,全球数据总量呈现指数式增长趋势,光通信凭借其大带宽、大容量、低损耗、低串扰等优势成为信息通信网络的重要组成部分。硅基光电子技术作为光电子集成技术的重要分支,是实现光通信小型化、多功能化的重要方法。在硅基光电子系统中,硅基调制器是完成信息传输与处理的核心功能单元。本文从硅基调制器的理论基础出发,综述硅基调制器的最新研究进展,按照材料体系的不同,分别对纯硅调制器与硅基异质材料调制器进行系统介绍,最后对该领域的未来发展进行详细讨论。

关键词：集成光学硅基调制器光电子学光通信光互连

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面向空间应用的集成光电子技术

中国科学：物理学、力学、天文学 2021年第2期51卷 67-83页

作者：陶源盛王兴军韩昌灏金明舒浩文北京大学信息科学技术学院电子学系区域光纤通信网与新型光通信系统国家重点实验室北京100871 北京大学教育部纳光电子前沿科学中心北京100871

随着空间技术的蓬勃发展,微电子集成电路已不能满足空间信息系统对传输容量、通信速率、电磁兼容方面的要求.基于分立器件搭建的传统光电子系统在尺寸、重量、功耗和成本方面存在限制.集成光电子技术是解决上述瓶颈问题的关键途径,逐渐... 详细信息

随着空间技术的蓬勃发展,微电子集成电路已不能满足空间信息系统对传输容量、通信速率、电磁兼容方面的要求.基于分立器件搭建的传统光电子系统在尺寸、重量、功耗和成本方面存在限制.集成光电子技术是解决上述瓶颈问题的关键途径,逐渐成为近年来的研究热点.本文从介绍铟磷、硅、氮化硅、薄膜铌酸锂等目前主要的集成光学材料的特性及研究基础出发,系统性地回顾了集成光电子技术在空间信息系统中的激光通信、微波光子、光学传感、自主导航与天文成像等应用方向的最新研究进展、技术瓶颈问题与发展思路.同时,对集成光电子器件在太空工作环境下的辐射效应和器件可靠性进行了介绍与分析.最后,对集成光电子技术在未来空间信息系统中的发展方向和应用前景做了分析与展望.

关键词：集成光电子空间应用光通信光传感辐射效应

基于增强型最大比例混合接收机的硅基调制器线性度补偿方法

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光学学报 2023年第23期43卷 118-129页

作者：秦军陶源盛金明韩昌灏 Rahul Kumar Gangwar 李月琴孙剑缪旻北京信息科技大学信息与通信工程学院信息与通信系统信息产业部重点实验室北京100101 北京信息科技大学信息与通信工程学院光电测试技术及仪器教育部重点实验室北京100101 北京大学电子学院区域光纤通信网与新型光通信系统国家重点实验室北京100871

硅基调制器具有体积小、功耗低、易集成等优势,但相较于铌酸锂调制器,线性度通常较差,从而限制了其在光载无线等通信系统中的性能。提出一种增强型最大比例混合接收机(EMRC-Rx),用以补偿硅基调制器对无源光接入网络带来的性能下降缺点。... 详细信息

硅基调制器具有体积小、功耗低、易集成等优势,但相较于铌酸锂调制器,线性度通常较差,从而限制了其在光载无线等通信系统中的性能。提出一种增强型最大比例混合接收机(EMRC-Rx),用以补偿硅基调制器对无源光接入网络带来的性能下降缺点。EMRC-Rx综合利用直接检测机(DD-Rx)和轻相干检测机(Lite CO-Rx)的优势,借助两种接收方式的最大信噪比占比,可以显著提升接收机的灵敏度,进而解决硅基调制器低线性度导致的系统性能下降问题。实验结果表明,当误码率高于KP4-FEC阈值1.0×10^(-4)时,相较于DD-Rx和Lite CO-Rx,EMRC-Rx的接收灵敏度分别提升5.5 dB和8.8 dB,误差矢量幅度(EVM)分别提升32.5%和41.1%,系统性能明显得到改善。通过进一步与铌酸锂调制器进行对比发现,相比采用铌酸锂调制器的Lite CO-Rx和DD-Rx,基于硅基调制器的EMRC-Rx的接收灵敏度分别提升3.5 dB和7.9 dB,且可取得与铌酸锂调制器中MRC-Rx接近的系统性能,验证了EMRC-Rx对硅基调制器低线性度带入的性能劣化的补偿效果。本工作对在5G时代利用硅基调制器构建高可靠、低成本的光子集成接入网具有指导意义。

关键词：硅基调制器直接检测轻相干检测无源光接入网调制器线性度

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基于单片机的移动存储器访问控制系统设计

中国科技论文在线精品论文 2020年第4期13卷 411-421页

作者：韩昌昊马莉胡方舟贾忠田济南大学信息科学与工程学院济南250022 济南大学科技处济南250022

与传统移动存储器的安全策略不同,本文提出了一个基于STC89C52单片机(single-chip microcomputer,SCM)的移动存储器访问控制方案.该访问控制系统包括USB接口模块、核心存储模块、连通性控制模块以及密码输入模块.USB接口模块经数据线连... 详细信息

与传统移动存储器的安全策略不同,本文提出了一个基于STC89C52单片机(single-chip microcomputer,SCM)的移动存储器访问控制方案.该访问控制系统包括USB接口模块、核心存储模块、连通性控制模块以及密码输入模块.USB接口模块经数据线连接于核心存储模块与电脑主机之间,连通性控制模块经供电线分别与USB接口模块和核心存储模块相连,密码输入模块接至连通性控制模块,用于控制供电电路的连通性.通过对供电电路的连通性控制进行身份认证,实现对供电电路的连通性掌控,使得对存储器的访问控制与数据加解密脱钩.实验证明电路连通性闭合瞬间完成,系统应用无需考虑操作系统的适配性,具有较高的用户体验水平、安全级别与系统兼容性.

关键词：计算机应用访问控制逻辑供电策略单片机