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The enhancement of sensitivity of HL-60 cells to arsenic trioxide by Bcl-2 siRNA

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The Chinese-German Journal of Clinical Oncology 2007年第5期6卷 500-502页

作者： haiyan hu yuan zhang dongmei he Institute of hematology Medical College of Jinan University Guangzhou 510623 China

Objective: To study whether the small-interference RNA (siRNA) targeting against Bcl-2 gene can enhance sensi-tivity of HL-60 cell to arsenic trioxide. Methods: SiRNA was transferred into the HL-60 cells. At 6 h after transfection, the cells were cultured with arsenic trioxide. The cell growth of the HL-60 cells was detected using MTT at 24, 48 and 72 h, respectively. The levels of the Bcl-2 protein and reactive oxygen species (ROS), as well as of the membrane potential of the mitochondrion were determined by flow cytometry. Results: The Bcl-2 siRNA significantly increased the inhibitory action of arsenic trioxide on growth of HL-60 cells. The combination of siRNA with arsenic trioxide resulted in decrease of the Bcl-2 protein level and increase of the ROS level, as well as significant descending of the membrane potential of mitochondrion of HL-60 (P he siRNA targeting Bcl-2 can increase the sensitivity of the HL-60 leukemia cells to arsenic trioxide by inhibiting the expression of Bcl-2 protein.

关键词： Bcl-2 siRNA arsenic trioxide sensitivity

Co/Co_(7)Fe_(3)heterostructures with controllable alloying degree on carbon spheres as bifunctional electrocatalyst forrechargeable zinc-air batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 476-487页

作者： Junkang Chen Yongyue Zhuang Yanxin Qiao Yu zhang Aihua yuan hu Zhou School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Exploring efficient and nonprecious metal electrocatalysts of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is crucial for developing rechargeable zinc-air batteries(ZABs).herein,an alloying-degree control strategy was employed to fabricate nitrogen-doped carbon sphere(NCS)decorated with dual-phase Co/Co_(7)Fe_(3)heterojunctions(CoFe@NCS).The phase composition of materials has been adjusted by controlling the alloying *** optimal CoFe_(0.08)@NCS electrocatalyst displays a half-wave potential of 0.80 V for ORR and an overpotential of 283 mV at 10 mA·cm^(-2)for OER in an alkaline *** intriguing bifunctional electrocatalytic activity and durability is attributed to the hierarchically porous structure and interfacial electron coupling of highly-active Co_(7)Fe_(3)alloy and metallic Co *** the CoFe_(0.08)@NCS material is used as air-cathode catalyst of rechargeable liquid-state zinc-air battery(ZAB),the device shows a high peak power-density(157 mW·cm^(-2))and maintains a stable voltage gap over 150 h,outperforming those of the benchmark(Pt/C+RuO_(2))-based *** particular,the as-fabricated solid-state flexible ZAB delivers a reliable compatibility under different bending *** work provides a promising strategy to develop metal/alloy-based electrocatalysts for the application in renewable energy conversion technologies.

关键词： bifunctional electrocatalysts oxygen reduction reaction oxygen evolution reaction zinc-air battery metal/alloy carbon sphere

Intelligent fire information system based on 3D GIS

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Virtual Reality & Intelligent Hardware 2023年第2期5卷 93-109页

作者： Jinxing hu Zhihan LV Diping yuan Bing he dongmei YAN Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China Department of Game Design Faculty of ArtsUppsala UniversitySweden Jilin Unicom Communication Co. Ltd.Jilin BranchJilin 132011China

Background This work aims to build a comprehensive and effective fire emergency management system based on the Internet of Things(IoT)and achieve an actual intelligent fire rescue.A smart fire protection information system was designed based on the IoT.A detailed analysis was conducted on the problem of rescue vehicle scheduling and the evacuation of trapped persons in the process of fire *** The intelligent fire visualization platform based on the three-dimensional(3D)Geographic Information Science(GIS)covers project overview,equipment status,equipment classification,equipment alarm information,alarm classification,alarm statistics,equipment account information,and other *** live video accessed through the visual interface can clearly identify the stage of the fire,which facilitates the arrangement of rescue equipment and *** vehicle scheduling model in the system primarily used two objective functions to solve the Pareto Non-Dominated Solution Set Optimization:emergency rescue time and the number of *** addition,an evacuation path optimization method based on the Improved Ant Colony(IAC)algorithm was designed to realize the dynamic optimization of building fire evacuation *** The experimental results indicate that all the values of detection signals were significantly larger in the smoldering fire scene at t=17s than the initial *** addition,the probability of smoldering fire and the probability of open fire were relatively large according to the probability function of the corresponding fire situation,demonstrating that this model could detect *** The IAC algorithm reported here avoided the passages near the fire and spreading areas as much as possible and took the safety of the trapped persons as the premise when planning the evacuation ***,the IoT-based fire information system has important value for ensuring fire safety and carrying out emergency rescue and is worthy of popularization

关键词： Smart fire protection information system Internet of things Rescue vehicle scheduling Optimal evacuation routes

Genome-wide mapping of QTL associated with heterosis in the RIL-based NCIII design

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Chinese Science Bulletin 2012年第21期57卷 2655-2665页

作者： he XiaoHong hu ZhongLi zhang yuan-Ming Section on Statistical Genomics State Key Laboratory of Crop Genetics and Germplasm Enhancement&Chinese National Center for Soybean ImprovementCollege of AgricultnreNanjing Agricultural UniversityNanjing 210095China State Key Laboratory of Hybrid Rice College of Life SciencesWuhan UniversityWuhan 430072China

heterosis represents one of the most revolutionary advancements in crop *** the genetic dissection of heterosis,NCIII design is one of the most powerful and widely used mating ***,the methodologies for quantitative trait loci (QTL) detection in the design were mostly based on composite interval ***,in this study,our purpose was to develop a statistical method for mapping epistatic QTL associated with heterosis in the RIL-based NCIII ***,we derivated the expectations of two classical linear transformations,Z 1 and Z 2,while a quantitative trait was controlled by two QTL with digenic epistasis and arbitrary linkage under the F ∞ and F 2 metric ***,we constructed an epistatic genetic model that includes all markers on the whole genome simultaneously,and estimated all the parameters in the model by the empirical Bayes ***,a series of Monte Carlo simulation experiments was carried out to confirm the proposed *** results show that:(1) all the augmented genetic parameters for main-effect QTL could be rightly identified with satisfactory statistical power and precision;(2) the statistical powers in the detection of augmented epistatic effects were substantively affected by the signs of pure epistatic effects;(3) it is more difficult to detect epistatic QTL than to detect main-effect QTL;(4) statistical power is higher in the RIL-based NCIII design than in the F 2-based NCIII design,especially in the detection of the augmented epistatic effect that consists of two pure epistatic effects in opposite directions.

关键词：数量性状位点全基因组杂种优势设计测绘上位性效应统计方法复合区间作图

Synthesis and characterization of yellow water-borne polyurethane using a diol colorant as extender

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Chinese Chemical Letters 2010年第2期21卷 143-145页

作者： zhang, he zhang, Xing yuan Dai, Jia Bing Li, Wei hu Univ Sci & Technol China Dept Polymer Sci & Engn CAS Key Lab Soft Matter Chem Hefei 230026 Peoples R China

A novel and facile method toward a series of yellow water-borne polyurethane was developed by using an intrinsically colored diol in this *** yellow aqueous dispersion PCLD-heNA-PU was synthesized based on isophorone diisocyanate(IPDI), polycaprolactonediol(PCLD) and 2,2-dimethylol propionic acid(DMPA) using a yellow diol N,N-bis(2-hydroxyethyl)-4-nitroaniline (heNA) as a chain *** to the complete reaction of OH group in colorant heNA with NCO group in diisocyanate,a series of stable yellow p...

关键词： Colored diol Extender Polycaprolactonediol N N-bis(2-hydroxyethyl)-4-nitroaniline Yellow polyurethane

Atomic-level insight of sulfidation-engineered Aurivillius-related Bi_(2)O_(2)SiO_(3) nanosheets enabling visible light low-concentration CO_(2) conversion

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Carbon Energy 2023年第2期5卷 1-11页

作者： Kai Wang Yue Du yuan Li Xiaoyong Wu haiyan hu Guohong Wang Yao Xiao Shulei Chou Gaoke zhang College of Urban and Environmental Sciences Hubei Key Laboratory of Pollutant Analysis and Reuse TechnologyInstitute for Advanced MaterialsHubei Normal UniversityHuangshiHubeiChina School of Resources and Environmental Engineering Wuhan University of TechnologyWuhanHubeiChina Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhouZhejiangChina

Unraveling atomic-level active sites of layered photocatalyst towards lowconcentration CO_(2) conversion is still ***,the yield and selectivity of photocatalytic CO_(2) reduction of the Aurivillius-related oxide semiconductor Bi_(2)O_(2)SiO_(3) nanosheet(BOSO)were largely improved using a surface sulfidation *** experiment and theoretical calculation confirmed that surface sulfidation of the Bi_(2)O_(2)SiO_(3) nanosheet(S-BOSO,6.28 nm)redistributed the charge-enriched Bi sites,extended the solar spectrum absorption to the whole visible range,and considerably enhanced the charge separation,in addition to creating new reaction active sites,as compared to pristine ***,surface sulfidation played a switchable role,wherein S-BOSO showed a very high CH_(3)OH generation rate(12.78μmol g^(-1) for 4 h,78.6%selectivity)from low-concentration CO_(2)(1000 ppm)under visible light irradiation,which outperforms most of the state-of-the-art photocatalysts under similar *** study presents an atomic-level modification protocol for engineering reactive sites and charge behaviors to promote solar-to-energy conversion.

关键词： [Bi_(2)O_(2)]^(2)+layer Bi_(2)O_(2)SiO_(3) low-concentration CO_(2)reduction photocatalysis sulfidation

Einstein Probe discovery of EP240408a: A peculiar X-ray transient with an intermediate timescale

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 222-240页

作者： Wenda zhang Weimin yuan Zhixing Ling Yong Chen Nanda Rea Arne Rau Zhiming Cai huaqing Cheng Francesco Coti Zelati Lixin Dai Jingwei hu Shumei Jia Chichuan Jin Dongyue Li Paul O’Brien Rongfeng Shen Xinwen Shu Shengli Sun Xiaojin Sun Xiaofeng Wang Lei Yang Bing zhang Chen zhang Shuang-Nan zhang Yonghe zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier Liming Dou Rob Eyles-Ferris Zhou Fan hua Feng Shaoyu Fu Johan P.U.Fynbo Lluis Galbany Saurabh W.Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong Li Bifang Liu Mingjun Liu Xing Liu yuan Liu Zhu Liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra Jeremy Sanders Roberto Soria Lian Tao Junfeng Wang Song Wang Tinggui Wang Zhongxiang Wang Qingwen Wu Xuefeng Wu Dong Xu Yanjun Xu Suijian Xue Yongquan Xue Zijian zhang Zipei Zhu hu Zou Congying Bao Fansheng Chen Houlei Chen Tianxiang Chen Wei Chen Yehai Chen Yifan Chen Chenzhou Cui Weiwei Cui Yanfeng Dai Dongwei Fan Ju Guan Dawei Han Dongjie Hou Haibo hu Maohai huang Jia huo Zhenqing Jia Bowen Jiang Ge Jin Chengkui Li Junfei Li Longhui Li Maoshun Li Wei Li Zhengda Li Tianying Lian Congzhan Liu heyang Liu huaqiu Liu Fangjun Lu Laidan Luo Jia Ma Xuan Mao Haiwu Pan Xin Pan Liming Song hui Sun Yunyin Tan Qingjun Tang Yihan Tao Hao Wang Juan Wang Lei Wang Wenxin Wang Yilong Wang Yusa Wang Qinyu Wu Haitao Xu Jingjing Xu Xinpeng Xu Yunfei Xu Zhao Xu Changbin Xue Yulong Xue Ailiang Yan Haonan Yang Xiongtao Yang Yanji Yang Juan zhang Mo zhang Wenjie zhang Zhen zhang Zhen zhang Ziliang zhang Donghua Zhao Haisheng Zhao Xiaofan Zhao Zijian Zhao Hongyan Zhou Yilin Zhou Yuxuan Zhu Zhencai Zhu National Astronomical Observatories Chinese Academy of Sciences School of Astronomy and Space Sciences University of Chinese Academy of Sciences Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Institute of Space Sciences (ICE) CSIC Institut d’Estudis Espacials de Catalunya (IEEC) Max Planck Institute for Extraterrestrial Physics Innovation Academy for Microsatellites Chinese Academy of Sciences Department of Physics University of Hong Kong School of Physics and Astronomy University of Leicester School of Physics and Astronomy Sun Yat-sen University Department of Physics Anhui Normal University Shanghai Institute of Technical Physics Chinese Academy of Sciences Physics Department Tsinghua University Nevada Center for Astrophysics University of Nevada Las Vegas Department of Physics and Astronomy University of Nevada Las Vegas South African Astronomical Observatory Department of Astronomy University of Cape Town Department of Physics University of the Free State Université Paris Cité CNRS Astroparticule et Cosmologie Université Paris Cité CEA Paris-Saclay IRFU/DAp-AIM Department of Astronomy Guangzhou University Cosmic Dawn Center (DAWN) Niels Bohr Institute University of Copenhagen Department of Physics and Astronomy Rutgers the State University of New Jersey Institute for Cosmic Ray Research The University of Tokyo ESA/ESTEC Department of Astronomy School of Physics huazhong University of Science and Technology INAF-Osservatorio Astrofisico di Torino Sydney Institute for Astronomy School of Physics The University of Sydney Department of Astronomy Xiamen University Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Department of Astronomy University of Science and Technology School of Astronomy and Space Sciences University of Science and Technology of China Institute of Deep Space Sciences Deep Space Exploration Laboratory Department of Astronomy School of Physics and Astronomy Yunnan University Shanghai Astronomical Observatory Chi

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for *** flare reached a peak flux of 3.9×10-9erg cm-2s-1in 0.5-4 ke V,～300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 ke V,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for ～4 d,followed by a steep decay till becoming undetectable ～10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of～10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

关键词： X-ray transients ${\bm~{Einstein~~Probe}}$

Rice Genomics: over the Past Two Decades and into the Future

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Genomics, Proteomics & Bioinformatics 2018年第6期16卷 397-404页

作者： Shuhui Song dongmei Tian zhang zhang Songnian hu Jun Yu BIG Data Center Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Domestic rice(Oryza sativa L.) is one of the most important cereal crops, feeding a large number of worldwide populations. Along with various high-throughput genome sequencing projects, rice genomics has been making great headway toward direct ?eld applications of basic research advances in understanding the molecular mechanisms of agronomical traits and utilizing diverse germplasm resources. here, we brie?y review its achievements over the past two decades and present the potential for its bright future.

关键词： Rice genome Genomic diversity heterosis Domestication

Manipulating non-collinear antiferromagnetic order and thermal expansion behaviors in triangular lattice Mn_(3)Ag_(1-x)Sn(Ge)_(x)N

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Journal of Materiomics 2024年第2期10卷 456-462页

作者： dongmei hu Sihao Deng Ying Sun Kewen Shi Xiuliang yuan Shihai An Lunhua he Jie Chen yuanhua Xia Cong Wang School of Physics Beihang UniversityBeijing100191China School of Integrated Circuit Science and Engineering Beihang UniversityBeijing100191China National Key Lab of Spintronics Institute of International InnovationBeihang UniversityYuhang DistrictHangzhou311115China Spallation Neutron Source Science Center Dongguan523803China Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China Institute of Physics Chinese Academy of SciencesBeijing100190China Songshan Lake Materials Laboratory Dongguan523808China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang621999China

Magnetic materials with non-collinear spin orderings provide an outstanding platform to probe spin-tronic phenomena owing to their strong spin-orbit coupling(SOC)and unique Berry *** is thus important to obtain a non-collinear antiferromagnetic(AFM)phase at room temperature(RT).Signifi-cantly,the discovery of novel materials with nearly zero thermal expansion(ZTE)property near RT is required and pursued for avoiding thermal stress and fracture in spintronic ***,the doping of Sn(Ge)at the Ag site in the triangular lattice Mn_(3)Ag_(1-x)Sn(Ge)_(x)N compounds increases effectively the Neel point and makes the interesting non-collinearГ^(5g)AFM phase exist above *** magnetic phase diagrams withГ^(5g)phase up to 498 K were built by the combined analysis of neutron powder diffraction(NPD),magnetic measurements,electronic transport,and differential scanning calorimetry(DSC).The thermal expansion behaviors of Mn_(3)Ag_(1-x)Sn(Ge)_(x)N were modulated,and the nearly ZTE above RT was achieved in Mn_(3)Ag_(0.5)Ge_(0.5)N withinГ^(5g)AFM *** findings offer an effective way to tailor the non-collinear AFM ordering and correlated thermal expansion behavior for potential use in the emerging field of thermal stress-free magnetic chip materials.

关键词： Non-collinear magnet Antiferromagnetic spintronics Nearly zero thermal expansion Neutron powder diffraction Antiperovskite