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DeepSVDNet:A Deep Learning-Based Approach for Detecting and Classifying Vision-Threatening Diabetic Retinopathy in Retinal Fundus Images

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Computer Systems Science & Engineering 2024年第2期48卷 511-528页

作者： Anas Bilal Azhar Imran Talha Imtiaz Baig Xiaowen Liu haixia long Abdulkareem Alzahrani Muhammad Shafiq College of Information Science and Technology Hainan Normal UniversityHaikou571158China Department of Creative Technologies Air UniversityIslamabadPakistan School of Life Science and Technology University of Electronic Science and Technology of China UESTCChengduChina School of Science and Technology University of Management and Technology UMTLahorePunjabPakistan Faculty of Computer Science&Information Technology Al Baha UniversityAl BahaSaudi Arabia School of Information Engineering Qujing Normal UniversityQujingChina

Artificial Intelligence(AI)is being increasingly used for diagnosing Vision-Threatening Diabetic Retinopathy(VTDR),which is a leading cause of visual impairment and blindness ***,previous automated VTDR detection methods have mainly relied on manual feature extraction and classification,leading to *** paper proposes a novel VTDR detection and classification model that combines different models through majority *** proposed methodology involves preprocessing,data augmentation,feature extraction,and classification *** use a hybrid convolutional neural network-singular value decomposition(CNN-SVD)model for feature extraction and selection and an improved SVM-RBF with a Decision Tree(DT)and K-Nearest Neighbor(KNN)for *** tested our model on the IDRiD dataset and achieved an accuracy of 98.06%,a sensitivity of 83.67%,and a specificity of 100%for DR detection and evaluation tests,*** proposed approach outperforms baseline techniques and provides a more robust and accurate method for VTDR detection.

关键词： Diabetic retinopathy(DR) fundus images(FIs) support vector machine(SVM) medical image analysis convolutional neural networks(CNN) singular value decomposition(SVD) classification

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Subsequent strategies and underlying mechanism of acquired resistance to PD-1 axis inhibitors in advanced non-small cell lung cancer

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Chinese Medical Journal 2024年第7期137卷 880-882页

作者： Huilan Wang Xinyu Cheng Fan Yang Lu Chen Anmei Zhang Liangzhi Zhong haixia long Bo Zhu Zhongyu Wang Institute of Cancer Xinqiao HospitalThird Military Medical UniversityChongqing 400037China Chongqing Key Laboratory of Immunotherapy Chongqing 400037China

To the Editor:With the widespread application of immune checkpoint inhibitors(ICIs)in clinical practice,acquired resistance(AR)to programmed death-1(PD-1)/programmed death ligand 1(PD-L1)axis inhibitors in advanced nonsmall cell lung cancer(NSCLC)develops and limits the durability of *** is a clinical condition in which a patient initially responds to ICIs but relapses and progresses after a period of *** rates of AR have not been routinely reported in lung cancer but typically range from 12.9%to 64%.[1]However,studies on subsequent management strategies and the mechanism of AR to PD-1/PD-L1 axis inhibitors in lung cancer are *** main exploratory strategies are immunotherapy rechallenge and the combination of ICIs with other therapies,including local therapy,chemotherapy,antiangiogenetic treatment,and cytotoxic T lymphocyte antigen 4(CTLA-4)inhibitors.[2]The purpose of this study was to characterize the clinical patterns of AR and compare different subsequent therapies and outcomes in NSCLC patients after AR to PD-1/PD-L1 ***,we explored the underlying mechanism of AR by analyzing the alterations in next-generation sequencing(NGS)data before and after AR.

关键词： routine alterations resistance

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陆军军医大学学报 2024年第9期46卷 1047-1056页

作者：杨学智侯俊雷朱恩健龙海霞查皓然朱波陆军军医大学(第三军医大学)第二附属医院全军肿瘤研究所重庆400037 中国人民解放军第九六四医院放射科长春130062 中国人民解放军火箭军特色医学中心肿瘤科北京100088

目的探讨肿瘤相关性贫血对外周血中新型冠状病毒特异性记忆CD8^(+)T细胞丰度的影响。方法纳入2023年6-7月在火箭军特色医学中心住院治疗的HLA-A*11∶01阳性中晚期实体瘤患者34例。根据血红蛋白浓度将患者分为无贫血组(HGB≥120 g/L,n=... 详细信息

目的探讨肿瘤相关性贫血对外周血中新型冠状病毒特异性记忆CD8^(+)T细胞丰度的影响。方法纳入2023年6-7月在火箭军特色医学中心住院治疗的HLA-A*11∶01阳性中晚期实体瘤患者34例。根据血红蛋白浓度将患者分为无贫血组(HGB≥120 g/L,n=14)、轻度贫血组(120 g/L> HGB≥90 g/L,n=14)与中重度贫血组(HGB<90 g/L,n=6)。分离外周血单个核细胞,利用新冠病毒抗原表位刺激并扩增记忆CD8^(+)T细胞,使用ELISPOT筛选阳性表位,构建Tetramer。利用扩增后细胞检测Tetramer+细胞比例、数量及ELISPOT斑点数,用以反映新冠病毒特异性记忆CD8^(+)T细胞丰度。分析患者血红蛋白浓度与Tetramer+细胞比例、数量及ELISPOT斑点数的相关性。分析不同贫血组Tetramer+细胞比例、数量及ELISPOT斑点数的差异。结果 34例患者中男性25例,女性9例;年龄36~78岁,中位年龄57岁。患者扩增后Tetramer+细胞比例、数量及ELISPOT斑点数与血红蛋白浓度均呈正相关关系(P<0.05);与无贫血组相比,中重度贫血组患者Tetramer+细胞比例、数量及ELISPOT斑点数均明显降低(P<0.05)。结论肿瘤患者外周血新冠病毒特异性记忆CD8^(+)T细胞的丰度与血红蛋白浓度正相关,提示肿瘤相关性贫血可能通过降低外周血中记忆CD8^(+)T细胞的丰度导致患者病毒易感性增高。

关键词：肿瘤相关性贫血记忆T细胞新型冠状病毒

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Increasing Crop Quality and Yield with a Machine Learning-Based Crop Monitoring System

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Computers, Materials & Continua 2023年第8期76卷 2401-2426页

作者： Anas Bilal Xiaowen Liu haixia long Muhammad Shafiq Muhammad Waqar College of Information Science Technology Hainan Normal UniversityHaikou571158China School of Information Engineering Qujing Normal UniversityQujing655011China Department of Computer Science COMSATS UniversityIslamabad45550Pakistan

Farming is cultivating the soil,producing crops,and keeping *** agricultural sector plays a crucial role in a country’s economic *** research proposes a two-stage machine learning framework for agriculture to improve efficiency and increase crop *** the first stage,machine learning algorithms generate data for extensive and far-flung agricultural areas and forecast *** recommended crops are based on various factors such as weather conditions,soil analysis,and the amount of fertilizers and pesticides *** the second stage,a transfer learningbased model for plant seedlings,pests,and plant leaf disease datasets is used to detect weeds,pesticides,and diseases in the *** proposed model achieved an average accuracy of 95%,97%,and 98% in plant seedlings,pests,and plant leaf disease detection,*** system can help farmers pinpoint the precise measures required at the right time to increase yields.

关键词： Machine learning computer vision trends in smart farming precision agriculture Agriculture 4.0

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基于史密斯模型的“港澳药械通”政策有效执行影响因素研究

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卫生软科学 2024年第4期38卷 45-47,51页

作者：贺书瑾龙海霞黄玥南方医科大学附属广东省人民医院/广东省医学科学院广东广州510080

结合粤港澳大湾区“港澳药械通”政策导向和政策执行成效,运用史密斯政策执行过程模型,从理想化政策、执行机构、目标群体和政策执行环境4个方面,对“港澳药械通”政策的执行过程进行研究分析,得出该政策存在政策本身限制、执行机构执... 详细信息

结合粤港澳大湾区“港澳药械通”政策导向和政策执行成效,运用史密斯政策执行过程模型,从理想化政策、执行机构、目标群体和政策执行环境4个方面,对“港澳药械通”政策的执行过程进行研究分析,得出该政策存在政策本身限制、执行机构执行力不足、目标群体意愿低、政策环境不利于发展等问题。提出了在后续政策优化中完善配套政策、压实各主体责任、提升信息化水平、加强真实世界研究等建议,以保障港澳药械安全有效可控,推动“港澳药械通”政策可持续发展,助力健康湾区建设。

关键词： “港澳药械通”政策史密斯模型政策执行粤港澳大湾区

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High-throughput single-сell sequencing in cancer research

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Signal Transduction and Targeted Therapy 2022年第6期7卷 1899-1918页

作者： Qingzhu Jia Han Chu Zheng Jin haixia long Bo Zhu Institute of Cancer Xinqiao HospitalArmy Medical UniversityChongqing 400037China Chongqing Key Laboratory of Immunotherapy Chongqing 400037China Center of Growth Metabolism and AgingKey Laboratory of Bio-Resources and Eco-EnvironmentCollege of Life SciencesSichuan UniversityChengdu 610064China Research Institute GloriousMed Clinical Laboratory Co.LtdShanghai 201318China

With advances in sequencing and instrument technology,bioinformatics analysis is being applied to batches of massive cells at single-cell ***-throughput single-cell sequencing can be utilized for multi-omics characterization of tumor cells,stromal cells or infiltrated immune cells to evaluate tumor progression,responses to environmental perturbations,heterogeneous composition of the tumor microenvironment,and complex intercellular interactions between these ***,single-cell sequencing of T cell receptors,alone or in combination with single-cell RNA sequencing,is useful in the fields of tumor immunology and *** insights obtained from single-cell analysis are critically important for exploring the biomarkers of disease progression or antitumor treatment,as well as for guiding precise clinical decision-making for patients with malignant *** this review,we summarize the clinical applications of single-cell sequencing in the fields of tumor cell evolution,tumor immunology,and tumor ***,we analyze the tumor cell response to antitumor treatment,heterogeneity of the tumor microenvironment,and response or resistance to immune checkpoint *** limitations of single-cell analysis in cancer research are also discussed.

关键词： instrument precise utilized

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Mechanism and effects of extramedullary hematopoiesis on anti-tumor immunity

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Cancer Biology & Medicine 2023年第7期20卷 477-482页

作者： Zefang Chen Xinyu Cheng Li Yang Xiaoming Cheng Bo Zhu haixia long Institute of Cancer Xinqiao HospitalThird Military Medical UniversityChongqing 400037China School of Pharmacy and Bioengineering Chongqing University of TechnologyChongqing 400054China Department of Respiratory Disease Xinqiao HospitalThird Military Medical UniversityChongqing 400037China

Cancer immunotherapy is a preferred strategy for boosting anti-tumor immunity to eliminate malignant cells and is considered a major breakthrough in the field of cancer treatment however,immunosuppressive cells in the tumor microenvironment(TME)pose a major obstacle to the efficacy of *** cells,such as tumor-a ssociated macrophages(TAMs)and myeloid-derived suppressor cells(MDSCs).

关键词： immunity immunotherapy Cancer

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Authors' response to “Maternal age as a potential explanation of the role of the L allele of the serotonin transporter gene in anxiety and depression in Asians”

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Neuroscience Bulletin 2014年第3期30卷 536-537页

作者： haixia long Bing Liu Bing Hou Chao Wang Jin Li Tianzi Jiang Brainnetome Center Institute of Automation Chinese Academy of Sciences National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Key Laboratory for NeuroInformation of Ministry of Education School of Life Science and Technology University of Electronic Science and Technology of China Queensland Brain Institute University of Queensland

In the letter to the editor, Dr. Comings et al. proposed a potential explanation of our findings that the L allele rather than S allele of 5-HTTLPR was associated with higher anxiety levels and reduced amygdala-prefrontal cortex （PFC） connectivity in Han Chinese[1], which demonstrated an ＇allele reversal＇ in the genetics of the 5-HTTLPR gene in Asians versus Caucasians. The authors alleged that this ＇allele reversal＇ might simply result from maternal age and suggested that we test this on our datasets. Unfortunately,

关键词： In Maternal age as a potential explanation of the role of the L allele of the serotonin transporter gene in anxiety and depression in Asians response to Authors gene

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A potential ethnic difference in the association between 5-HTTLPR polymorphisms and the brain default mode network

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Chinese Science Bulletin 2014年第13期59卷 1355-1361页

作者： haixia long Bing Liu Bing Hou Chao Wang Keith M. Kendrick Chunshui Yu Tianzi Jiang Brainnetome Center Institute of Automation Chinese Academy of Sciences National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Key Laboratory for NeuroInformation of Ministry of Education School of Life Science and Technology University of Electronic Science and Technology of China Department of Radiology Tianjin Medical University General Hospital Queensland Brain Institute University of Queensland Brisbane QLD 4072 Australia

The serotonin-transporter-linked polymorphic region(5-HTTLPR)is associated with mood *** association is thought to be due to amygdala hyperresponsiveness to negative emotional stimuli as a result of reduced frontal cortical *** Caucasians,the short form is associated with this effect,but in Han Chinese we recently found that the long form is *** receptors have rich expression in default mode network(DMN)regions and the recent studies have found an association between the short form of the 5-HTTLPR and DMN functional connectivity(FC)in *** present study has investigated whether there may also be anethnic difference in this influence of 5-HTTLPR on the *** recruited 233 young Han Chinese subjects and calculated the resting-state default-network *** study found that the L carriers had decreased FC in the bilateral medial prefrontal cortex,right parahippocampal gyrus,left middle temporal gyrus,and increased FC in left precuneus(Pcu)compared to *** PCC-Pcu FC in L carriers was significantly negatively correlated with the depression *** findings,therefore,suggest that there is also a difference between Caucasian and Han Chinese subjects in the association between the different forms of the5-HTTLPR and DMN functional connectivity.

关键词：网络表多态性关联种族差异大脑中国汉族消极情绪前额叶皮质

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The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala

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Neuroscience Bulletin 2013年第1期29卷 4-15页

作者： haixia long Bing Liu Bing Hou Chao Wang Jin Li Wen Qin Dawei Wang Yuan Zhou Keith M. Kendrick Chunshui Yu Tianzi Jiang LIAMA Center for Computational Medicine National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Key Laboratory for NeuroInformation of the Ministry of Education School of Life Science and Technology University of Electronic Science and Technology of China Department of Radiology Tianjin Medical University General Hospital Key Laboratory of Behavioral Science Institute of Psychology Chinese Academy of Sciences Queensland Brain Institute University of Queensland Brisbane QLD 4072 Australia

The short allele of the serotonin-transporter gene is associated with higher risk for anxiety and depression in Caucasians, but this association is still unclear in Asians. Here, we addressed this issue using behavioral and multi-modal MRI approaches in a large group of healthy Han Chinese participants （n = 233）. In contrast to findings in Caucasians, we found that long-allele （L） carriers had higher anxiety scores. In another group （n = 64） experiencing significant levels of depression or anxiety, the L-allele frequency was also significantly higher. In healthy participants, L-carriers had reduced functional and anatomical connectivity between the amygdala and prefrontal cortex （PFC）, which was correlated with anxiety or depression scores. Our findings demonstrated that in Chinese Han participants, in contrast to Caucasians, the L-allele confers vulnerability to anxiety or depression and weakens top-down emotional control between the PFC and amygdala. Therefore, ethnic background should be taken into account in gene-related studies and their potential clinical applications.

关键词： 5-HTTLPR functional and anatomical connectivity amygdala prefrontal cortex Han Chinese

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