High-throughput single-сell sequencing in cancer research
作者机构：Institute of CancerXinqiao HospitalArmy Medical UniversityChongqing 400037China Chongqing Key Laboratory of ImmunotherapyChongqing 400037China Center of GrowthMetabolism and AgingKey Laboratory of Bio-Resources and Eco-EnvironmentCollege of Life SciencesSichuan UniversityChengdu 610064China Research InstituteGloriousMed Clinical Laboratory Co.LtdShanghai 201318China
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2022年第7卷第6期
页 面：1899-1918页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学]
主 题：instrument precise utilized
摘 要：With advances in sequencing and instrument technology,bioinformatics analysis is being applied to batches of massive cells at single-cell ***-throughput single-cell sequencing can be utilized for multi-omics characterization of tumor cells,stromal cells or infiltrated immune cells to evaluate tumor progression,responses to environmental perturbations,heterogeneous composition of the tumor microenvironment,and complex intercellular interactions between these ***,single-cell sequencing of T cell receptors,alone or in combination with single-cell RNA sequencing,is useful in the fields of tumor immunology and *** insights obtained from single-cell analysis are critically important for exploring the biomarkers of disease progression or antitumor treatment,as well as for guiding precise clinical decision-making for patients with malignant *** this review,we summarize the clinical applications of single-cell sequencing in the fields of tumor cell evolution,tumor immunology,and tumor ***,we analyze the tumor cell response to antitumor treatment,heterogeneity of the tumor microenvironment,and response or resistance to immune checkpoint *** limitations of single-cell analysis in cancer research are also discussed.
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