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The Innovation 2024年第1期5卷 23-25页

作者： Guosheng Xu Zhiyuan Lu Dehong Chen Baonian Wan Institute of Plasma Physics Chinese Academy of SciencesHefei 230031China

The stellarator has inherent advantages over the tokamak in achieving steady-state operation,especially due to its absence of disruptions and lack of need for current drive and the associated recirculating power.In recent years,there have been remarkable advances in the field of stellarator optimization,where precisely quasi-symmetric and precisely quasi-isodynamic magnetic configurations have been achieved with coils,allowing the neoclassical transport and energetic particle losses of stellarators to be reduced to levels comparable to those of tokamaks.At the same time,the development of high-temperature superconducting magnet technology will potentially double the magnetic field strength of stellarators.While these strong fields are expected to introduce new challenges,and while turbulent transport remains a common challenge for both stellarators and tokamaks,the combination of these physical and technological advances results in the expectation that stellarators will become a competitive approach to tokamaks for realizing steady-state fusion.

关键词： field approach precise

Self-consistent and precise measurement of time-dependent radiative albedo of gold based on specially symmetrical triple-cavity Hohlraum

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Matter and Radiation at Extremes 2024年第3期9卷 57-64页

作者： Zhiyu Zhang Yang Zhao Xiaoying Han Liling Li Bo Qing Lifei Hou Yulong Li YuXue Zhang Huan Zhang Xiangming Liu Bo Deng Gang Xiong Min Lv Tuo Zhu Chengwu Huang Tianming Song Yan Zhao Yingjie Li Lu Zhang Xufei Xie Jiyan Zhang Jiamin Yang Laser Fusion Research Center China Academy of Engineering PhysicsMianyang 621900China National Key Laboratory of Plasma Physcis Mianyang 621900China Institute of Applied Physics and Computational Mathematics Beijing 100088China

A self-consistent and precise method to determine the time-dependent radiative albedo,i.e.,the ratio of the reemission flux to the incident flux,for an indirect-drive inertial confinement fusion Hohlraum wall material is proposed.A specially designed symmetrical triple-cavity gold Hohlraum is used to create approximately constant and near-equilibrium uniform radiation with a peak temperature of 160 eV.The incident flux at the secondary cavity waist is obtained from flux balance analysis and from the shock velocity of a standard sample.The results agree well owing to the symmetrical radiation in the secondary cavity.A self-consistent and precise time-dependent radiative albedo is deduced from the reliable reemission flux and the incident flux,and the result from the shock velocity is found to have a smaller uncertainty than that from the multi-angle flux balance analysis,and also to agree well with the result of a simulation using the HYADES opacity.

关键词： precise cavity radiative

基于纳米孔道电荷传输的单分子单细胞精准测量

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Science Bulletin 2021年第16期66卷 1599-1600页

作者：黄羽薛慧颍娄筱叮夏帆 Engineering Research Center of Nano-Geomaterials of Ministry of Education Faculty of Material Science and ChemistryChina University of GeosciencesWuhan 430074China Zhejiang Institute China University of GeosciencesHangzhou 311305China

Diseases often come from a cell or even a molecule misperforms its function.Obtaining fluctuation of nucleic acids,proteins,glycans and other biomolecules is helpful to reveal the molecular mechanism of diseases and promote the development of biology and medicine.To date,precise measurement of single molecule and single cell in the life systems has become a significant research topic of analytic chemistry,and also an important way for chemists devoting to“Healthy China Strategy”

关键词： function. 单分子 precise

precise genome-editing in human diseases:mechanisms,strategies and applications

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1065-1085页

作者： Yanjiang Zheng Yifei Li Kaiyu Zhou Tiange Li Nathan J.VanDusen Yimin Hua Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE Department of PediatricsWest China Second University HospitalSichuan UniversityChengduSichuan 610041China Department of Cardiovascular Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of Pediatrics Herman B Wells Center for Pediatric ResearchIndiana University School of MedicineIndianapolisIN 46202USA

precise genome-editing platforms are versatile tools for generating specific,site-directed DNA insertions,deletions,and substitutions.The continuous enhancement of these tools has led to a revolution in the life sciences,which promises to deliver novel therapies for genetic disease.precise genome-editing can be traced back to the 1950s with the discovery of DNA’s doublehelix and,after 70 years of development,has evolved from crude in vitro applications to a wide range of sophisticated capabilities,including in vivo applications.Nonetheless,precise genome-editing faces constraints such as modest efficiency,delivery challenges,and off-target effects.In this review,we explore precise genome-editing,with a focus on introduction of the landmark events in its history,various platforms,delivery systems,and applications.First,we discuss the landmark events in the history of precise genome-editing.Second,we describe the current state of precise genome-editing strategies and explain how these techniques offer unprecedented precision and versatility for modifying the human genome.Third,we introduce the current delivery systems used to deploy precise genome-editing components through DNA,RNA,and RNPs.Finally,we summarize the current applications of precise genome-editing in labeling endogenous genes,screening genetic variants,molecular recording,generating disease models,and gene therapy,including ex vivo therapy and in vivo therapy,and discuss potential future advances.

关键词： precise generating editing

precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting

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Signal Transduction and Targeted Therapy 2020年第1期5卷 279-293页

作者： Xianglei Fu Yanbin Shi Tongtong Qi Shengnan Qiu Yi Huang Xiaogang Zhao Qifeng Sun Guimei Lin Department of Pharmaceutics Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012 ShandongChina School of Mechanical and Automotive Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353 ShandongChina The Second Hospital Cheeloo College of MedicineShandong UniversityJinan 250033 ShandongChina

Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to reach their final targets.The optimal targets of most cancer therapeutic agents are usually biological macromolecules at the subcellular level,which play a key role in carcinogenesis.Therefore,to improve the therapeutic efficiency of drugs,researchers need to focus on delivering not only the therapeutic agents to the target tissues and cells but also the drugs to the relevant subcellular structures.In this review,we discuss the most recent construction strategies and release patterns of various cancer cell subcellular-targeting nanoformulations,aiming at providing guidance in the overall design of precise nanomedicine.Additionally,future challenges and potential perspectives are illustrated in the hope of enhancing anticancer efficacy and accelerating the translational progress of precise nanomedicine.

关键词： therapeutic drugs precise

A simple and precise method(Y2H-in-frame-seq) improves yeast two-hybrid screening with cDNA libraries

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Journal of Genetics and Genomics 2022年第6期49卷 595-598页

作者： Yinghui Gu Guannan Li Ping Wang Yan Guo Jingrui Li State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China

As the most powerful and widely used binary interaction assay,the yeast two-hybrid(Y2H) system has been developed for more than 30 years to improve the efficiency and quality of proteinprotein interaction(PPI) explora... 详细信息

关键词： precise interaction improve

Highly sensitive H_(2)O_(2)-scavenging nano-bionic system for precise treatment of atherosclerosis

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Acta Pharmaceutica Sinica B 2023年第1期13卷 372-389页

作者： Xiaoyu Liang Huiyang Li Xuanling Li Xinxin Tian Aiai Zhang Qingzhi Luo Jianwei Duan Youlu Chen Liyun Pang Chen Li Xing-Jie Liang Yong Zeng Jing Yang Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical EngineeringChinese Academy of Medical Science and Peking Union Medical CollegeTianjin 300192China Beijing Anzhen Hospital of Capital Medical University Beijing 100029China Medical College of Qinghai University Xining 810016China CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBejing 100190China The First Affiliated Hospital of Hebei North University Zhangjiakou 075061China First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300381China

In atherosclerosis,chronic inflammatory processes in local diseased areas may lead to the accumulation of reactive oxygen species(ROS).In this study,we devised a highly sensitive H_(2)O_(2)-scavenging nanobionic system loaded with probucol(RPP-PU),to treat atherosclerosis more effectively.The RPP material had high sensitivity to H_(2)O_(2),and the response sensitivity could be reduced from 40 to 10μmol/L which was close to the lowest concentration of H_(2)O_(2)levels of the pathological environment.RPP-PU delayed the release and prolonged the duration of PU in vivo.In Apolipoprotein E deficient(ApoE-/-)mice,RPP-PU effectively eliminated pathological ROS,reduced the level of lipids and related metabolic enzymes,and significantly decreased the area of vascular plaques and fibers.Our study demonstrated that the H_(2)O_(2)-scavenging nanobionic system could scavenge the abundant ROS in the atherosclerosis lesion,thereby reducing the oxidative stress for treating atherosclerosis and thus achieve the therapeutic goals with atherosclerosis more desirably.

关键词： Highly sensitive H_(2)O_(2)-scavenging Nano-bionic system Atherosclerosis Oxidative stress precise Target Pathological environment

Surface ligand engineering on the optical properties of atomically precise AuAg nanoclusters

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Chinese Journal of Structural Chemistry 2023年第9期42卷 1-5页

作者： Xiang Liu Yifei Zhang Zhiwen Li Gao Li Farid Taherkhani Hunan Drug Inspection Center Hunan Institute for Drug ControlChangsha410013China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China Institute of Catalysis for Energy and Environment College of Chemistry and Chemical EngineeringShenyang Normal UniversityShenyang110034China University of Chinese Academy of Sciences Beijing100049China Departments of Production Engineering Universität Bremen Bibliothekstraße 128359Germany

1.Introduction In recent decade,atomically precise metal nanoclusters,comprised of metal kernel and surface protecting ligands,have appeared as a new and promising nanomaterial for abundant applications,such as nanocatalysis,sensor,photoluminescence,a few to name,which is attributed to their electron energy quantization arising from quantum size effect[1].And the very recent investigations showed that the configuration of metal kernel and the electronic properties of metal nanoclusters with the same metal core are largely affected by the surface protecting ligands[[2],[3]].For example,the surface ligands can significantly alter the catalytic performance of metal nanocluster catalysts(e.***.activity and selectivity)in a positive way.We have found that the Au_(25)(SR)_(18)nanocluster with the aromatic ligands can give higher conversions and a markedly increasing selectivity toward the desired product[4].

关键词： precise clusters selectivity

Phase transferring atomically precise gold nanoclusters to aqueous solution via single stranded DNA

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Science China Chemistry 2022年第6期65卷 1003-1004页

作者： Qiangbin Wang CAS Key Laboratory of Nano-Bio Interface Division of Nanobiomedicine and i-LabSuzhou Institute of Nano-Tech and Nano-BionicsSuzhou215123China

Atomically precise gold nanoclusters (Au NCs) are an emerging class of quantum-sized nanomaterials. The intrinsic discrete electronic energy levels endowed them with fascinating electronic and optical properties [1]. However,the prepared Au NCs are often protected with hydrophobic ligands and are not dispersible in aqueous solutions, which restricts their biological applications. To overcome this limitation, some phase transfer agents have been devoted to transferring hydrophobic Au NCs into the aqueous solution[2]. However, the resulting Au NCs are generally heterogeneous and aggregated, which makes their subsequent biofunctionalization difficult to control.

关键词： materials precise clusters

precise Droplet Manipulation Based on Surface Heterogeneity

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Accounts of Materials Research 2021年第4期2卷 230-241页

作者： Huizeng Li An Li Zhipeng Zhao Luanluan Xue Mingzhu Li Yanlin Song Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190P.R.China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049P.R.China

The control of droplet behavior has been investigated for several centuries due to its universality and significance in nature,daily life,and industrial applications.Diverse strategies have been developed and employed to regulate droplet behavior,and great progress has been achieved such as accelerated droplet bouncing,controlled droplet dispensing,and enhanced droplet adhesion.Compared with the strategies utilizing external fields including magnets,heat,light,and electricity as well as various topological structures,the heterogeneous wettability surface provides a facile and efficient way to manipulate droplet behavior and thus has aroused increasing research interest in many fields.The heterogeneous wettability substrate integrates wettable and less wettable regions onto an individual surface,with rational design and a geometrical arrangement.Therefore,it shows more precise,diverse,and controllable interactions with droplets than homogeneous surfaces.In addition to confining the droplet position and morphology and regulating the droplet dynamics,the nonuniformity in wettability can induce a difference in electrical conductivity,nucleation energy barriers,and so forth,which greatly extends its application in the fields of functional materials deposition and device fabrication.In this Account,recent progress in the precise droplet manipulation based on heterogeneous wettability is summarized.First,the principle of droplet control by a heterogeneous surface and the development of the green printing technique based on this principle are introduced.Then the droplet manipulation,categorized as droplet patterning,droplet isolation,and droplet dynamics,is described.Meanwhile,related applications,such as high-capacity information coding,highly sensitive detection,and high-performance optic/electric device fabrication,are demonstrated.In addition,the general principle for controlling the droplet impact using heterogeneous wettability substrates is highlighted.Finally,a brief summary of this Account,with challenges and op

关键词： precise arrangement utilizing