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Journal of Rare Earths 2024年第4期42卷 660-667页

作者： Guangying Fu Dongsen mao jun Yu Qiangsheng Guo School of Chemical and Environmental Engineering Shanghai Institute of TechnologyShanghai21418 China The ZeoMat Group Qingdao Institute of Bioenergy and Bioprocess TechnologyCASQingdao26611China

Several ternary oxides CuCeZrO_(y)(CCZ)were synthesized by a facile grinding method followed by calcination at high temperatures,and used as catalysts for CO oxidation at low temperatures.The influences of calcination temperature(400-600℃)on the physicochemical properties of the assynthesized ternary oxides were investigated by thermogravimetric analysis/differential scanning calorimetry(TGA/DSC),X-ray diffraction(XRD),transmission electron microscopy(TEM),Raman,inductively coupled plasma-optical emission spectrometry(ICP-OES),N_(2) adsorption,H_(2)-temperature programmed reduction(H_(2)-TPR),and X-ray photoelectron spectroscopy(XPS)characterizations.The results show that the increase in calcination temperature from 400 to 500℃is conducive to the high dispersion of CuOx on catalyst surface and the incorporation of Cu species into the support to form the Cu-Ce-Zr-O solid solution.Further raising of calcination temperature from 500 to 600℃,however,leads to the segregation of Cu species from the solid solution to aggregate on support surface and growth of highly dispersed CuOx nanoparticles.The highest catalytic activity is acquired over the CCZ calcined at 500℃,which can be ascribed to the largest contents of Cu+species and oxygen vacancies owing to the formation of the maximum amount of Cu-Ce-Zr-O solid solution.

关键词： CuCeZrO_(y)catalyst co oxidation Calcination temperature Grinding method Oxalate precursor Rare earths

Babao Dan Inhibits Gastric Cancer Progression in vivo Through Multiple Signaling Pathways

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 14-21页

作者： hai-Xia Shang Yi Fang Bin Guan Jian-Hua Guan jun Peng Jin-Yan Zhao Jiu-mao Lin Institute of Oncology of Academy of Integrative Medicine Fujian University of Traditional Chinese MedicineFuzhouFujianChina Key Laboratory of Integrative Medicine of Fujian Province University Fujian University of Traditional Chinese MedicineFuzhouFujianChina Fujian Key Laboratory of Integrative Medicine on Geriatric Fujian University of Traditional Chinese MedicineFuzhouFujianChina Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhouFujianChina Xiamen Traditional Chinese Medicine Co. Ltd.XiamenFujianChina

Objective:The aim of this study was to explore the effects of Babao dan(BBD),a traditional Chinese medicine,on gastric cancer(GC)progression in vivo.Materials and Methods:A subcutaneous xenograft mouse model of GC was established using MGC80-3 cells.The terminal deoxynucleotidyl transferase-mediated dUTP:2'-deoxyuridine 5'-triphosphate-biotin nick-end labeling method was adopted to detect cell apoptosis in vivo.The expression levels of proteins associated with proliferation,apoptosis,and angiogenesis were measured by immunohistochemical staining or western blotting(WB).The activation and protein levels of p-c-jun N-terminal kinase(JNK),p-p38,p-extracellular-regulated kinase 1/2,p-nuclear factor-κB(NF-κB),and p-STAT3 were examined by Bio-plex and WB.Results:BBD significantly inhibited tumor growth in GC mouse models with no adverse effect on body weight or organ function.It was also found that BBD significantly suppressed the proliferation of GC tumor cells,induced the apoptosis of tumor cells,and inhibited angiogenesis through inactivating with mitogen-activated protein kinase,NF-κB,and STAT3 pathways.Conclusions:BBD exerts suppressive effects on GC tumor growth by regulating multiple pathways in vivo,which may provide a novel treatment option for GC therapy.

关键词： Babao dan gastric cancer multiple signaling pathways proliferation traditional Chinese medicine

Ferritinophagy: A new idea for liver diseases regulated by ferroptosis

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 160-170页

作者： Zi-Bing Qian jun-Feng Li Wan-Yuan Xiong Xiao-Rong mao The First Clinical Medical College of Lanzhou University Lanzhou 730000China Institute of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000China Department of Infectious Disease The First Hospital of Lanzhou UniversityLanzhou 730000China

Background:The discovery of regulatory cell death has led to a breakthrough in the therapeutic field.Various forms of cell death,such as necrosis,apoptosis,pyroptosis,autophagy,and ferroptosis,play an important role in the development of liver diseases.In general,more than one form of cell death pathways is responsible for the disease state.Therefore,it is particularly important to study the regulation and interaction of various cell death forms in liver diseases.Data sources:We performed a PubMed search up to November 2022 with the following keywords:ferritinophagy,ferroptosis,and liver disease.We also used terms such as signal path,inducer,and inhibitor to supplement the query results.Results:This review summarized the basic characteristics of ferritinophagy and ferroptosis and the regulation of ferroptosis by ferritinophagy and reviewed the key targets and treatment strategies of ferroptosis in different liver diseases.Conclusions:Ferritinophagy is a potential therapeutic target in ferroptosis-related liver diseases.

关键词： Ferritinophagy Ferroptosis Liver disease

Perioperative complication incidence and risk factors for retroperitoneal neuroblastoma in children:analysis of 571 patients

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World Journal of Pediatrics 2024年第3期20卷 250-258页

作者： Min He Jia-Bin Cai Xuan Wu Yin-Bing Tang Jin-Yan Wang jun-Qin mao Ji-jun Chen Li-Feng Zhang Zhong-hai Guan Jie-Ni Xiong Wan-Xin Peng Jin-Hu Wang Ting Tao Pediatric Cancer Research Center National Clinical Research Center for Child HealthHangzhouChina Department of Surgical Oncology Children's HospitalZhejiang University School of MedicineHangzhouChina Cancer Center Zhejiang UniversityNo.3333 Binsheng RodeHangzhouChina

Background Surgery plays an important role in the treatment of neuroblastoma.Perioperative complications may impact the course of neuroblastoma treatment.To date,comprehensive analyses of complications and risk factors have been lacking.Methods Patients with retroperitoneal neuroblastoma undergoing tumor resection were retrospectively analyzed between 2014 and 2021.The data collected included clinical characteristics,operative details,operative complications and postopera-tive outcomes.Risk factors for perioperative complications of retroperitoneal neuroblastoma were analyzed.Results A total of 571 patients were enrolled in this study.Perioperative complications were observed in 255(44.7%)patients.Lymphatic leakage(28.4%),diarrhea(13.5%),and injury(vascular,nerve and organ;7.5%)were the most frequent compli-cations.There were three operation-related deaths(0.53%):massive hemorrhage(n=1),biliary tract perforation(n=1)and intestinal necrosis(n=1).The presence of image-defined risk factors(IDRFs)[odds ratio(OR)=2.09,P<0.01],high stage of the International Neuroblastoma Risk Group staging system(INRGSS)(OR=0.454,P=0.04),retroperitoneal lymph node metastasis(OR=2.433,P=0.026),superior mesenteric artery encasement(OR=3.346,P=0.003),and inferior mesenteric artery encasement(OR=2.218,P=0.019)were identified as independent risk factors for perioperative complications.Conclusions Despite the high incidence of perioperative complications,the associated mortality rate was quite low.Perio-perative complications of retroperitoneal neuroblastoma were associated with IDRFs,INRGSS,retroperitoneal lymph node metastasis and vascular encasement.Patients with high-risk factors should receive more serious attention during surgery but should not discourage the determination to pursue total resection of neuroblastoma.

关键词： Complication Neuroblastoma Risk factors Surgery

Thoracic spinal cord injury and paraplegia caused by intradural cement leakage after percutaneous kyphoplasty: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1837-1843页

作者： Zi mao Zhi-Hong Xiong jun-Feng Li Department of Pain Management The Affiliated Hospital of Yunnan UniversityKunming 650000Yunnan ProvinceChina Department of Medical Administration The Affiliated Hospital of Yunnan UniversityKunming 650000Yunnan ProvinceChina

BACKGROUND Percutaneous kyphoplasty(PKP)is a pivotal intervention for osteoporotic fractures,pathological vertebral compression fractures,and vertebral bone tumors.Despite its efficacy,the procedure presents challenges,notably complications arising from intradural cement leakage.Timely and accurate diagnosis,coupled with emergent intervention is imperative to improve patient prognosis.This case report illuminates the intricacies and potential complications associated with PKP,emphasizing the critical need for vigilant monitoring,prompt diagnosis,and immediate intervention to mitigate adverse outcomes.CASE SUMMARY A 58-year-old male patient,experiencing a T7 osteoporosis-related pathological compression fracture,underwent PKP at a local hospital.Two weeks postprocedure,the patient developed paraplegic and dysuric symptoms,necessitating emergency decompression surgery.Gradual improvement was achieved,marked by the restoration of muscle strength,sensation,and mobility.CONCLUSION PKP Intradural cement leakage following PKP is unusual and potentially fatal.Prompt imaging examinations,urgent evaluation,and the decompression surgery are essential,which help alleviate symptoms associated with spinal damage,markedly improving the overall prognosis.

关键词： Percutaneous kyphoplasty Intradural cement leakage Complication Decompression surgery Case report

Effect of foot reflexology on an infant with sensorineural hearing loss:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1437-1441页

作者： Yu-jun Lee mao-Qing Chen Jie Dong Graduate School Xi'an International Studies UniversityNorth Sichuan Medical UniversityXi'an 710061Shaanxi ProvinceChina Department of Neural Disease North Sichuan Medical UniversityNanchong 635200Sichuan ProvinceChina Department of Nursing North Sichuan Medical UniversityNachong 635200Sichuan ProvinceChina Key Laboratory for Artificial Intelligence and Cognitive Neuroscience of Language Xi’an International Studies UniversityXi’an 710128Shaanxi ProvinceChina

BACKGROUND Our study contributes to the further understanding of the mechanism of foot reflexology.Foot reflexology has been reported to affect hearing recovery,but no physiological evidence has been provided.This lack of evidence hampers the acceptance of the technique in clinical practice.CASE SUMMARY A girl was taken to North Sichuan Medical University Affiliated Hospital for a hearing screen by her parents.Her parents reported that her hearing level was the same as when she was born.The girl was diagnosed with sensorineural hearing loss(SNHL)by a doctor in the otolaryngology department.After we introduced the foot reflexology project,the parents agreed to participate in the experiment.After 6 months of foot reflexology treatment,the hearing threshold of the girl recovered to a normal level,below 30 dB.CONCLUSION Foot reflexology should be encouraged in clinical practice and for families of infants with SNHL.

关键词： Infant with sensorineural hearing loss Foot reflexology Functional connectivity Language development Case report

Inclusions modification by rare earth in steel and the resulting properties: A review

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Journal of Rare Earths 2024年第3期42卷 431-445,I0001页

作者： Xiaoqiang Wang Zhiwei Wu Bing Li Wenxiong Chen jun Zhang Jian mao College of Materials Science and Engineering Sichuan UniversityChengdu610065China Chengdu Advanced Metal Materials Industry Technology Research Institute Co. Ltd.Chengdu610303China State Key Laboratory of Metal Material for Marine Equipment and Application Anshan114009China

Rare earth(RE) elements are excellent modifiers for non-metallic inclusions that inevitably appear in steel and affect steel properties. This paper reviews the research status of inclusions modification by RE elements and the changes it cause on steel properties. First, the inclusion changes caused by RE modification are described. Generally, after adding pure RE, the main evolution of inclusions occurs as M →M + RE-Al-O → RE-Al-O + RE_(2)O_(2)S → RE_(2)O_(2)S + RE—S/RE_(2)O_(2)S + RE-O with an increase in the RE content(M represents the inclusions before RE addition). The type of final inclusion obtained after RE modification is related to the relative contents of S and O in the steel. Moreover, fine, regular, and uniformly distributed inclusions can be obtained with appropriate RE addition. However, the effectiveness of inclusions modification by adding both RE and non-RE elements is closely related to the order of their addition. Second, the applications and advantages of thermodynamic calculations in the study of RE-modified inclusions are introduced. Third, the changes in the corrosion resistance, impact properties,and other properties of steel caused by the modification of inclusions by RE are reviewed. Finally, the perspectives and trends of inclusions modified by RE elements in the steel industry are presented.

关键词： Rare earths Inclusions Modification Thermodynamic calculation Properties change

Association between Gene Polymorphisms and SNP-SNP Interactions of the Matrix Metalloproteinase 2 Signaling Pathway and the Risk of Vascular Senescence

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Biomedical and Environmental Sciences 2024年第2期37卷 146-156页

作者： LIAO Zhen Yu YANG Shuo HU Song LIU Jia mao Yong jun SUN Shu Qin Department of Geriatrics the Affiliated Hospital of Qingdao UniversityQingdao 266000ShandongChina Department of Critical Care Medicine the Affiliated Hospital of Qingdao UniversityQingdao 266000ShandongChina

Objective This study aimed to explore the association of single nucleotide polymorphisms(SNP)in the matrix metalloproteinase 2(MMP-2)signaling pathway and the risk of vascular senescence(VS).Methods In this cross-sectional study,between May and November 2022,peripheral venous blood of151 VS patients(case group)and 233 volunteers(control group)were collected.Fourteen SNPs were identified in five genes encoding the components of the MMP-2 signaling pathway,assessed through carotid-femoral pulse wave velocity(cf PWV),and analyzed using multivariate logistic regression.The multigene influence on the risk of VS was assessed using multifactor dimensionality reduction(MDR)and generalized multifactor dimensionality regression(GMDR)modeling.Results Within the multivariate logistic regression models,four SNPs were screened to have significant associations with VS:chemokine(C-C motif)ligand 2(CCL2)rs4586,MMP2 rs14070,MMP2rs7201,and MMP2 rs1053605.Carriers of the T/C genotype of MMP2 rs14070 had a 2.17-fold increased risk of developing VS compared with those of the C/C genotype,and those of the T/T genotype had a19.375-fold increased risk.CCL2 rs4586 and MMP-2 rs14070 exhibited the most significant interactions.Conclusion CCL2 rs4586,MMP-2 rs14070,MMP-2 rs7201,and MMP-2 rs1053605 polymorphisms were significantly associated with the risk of VS.

关键词： Vascular senescence Pulse wave velocity(PWV) Single nucleotide polymorphism(SNP) Matrix metalloproteinase 2(MMP-2) Extracellular matrix(ECM) Structural degradation Multifactor dimensionality reduction(MDR)

Iterative physical optics method based on efficient occlusion judgment with bounding volume hierarchy technology

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Journal of Electronic Science and Technology 2024年第1期22卷 1-12页

作者： Yang Su Yu-mao Wu jun Hu Key Laboratory for Information Science of Electromagnetic Waves(MoE) School of Information Science and TechnologyFudan UniversityShanghai200433China School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China

This paper builds a binary tree for the target based on the bounding volume hierarchy technology,thereby achieving strict acceleration of the shadow judgment process and reducing the computational complexity from the original O(N^(3))to O(N^(2)logN).Numerical results show that the proposed method is more efficient than the traditional method.It is verified in multiple examples that the proposed method can complete the convergence of the current.Moreover,the proposed method avoids the error of judging the lit-shadow relationship based on the normal vector,which is beneficial to current iteration and convergence.Compared with the brute force method,the current method can improve the simulation efficiency by 2 orders of magnitude.The proposed method is more suitable for scattering problems in electrically large cavities and complex scenarios.

关键词： Bounding volume hierarchy Cavity scattering Iterative physical optics(IPO)

Assessment of the induced radioactivity in the treatment room of the heavy-ion medical machine in Wuwei using PHITS

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Nuclear Science and Techniques 2023年第2期34卷 153-166页

作者： Ying Luo Sheng‑Cong Huang Hui Zhang hai‑jun mao Qiang Li Zhong‑Ying Dai Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Science Lanzhou 730000China Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine Lanzhou 730000China Lanzhou University Lanzhou 730000China

Carbon-ion radiotherapy(CIRT)offers unique physical and biological advantages over photon radiotherapy.However,some materials and devices in the CIRT treatment room become radioactive under bombardment by therapeutic carbon-ion beams due to nuclear reactions,thereby leading to possible radiation hazards to medical staff and additional and unwanted doses to patients.This study assessed the level of induced radioactivity in the treatment room of the Heavy-Ion Medical Machine(HIMM)in Wuwei.Monte Carlo simulations using PHITS were performed for a conservative case under the conditions of maximum beam energy and intensity provided by the HIMM facility.The geometry and configuration of Treatment Room 2 of the HIMM facility in Wuwei were adopted.We evaluated the activation of air,the phantom,and the components of the beamline,such as the primary collimator(PC),ridge filter(RF),and multileaf collimator(MLC).For air activation,we calculated the medical staff immersion external exposure and inhalation internal exposure caused by the corresponding radionuclides.For phantom activation,we estimated the additional dose to the patient’s family members owing to secondary photons after treatment.In addition,the exemption or non-exemption of the component material activation was assessed.The results showed that external radiation caused by air activation was the main source of the annual effective dose at approximately 0.5 mSv/y.The induced radioactivity exposure to family members of a patient after CIRT was approximately 40μSv,sufficiently lower than the public dose limit of 1 mSv/a.The induced radioactivity of the PC,RF,and MLC was all above the exempt levels after the devices were retired,whereas the induced radioactivity of the RS and compensator could reach the exempt levels after one patient session.Our study indicated that medical staff engaged in CIRT should stay away from the high-dose-rate area of induced radioactivity along the beam direction,shorten the residence time in the treatment room as much as possible,and store

关键词： activation approximate thereby