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Acute effects of human protein S administration after traumatic brain injury in mice

Neural Regeneration Research 2020年第11期15卷 2073-2081页

作者： Xiaowei Wang Jing Tong Xiaodi han Xiaoming qi Jun Zhang Erxi Wu Jason h.huang Center for Translational Neuromedicine University of RochesterRochesterNYUSA Department of Neurosurgery 4th Affiliated Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery Tiantan HospitalBeijingChina Department of Neurosurgery Baylor Scott&White HealthTempleTXUSA Department of Neurosurgery PLA General HospitalBeijingChina College of Medicine Texas A&M Health Science CenterTempleTXUSA

Despite years of effort,no effective acute phase treatment has been discovered for traumatic brain *** impediment to successful drug development is entangled secondary injury *** we show that protein S,a natural multifunctional protein that regulates coagulation,inflammation,and apoptosis,is able to reduce the extent of multiple secondary injuries in traumatic brain injury,and therefore improve *** subjected to controlled cortical impact were treated acutely(10–15 minutes post-injury)with a single dose of either protein S(1 mg/kg)or vehicle phosphate buffered saline via intravenous *** 24 hours post-injury,compared to the non-treated group,the protein S treated group showed substantial improvement of edema and fine motor coordination,as well as mitigation of progressive tissue *** and western blot targeting caspase-3,B-cell lymphoma 2(Bcl-2)along with terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assay revealed that apoptosis was suppressed in treated *** targeting CD11 b showed limited leukocyte infiltration in the protein S-treated ***,protein S treatment increased the ipsilesional expression of aquaporin-4,which may be the underlying mechanism of its function in reducing *** results indicate that immediate intravenous protein S treatment after controlled cortical impact is beneficial to traumatic brain injury *** Use Protocols(AUPs)were approved by the University Committee on Animal Resources(UCAR)of University of Rochester Medical Center(approval ***-2008-102 R)on November 12,2013.

关键词： apoptosis aquaporin-4 controlled cortical impact edema inflammation protein S TBI therapy traumatic brain injury

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Robust h-infinity control of uncertain stochastic time-delay linear repetitive processes

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控制理论与应用（英文版） 2010年第4期8卷 491-495页

作者： Yanhui LI Ji qi Xiaoyu qi Electrical and Information Engineering College Northeast Petroleum University Daqing Heilongiiang 163318 China Institute of Computer and Control Engineering Qiqihar University Qiqihar Heilongjiang 161006 China

Repetitive processes are a distinct class of 2D systems of both theoretic and practical *** robust h-infinity control problem for uncertain stochastic time-delay linear continuous repetitive processes is investigated in this ***,sufficient conditions are proposed in terms of stochastic Lyapunov stability theory,It o differential rule and linear matrix inequality *** corresponding controller design is then cast into a convex optimization *** is focused on constructing an admissible controller,which guarantees that the closed-loop repetitive processes are mean-square asymptotically stable and have a prespecified h-infinity performance γ with respect to all energy-bounded input signals.A numerical example illustrates the effectiveness of the proposed design scheme.

关键词： Stochastic time-delay repetitive processes h-infinity control LMI Parameter uncertainty

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Analysis of Carbon Functional Groups in Mobile humic Acid and Recalcitrant Calcium humate Extracted from Eight US Soils

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Pedosphere 2013年第6期23卷 705-716页

作者： hE Zhong-qi CAO Xiao-Yan MAO Jing-Dong T.OhNO h.M.WALDRIP USDA-ARS Southern Regional Research Center Department of Chemistry and Biochemistry Old Dominion University Department of Plant Soiland Environmental SciencesUniversity of Maine USDA-ARS Conservation and Production Research Laboratory

Solid state 13C nuclear magnetic resonance （NMR） spectroscopy is a common tool to study the structure of soil humic fractions; however, knowledge regarding carbon structural relationships in humic fractions is limited. In this study, mobile humic acid （MhA） and recalcitrant calcium humate （CallA） fractions were extracted from eight soils collected from six US states and representing a variety of soils and ecoregions, characterized by this spectroscopic technique and analyzed for statistical significance at P 〈 0.05. We found that the abundances of COO and N-C=O functional groups in the MhA fractions were negatively correlated to soil sand content, but were positively correlated to silt, total N and soil organic carbon contents. In contrast, the abundances of the COO and N-C=O functional groups were only positively correlated to the content of clay in the CallA fractions, indicating that the two humic fractions were associated with different soil components. The two 13C NMR peaks representing alkyls and OCh3/NCh were negatively correlated to the peaks representing aromatics, aromatic C-O and N-C=O/COO. Comparison of the sets of data from 13C NMR spectroscopy and ultrahigh resolution mass spectrometry revealed that the aromatic components identified by the two methods were highly consistent. The comparison further revealed that protein in MhA was associated with, or bound to, the nonpolar alkyl groups, but a component competitively against （or complementary to） aromatic groups in the MhA composition. These observations provided insight on the internal correlations of the functional groups of soil humic fractions.

关键词： correlation analysis humic substances nuclear magnetic resonance soil organic matter ultrahigh resolution mass spectrometry

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Antitumor effect of Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, combined with cytotoxic agent on murine hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第9期11卷 1382-1386页

作者： Bu-DongZhu Shou-JunYuan qi-ChengZhao XinLi qi-YingLu DepartmentofMedicalOncology PekingUniversitySchoolofOncologyandBeijingInstituteforCancerResearchBeijingCancerHospitalBeijing100036China InstituteofRadiationMedicine AcademyofMilitaryMedicalSciencesBeijing100850China

AIM: To investigate the inhibitory effect of gefitinib combined with cytotoxic agent cisplatin (CDDP) on hepatocellular carcinoma (hCC). METhODS: Female Kunming mice and h22 hepatocarcinoma cells were used. Gefitinib at daily dose of 100 mg/kg body weight (BW) or lecithin liquid was given by gastrogavage once a day for 5 or 10 successive days. CDDP or normal saline (NS) was administered intraperitoneally (i.p.) once a day for 5 successive days. Mice were randomly divided into control group (lecithin, or NS, i.p.), CDDP group (daily dose, 1.2 mg/kg BW; d1-5, or d6-10), Gefitinib (d1-5, or d6-10, or d1-10), and Gefitinib combined with CDDP groups. The inhibitory rate (IR) of tumor, net BW, spleen index (SI), thymus index (TI) and the amount of peripheral blood cells of mice were detected on the 12th experiment day. RESULTS: The growth of hCC in mice was inhibited by Gefitinib alone (IR: 41% in d1-10 group and 30% in d1-5 group, respectively) or CDDP alone (IR: 32-54% in d1-5 group or d6-10 group). The highest inhibitory effect (IR: 56%) on hCC growth was observed in Gefitinib (d1-10) combined with CDDP (d1-5) group. higher inhibition was also observed in CDDP (d1-5) followed by Gefitinib (d6-10) group than that in Gefitinib (d1-5) followed by CDDP (d6-10) group (IR: 61% vs 36%, Phe independent study. Net BW, SI, TI and the amount of blood cells of mice in Gefitinib alone group were not significantly different from those in control groups. CONCLUSION: Gefitinib can significantly inhibit the growth of murine h22 hepatocellular carcinoma. If Gefitinib is used after CDDP treatment in animal experiments, the inhibitory effect could be enhanced.

关键词： Neoplasms Gefitinib Therapy carcinoma hepatocellular cisplatin

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AMINO-TRIS-(METhYLENEPhOSPhONIC ACID)LAYERS ADSORPTION ON AA6061 ALUMINUM ALLOY

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Acta Metallurgica Sinica(English Letters) 2008年第5期21卷 355-361页

作者： S.h. Wang C.S. Liu F.J. Shan G.C. qi Key Laboratory for Anisotropy and Texture of Materials Ministry of Education Northeastern University Shenyang 110004 China Material＆ Chemical Engineering College Liaoning University of Technology Jinzhou 121001 China

The amino-tri-（methylenephosphonic acid） layers were adsorbed on the surface of AA6061 aluminum alloy for improving the lacquer adhesion and corrosion inhibition as a substitute for chromate coatings. The surface structure and characteristic of the amino-tri-（methylenephosphonic acid） layers on AA6061 aluminum alloy were investigated by means of XPS and ATR-FTIR analysis. The analyzed results showed that the amino-tri-（methylenephosphonic acid） adsorption layers adsorb on the surface of aluminium alloy via acid-base interaction in a bi-dentate conformation. After the amino-tri-（methylenephosphonic acid） layers were coated with epoxy resin, the layers showed good adhesive strength and favorable corrosion resistance in contrast to chromate coatings.

关键词： Amino-tri-(methylenephosphonic acid) layer Organophosphonate Aluminum alloy Corrosion resistance

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Conductive polypyrrole incorporated nanocellulose/MoS_(2)film for preparing flexible supercapacitor electrodes

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Frontiers of Materials Science 2021年第2期15卷 227-240页

作者： qi YUAN Ming-Cuo MA Research Center of Biomass Clean Utilization Beijing Key Laboratory of Lignocellulosic ChemistryCollege of Materials Science and TechnologyBeijing Forestry UniversityBeijing 100083China

Conductive films have emerged as appealing electrode materials in flexible supercapacitors owing to their conductivity and mechanical ***,the unsatisfactory electrode structure induced poor output performance and undesirable cycling stability limited their ***,a well-designed film was manufactured by the vacuum filtration and in-situ polymerization method from cellulose nanofibrils(CNFs),molybdenum disulfide(MoS_(2)),and *** electrode presented an outstanding mechanical strength(21.3 MPa)and electrical conductivity(9.70 S cm^(-1)).Meanwhile,the introduce of hydrophilic CNFs induced a desirable increase in diffusion path of electrons and ions,along with the synergistic effect among the three components,further endowed the electrode with excellent specific capacitance(0.734 F·cm^(-2))and good cycling stability(84.50%after 2000 charge/discharge cycles).More importantly,the flexible all-solid-state symmetric supercapacitor delivered a high specific capacitance(1.39 F·cm^(-2)at 1 mA·cm^(-2))and a volumetric energy density(6.36 mW·h·cm^(-3)at the power density of 16.35 mW cm^(-3)).This work provided a method for preparing composite films with desired mechanical and electrochemical performance,which can broaden the high-value applications of nanocellulose.

关键词： cellulose nanofibril molybdenum disulfide polypyrrole flexible supercapacitor

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一元溶剂体系TKX-50结晶形貌的分子动力学模拟

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原子与分子物理学报 2025年第4期42卷 163-167页

作者：董羚陈芳李天浩郭国琦贾翔宇米方琦宁瑞星中北大学化学与化工学院太原030051

本文应用分子动力学方法(MD)和修正的Dreiding-TKX-50力场计算了三种单溶剂作用下TKX-50重要晶面层与溶剂层的相互作用能,采用修正的附着能模型预测了TKX-50在不同溶剂中的结晶形貌并与实验结果进行了对比.计算结果表明,TKX-50晶体真空... 详细信息

本文应用分子动力学方法(MD)和修正的Dreiding-TKX-50力场计算了三种单溶剂作用下TKX-50重要晶面层与溶剂层的相互作用能,采用修正的附着能模型预测了TKX-50在不同溶剂中的结晶形貌并与实验结果进行了对比.计算结果表明,TKX-50晶体真空形貌中的重要晶面为(020)、(011)、(11-1)和(100).水(h_(2)O)溶剂和N,N-二甲基甲酰胺(DMF)溶剂作用后所预测的TKX-50晶体形貌近似梭形,纵横比为1.857和2.073.乙二醇(EG)溶剂作用后所预测的TKX-50晶体形貌为块体,纵横比为2.320.

关键词：附着能结晶形貌分子动力学 TKX-50 溶剂

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Intra-and interspecific diversity analyses in the genus Eremurus in Iran using genotyping-bysequencing reveal geographic population structure

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horticulture Research 2020年第1期7卷 2382-2394页

作者： hanieh hadizadeh Bochra A.Bahri Peng qi h.Dayton Wilde Katrien M.Devos Department of horticulture Faculty of AgricultureTarbiat Modares UniversityTehranIran Laboratory of Bioaggressors and Integrated Protection in Agriculture The National Agronomic Institute of TunisiaUniversity of Carthage1082 TunisTunisia Institute of Plant Breeding Genetics and Genomics(Department of Crop and Soil Sciences)and Department of Plant BiologyUniversity of GeorgiaAthensGA 30602USA Institute of Plant Breeding Genetics and Genomics(Department of Horticulture)University of GeorgiaAthensGA 30602USA Present address:Department of Plant Pathology University of GeorgiaGriffinGA 30223USA

Eremurus species,better known as‘Foxtail Lily’or‘Desert Candle’,are important worldwide in landscaping and the cutflower *** of the centers of highest diversity of the genus Eremurus is Iran,which has seven ***,little is known about the genetic diversity within the genus *** the advent of genotyping-bysequencing(GBS),it is possible to develop and employ single nucleotide polymorphism(SNP)markers in a costefficient manner in any species,regardless of its ploidy level,genome size or availability of a reference *** structure and phylogeographic analyses of the genus Eremurus in Iran using a minimum of 3002 SNP markers identified either at the genus level or at the species level from GBS data showed longitudinal geographic structuring at the country scale for the genus and for the species *** and ***,and at the regional scale for *** analyses furthermore showed a close genetic relatedness between *** and *** to the extent that they should be considered subspecies within an ***/stenophyllus species *** close genetic relatedness may explain why crosses between these two(sub)species have been found in the wild and are exploited extensively as ***,current species identification,while robust,relies on flower morphology.A subset of seven SNPs with species-specific(private)alleles were selected that differentiate the seven Eremurus *** markers will be especially useful for cultivar protection and in hybrid production,where true hybrids could be identified at the seedling stage.

关键词： structure furthermore centers

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Interfacial engineering of perfluoroalkyl functionalized covalent organic framework achieved ultra-long cycled and dendrite-free lithium anodes

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Nano Research 2023年第7期16卷 9289-9298页

作者： Yongxin Yang Conghui Zhang Zhiyuan Mei Yongjiang Sun qi An qi Jing Genfu Zhao hong Guo International Joint Research Center for Advanced Energy Materials of Yunnan Province Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon TechnologiesSchool of Materials and EnergyYunnan UniversityKunming 650091China

The finite lithium-ion utilization,short cycling life,and lower capacity retention caused by irreversible dendrite growth become the maximum dilemma in lithium metal batteries’(LMBs’)***,a perfluoroalkyl-functionalized covalent organic framework(COF-F6)equipped with high stability and supernal proton conduction is introduced as an artificial solid electrolyte interface to stable the lithium metal *** from the strong electron-withdrawing effect of perfluoroalkyl,Li^(+)will be freed more by the competition of electronegative fluorine(F)and bis(trifluoromethanesulphonyl)imide anion(TFSI^(-)).The dissociation of LiTFSI and process of Li^(+)desolvation are easier to *** addition,high electronegative fluorine can also regulate local electron-cloud density to induce the fast immigration of Li^(+).All the above roles contribute to improving the Li^(+)transfer number(0.7)and achieving the goal of inhibiting Li *** a result,the perfluoroalkyl COF-F6 modified LMB presents outstanding cycling *** symmetric batteries accomplish an overlong life-span of more than 5000 h with a lower hysteresis voltage(11 mV)at 5 mA·cm^(-2).Also,no dendrites are observed when using an in-situ optical microscope to learn the process of Li ***,this dendrite-free protection tactic holds broad prospects for the practical application of Li metal anodes.

关键词： perfluoroalkyl-functionalized covalent organic framework(COF-F6) artificial solid electrolyte interface strong electronwithdrawing effect dendrite-free lithium metal anode

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On Characteristic Functions of De Bruijn Sequences

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Chinese Journal of Electronics 2016年第2期25卷 304-311页

作者： TANG Zhenwei qi Wenfeng TIAN Tian Department of Applied Mathematics Zhengzhou Information Science and Technology Institute

In 1982, h. Fredricksen presented the upper and lower bounds of the number of ones in the truth table of characteristic functions of de Bruijn sequences. In this paper, the distribution of ones in the truth table of characteristic functions of de Bruijn sequences is further studied. We provide the upper and lower bounds of the number of ones in the partial truth table of characteristic functions of de Bruijn sequences. Furthermore, the two bounds are tight.

关键词： Nonlinear feedback shift registers De Bruijn sequences Weight of the truth table

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