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Removal of decabromodiphenyl ether （BDE-209） by sepiolite-supported nanoscale zerovalent iron

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Frontiers of Environmental Science & Engineering 2015年第5期9卷 867-878页

作者： Rongbing fu Na MU Xiaopin guo Zhen xu Dongsu BI School of Chemical and Environmental Engineering Shanghai Institute of Technology Shanghai 201418 China Shanghai Academy of Environmental Sciences Shanghai 200233 China

Nanoscale zerovalent iron （nZVI） synthesized using sepiolite as a supporter was used to investigate the removal kinetics and mechanisms of decabromodiphenyl ether （BDE-209）. BDE-209 was rapidly removed by the prepared sepiolite-supported nZVI with a reaction rate that was 5 times greater than that of the conventionally prepared nZVI because of its high surface area and reactivity. The degradation of BDE-209 occurred in a stepwise debromination manner, which followed pseudo- first-order kinetics. The removal efficiency of BDE-209 increased with increasing dosage of sepiolite-supported nZVI particles and decreasing pH, and the efficiency decreased with increasing initial BDE-209 concentrations. The presence of tetrahydrofuran （THF） as a cosolvent at certain volume fractions in water influenced the degrada- tion rate of sepiolite-supported nZVI. Debromination pathways of BDE-209 with sepiolite-supported nZVI were proposed based on the identified reaction intermedi- ates, which ranged from nona- to mono-brominated diphenylethers （BDEs） under acidic conditions and nonato penta-BDEs under alkaline conditions. Adsorption on sepiolite-supported nZVI particles also played a role in the removal of BDE-209. Our findings indicate that the particles have potential applications in removing environ- mental pollutants, such as halogenated organic contami- nants.

关键词： sepiolite-supported nanoscale zerovalent iron,decabromodiphenyl ether debromination adsorption,mechanism

Esophageal granular cell tumors:Report of 9 cases and a literature review

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World Journal of Gastroenterology 2012年第47期18卷 7118-7121页

作者： guo-Qiang xu Hong-Tan Chen Cheng-fu xu Xiao-Dong Teng Department of Gastroenterology the First Affiliated HospitalCollege of MedicineZhejiang University Department of Pathology the First Affiliated HospitalCollege of MedicineZhejiang University

Esophageal granular cell tumors(GCTs) are rare tumors of the *** evaluated the clinical and pathologic features of 9 esophageal GCT patients(5 men and 4 women) from our institute and reviewed the related disease *** age ranged from 25 to 53 years(mean:41 years).All the patients were asymptomatic or presented with non-specific *** GCTs occurred in the distal esophagus and were less than 6 mm in *** analysis showed that the average gray-scale endoscopic ultrasound images of esophageal GCTs were greater than that of esophageal *** patients were treated by endoscopic resection,and 1 patient underwent surgical *** post-therapy recurrence or metastasis developed during follow-up(mean:36.4 mo,range:1-72 mo).

关键词： Esophageal granular cell tumor Endoscopic ultrasonography Computer images analysis

Deconfinement Phase Transition Including Perturbative QCD Corrections in (Proto)neutron Star Matter

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Communications in Theoretical Physics 2008年第2期49卷 461-466页

作者： GU Jian-Fa guo Hua LEE Xi-guo LIU Yu-Xin xu fu-Rong Department of Technical Physics and MOE Laboratory of Heavy Ion Physics Peking University Beijing 100871 China Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator Lanzhou 730000 China Institute of Modern Physics The Chinese Academy of Sciences Lanzhou 730000 China Department of Physics Peking University Beijing 100871 China

Deconlinement phase transition and neutrino trapping in （proto）neutron star matter are investigated in a chiral hadronic model （also referred to as the FST model） for the hadronic phase （HP） and in the color-flavor-locked （CFL） quark model for the deconlined quark phase. We include a perturbative QCD correction parameter αs in the CFL quark matter equation of states. It is shown that the CFL quark core with K^0 condensation forms in neutron star matter with the large value of αs. If the small value of αs is taken, hyperons suppress the CFL quark phase and the liP is dominant in the high-density region of （proto）neutron star matter. Neutrino trapping makes the fraction of the CFL quark matter decrease compared with those without neutrino trapping. Moreover, increasing the QCD correction parameter as or decreasing the bag constant B and the strange quark mass ms can make the fraction of the CFL quark matter increase, simultaneously, the fraction of neutrino in protoneutron star matter increases, too. The maximum masses and the corresponding radii of （proto）neutron stars are not sensitive to the QCD correction parameter αs.

关键词： deconfinement phase transition neutrino trapping neutron star matter

Antikaon Condensation and In-medium Kaon and Antikaon Production in Protoneutron Stars

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Communications in Theoretical Physics 2007年第1期47卷 111-118页

作者： GU Jian-Fa guo Hua LI Xi-guo LIU Yu-Xin xu fu-Rong Department of Technical Physics and MOE Laboratory of Heavy Ion Physics Peking University Beijing 100871 China Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator Lanzhou 730000 China Institute of Modern Physics The Chinese Academy of Sciences Lanzhou 730000 China Department of Physics Peking University Beijing 100871 China

Antikaon condensation and kaon and antikaon production in protoneutron stars are investigated in a chiral hadronic model （also referred to as the FST model in this paper）. The effects of neutrino trapping on protoneutron stars are analyzed systematically. It is shown that neutrino trapping makes the critical density of K^- condensation delay to higher density and fifo condensation not occur. The equation of state （EOS） of （proto）neutron star matter with neutrino trapping is stiffer than that without neutrino trapping. As a result, the maximum masses of （proto）neutron stars with neutrino trapping are larger than those without neutrino trapping. If hyperons are taken into account, antikaon does not form a condensate in （proto）neutron stars. Meanwhile, the corresponding EOS becomes much softer, and the maximum masses of （proto）neutron stars are smaller than those without hyprons. Finally, our results illustrate that the Q values for K^＋ and K^- production in （proto）neutron stars are not sensitive to neutrino trapping and inclusion of hyperons.

关键词： protoneutron stars antikaon condensation neutrino trapping

NIR-Ⅱ responsive Janus nanoparticles amplify immunogenic cell death for enhanced cancer immunotherapy

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Science China(Technological Sciences) 2024年第1期67卷 321-329页

作者： CHEN BeiBei guo KangLi WANG HaoRan xu fu-Jian WANG JuLin ZHAO NaNa State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China Key Laboratory of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical Technology) Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing 100029China College of Materials Sciences and Engineering Beijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Electrochemical Process and Technology for Materials Beijing University of Chemical TechnologyBeijing 100029China

Immunotherapy brings new hope for tumor treatment by inducing immunogenic cell death(ICD)of tumor ***,insufficient immunogenicity and low immune response rate greatly limit antitumor ***,by optimizing the composition and morphology,the rational design of Janus nanoparticles composed of Fe_(3)O_(4) nanospheres and SiO_(2)nanorods was realized for enhanced cancer immunotherapy through amplified *** glucose oxidase(GOx)was loaded by the Janus nanoparticles,the resultant M-FS-GOx consumes glucose at tumor sites to generate gluconic acid and hydrogen peroxide(H_(2)O_(2))for starvation therapy while the H_(2)O_(2)supply promotes the production of highly toxic·OH to achieve effective chemodynamic therapy(CDT).Under a 1064 nm light irradiation,the photothermal effect of M-FS-GOx enhances the enzyme activity of GOx for improved starvation ***,both tumor-associated antigens released during the process of ICD and the intrinsic immunoadjuvant property of M-FS-GOx stimulate dendritic cell maturation to activate antitumor immune *** work provides a promising strategy for the construction of Janus nanoparticles to achieve enhanced cancer immunotherapy through combination therapy-amplified ICD.

关键词： Janus nanoparticles immunogenic cell death cancer immunotherapy

基于GRP78/PERK/CHOP通路探讨车叶草苷对胰腺癌细胞增殖、凋亡的影响

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现代消化及介入诊疗 2022年第10期27卷 1282-1287页

作者：曹龄之付国旭杨凡慧文丹李素平川北医学院附属医院核医学科 637000 绵阳第三人民医院核医学科 621000

目的探究车叶草苷(Asperuloside,Asp)通过调节葡萄糖调节蛋白78(glucose-regulated protein 78,GRP78)/蛋白激酶R样内质网激酶(protein kinase R-like ER kinase,PERK)/CCAAT/增强子结合蛋白同源蛋白(CCAAT/enhancer binding protein homologous protein,CHOP)信号通路对胰腺癌细胞增殖、凋亡的影响。方法收集42例胰腺癌组织及其癌旁的正常组织,并将胰腺癌组织分为24例转移组织和18例未转移组织。将sw1990细胞分为sw1990组(未作任何处理的sw1990细胞)、L-Asp组(1 mmol/L Asp)、M-Asp组(2 mmol/L Asp)、H-Asp组(3 mmol/L Asp)、4-PBA组(3 mmol/L Asp+1 mmol/L 4-PBA处理sw1990细胞)。CCK-8和Edu检测sw1990细胞增殖;流式细胞术检测sw1990细胞凋亡;划痕实验检测细胞迁移率;Transwell法检测sw1990细胞侵袭;Western blot检测上皮间质转化(EMT)蛋白、自噬、凋亡蛋白以及通路相关蛋白水平。结果正常组织、无转移的胰腺癌组织、有转移的胰腺癌组织GRP78、PERK、p-CHOP/CHOP蛋白水平依次显著降低(P<0.05)。与sw1990组相比,L-Asp组、M-Asp组、H-Asp组的sw1990细胞生长率、阳性率、迁移率以及侵袭细胞数量、vimentin、Twist1、Bcl-2蛋白水平依次显著下降(P<0.05),细胞凋亡率、E-cadherin、Bax、cleaved-Caspase-12、GRP78、PERK、p-CHOP/CHOP、Beclin1、LC3-II/I蛋白水平依次显著升高(P<0.05);与H-Asp组相比,4-PBA组sw1990细胞生长率、阳性率、迁移率以及侵袭细胞数量、vimentin、Twist1、Bcl-2蛋白水平显著上升(P<0.05),细胞凋亡率、E-cadherin、Bax、cleaved-Caspase-12、GRP78、PERK、p-CHOP/CHOP、Beclin1、LC3-II/I蛋白水平依次显著下降(P<0.05)。结论Asp可能通过上调GRP78/PERK/CHOP信号通路来抑制胰腺癌细胞的增殖,促进其凋亡。

关键词：车叶草苷 GRP78/PERK/CHOP信号通路胰腺癌增殖凋亡

车叶草苷通过内质网应激促进胰腺癌细胞凋亡的机制研究

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川北医学院学报 2023年第11期38卷 1469-1474页

作者：曹龄之付国旭陈飞李素平杨凡慧川北医学院附属医院核医学科四川南充637000 绵阳市第三人民医院核医学科四川绵阳621000

目的:探讨车叶草苷(ASP)通过内质网应激(ERS)诱导胰腺癌(PC)细胞凋亡的机制。方法:选取人胰腺癌PANC-1细胞作为研究对象。将PANC-1细胞按照随机数字表法分为4组,分别为对照组、ASP组、ERS抑制剂4-苯基丁酸(4-Phenylbutyric acid,4-PBA)... 详细信息

目的:探讨车叶草苷(ASP)通过内质网应激(ERS)诱导胰腺癌(PC)细胞凋亡的机制。方法:选取人胰腺癌PANC-1细胞作为研究对象。将PANC-1细胞按照随机数字表法分为4组,分别为对照组、ASP组、ERS抑制剂4-苯基丁酸(4-Phenylbutyric acid,4-PBA)组和ASP+4-PBA组。采用CCK-8检测细胞增殖情况,采用流式细胞术检测细胞凋亡情况,Transwell法检测细胞迁移,蛋白质印迹法检测细胞中活化转录因子6(ATF6)、C/BEP环腺苷酸反应元件结合转录因子同源蛋白(CHOP)、活化的半胱氨酸蛋白酶3(cleaved-caspase 3)、蛋白激酶R样内质网激酶(PERK)及肌醇依赖性激酶1α磷酸化蛋白(p-IRE1α)相对表达水平。结果:随着ASP浓度的增加,PANC-1细胞增殖率呈下降趋势。与对照组相比,ASP组迁移细胞数量降低,细胞凋亡率增加,ATF6、CHOP、cleaved-caspase-3、PERK及p-IRE1α蛋白相对表达水平上升,差异均有统计学意义(P<0.05)。与ASP组相比,ASP+4-PBA组细胞迁移数量增多、细胞凋亡率下降(P<0.05),ATF6、CHOP、cleaved-caspase-3、PERK及p-IRE1α蛋白相对表达水平下降,差异均有统计学意义(P<0.05)。结论:ASP能够从细胞增殖、迁移、凋亡三个方面降低胰腺癌细胞活性,其作用机制可能与激活ERS有关。

关键词：胰腺癌车叶草苷内质网应激细胞凋亡

Impact of the CoFe microstructure etched surface oxidation on Co spin and orbital moment

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Science China(Physics,Mechanics & Astronomy) 2013年第3期56卷 588-592页

作者： guo YuXian ZHANG ZiJun WANG Jie fu ShaoJun xu PengShou Department of Mathematics & Physics Anhui University of Architecture National Synchrotron Radiation Laboratory University of Science and Technology of China

Patterned ferromagnetic thin film shows promising applications in ultra-high density magnetic storage,magnetoresistive transducer,magnetic random access memory and many other *** the performance of these devices is closely associated with the magnetic properties of the etched patterns,it is necessary to study the effects of freshly etched surface oxidation on the magnetic properties of the patterned *** the current work,were carried out an X-ray Magnetic Circular Dichroism(XMCD) study on a 50 nm Co 0.9 Fe 0.1 continuous thin film and a related patterned Co 0.9 Fe 0.1 grating structure etched with a 2 μm *** on the sum rules,the spin and orbital moments were calculated for these two samples,*** results indicated that the spin and orbital moments of grating structure(1.34μ B and 0.24μ B,respectively) decreased 17.3% compared with the corresponding continuous film(1.62μ B and 0.29μ B,respectively).We proposed that the moment decreasing of the patterned grating structure was mainly caused by the etched surface oxidation during the pattern manufacture *** oxidation ratio of Co element in the patterned grating structure is 14.4% calculated from X-ray absorption spectroscopy(XAS) *** the oxidation ratio,we amend the spin and orbital moment of Co and the amended result is basically in accordance with that of continuous film,demonstrating that the difference of the spin and orbital moments between the sub-micron grating unit and the continuous film is really caused by the oxidation.

关键词： magnetic grating structure X-ray Magnetic Circular Dichroism(XMCD) spin moment orbital moment absorption spectrum fitting

Variation characteristic of drilling force and influence of cutting parameter of SiCp/Al composite thin-walled workpiece

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Advances in Manufacturing 2019年第3期7卷 288-302页

作者： Shu-Tao Huang Chao Li Li-fu xu Lin guo Xiao-Lin Yu School of Automobile and Traffic Shenyang Ligong UniversityShenyang 110159People's Republic of China School of Mechanical Engineering Dalian University of TechnologyDalian 116024LiaoningPeople's Republic of China School of Mechanical Engineering Shenyang Ligong UniversityShenyang 110159People's Republic of China

In this paper,the variation characteristic of the drilling force,and the influences of cutting speed,feed rate,and workpiece thickness on the drilling force,were eval・uated when drilling a silicon carbide particle reinforced aluminum matrix(SiCp/Al)composite thin-walled workpiece with a high volume *** the condition that the workpiece thickness was less than the drill tip height,three characteristic stages of drilling force variation were *** results indicate that there is a sign币cant difference between the variations in the drilling force when drilling a thin-walled workpiece compared to thick-walled *** the chisel edge drills out the lower surface of the workpiece,there is an abrupt decrease in the thrust forces of the thin-walled and thick-walled *** addition,there is an abrupt decrease in the torque of the thick-walled workpiece,whereas that of the thinwalled workpiece *** to the thickness of the thin-walled workpiece,the instant of the abrupt decrease in the thrust force may lead or lag behind the theoretical instant at which the chisel edge reaches the lower surface of the workpiece without *** drilling a thin-walled hole,the cutting speed has a slight influence on the thrust force,and there is a slight increase in the torque in accordance with an increase in the cutting *** thrust force and torque increase in accordance with an increase in the feed *** drilling a thinwalled workpiece with a thickness of 1 mm,the critical thickness of workpiece cracking decreases in accordance with an increase in the cutting speed,and increases in accordance with an increase in the feed *** drilling a thin-walled workpiece with a thickness of 0.5 mm,the concave deformation of the workpiece and the critical thickness of the workpiece cracking increase in accordance with an increase in the feed ***,the increment in the critical thickness of the workpiece cracking is less than that in

关键词： SiCp/Al composites Thin-walled workpiece Drilling Drilling force