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Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan Liu Rui-Xia Ma Xian-Bao Cao Hua Zhang Shui-Hong Zhou Wei-Hong Jiang Yan Jiang Jing-Wu Sun Qin-Tai Yang Xue-Zhong Li Ya-Nan Sun Li Shi Min Wang Xi-Cheng Song Fu-Quan Chen Xiao-Shu Zhang Hong-Quan Wei Shao-Qing yu dong-dong Zhu Luo Ba Zhi-Wei Cao Xu-Ping Xiao Xin Wei Zhi-Hong Lin Feng-Hong Chen Chun-Guang Shan Guang-Ke Wang Jing Ye Shen-Hong Qu Chang-Qing Zhao Zhen-Lin Wang Hua-Bin Li Feng Liu Xiao-Bo Cui Sheng-Nan Ye Zheng Liu yu Xu Xiao Cai Wei Huang Ru-Xin Zhang yu-Lin Zhao guo-dong yu Guang-Gang Shi Mei-Ping Lu Yang Shen yu-Tong Zhao Jia-Hong Pei Shao-Bing Xie Long-Gang yu Ye-Hai Liu Shao-Wei Gu yu-Cheng Yang Lei Cheng Jian-Feng liu Graduate School of Beijing University of Chinese Medicine BeijingChina Department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina Department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina Department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina Department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina Department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina Department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

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大宁—吉县地区5号煤层现今地应力预测及其对煤层气开发的影响

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科学技术与工程 2024年第13期24卷 5286-5295页

作者：于国栋鞠玮杨兆彪中国矿业大学煤层气资源与成藏过程教育部重点实验室徐州221008 中国矿业大学资源与地球科学学院徐州221116

现今地应力场对煤储层渗透率具有极其重要的控制作用。中国鄂东大宁—吉县地区煤层气资源丰富,然而该区现今地应力研究程度较低,限制着该区煤层气的高效开发。为查明大宁—吉县地区主采煤层现今地应力场特征,利用三维有限元数值模拟方... 详细信息

现今地应力场对煤储层渗透率具有极其重要的控制作用。中国鄂东大宁—吉县地区煤层气资源丰富,然而该区现今地应力研究程度较低,限制着该区煤层气的高效开发。为查明大宁—吉县地区主采煤层现今地应力场特征,利用三维有限元数值模拟方法对下二叠统山西组5号煤层现今地应力分布进行预测。结果表明,5号煤层现今地应力表现为正断型应力机制。鄂东大宁—吉县5号煤层最大水平主应力在15.4~21.6 MPa,最小水平主应力在9.8~14.4 MPa,构造变形的复杂性影响地应力分布。现今地应力控制压裂裂缝扩展,研究区现今地应力状态下的压裂缝沿NNW-SSE向垂直扩展。研究区5号煤层应力差大部分小于6 MPa,具备形成复杂裂缝网络的地应力基础。煤层渗透率随有效地应力的增大呈指数减小,有效地应力越大,煤储层的渗透性越差。研究区东南部远离断层,地应力值相对较低,有利于形成煤层气富集区。研究成果可为大宁—吉县地区煤层气效益开发提供地质基础与科学指导。

关键词：现今地应力大宁—吉县地区 5号煤层数值模拟渗透率

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川南泸州区块五峰-龙马溪组现今地应力特征与页岩气开发

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科学技术与工程 2024年第8期24卷 3200-3206页

作者：刘钰洋鞠玮熊伟郭为宁卫科于国栋梁孝柏李永康中国石油天然气股份有限公司勘探开发研究院北京100083 煤层气资源与成藏过程教育部重点实验室徐州221008 中国矿业大学资源与地球科学学院徐州221116

川南泸州区块是中国重要的页岩气产区,其内五峰-龙马溪组页岩气资源丰富,勘探-开发潜力巨大。现今地应力在页岩气运移与富集规律分析、钻完井工程、储层压裂改造以及井网部署等方面均具有重要应用。分析泸州区块五峰-龙马溪组深层页岩... 详细信息

川南泸州区块是中国重要的页岩气产区,其内五峰-龙马溪组页岩气资源丰富,勘探-开发潜力巨大。现今地应力在页岩气运移与富集规律分析、钻完井工程、储层压裂改造以及井网部署等方面均具有重要应用。分析泸州区块五峰-龙马溪组深层页岩气储层现今地应力状态,并探讨在其影响下的天然裂缝活动性与压裂裂缝扩展。结果表明:五峰-龙马溪组页岩气储层现今地应力方向呈现WNW-ESE的优势方位;现今地应力值大小为:水平最大主应力最大、垂向主应力居中、水平最小主应力最小,指示走滑型地应力机制。五峰组和龙一11小层水平主应力差分别介于11.90~15.76 MPa和11.80~16.75 MPa范围内,具备形成复杂压裂缝网的地应力条件。在现今地应力条件下,川南泸州区块五峰-龙马溪组页岩气储层天然裂缝不活动,随着开发流体的注入,天然裂缝逐渐活化,其压力增量的临界值为15~23 MPa;压裂后主要形成垂向延伸的裂缝系统。研究成果可为川南泸州区块深层页岩气效益开发提供现今地应力分析的基础与科学依据。

关键词：现今地应力地应力剖面裂缝活动性深层页岩气泸州区块

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Generation of Four-Mode Cluster-Type Entangled Coherent States in Free-Traveling Optical Fields

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Communications in Theoretical Physics 2011年第3期55卷 426-430页

作者： HE Dai-guo dong yu-Li FANG Jian-Xing QIAN Li HU Jie School of Physical Science and Technology Suzhou University Suzhou 215006 China

In this paper, we propose an optical scheme to generate four-mode cluster-type entangled coherent states （ECSs） in free traveling optical fields by using two single-photon sources, coherent state sources, beam splitters, pho- todetectors, cross-Kerr media, and phase shifters. And the success probability of the states preparation is calculated. At last we discuss the experimental feasibility of such proposal.

关键词： cluster states coherent states beam splitters cross-Kerr media

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Tailoring the austenite characteristics via dual nanoparticles to synergistically optimize the strength-ductility in cold rolled medium Mn steel

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Journal of Materials Science & Technology 2024年第2期169卷 158-171页

作者： Qizhe Ye Haokai dong Qinyi guo Yishuang yu Lijie Qiao yu Yan Beijing Advanced Innovation Center for Materials Genome Engineering Corrosion and Protection CenterInstitute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou 510641China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

In this work,we proposed a novel Cu/θdual nanoparticles strategy to tailor the austenite characteris-tics of a medium Mn steel via a tempering-annealing process to optimize the mechanical *** explored the effects of Cu-rich particles and cementite precipitated in the tempering process on the austenite reversion during the subsequent annealing *** experiments and numerical simula-tions verified that the austenite inherited from cementite had a finer size and a higher Mn enrichment compared with the austenite originating from the tempered martensite *** addition,quantitative evaluations revealed that the pinning effect exerted by the Cu-rich particles could significantly hinder theα/γinterface migration and the recrystallized grain growth,thereby further refining the final *** contributions from the effects of dual nanoprecipitates on the austenite reversion,the heterogeneous austenite grains inherited from varying nucleation sites ensured the sustained and gradual deformation-induced martensite and twinning ***,the Cu-added steels subjected to a tempering-annealing process achieved synergetic enhancement of the tensile strength from 1055 MPa to 1250 MPa and elongation from 33%to 45%.This strategy may provide new guidance for the development and alloy design of high-performance medium Mn steels.

关键词： Dual nanoparticles Medium Mn steel Tempering-annealing process Austenite reversion Mechanical properties

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Facial landmark disentangled network with variational autoencoder

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Applied Mathematics(A Journal of Chinese Universities) 2022年第2期37卷 290-305页

作者： LIANG Sen ZHOU Zhi-ze guo yu-dong GAO Xuan ZHANG Ju-yong BAO Hu-jun CAD&CG State Labs Zhejiang UniversityHangzhou 310027China School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026China.

Learning disentangled representation of data is a key problem in deep ***,disentangling 2D facial landmarks into different factors(e.g.,identity and expression)is widely used in the applications of face reconstruction,face reenactment and talking head et al..However,due to the sparsity of landmarks and the lack of accurate labels for the factors,it is hard to learn the disentangled representation of *** address these problem,we propose a simple and effective model named FLD-VAE to disentangle arbitrary facial landmarks into identity and expression latent representations,which is based on a Variational Autoencoder ***,we propose three invariant loss functions in both latent and data levels to constrain the invariance of representations during training ***,we implement an identity preservation loss to further enhance the representation ability of identity *** the best of our knowledge,this is the first work to end-to-end disentangle identity and expression factors simultaneously from one single facial landmark.

关键词： disentanglement representation deep learning facial landmarks variational autoencoder

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Multi-physical fields distribution in billet during helical electromagnetic stirring:A numerical simulation research

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China Foundry 2024年第1期21卷 51-59页

作者： dong Pan Qing-tao guo Kai-lun Zhang Fu-zhi yu yu-ying Li yu-bao Xiao State Key Laboratory of Metal Materials for Marine Equipment and Application Anshan 114009LiaoningChina Ansteel Beijing Research Institute Co. Ltd.Beijing 102200China

Electromagnetic stirring is one of the widely applied techniques to modify the quality of casting *** from conventional rotate stirring,the helical stirring is more professional in assisting multi-dimensional flow of molten metal and eliminating solidification *** this study,the single-winding helical stirring(SWHS)was introduced,offering advantages such as smaller volume and lower electromagnetic shielding compared to traditional helical stirring *** a comprehensive numerical simulation,the stirring parameters of SWHS were adjusted to yoke inclination angle of 43°and frequency of 12 *** higher electromagnetic force and flow velocity in drawing direction,as well as the lower temperature gradient induced by the SWHS,are positive factors for homogeneous solidification of *** experimental results on Al-8%Si alloy and 0.4%C-1.1%Mn steel demonstrate that compared to rotate stirring,the SWHS process can induce better billet quality and is more effective in accelerating the equiaxed expansion and reducing element *** SWHS process can enhance the equiaxed ratio of the billet by 58.3%and reduce segregation degree of carbon element by 10.97%.Consequently,SWHS holds great promise as a potential approach for improving the quality of continuous casting billets.

关键词： billet electromagnetic stirring helical solidification element segregation numerical simulation

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Proposal for valleytronic materials:Ferrovalley metal and valley gapless semiconductor

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Frontiers of physics 2024年第2期19卷 131-139页

作者： San-dong guo yu-Ling Tao Guangzhao Wang Shaobo Chen dong Huang Yee Sin Ang School of Electronic Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121China Key Laboratory of Extraordinary Bond Engineering and Advanced Materials Technology of Chongqing School of Electronic Information EngineeringYangtze Normal UniversityChongqing 408100China College of Electronic and Information Engineering Anshun UniversityAnshun 561000China Science Mathematics and Technology(SMT)Singapore University of Technology and Design(SUTD)8 Somapah RoadSingapore 487372Singapore

Valleytronic materials can provide new degrees of freedom to future electronic *** this work,the concepts of the ferrovalley metal(FVM)and valley gapless semiconductor(VGS)are proposed,which can be achieved in valleytronic bilayer systems by electric field *** valleytronic bilayer systems,the interaction between out-of-plane ferroelectricity and A-type antiferromagnetism can induce layer-polarized anomalous valley Hall(LP-AVH)*** K and−K valleys of FVM are both metallic,and electron and hole carriers simultaneously *** the extreme case,the FVM can become VGS by analogizing spin gapless semiconductor(SGS).Moreover,it is proposed that the valley splitting enhancement and valley polarization reversal can be achieved by electric field engineering in valleytronic bilayer *** the bilayer RuBr_(2)as an example,our proposal is confirmed by the first-principle *** FVM and VGS can be achieved in bilayer RuBr_(2)by applying electric *** appropriate electric field range,increasing electric field can enhance valley splitting,and the valley polarization can be reversed by flipping electric field *** effectively tune valley properties by electric field in bilayer systems,the parent monolayer should possess out-of-plane magnetization,and have large valley *** results shed light on the possible role of electric field in tuning valleytronic bilayer systems,and provide a way to design the ferrovalley-related material by electric field.

关键词： valleytronics electric field bilayer

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Resonance mechanism of flapping wing based on fluid structure interaction simulation

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Chinese Journal of Aeronautics 2024年第5期37卷 243-262页

作者： yueyang guo Wenqing YANG yuanbo dong dong XUE National Key Laboratory of Science and Technology on Aerodynamic Design and Research School of AeronauticsNorthwestern Polytechnical UniversityXi'an 710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518063China Yangtze River Delta Research Institute of Northwestern Polytechnical University Taicang 215400China

Certain insect species have been observed to exploit the resonance mechanism of their *** order to achieve resonance and optimize aerodynamic performance,the conventional approach is to set the flapping frequency of flexible wings based on the Traditional Structural Modal(TSM)***,there exists controversy among researchers regarding the relationship between frequency and aerodynamic *** that the structural response of wings can be influenced by the surrounding air vibrations,an analysis known as Acoustic Structure Interaction Modal(ASIM)is introduced to calculate the resonant *** this study,Fluid Structure Interaction(FSI)simulations are employed to investigate the aerodynamic performance of flapping wings at modal frequencies derived from both TSM and ASIM *** performance is evaluated for various mass ratios and frequency ratios,and the findings indicate that the deformation and changes in vortex structure exhibit similarities at mass ratios that yield the highest aerodynamic ***,the flapping frequency associated with the maximum time-averaged vertical force coefficient at each mass ratio closely aligns with the ASIM frequency,as does the frequency corresponding to maximum ***,the ASIM analysis can provide an effective means for predicting the optimal flapping frequency for flexible ***,it enables the prediction that flexible wings with varying mass ratios will exhibit similar deformation and vortex structure *** paper offers a fresh perspective on the ongoing debate concerning the resonance mechanism of Flexible Flapping Wings(FFWs)and proposes an effective methodology for predicting their aerodynamic performance.

关键词： Flexible Flapping Wing(FFW) Acoustic Structure Interaction Modal(ASIM) Fluid Structure Interaction(FSI) Resonance mechanism Aerodynamic performance

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Novel variants in DNAH6 cause male infertility associated with multiple morphological abnormalities of the sperm flagella(MMAF)and ICSI outcomes

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Asian Journal of Andrology 2024年第1期26卷 91-98页

作者： Zhong-Mei Shao yu-Tong Zhu Meng Gu Sen-Chao guo Hui yu Kuo-Kuo Li dong-dong Tang yu-Ping Xu Ming-Rong Lv Reproductive Medicine Center Department of Obstetrics and Gynecologythe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Obstetrics and Gynecology Fuyang Hospital of Anhui Medical UniversityFuyang 236112China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University) Hefei 230032China Key Laboratory of Population Health Across Life Cycle(Anhui Medical University) Ministry of Education of the People'sRepublicof ChinaHefei 230032China

Variations in the dynein axonemal heavy chain gene,dynein axonemal heavy chain 6(DNAH6),lead to multiple morphological abnormalities of the *** studies have reported that these deficiencies may result in sperm head ***,whether DNAH6 is also involved in human acrosome biogenesis remains *** purpose of this study was to investigate DNAH6 gene variants and their potential functions in the formation of defective sperm heads and ***-exome sequencing was performed on a cohort of 375 patients with asthenoteratozoospermia from the First Affiliated Hospital of Anhui Medical University(Hefei,China).Hematoxylin and eosin staining,scanning electron microscopy,and transmission electron microscopy were performed to analyze the sperm morphology and *** staining and Western blot analysis were conducted to examine the effects of genetic *** identified three novel deleterious variants in DNAH6 among three unrelated *** absence of inner dynein arms and radial spokes was observed in the sperm of patients with DNAH6 ***,deficiencies in the acrosome,abnormal chromatin compaction,and vacuole-containing sperm heads were observed in these patients with DNAH6 *** decreased levels of the component proteins in these defective structures were further confirmed in sperm from patients with DNAH6 variants using Western *** intracytoplasmic sperm injection(ICSl)treatment,the partner of one patient with a DNAH6 variant achieved successful ***,novel variants in DNAH6 genes that contribute to defects in the sperm head and flagella were identified,and the findings indicated Icsl as an effective clinical treatment for such patients.

关键词： asthenoteratospermia DNAH6 intracytoplasmic sperm injection male infertility

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